PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment.

The PI3K/AKT/mTOR signaling axis is a pivotal regulator of key cellular functions, including proliferation, metabolism, survival, and immune modulation. In cancer, its dysregulation drives malignant transformation, tumor progression, therapeutic resistance, and immune evasion. Despite numerous studies, an integrated understanding of this pathway's multifaceted role in tumor biology and treatment remains incomplete.

First record of Logunov & Jäger, 2015 (Araneae, Selenopidae) from China, with first description of the female.

Background: Logunov & Jäger, 2015 was originally described, based on a male specimen collected from Vietnam, with the female remaining unknown.

New Information: Based on specimens collected from Shenzhen City, Guangdong Province, the female of Logunov & Jäger, 2015 is described for the first time. This species is newly recorded from China.

Exploring the potential molecular targets and therapeutic mechanisms of Cyperi Rhizoma in treating diabetic cardiomyopathy: a computational approach.

Diabetic cardiomyopathy (DCM) is a major contributor to heart failure in diabetic patients, characterized by complex pathophysiological mechanisms and a lack of effective targeted therapies. Cyperi Rhizoma (CR), a traditional Chinese medicinal herb, has shown potential in regulating Qi and improving metabolic disorders, yet its therapeutic mechanisms in DCM remain unclear. This study systematically explored the bioactive components and underlying mechanisms of CR in the treatment of DCM by integrating network pharmacology, molecular docking, molecular dynamics simulation (MDS), and experiments.

On small huntsman spiders (Araneae, Philodromidae) occurring in Guizhou and Hubei provinces, China.

Spiders of the family Philodromidae Thorell, 1869 from Guizhou and Hubei provinces, China are studied. A total of three genera and seven species are reported and illustrated, comprising (newly recorded genus for Hubei), and all known species from both provinces: L. Koch, 1878, Long & Yu, 2022, Bösenberg & Strand, 1906, Jang, Lee, Yoo & Kim, 2024 (the previously records of Simon, 1895 from Guizhou and Hubei are presumed to be misidentifications, and should belong to ), Walckenaer, 1826 (new record for Hubei) and Efimik, 1999 (new record for Hubei).

Influencing Factors of Chinese Consumers' Acceptance of Irradiated Food.

Food irradiation enhances food safety and shelf life, but consumer acceptance in China is hindered by radiation-related misconceptions and low awareness. This study investigated 556 Chinese consumers through an online survey, analyzing demographic influences and attitudes via SPSSAU. The key findings revealed a strong preference for the term "ionized food" (69% acceptance) over "irradiated food" (31%), particularly among those with nuclear risk concerns.

New data on the huntsman spiders (Araneae, Sparassidae) of China.

Background: Sparassidae Bertkau, 1872 is the tenth largest family of Araneae, with 11 genera and 288 species known in China.

New Information: In the current paper, four newly-recorded species from China are provided: Korai & Jäger, 2024, (Kroneberg, 1875), Jäger, 2012 and Jäger, 2003, of which is re-described, based on specimens collected from Xinjiang Uygur Autonomous Region, China. Additionally, a new species, sp.

Re-description of Dankittipakul & Jocqué, 2004 (Araneae, Zodariidae), with a first description of the male.

Background: Dankittipakul & Jocqué, 2004 was described, based on a single female from Doi Luang National Park, Thailand and no additional specimens have been recorded since.

New Information: is re-described and illustrated, based on new material from Xishuangbanna, China. The male is described and illustrated for the first time.

Re-description of Zhong, Jäger, Chen & Liu, 2019 (Araneae, Sparassidae), with a first description of the female.

Background: Jäger, 1999 is a relatively large spider genus that currently comprises 141 species distributed worldwide. However, the genus remains inadequately studied because nearly half of the species are known from a single sex or juvenile specimens. Zhong, Jäger, Chen & Liu, 2019 was described, based on two male specimens from Damingshan National Nature Reserve, Guangxi Zhuang Autonomous Region, China and no additional specimens have been recorded since.

