The X-Age Project to construct a Chinese aging clock.

The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.

Tibia-Fibula Relative Motion During Gait Cycle by 2D-3D Registration.

Injuries to the distal tibiofibular joint are often associated with ankle fractures, sports-related injuries, or instability, whereas proximal tibiofibular joint injuries are more commonly present with lateral- or posterolateral-compartment lesions of the knee. These conditions may be related to the relative motion between the tibia and fibula; however, precise movement patterns have yet to be fully elucidated. This study analyzes the relative motion of the tibia and fibula in 16 healthy adults (32 bones; 8 males and 8 females) throughout a normal gait cycle.

Effects of Aerobic Exercises at Different Intensities on Sleep Quality in Individuals with Depression: A Systematic Review and Meta-Analysis.

Purpose: Depression patients frequently report sleep disorder. Aerobic exercise is believed to improve sleep quality, but its effect on the overall sleep of depressed patients remains uncertain. This study systematically evaluates the effects of aerobic exercises at different intensities on subjective and objective sleep quality in participants diagnosed with depression or at high risk of depression, from studies covering various depression subtypes (including but not limited to geriatric depression, prenatal depression, and poststroke depression), and examines changes in depression, anxiety, and quality of life following aerobic exercise.

Evaluating the Effectiveness of a Hybrid Tai Chi Cardiac Rehabilitation Programme for Psychological Stress Reduction and Oxidative Stress in Patients With Chronic Coronary Syndrome: A Randomized Controlled Trial.

Preliminary evidence suggests that Tai Chi may effectively relieve pain symptoms, increase quality of life, and reduce cardiovascular risk in patients with chronic coronary syndrome (CCS). However, few randomized controlled trials have specifically investigated the potential benefits of Tai Chi in patients with CCS, particularly regarding its effects on psychological stress and cellular stress levels. To evaluate the effectiveness of a hybrid Tai Chi cardiac rehabilitation programme in reducing perceived stress and oxidative stress in diagnosed patients.

Biomechanical characteristics of swing techniques using different clubs in college male golfers.

Background: Golf is a sophisticated sport that integrates precision, skillfulness, and strategic thinking, with swing techniques of different clubs exhibiting distinct biomechanical characteristics. This study aims to investigate the biomechanical characteristics of golfers' full swings with different clubs from kinematic and dynamics perspectives, thereby providing insights for optimizing full swing techniques.

Methods: Ten low-handicap right-handed college male golfers were recruited, and their full swing parameters with the driver, 5-iron, and 7-iron (each club was successfully collected 10 times) were synchronously collected using a 250 Hz infrared motion capture system and a 1000 Hz three-dimensional force platform.

Biodynamic Analysis of Alpine Skiing with a Skier-Ski-Snow Interaction Model.

Purpose: Develop a musculoskeletal-environment interaction model to reconstruct the dynamic-interaction process in skiing.

Methods: This study established a skier-ski-snow interaction (SSSI) model that integrated a 3D full-body musculoskeletal model, a flexible ski model, a ski boot model, a ski-snow contact model, and an air resistance model. An experimental method was developed to collect kinematic and kinetic data using IMUs, GPS, and plantar pressure measurement insoles, which were cost-effective and capable of capturing motion in large-scale field conditions.

The effects of French contrast training on lower limb athletic performance in healthy adults: a systematic review and meta-analysis.

Background: French Contrast Training (FCT) is a unique complex training (CT) method that has gained attention in sports science. Participant characteristics, training protocols, and control group types may influence the effects of FCT on lower limb athletic performance.

Objective: The aim of this systematic review and meta-analysis was to assess the effects of FCT on jump, sprint, and maximal strength in healthy adults and to identify potential moderators of training effects.

Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potential.

Background: Musculoskeletal diseases (MSDs) are a common group of conditions involving bones, muscles, cartilage, ligaments, and nerves, which significantly impact patients' quality of life and ability to participate in society. Anthocyanins (ACNs), as phytochemicals, possess various pharmacological and biological activities, including anti-apoptotic, antioxidant, anti-inflammatory, and immunosuppressive properties. In recent years, ACNs have shown remarkable potential in improving MSDs.

