Gene as a Molecular Target Potentially Shared by Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension: Drug Repurposing Prospect with Aminoglutethimide.

Idiopathic pulmonary fibrosis (IPF) and pulmonary hypertension (PH) are two chronic conditions that can coexist occasionally, resulting in high morbidity and mortality. Despite their clinical association, the underlying genetic mechanisms and therapeutic targets that might link these two chronic disorders remain poorly understood. The present study used analyses and machine learning to uncover genetic features and potential therapeutic targets shared by IPF and PH.

Chitosan nanocarriers: A promising approach for glioblastoma therapy.

Glioblastoma is a rapidly growing form of brain tumour originating from the supportive tissues present in the brain or spinal cord. The conventional therapeutic options include the use of alkylating agents, radiation and surgical procedures, that exhibits numerous limitations. The considerably less survival rate, very high incidence of recurrence and lack of effective therapeutic options has made the disease as the most lethal brain cancer.

Chemically modified hyaluronic acid derivatives as ocular drug carriers: A review.

Ocular delivery of therapeutic agents has always been challenging due to the sensitive nature of the eye, restricted permeability through the ocular barrier, and easy wash out of dosage form from ocular surface. These issues have limited the choice of polysaccharides for ocular delivery. In recent times hyaluronic acid (HA) has gained considerable attention as a pharmaceutical excipient in drug delivery.

Advance in prostate cancer biomarker discovery: bridging detection, prognosis and therapeutics.

Prostate cancer is the second leading malignancy in males. Prostate cancer can be easily curable if it is diagnosed at an early stage. The prognosis of patients with metastatic or resistant cases can also be improved if adequately characterized with biomarkers.

The Efficacy of a Novel Water-Soluble Anti-Mycotoxin Solution in Improving Broiler Chicken Performance Under Mycotoxin Challenge.

Mycotoxins like aflatoxins (AFs), fumonisins (FBs), and ochratoxin A (OTA) pose serious health risks to humans and animals. Fruit pomace extracts, rich in natural nutrients and bioactive compounds, have the potential to enhance animal health and mitigate mycotoxin toxicity. This study evaluated a novel liquid anti-mycotoxin solution (LAS), a combination of grape and olive pomace extract administered to broiler chickens through drinking water (2 L:1000 L) for 1-42 days under a natural multi-mycotoxin challenge.

A review of deoxyribonucleic acid-based single-nucleotide polymorphisms in diabetic kidney disease among Asian populations: Challenges and future directions.

Diabetic kidney disease (DKD) is a persistent disorder that occurs as a result of long-term diabetes mellitus with genetic and environmental risk factors. The identification of DKD associated single-nucleotide polymorphisms (SNPs) is pivotal for patient screening. This manuscript briefly outlines the pathophysiology and the role of genetic factors in DKD expansion.

Navigating the evolution: a comprehensive review of sustainable finance in mergers and acquisitions.

Background: The global shift in corporate philosophy from wealth maximization to share value creation has propelled sustainable finance into the forefront of research endeavours. Despite its significance, the realm of sustainable finance, especially in the context of mergers and acquisitions, remains relatively underexplored.

Objective: This research intends to identify the gap by conducting a cutting-edge and expansive systematic review, unravelling the intricate layers of sustainable finance concerning mergers and acquisitions.

Carbon dots embedded carrageenan based compostable functional packaging films with barrier bio-coating for prawns freshness monitoring.

Biopolymer based intelligent packaging films with barrier properties are gaining significant attention in the food industry due to the compostability, food freshness monitoring potential and shelf life increment capability. In this work, ∼10 nm sized urea- dithiosalicilic acid based carbon dots (UCDs) with aggregation-induced emission (AIE) property are prepared and incorporated into carrageenan biopolymer to develop amine sensing packaging material. Composite film is coated with zein-stearic acid (Z/SA) mixture to improve the water barrier property with water vapour transmission rate value ≤40 g/(m.

