Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Associations were assessed between demographic/lifestyle factors and tear film breakup time (TBUT) defined dry eye disease (DED) in China.
Methods: The cross-sectional study involved 50,280 subjects (54 ± 17 y) in 217 clinics (25 provinces). Data included sleep disorders; digital screen exposure; and use of cosmetics, contact lenses, and eye drops (for asthenopia). Clinical examinations included TBUT; Schirmer I test; meibomian gland plug status. TBUT-defined DED was TBUT <10 s, with TBUT ≤5 s also considered (i.e., short TBUT-type DED), either unilateral or bilateral.
Results: TBUT-defined DED was present in 81.6 % overall. The highest rates were in those 71 years or older, living in the north, with chronic daily sleep disorder, or daily cosmetic application; or daily digital screen exposure for 5 years, contact lenses 4 h, or 3 months eye drops. Compared with those without TBUT-defined DED, those with TBUT-defined DED showed lower Schirmer I results and more severe meibomian gland plug status (each, P < 0.001). Independent risk factors of DED were: aging; living in the southwest; daily digital screen exposure ≥3 h; and occasional cosmetic use. Risk factors of DED TBUT ≤5 s were: living in the southwest; wearing contact lenses (>3 y); and using eye drops. Rates of unilateral and bilateral DED were comparable.
Conclusions: DED in China is more likely in the aged and those in the north/southwest. DED rates increase with digital screen exposure, and use of cosmetics, contact lenses, or eye drops for asthenopia. Unilateral DED should be treated as promptly as bilateral.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jtos.2024.07.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies.
Hum Cell
September 2025
Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Age-related eye diseases (AREDs) are the leading cause of visual impairment in the elderly, affecting the structure of the anterior and posterior segments of the eye, significantly reducing the quality of life of patients, and even leading to irreversible blindness. Typical AREDs include age-related cataract (ARC), dry eye disease (DED), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR), the global prevalence of which continues to rise, becoming a serious public health concern. SIRT1 is an NAD + dependent deacetylase, which plays an important physiological regulatory role in ocular tissues, mainly affecting gene expression and various cellular processes by regulating the acetylation status of substrate proteins.
View Article and Find Full Text PDFDry eye symptoms in midlife women: A cross-sectional analysis of prevalence, risk factors, and quality-of-life outcomes.
Maturitas
August 2025
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand. Electronic address:
Objectives: To assess the prevalence, associated factors, and quality-of-life impact of dry eye symptoms among perimenopausal and postmenopausal women in Thailand.
Study Design: This cross-sectional study, conducted from September to December 2024, included 262 women aged 41-60 years attending a gynaecology and menopause clinic at Ramathibodi Hospital. Participants completed the Ocular Surface Disease Index and the Menopause-Specific Quality of Life questionnaires.
Health-Related Quality-of-Life Outcomes for Upper Blepharoplasty and Blepharoptosis Surgery: A Report by the American Academy of Ophthalmology.
Ophthalmology
September 2025
Ophthalmic Plastic Surgery, Lions Eye Institute, Department of Ophthalmology, Albany Medical Center, Albany (Slingerlands), New York.
Purpose: To review the literature and identify the health-related quality-of-life (HRQL) outcomes that used a validated instrument in the assessment of upper blepharoplasty, blepharoptosis surgery, or combination surgery.
Methods: A literature search was last conducted in the PubMed database in January 2025 to identify all studies in the English language investigating HRQL outcomes that used a validated instrument in the assessment of upper blepharoplasty, blepharoptosis surgery, or combination surgery. The literature search yielded 773 citations, and 20 studies met the inclusion criteria.
Association between atrial fibrillation and age-related macular degeneration: A nationwide cohort study.
Eye (Lond)
September 2025
Department of Ophthalmology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Background/objectives: Atrial fibrillation (AF) and age-related macular degeneration (AMD) are common debilitating conditions that share pathomechanisms involving chronic inflammation and oxidative stress. However, the association between AMD and AF, which is important for comprehending the pathogenesis, referral, and treatment strategies of these diseases, remains unknown.
Subjects/methods: This nationwide population-based retrospective cohort study used claims data from the National Health Insurance Research Database of Taiwan.
Blue light pollution induces dry eye by damaging conjunctival stem cells through cAMP-PKA-Pax6 signaling pathway.
Ecotoxicol Environ Saf
September 2025
Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address:
Purpose: Blue light exposure constitutes a risk factor for dry eye. The research explores the influence of conjunctival stem cells (CjSCs) by blue light, elucidating the pathogenesis of blue light-induced dry eye.
Materials And Methods: Primary SD rat CjSCs and rats were irradiated with blue light at 460 nm.