Guidelines for external radiotherapy and brachytherapy procedures: 4th edition.

The purpose of the first three editions of the guidelines for external radiotherapy procedures (RecoRad™, published in 2008, 2016 and 2021 respectively), was to issue recommendations aimed at optimising, harmonising and standardising practices. The purpose of this fourth edition, follow the same plan and takes into account recent technological improvements along with findings from literature. Part one describes the daily use of general principles; part two describes every step of the process treatment for the main types of cancer.

Infectious endocarditis caused by Elizabethkingia spp.: Two case reports and a literature review.

We report two cases of Elizabethkingia-related infective endocarditis, highlighting key risk factors such as prosthetic valve replacement. These cases underscore the need to consider endocarditis in the setting of persistent or recurrent bacteremia. Diagnosis proved challenging and required multiple imaging modalities, with positron emission tomography (PET) scan providing critical value when echocardiography was non-contributory.

Centrifugal partition chromatography approach to separate additives from PVC resin to support recycling processes.

Plastics are widely used materials composed of polymers and various additives to achieve specific properties. Their composition is often highly complex, particularly in post-consumer plastic waste. As mechanical recycling faces increasing limitations, chemistry-driven strategies are attracting growing interest to improve plastic recovery.

Male Reproductive Senescence in Mammals Is Pervasive and Aligned With the Slow-Fast Continuum.

Reproductive senescence, the decline in any component of offspring recruitment with increasing age, has been well documented in mammalian females. Male reproductive senescence, however, is much less understood, partly due to the past complexities of getting reliable paternity assignment in the wild. Through a standardised literature search, we compiled age-specific reproductive data on both mating and reproductive success on 57 species encompassing 73 populations.

Robotic upper urinary tract reconstruction for ureteral stricture: a single-center series.

The surgical approach of ureteral stricture has changed dramatically over the past 15 years with the rise of robotic upper urinary tract reconstruction. This study aimed to evaluate the outcomes of all robotic ureteral reconstructions performed at a single academic center for ureteral stricture and to assess the predictive factors of stricture recurrence. The charts of all patients who underwent robot-assisted ureteral reconstruction between 2013 and 2024 at a single academic center were retrospectively reviewed.

Estimating Health State Utilities for IDH-Mutant Diffuse Glioma.

Background: Isocitrate dehydrogenase-mutant (mIDH) gliomas are malignant central nervous system tumours. After initial resection, patients with mIDH gliomas with favourable prognosis may live without receiving oncologic treatment for years, but ultimately patients will experience recurrence and require radio- and/or chemotherapy (RT/CT). Cost-utility analyses (CUA) can explore the value of treatments that delay recurrence and initiation of RT/CT.

Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis.

Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.

Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer.

[Psychological health of oncologists: Determinants and consequences in care].

Introduction: While many publications have been made on burnout of oncologists, few publications have been made on oncologists in France, and none focuses on positive markers of their psychological health. Our study is a national study that studies the role of exercise mode, determinants and consequences of positive markers of psychological health of oncologists in France.

Methodology: The survey was disseminated to oncologists (n=606) by the learned societies or cooperative groups of the different cancer specialties from May to July 2022.

[Prevention and management of heavy uterine bleeding in pediatric patients treated for an acute leukemia: Guidelines of the SFCE leukemia committee].

The harmonization workshops of the leukemia committee of the Société française des cancers de l'enfant (SFCE) aim to establish practical recommendations based on the one hand, on data from the literature and international recommendations and, on the other hand, by consensus in the absence of formally proven data. Adolescent pubescent girls and young adults undergoing intensive chemotherapy treatment may present with heavy uterine bleeding (HUB). Data collected from 25 French centers showed that there was considerable heterogeneity in the management of HUB either in prophylaxis or curative strategy.

[The transversal specialized formation in oncology for medical gynecology residents: A five-year review].

Introduction: The transversal specialized formation (TSF) in oncology has been enabling non-oncologist physicians to acquire oncology skills for five years. This study aims to assess the TSF for medical gynecology residents.

Materials And Methods: A 23-item questionnaire was sent to physicians from the specialized medical degree (SMD) in medical gynecology who completed the TSF between 2020 and 2023.

[Evaluation of a consultation dedicated to informal caregivers in a cancer treatment centre].

Introduction: In France, several national strategies have highlighted the importance of identifying and supporting informal caregivers. Given the major multidimensional impact of the caregiving situation in cancerology, the Cancer Center in Lyon, has set up a consultation dedicated to assessing the needs of informal caregivers and providing them with support. The aim of the current study is to assess the uptake of this consultation by informal caregivers and to describe its specific features.

[Acute graft-versus-host disease therapy: Which third line treatment after steroids and ruxolitinib? (SFGM-TC)].

Acute graft-versus-host disease (GVHDa) is one of the leading causes of morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT) patients. While the first-line consensus treatment has been based on systemic corticosteroid therapy for many years, ruxolitinib has recently been approved and has become the standard second-line treatment. Nevertheless, the effectiveness of ruxolitinib remains limited to 40 % of cortico-resistant patients, raising the crucial question of selecting a third-line treatment.

Ovarian mature teratomas: Differences in management and outcomes in adolescents cared for by gynecologic and pediatric surgeons.

Background: Ovarian mature teratomas (OMTs) are the most common benign ovarian tumors in pediatric patients. Management in adolescents can be performed by pediatric (PSs) or gynecologic surgeons (GSs). The aim of this study was to assess the differences in OMT management and the repercussions according to the risk of secondary events.

Pharmacogenetics in oncology: Unveiling its potential in treatment personalization and beyond.

The effectiveness and tolerability of medicines can vary considerably from person to person, even at the same dose. This variation is influenced by many factors, including constitutional genetic characteristics. In fact, some people have genetic variations that are common and neutral in the population, known as polymorphisms, which can affect drug metabolism or make them more susceptible to certain adverse effects.

Role for long term treatment in NMOSD induced by the immune checkpoint inhibitor cemiplimab.

We present the case of a 54-year-old patient treated with cemiplimab, an immune checkpoint inhibitor (ICI), for multiple basal cell carcinomas in the context of Gorlin Goltz syndrome. Gorlin Goltz syndrome is an autosomal dominant multisystem disorder characterized, among other features, by multiple early-onset basal cell carcinomas (BCCs). After receiving Cemiplimab, she developed aquaporin-4 antibody (AQP4-Ab) positive neuromyelitis optica spectrum disorder (NMOSD).