Replication stress response and radioresistance in lung cancer: Mechanistic insights and advanced therapeutic approaches.

Lung cancer, the leading cause of cancer mortality globally, comprises mainly non-small cell lung cancer and small cell lung cancer. Its pathogenesis involves genetic mutations, environmental exposures, chronic inflammation, and tumor microenvironment interactions. Critical genes like TP53, RB1, KRAS, and EGFR often mutate, driving uncontrolled cell growth.

Drug Design in the Age of Network Medicine and Systems Biology: Transcriptomics Identifies Potential Drug Targets Shared by Sarcoidosis and Pulmonary Hypertension.

Network medicine considers the interconnectedness of human diseases and their underlying molecular substrates. In this context, sarcoidosis and pulmonary hypertension (PH) have long been thought of as distinct diseases, but there is growing evidence of shared molecular mechanisms. This study reports on common differentially expressed genes (DEGs), regulatory elements, and pathways between the two diseases.

Exploring the Impact of Polysaccharide-Based Nanoemulsions in Drug Delivery.

Nanoemulsions are tiny mixtures of water and oil stabilized by surfactants, and they have become increasingly popular across various industries, including medicine. With droplet sizes in the nanometer scale, these mixtures are both compact and effective. This discussion explores the potential of polysaccharide-based nanotechnology as an innovative approach to drug delivery.

Targeting friend leukemia integration 1: A promising approach for prevention and treatment of solid tumors.

Friend leukemia integration 1 (FLI1) is an ETS transcription factor first identified in erythroleukemia. This protein contributes to various cellular functions such as cell growth and proliferation, apoptosis, angiogenesis, etc. FLI1 is also known to be involved in tumorigenesis.

Identification of Overlapping Genetic Signatures Between Obstructive Sleep Apnea and Lung Cancer: Moving Beyond "One Drug, One Disease" Paradigm of Pharmaceutical Innovation.

Traditional paradigms of pharmaceutical innovation have long relied on the "one drug, one disease" premise. However, a network mindset in unpacking disease mechanisms can be fruitful to move toward a "one drug, polydisease" paradigm of drug discovery and development. A case in point is obstructive sleep apnea (OSA) and lung cancer, which are two prevalent respiratory disorders that share common risk factors and may potentially exhibit overlapping molecular mechanisms.

Amplifying therapeutic potential through optimization of bioavailability of poorly soluble flavonols via albumin-based nanoparticles.

Objective: Flavonols have different pharmacological actions that render them highly promising therapeutic targets. However, their water solubility and bioavailability are low, which restricts their therapeutic potential. ABNPs, albumin-based nanoparticles, are potential nanocarriers that enhance flavonol solubility, stability, and targeted delivery.

Directed mutagenesis in fruit crops.

Fruit crops are rich source of important vitamins, minerals, and dietary fibres. They are essential for global agriculture with respect to nutritional security. Globally, there is a rapid decline in the genetic base of fruit crops warranting breeding strategies to overcome the challenge.

Metronidazole induces prostaglandin E2 formation via arachidonic acid production in protozoan parasite Giardia lamblia.

The causative agent of giardiasis in human and animals is the amitochondriate Giardia lamblia. We observed that exposing Giardia trophozoites to MTZ led to an increase in lipid peroxidation compared to the control group, which was expressed in terms of menadione production as it is the marker for lipo-peroxidation. Oxidative stress generated by reactive nitrogen species and peroxidation of membrane phospholipids are positively correlated with the enhanced PLA2 activity in several organisms to produce arachidonic acid (AA).

Insights on immune profile, pathogenesis and differential diagnosis of hypersensitivity pneumonitis and pulmonary sarcoidosis-A holistic review and bibliometric analysis.

Hypersensitivity pneumonitis (HP) and sarcoidosis are granulomatous interstitial lung diseases with overlapping clinical and immunological features, posing diagnostic and therapeutic challenges. This review offers a comprehensive assessment of their immune mechanisms, etiology, and pathogenesis. HP is predominantly triggered by exposure to environmental antigens, while sarcoidosis involves an exaggerated immune response to elusive antigens.

MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance.

MicroRNAs (miRNAs) are a class of small non-coding RNAs which are associated with post-transcriptional regulation of gene expression. Dysfunction or aberrant expression of miRNAs is predominant in various malignancies including lung cancer. Lung cancer is one of the commonest causes of cancer-related death worldwide, with a five-year survival of only 10-20%.

Ensemble stacking of machine learning models for air quality prediction for Hyderabad city in India.

Hyderabad, one of the rapidly developing cities in India, is facing with severe air pollution due to rapid urbanization, industrial operations, and climatic factors. To alleviate the negative impact on human health and the environment, accurate monitoring and forecasting of air quality are essential. This research utilized various machine learning models, such as XGBoost, LarsCV, Bayesian Ridge, AdaBoost, and ensemble stacking methods, to forecast the air quality index (AQI) using data from August 2016 to October 2023, which included 18 different air pollutants, including meteorological parameters.

Understanding the Impact of the Gut Microbiome on Mental Health: A Systematic Review.

Mental health is a serious issue, with mental health disorders affecting millions of people globally. Gut microbiota has received considerable attention because of its potential role in the pathogenesis of mental health disorders. This systematic review synthesized 15 studies exploring the effects of the gut microbiome on depression, anxiety, schizophrenia, and bipolar disorder, with qualitative and quantitative insights.

Enhancing vaginal drug delivery: the nanoemulsion gel strategy.

In the 21st century, 75 % of women encounter vaginal malfunctions (cervicitis, mucoid ectopy, aerobic vaginitis, candidiasis, bacterial vaginosis, degenerated vaginitis, desquamative chronic vaginitis, and sexually transmitted infections) that clinically manifest as irritation, awkwardness, irregular bleeding, or evacuation. Vaginal drug delivery, an approach to treat the aforementioned diseases, primarily focuses on vaginal epithelium thickness, cyclic changes, vaginal secretions, mucus and enzymatic activity, pH, local microflora, and the presence of efflux transporters for their fabrication. There has been a growing interest in nanoemulsion gel for drug delivery to the vagina in comparison to conventional vaginal delivery systems (rings and gels).

Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation.

Promoting neuroplasticity for better recovery and function restoration has lately become the focus of rehabilitation techniques for individuals with neurologic disorders. A rapidly expanding medical specialty, neuromodulation includes a broad variety of methods for activating particular neurological pathways, such as Transcranial magnetic stimulation (TMS), Transcranial direct current stimulation (tDCS), peripheral nerve stimulation, and SCS, among many others. Research on the use of neuromodulation in the context of spinal cord injury (SCI) is limited, in contrast to the abundance of literature on its potential benefits in chronic pain treatment.

CTGF (CCN2): a multifaceted mediator in breast cancer progression and therapeutic targeting.

Breast cancer, with its diverse subtypes like ER-positive, HER-2-positive, and triple-negative, presents complex challenges demanding personalized treatment approaches. The intricate interplay of genetic, environmental, and lifestyle factors underscores its status as a primary contributor to cancer-related fatalities in women globally. Understanding the molecular drivers specific to each subtype is crucial for developing effective therapies.

Antidiabetic activities of aerial part of Willd. extract: an , , and approach.

Willd., a significant medicinal plant in India's Darjeeling Himalayan region. The current study aims to assess the antidiabetic efficacy of the aerial part of Willd.

Correction: Structure-directing effect of terephthalate in bridging Zn(II)- and Cd(II)-based coordination polymers towards application in the detection of trace quantities of Pd in aqueous media and their electrical conductivities.

Correction for 'Structure-directing effect of terephthalate in bridging Zn(II)- and Cd(II)-based coordination polymers towards application in the detection of trace quantities of Pd in aqueous media and their electrical conductivities' by Koushik Saha , , 2025, https://doi.org/10.1039/d4dt03075c.