Dimeric Co(II) Complexes as Excellent Electrocatalysts Toward Efficient Hydrogen and Oxygen Evolution Reactions and Electrochemical Water Splitting.

Production of sustainable green hydrogen is a topic of global interest. Electrochemical water splitting is considered as a highly promising method for generating hydrogen from water using renewable electrical energy without causing environmental pollution. Now, electrocatalysts with decent performance are used for the cathodic hydrogen evolution reaction (HER) and anodic oxygen evolution reaction (OER) in alkaline water electrolysis.

Synthesis, characterization, crystal engineering, DFT, and biological evaluation of a novel Cu(II)-perchlorate Schiff base complex.

Today's crystal engineering in coordination chemistry community offers diverse applications and innovative bonding concepts in crystal assembly. The current research delves into synthesizing one novel Cu(II) complex, [(NO)Cu(HO)(L)(μ-HO)Cu(L)](HO)ClO (L = Schiff base) with NaClO. A combination of standard spectroscopic methods, including SEM-EDX, XPS, and SCXRD (single-crystal X-ray diffraction) study, was used to characterize the complex.

Harnessing (Phenylsulfonyl)difluoromethyl Sulfonium Salt: A Radical Approach to Photoredox-Catalyzed Functionalization of Unsaturated Compounds with the PhSOCF Group.

A photoredox-catalyzed, modular method for the synthesis of versatile (phenylsulfonyl)-difluoromethylated compounds is presented. The key step in this transformation is the light-driven generation of a fluoroalkyl radical from our in-house-designed (phenylsulfonyl)-difluoromethyl sulfonium salt. Tuning the reactivity of this fluorinated sulfonium salt under photocatalysis provided an efficient tool for the direct functionalization of readily available olefins.

The topological way-A new methodology to construct symmetric sets of valence-bond structures.

Classical valence bond (VB) theory has advanced significantly in recent years, evolving into a quantitative tool comparable to molecular orbital-based methods. A key advantage of VB is its high interpretability through Lewis-like resonance structures. However, traditional VB theory faces challenges with symmetric systems, as it often fails to generate symmetric sets of structures, leading to a loss of wavefunction interpretability.

Structure-Nanomechanical Property Correlation in Photosalient Isostructural Metal-Organic Crystals.

Dynamic photoactuating crystals are making waves for their ability to transform industries, offering groundbreaking possibilities in fields such as medical technology, robotics, and flexible electronics. These crystals respond to light, enabling innovations such as smart devices, artificial muscles, molecular machines, sensors, and microrobots, heralding a new era of highly adaptive and efficient technologies. Herein, we report two iso-structural metal-organic crystals [Cd(quin)(4-nvp)] and [Zn(quin)(4-nvp)] [Hquin = quinoline-2-carboxylic acid and 4-nvp = 4-(1-naphthylvinyl)pyridine] based on Cd(II) and Zn(II) ions respectively, that undergo solid-state photochemical [2 + 2] cycloaddition reaction accompanied by photosalient (PS) effect, wherein both the crystals show popping, swelling, and splitting upon UV irradiation, explicitly probed by nanoindentation studies.

Microfluidic captured patient-derived circulating endothelial cells identify novel targets of pulmonary arterial hypertension.

Endothelial cell (EC) dysfunction and gene expression abnormalities in pulmonary arterial hypertension (PAH) vary among patients. Existing PAH cell sources, often from lung transplant patients, are influenced by drug treatments and are inadequate for identifying early-stage PAH genes. We propose isolating viable circulating endothelial cells (CECs) from the whole blood of PAH patients to evaluate their potential as surrogates for PAH-ECs and discover novel gene expression profiles relevant to PAH.

Light-driven structural transformations in isotypical Cd(II) complexes: stereoselectivity and photosalient motion.