Impact of muscle strength decline and exercise intervention on multimorbidity of chronic diseases in older adults.

Multimorbidity of chronic diseases is one of the most common health issues among older adults, and the resulting demand for long-term medical care and management imposes a considerable burden on healthcare systems. Muscle strength, a core indicator of overall health status, is closely associated with the risk of developing multimorbidity of chronic diseases in older adults. Decline in muscle strength not only increases the risk of multimorbidity of chronic diseases but also interacts with it to exacerbate disease burden.

An Aggrecanase-Responsive Delivery Hydrogel System of miRNA-17 Facilitates Microfracture-Mediated Articular Cartilage Regeneration by Reprogramming Hostile Inflammatory Niche.

In situ articular cartilage (AC) regeneration is a meticulously coordinated process. Microfracture has been the most extensive clinical approach in AC repair, but it faces challenges such as matrix degradation, generation, and remodeling within a local inflammatory microenvironment. So far, it remains a challenge to establish a multistage regulatory framework for coordinating these cellular events, particularly the immune response and chondrocyte proliferation in microfracture-mediated AC repair microenvironments, which is crucial for promoting AC regeneration quality.

Mediation analysis of metabolic and inflammatory markers in the association between physical activity and musculoskeletal disease: Findings from NHANES 2013-2018.

Background: Musculoskeletal disease (MSD), including osteoarthritis, rheumatoid arthritis, osteoporosis, and sarcopenia, poses a serious social burden. While physical activity (PA) benefits musculoskeletal health, the optimal PA level for MSD prevention remains unclear. Clarifying risk factors and biological mechanisms is essential.

Longitudinal associations between 24-hour movement behaviors and physical fitness in preschoolers: a compositional isotemporal substitution analysis.

This study investigated the prospective associations between changes in 24-h movement behaviors and physical fitness (PF) components in preschool children; and examined how the reallocation of time between movement behaviours was associated with longitudinal changes in PF. This is a two-year longitudinal study of 200 Chinese children aged 3-4 years old. At baseline and follow-up, 24-h movement behaviors including moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), screen-based sedentary behavior (SSB), non-screen-based sedentary behavior (NSB), and sleep were assessed.

Machine learning- and multilayer molecular network-assisted screening hunts fentanyl compounds.

Fentanyl and its analogs are a global concern, making their accurate identification essential for public health. Here, we introduce Fentanyl-Hunter, a screening platform that uses a machine learning classifier and multilayer molecular network to select and annotate fentanyl compounds using mass spectrometry (MS). Our classification model, based on 772 fentanyl spectra and spectral binning feature engineering, achieved an score of 0.

The effect of digital media on college students' sports participation: The mediating role of sports cognition and the moderating role of self-efficacy.

Background: With the increasing integration of digital media into daily life, its influence on college students' sport-related behaviors has become a growing area of interest. While prior research highlights the general benefits of media exposure, the specific psychological mechanisms through which digital media use affects sports participation remain insufficiently understood.

Methods: Drawing on Social Cognitive Theory (SCT), this study explores how digital media use influences sports participation through the mediating role of sports cognition and the moderating role of self-efficacy.

Correction: Supramaximal interval training using anaerobic speed reserve or sprint interval training in rowers.

[This corrects the article DOI: 10.3389/fphys.2025.

Mental well-being of college students: focus on sex differences and psycho physiological indices.

Background: Questionnaires that assess psychological functioning are 21 limited by their subjective nature, while HRV can serve as a more objective 22 (but also complex) index of such functioning. This study aims to validate sex 23 differences in college students' mental well-being using psychological scales 24 and HRV, and to investigate the correlation between psychological scales 25 and HRV for each sex.

Method: 240 college students (120 males and 120 females, aged 18-22 27 years) were recruited via cluster sampling from 1st Sept.

Impact of prehospital delay on postoperative complications and 5-year mortality in older adults with hip fractures.

Purpose: Guidelines recommended early surgery for hip fracture to improve outcomes, yet it is often hindered by prehospital delays. However, it remains unclear whether prehospital delay independently leads to poor outcomes of the well-recognized impact of in-hospital delay for hip fracture surgery.

Methods: We included patients aged over 60 years old who underwent surgery for their first acute hip fracture between 2000 and 2022 at a national trauma center in Beijing, China.

