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Article Abstract
In this paper, we reported a coumarin-based fluorescent probe for selective detection of HO/SO derivatives via ICT process. To the best of our knowledge, it was few reported with the same probe to enable visual detection of HO/SO derivatives in vivo and in vitro. HO and SO were selectively sensed over other analytes, and the probe displayed 20-fold and 220-fold relative fluorescence intensity respectively, as well as the good linear relationship and the excellent detection limits of 2.7 * 10 nM and 19.3 nM. Furthermore, the probe was successfully used for fluorescence imaging of the HeLa cells and the mice to monitor exogenous and endogenous HO and SO, suggesting its potential biomedical application for investigation and detection the intermediate indicator of oxidative stress in vitro and in vivo.
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| http://dx.doi.org/10.1016/j.saa.2022.121955 | DOI Listing |
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