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Article Abstract
Adaptive optics scanning light ophthalmoscopy (AOSLO) enables high-resolution retinal imaging, eye tracking, and stimulus delivery in the living eye. AOSLO-mediated visual stimuli are created by temporally modulating the excitation light as it scans across the retina. As a result, each location within the field of view receives a brief flash of light during each scanner cycle (every 33-40 ms). Here, we used in vivo calcium imaging with AOSLO to investigate the impact of this intermittent stimulation on the retinal ON and OFF pathways. Raster-scanning exaggerated existing ON-OFF pathway asymmetries at high light levels, leading to high baseline activity in ON cells and increased rectification in OFF cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265502 | PMC |
| http://dx.doi.org/10.1364/BOE.566008 | DOI Listing |
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