Nucleotide Metabolism and Immune Genes Can Predict the Prognostic Risk of Hepatocellular Carcinoma and the Immune Microenvironment.

The overall survival of hepatocellular carcinoma (HCC) remains poor, highlighting the need for better prognostic tools. Nucleotide metabolism fuels tumor progression, while the immune microenvironment dictates therapy response, but integrated models combining both features are lacking. Using TCGA-LIHC transcriptomic/clinical data, we identified nucleotide metabolism and immune-related differentially expressed genes (NMIRGs), which stratified HCC patients into two subtypes via non-negative matrix factorization.

Mechanisms of the Ershiwuwei Guijiu Pill in Treating Postmenopausal Osteoporosis Based on Network Analysis and Experimental Validation.

BackgroundThe Tibetan medicine Ershiwuwei Guijiu Pill (EWGP), a classic Tibetan medicine prescription for the treatment of postmenopausal osteoporosis (PMOP) in the Qinghai-Tibet region, has attracted extensive attention due to its curative effects on gynecological diseases. However, its chemical ingredients and molecular mechanism are still unclear.Aim of the studyTo analyze the chemical constituents and effective serum chemical metabolites of EWGP and to explore the molecular mechanism of EWGP in treating PMOP through network analysis and experimental validation.

Development of a physical literacy assessment framework for Chinese preschool children: a Delphi-AHP approach.

Purpose: Physical literacy (PL) during early childhood is crucial for establishing a foundation for lifelong physical activity and holistic development. However, China currently lacks a developmentally appropriate and culturally relevant PL framework for preschool-aged children. This study aimed to develop such a framework using a modified Delphi method and determine the relative importance of its components through the Analytic Hierarchy Process (AHP).

Microplastics and exercise: impacts on performance and physiological health.

Microplastics, a widespread and growing environmental pollutant, have raised global concerns due to their pervasive presence in both urban and natural environments. The extensive use of plastics has led to human exposure through inhalation, ingestion, and skin contact, posing potential risks to athletes and fitness enthusiasts during exercise. Studies suggest microplastics may impair exercise performance and health, though research remains limited.

Mobile phone dependency and adolescent exercise participation: a CB-SEM and fsQCA study on the roles of self-control, time management, and health awareness.

Objective: The study examined how mobile phone dependency (MPD) is linked to adolescents' engagement in structured exercise and whether this association operates through three theoretically derived mechanisms-self-control (SC), time management (TM), and health awareness (HA). A complementary configurational analysis explored alternative combinations of these factors that lead to high or low exercise participation.

Methods: A cross-sectional survey was administered to 1,404 Chinese students in Grades 5-9 (49.

[Study on the method of estimating upper limb reachable workspace based on shoulder joint dynamic positioning].

To propose a functional method for locating the shoulder joint center of rotation aimed at rapid estimation of the upper limb reachable domain envelope, thereby informing ergonomic design and task optimization. In March 2024, shoulder kinematics during gait were recorded from ten adults using a three-dimensional motion-capture system. Assuming the existence of a point near the glenohumeral joint that maintains a fixed spatial relationship to the humerus and the acromion, we estimated both static and dynamic centers of rotation.

Relationships between lower extremity kinematics and impact load or joint work contribution during landing in individuals with and without patellofemoral pain.

Higher lower limb impact load during landing in individuals with patellofemoral pain (PFP) is associated with increased risk of musculoskeletal injuries. This study aimed to investigate differences in landing kinematics, impact load and joint work contribution between individuals with and without PFP, and to identify relationships between kinematics and kinetics variables. Twenty-three PFP patients and nineteen healthy controls performed drop jump tests.

Assessment of synergy-assisted EMG-driven NMSK model for upper limb muscle activation prediction in cross-country sit-skiing double poling.

Introduction: Cross-country sit-skiers are often individuals with spinal cord injuries, cerebral palsy, or lower limb disabilities, relying heavily on upper limb strength to generate propulsion during skiing. However, frequent shoulder joint movements significantly increase the incidence of shoulder joint disorders. Therefore, quantifying muscle forces during movement is crucial for understanding upper limb force generation patterns.