Expression profiling of KRAS and NOXA genes as prospective biomarkers in ovarian carcinoma.

Background: Ovarian cancer (OC) is a leading cause of cancer deaths in women. Comprehensive molecular studies are required to understand OC pathogenesis. KRAS and NOXA genes are involved in tumorigenesis and disease progression.

Scarred and complex colorectal polyps: Traditional techniques and emerging alternatives.

Colorectal polyps remain a significant health concern because they can develop into cancer. Therefore, accurate assessment and diagnosis of polyps, along with appropriate treatment decisions, are crucial in preventing complications or malignant transformation. Some polyps are classified as complex polyps, which means they fail to elevate due to a scar from a previously removed polyp or can be determined by a scoring system like the size/morphology/site/access score, which considers factors like site, morphology, size, and access.

The efficacy and safety of endoscopic submucosal resection in periappendiceal lesions: a systematic review and meta-analysis.

Introduction: Endoscopic submucosal dissection (ESD) is a promising technique for early-stage gastrointestinal neoplasms; however, its use for periappendiceal lesions poses challenges because of anatomical complexities and the potential risk of appendicitis or perforation. As a result, these lesions are often managed surgically. This systematic review and meta-analysis evaluate the safety and efficacy of ESD for periappendiceal lesions.

Spatial profiling of longitudinal glioblastoma reveals consistent changes in cellular architecture, post-treatment.

Background: Glioblastoma (GBM), the most aggressive adult brain cancer, comprises a complex tumour microenvironment (TME) with diverse cellular interactions that drive progression and pathobiology. The aim of this study was to understand how these spatial patterns and interactions evolve with treatment.

Methods: To explore these relationships, we employed imaging mass cytometry to measure the expression of 34 protein markers, enabling the identification of GBM-specific cell types and their interactions at single-cell protein level in paired primary (pre-treatment) and recurrent (post-treatment) GBM samples from five patients.

Unveiling the photothermal mechanism and therapeutic potential of quercetin-loaded MXene-ZMOF@Chitosan in MCF-7 breast cancer.

Breast cancer remains a significant global health challenge, necessitating innovative therapeutic strategies. This study introduces a novel Q-MX-ZMOF@CH nanocomposite, integrating MXene with zinc-based metal-organic frameworks (ZMOF) and chitosan (CH) to targeted quercetin (Q) delivery and enhanced photothermal therapy (PTT) for breast cancer therapy. TEM imaging of Q-MX-ZMOF@CH indicated spherical morphologies with size distribution (∼60 nm).