This work describes the photoreactivity and photosalient (PS) behavior of five new isotypical Cd(II) coordination complexes [Cd(bz)(4-nvp)] (1), [Cd(4-clbz)(4-nvp)] (2) and (3), and [Cd(4-brbz)(4-nvp)] (4) and (5) [Hbz = benzoic acid, H4-clbz = 4-chlorobenzoic acid, and H4-brbz = 4-bromobenzoic acid]. Complexes 2 and 3 are 4-clbz based polymorphs, while 4 and 5 are 4-brbz based polymorphs. Interestingly, complexes 1, 2 and 4 form head-to-head (HH) dimers, while 3 and 5 form head-to-tail (HT) dimers through photodimerization.

8-Aminoquinoline-Based Promising Zn Complexes with Dicyanamide and Tricyanomethane Anions: Supramolecular (8)/ (16) Synthons, DFT Rationalization, and Biological Insights.

Considering the new crystal engineering integrity utilizing the DFT and the issues surrounding antimicrobial resistance in complexes, there is a pressing need to tackle antifungal photodynamic therapy about global health challenges. Within the sphere of this study, we meticulously introduce the synthesis, characterization, and single-crystal structure of two 8-aminoquinoline-based Zn complexes [Zn{(8-AMQ) (X)}], X = dca () and TCM (). The X-ray study reveals that the complexes crystallize in the monoclinic and triclinic space groups 2/ and -1.

In Vitro Structural and Functional Studies of a Novel Cupredoxin, FtrB, from 2308.

FtrABCD is a four-component iron transporter found in several Gram-negative bacteria. Previous data confirm that FtrABCD can only utilize Fe and the inner membrane permease, FtrC, from this system, like its eukaryotic homologue, Ftr1p, is predicted to utilize the free energy released during Fe oxidation for the transport. Periplasmic FtrB from this system is coancestral with known copper oxidases, and the conserved D118 and H121 are predicted to bind to Cu, forming an active enzyme.

Directed mutagenesis in fruit crops.

Fruit crops are rich source of important vitamins, minerals, and dietary fibres. They are essential for global agriculture with respect to nutritional security. Globally, there is a rapid decline in the genetic base of fruit crops warranting breeding strategies to overcome the challenge.

Stromal fibrin shapes immune infiltration landscape of pancreatic ductal adenocarcinoma.

In pancreatic ductal adenocarcinoma (PDAC), in-situ coagulation creates a thrombotic, crosslinked fibrin (x-fibrin)-rich tumor stroma (FibTS), whose impact on immune cell behavior remains unclear. We aimed to elucidate how FibTS in PDAC regulates immune cell infiltration, polarization, and crosstalk that favors immunosuppressive microenvironment and tumor growth. We assessed the spatial distribution of immune cells by multiplex immunostaining of human PDAC tissues, along with novel bioengineering and mouse tumor models.

Involvement of COX inhibitor and arachidonic acid in manipulating obesity and obesity-induced bone resorption markers in obese mice.

Obesity and bone-loss have remained a focus of research. Obesity stimulates adipose tissue expansion and adipocyte hypertrophy, resulting in chronic low-grade inflammation in the adipocytes. This enlarged adipocyte secretes a variety of pro-inflammatory chemicals.

Geometrically Frustrated, Mechanical Metamaterial Membranes: Large-Scale Stress Accumulation and Size-Selective Assembly.

We study the effect of geometric frustration on dilational mechanical metamaterial membranes. While shape frustrated elastic plates can only accommodate nonzero Gaussian curvature up to size scales that ultimately vanish with their elastic thickness, we show that frustrated metamembranes accumulate hyperbolic curvatures up to mesoscopic length scales that are ultimately independent of the size of their microscopic constituents. A continuum elastic theory and discrete numerical model describe the size-dependent shape and internal stresses of axisymmetric, trumpetlike frustrated metamembranes, revealing a nontrivial crossover to a much weaker power-law growth in elastic strain energy with size than in frustrated elastic membranes.

New Opportunities to Access Fluorinated Molecules Using Organophotoredox Catalysis via C(sp)-F Bond Cleavage.

Fluorinated molecules are of paramount importance because of their unique properties. As a result, the search for innovative approaches to the synthesis of this class of compounds has been relentless over the years. Among these, the combination of photocatalysis and organofluorine chemistry turned out to be an effective partnership to access unattainable fluorinated molecules.