Metal free C-O bond cleavage: a new strategy for the synthesis of substituted oxazoles.

A strategy for the efficient metal-free C-O bond cleavage of ester using amines for the synthesis of substituted oxazoles was developed for the first time. The synthesis proceeded smoothly under metal-free conditions, combining C-O bond cleavage as well as C-N and C-O bond formation in one pot to yield desired products in moderate to excellent yields, and accommodated a wide range of functional groups and substrates.

One new species of Jäger, 2000 from Shennongjia, Central China (Araneae, Sparassidae).

Background: Jäger, 2000 is currently the largest genus in the family Sparassidae Bertkau, 1872, comprising 255 species. Of these, 154 species have been recorded in China, representing 60.4% of the global species.

Dichroic switching of core-shell plasmonic nanoparticles on reflective surfaces.

Plasmonic metal nanostructures can simultaneously scatter and absorb light, with resonance wavelength and strength depending on their morphology and composition. This work demonstrates that unique dichroic effects and high-contrast colour-switching can be achieved by leveraging the resonant scattering and absorption of light by plasmonic nanostructures and the specular reflection of the resulting transmitted light. Using core/shell nanostructures comprising a metal core and a dielectric shell, we show that their spray coating on reflective substrates produces dichroic films that can display colour switching at different viewing angles.

Facile preparation of a CoNiS/CF electrode by SILAR for a high sensitivity non-enzymatic glucose sensor.

The nanomaterials for non-enzymatic electrochemical sensors are usually pre-synthesized and coated onto electrodes by methods. In this work, amorphous cobalt-nickel sulfide (CoNiS) nanoparticles were facilely prepared on copper foam (CF) by the successive ionic layer adsorption and reaction (SILAR) method, and as-prepared CoNiS/CF was studied as an electrode for non-enzymatic glucose sensing. It was analyzed by field emission scanning electron microscopy (FESEM), energy dispersive X-ray analysis (EDAX) and X-ray photoelectron spectroscopy (XPS).

A missense variant causes brachydactyly type A1 and multiple-synostoses syndrome 2.

Objective: This study aimed to identify the molecular defects and clinical manifestations in a Chinese family with brachydactyly (BD) type A1 (BDA1) and multiple-synostoses syndrome 2 (SYNS2).

Methods: A Chinese family with BDA1 and SYNS2 was enrolled in this study. Whole-exome sequencing was used to analyze the gene variants in the proband.

First description of the male of Hu & Li, 1987 (Araneae, Oecobiidae) from Shigatse City, Tibet, China.

Background: With 90 described species, the genus Lucas, 1846 is the largest genus of the family Oecobiidae Blackwall, 1862, five of which are known from China. Since was described by Hu & Li in 1987, no males of this species have ever been reported.

New Information: The male of is described for the first time, based on the specimens collected in Tibet Autonomous Region.

Research on irradiated food status and consumer acceptance: A Chinese perspective.

China is currently the world's largest producer of food irradiation. Despite the long-standing (about 100 years) evidence supporting the safety of food irradiation, consumers' acceptance of irradiated foods remains limited. This study aimed to investigate the development of food irradiation in China and identify the barriers that keep consumers away from irradiated foods.

Two new species of from China, with first description of the male of Zhong, Cao & Liu, 2017 (Araneae, Sparassidae).

Three species of spider genus Jäger, 1999 are reported from southern China. Two of them are described as new to science: Zhang, Yu & Zhong, and Zhang, Yu & Zhong, , both from Guizhou Province. The male of Zhong, Cao & Liu, 2017 is described for the first time based on new material from the type locality, Wuyishan National Nature Reserve, Fujian Province, China.

A new species of the -group (Araneae, Clubionidae) from Jiugong Mountains, Hubei Province, central China.

Background: The group is one of most diverse species-group in genus Latreille, 1804. Currently, a total of 81 group species are known worldwide, amongst them 67 were recorded from China. However, the diversity of this group in China is still insufficiently known.

Intra-muscular extraskeletal myxoid chondrosarcoma of the thigh: a case report.