Colorectal Cancer Label-Free Impedimetric Immunosensor for Blood-Based Biomarker CCSP-2.

Colorectal cancer (CRC) is one of the most treatable cancers, yet it ranks second in mortality worldwide. Early detection significantly impacts treatment outcomes, but early stage CRC often presents no symptoms or nonspecific symptoms. The current screening methods are invasive and lacks specificity, hindering widespread CRC screening efforts.

Shapeshifting Gabriel Amine Synthesis with Iodo-BCPs.

The Gabriel amine synthesis is a textbook method for the preparation of primary amines from alkyl halides. In this work, we demonstrate a Gabriel amine synthesis with iodo-bicyclopentanes to make aminomethyl bicyclobutanes. DFT studies support the concerted rearrangement of a bicyclo[1.

Modulation of adiposity and adipocyte inflammation by methanol extracts leaf in high-fat-diet induced-obese mice: Involvement of COX-2 and PPAR-γ.

Obesity is a worldwide problem linked to several lifestyle disorders like diabetes, hypertension, heart failure, dyslipidaemias, asthma, etc. Finding a cure for obesity and its consequences is essential. , a plant from the Zingiberaceae family, has been reported for several medicinal properties.

Programming scheduled self-assembly of circadian materials.

Active biological molecules present a powerful, yet largely untapped, opportunity to impart autonomous regulation of materials. Because these systems can function robustly to regulate when and where chemical reactions occur, they have the ability to bring complex, life-like behavior to synthetic materials. Here, we achieve this design feat by using functionalized circadian clock proteins, KaiB and KaiC, to engineer time-dependent crosslinking of colloids.

The eco-evolutionary dynamics of two strategic species: From the predator-prey to the innocent-spreader rumor model.

Species frequently engage in both competitive and cooperative interactions, delicately balancing these dynamics to optimize their chances of survival and reproduction. While competition drives individuals to compete for limited resources, cooperation can emerge as a strategic response, mitigating risk and enhancing collective payoff. To bridge theoretical game approaches such as payoff, cooperation, and defections in ecological systems, we propose a two-species predator-prey model inspired by the principles and variations of the prisoner's dilemma game.

New functions of pirin proteins and a 2-ketoglutarate: Ferredoxin oxidoreductase ortholog in Bacteroides fragilis metabolism and their impact on antimicrobial susceptibility to metronidazole and amixicile.

The understanding of how central metabolism and fermentation pathways regulate antimicrobial susceptibility in the anaerobic pathogen Bacteroides fragilis is still incomplete. Our study reveals that B. fragilis encodes two iron-dependent, redox-sensitive regulatory pirin protein genes, pir1 and pir2.

Development and Enhancement of PCF-based Sensors for Terahertz-frequency Region Breast Cancer Cell Detection.

In today's medical research, breast cancer is a severe problem, so it is imperative to develop a reliable and efficient approach for identifying cancerous breast cells. PCF, with its exceptional sense-making abilities, simplifies and distinguishes that procedure. The research presents a unique structural hybrid PCF for detecting breast cancer cells using sensors based on PCF that are specifically built for the terahertz-frequency range.

Infrared thermogram image guided discontinuous appearances of hyaluronic acid for classification of arthritic knee joints.

The liveliness of a human potentially depends on his/her smooth movability. To accomplish the work of daily life, the joints of the body need to be healthy. However, the occurrence of Rheumatoid arthritis and Osteoarthritis has a significant prevalence towards the immovability of humankind.

Synthesis, characterization, crystal structure, and fabrication of photosensitive Schottky device of a binuclear Cu(ii)-Salen complex: a DFT investigations.

This work explores one centrosymmetric binuclear Cu(ii)-Salen complex synthesis, characterization, photosensitive Schottky barrier diode (PSBD) function, and DFT spectrum. The crystal growth involves HL and Cu(NO)·3HO in CHOH + ACN (acetonitrile) solvent medium. Herein, structural characterization employs elemental, IR/Raman, NMR, UV-VIS, DRS, SEM-EDX, PXRD, SCXRD, and XPS analyses.