Soft tissue sarcomas are mesenchymal tumors that account for about 1% of all malignancies. We retrospectively analyzed a rare case of a painful intra-muscular extraskeletal myxoid chondrosarcoma in the thigh of a 35-year-old man, that had undergone excision. Histological and immunohistochemical analysis of the mass revealed extraskeletal myxoid chondrosarcoma.

USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1.

Deubiquitinating enzyme dysregulation has been linked to the development of a variety of human malignancies, including breast cancer. However, the exact involvement of the deubiquitinating enzyme USP39 in the progression of breast cancer is yet unknown. Cell viability and colony formation analysis was used to assess the effects of USP39 knockdown on breast cancer cells in this study.

[Protective effect of salidroside on high fat-induced apoptosis in H9c2 cardiomyocytes through AMPK/mTOR/p70S6K pathway].

The study explored the effect of salidroside(SAL) on high fat-induced apoptosis in H9 c2 cardiomyocytes based on AMPK/mTOR/p70 S6 K pathway.H9 c2 cardiomyocytes were cultured in vitro and the lipotoxicity model of H9 c2 cardiomyocytes was constructed by 0.2 mmol·L~(-1) palmitic acid(PA) treatment for 24 hours.

Field investigation- and dietary metabarcoding-based screening of arthropods that prey on primary tea pests.

Predatory natural enemies play key functional roles in biological control. Abundant predatory arthropod species have been recorded in tea plantation ecosystems. However, few studies have comprehensively evaluated the control effect of predatory arthropods on tea pests in the field.

Improving the curing and flame retardancy of epoxy resin composites by multifunctional Si-containing cyclophosphazene derivatives.

Novel star-like molecules containing P, N and Si with dual functions of flame retardance and curing promotion (abridged as HCCP-KH540) were successfully synthesized through the nucleophilic substitution reaction of hexachlorocyclotriphosphazene (HCCP) and 3-aminopropyltrimethoxysilane (KH540). HCCP-KH540 was incorporated with the matrix of epoxy resin (EP) to form a flame retardant composite abridged as E-HK. The activation energy of the curing reaction of the E-HK composite was reduced but the curing reaction rate was accelerated by HCCP-KH540.

Radiation-initiated high strength chitosan/lithium sulfonate double network hydrogel/aerogel with porosity and stability for efficient CO capture.

Developing efficient and inexpensive CO capture technologies is a significant way to reduce carbon emissions. In this work, a novel chitosan/lithium sulfonate double network high strength hydrogel is synthesized by electron beam radiation. Due to the electron beam having a wide radiation area and certain penetrating power, the free radical polymerization can be initiated more uniformly and quickly in the hydrogel.

Nitrogen-doped lignin-derived carbon for catalytic reduction of hexavalent chromium HCOOH-mediated hydrogenation.

It is highly desirable to explore efficient catalysts for reducing toxic Cr to benign Cr under mild and eco-friendly conditions. This article describes a facile fabrication of nitrogen doped carbon (N@C-g-CN) as a metal-free catalyst for Cr reduction using lignin as a carbon source and g-CN nanosheets as a nitrogen source. The structural properties of the N@C-g-CN catalyst are characterized by TEM, HR-TEM, XRD, TGA, Raman, EDS-mapping, XPS and BET techniques.

Effects of the direct anterior approach and Orthopadisehe Chirurgie Munchen on early joint function after primary hip arthroplasty in young adults.

Objective: To compare the effect of Direct Anterior Approach (DAA) and Orthopadisehe Chirurgie Munchen (OCM) in the prone position on early joint function after primary hip arthroplasty in young adults.

Methods: In this retrospective analysis, 85 patients who received primary hip arthroplasty between September 2018 and January 2020 were enrolled and divided into the OCM group (43 cases with OCM) and the DAA group (42 cases with DAA) according to the different surgical methods. The general operative conditions, postoperative conditions and imaging manifestations, postoperative pain, changes in WOMAC scale scores, and the occurrence of adverse reactions were compared between the two groups.