Analysis of Bacterial Community During Cow Manure and Wheat Straw Composting and the Isolation of Lignin-Degrading Bacteria from the Compost.

Biodegradation is a green and efficient method for lignin depolymerization and conversion. In order to screen potential bacterial strains for efficient lignin degradation, composts of cow dung and wheat straw were prepared, and the dynamic changes in the predicted bacterial community structure and function in different periods of the composts were investigated. Then, bacteria with an efficient lignin degradation ability were finally screened out from the compost samples.

Honeybee-Gilliamella synergy in carbohydrate metabolism enhances host thermogenesis in cold acclimation.

How gut symbionts contribute to host adaptation remains largely elusive. Studying co-diversified honeybees and gut bacteria across climates, we found cold-adapted species (Apis mellifera, A. cerana) exhibit enhanced genomic capacity for glucose, pyruvate, lipid and glucuronate production versus tropical species.

Comprehensive analysis of exosome-related gene signature in multiple myeloma prognosis and immune microenvironment evaluation.

Multiple myeloma (MM) is a genetically complicated plasma cell malignancy characterized by malignant plasma cell proliferation and monoclonal immunoglobulin synthesis. As a disease that remains incurable, enhancing prognostic accuracy is of paramount importance. Tumor-derived exosomes (TDEs) play key roles in modulating the tumor microenvironment, angiogenesis and immune system.

Development of a cuproptosis-related prognostic signature to reveal heterogeneity of the immune microenvironment and drug sensitivity in acute lymphoblastic leukemia.

Background: Cuproptosis is a brand-new copper-dependent type of cell death that has been linked to various tumors. However, the relationship between cuproptosis and acute lymphoblastic leukemia (ALL) remains to be further elaborated.

Methods: In ALL, 12 cuproptosis-related genes (CRGs) were analyzed at genetic and single-cell levels.

Interspecies interactions promote dual-species biofilm formation by Lactiplantibacillus plantarum and Limosilactobacillus fermentum: Phenotypic and metabolomic insights.

Probiotics are live microorganisms offering various health benefits to hosts, but exposure to adverse conditions can compromise their viability during gastrointestinal transit. Probiotics in the biofilm state have been proven as an alternative way to the probiotic survival challenge; however, knowledge of mixed-species biofilms by probiotics is limited. This study aimed to examine the ecological interactions between Lactiplantibacillus plantarum LP-52 and Limosilactobacillus fermentum LF-56 from a phenotypic and metabolomics perspective during their mixed-species biofilm development.

Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma.

Background: Disulfidptosis is an emerging type of programmed cell death related to ROS accumulation and aberrant disulfide bond formation. Multiple myeloma (MM) is the second most prevalent hematologic malignancy characterized by a high synthesis rate of disulfide bond-rich proteins and chronic oxidative stress. However, the relationship between disulfidptosis and MM is still unclear.

Global landscape of cervical cancer incidence and mortality in 2022 and predictions to 2030: The urgent need to address inequalities in cervical cancer.

Cervical cancer remains a major public health challenge worldwide, despite being largely preventable through effective interventions. Timely evidence regarding the global landscape of cervical cancer is crucial for measuring the magnitude of inequalities and monitoring progress towards cervical cancer elimination. We aimed to provide an updated overview of the global burden of cervical cancer using the GLOBOCAN 2022 database.

The prognostic and clinical significance of substantial lymphovascular space invasion in early-stage endometrial carcinoma.

Objectives: Substantial lymphovascular space invasion (LVSI) has been incorporated into the 2023 International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial carcinoma. This study aims to evaluate whether classifying LVSI into substantial LVSI (≥5 involved vessels) and no/focal LVSI (≤4 involved vessels) provides meaningful prognostic differentiation in early-stage endometrial carcinoma.

Methods: We retrospectively enrolled patients with FIGO 2009 stage I-II endometrial carcinoma who underwent surgical staging between January 2013 and August 2020.

Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma.

Significant progress has been achieved in the management of multiple myeloma (MM) by implementing high-dose therapy and stem cell transplantation. Moreover, the prognosis of patients has been enhanced due to the introduction of novel immunomodulatory drugs and the emergence of new targeted therapies. However, predicting the survival rates of patients with multiple myeloma is still tricky.

Multiple signal-enhanced electrochemiluminescence aptamer sensors based on carboxylated ruthenium (II) complexes for acetamiprid detection.

Background: Rapid and sensitive detection for acetamiprid, a kind of widely used neonicotinoid insecticide, is very meaningful for the development of modern agriculture and the protection of human health. Highly stable electrochemiluminescence (ECL) materials are one of the key factors in ECL sensing technology. ECL materials prepared by porous materials (e.

Prognostic significance of β2-microglobulin decline index in multiple myeloma.

Purpose: To assess the prognostic significance of β2-microglobulin decline index (β2M DI) in multiple myeloma (MM).

Methods: 150 MM patients diagnosed with MM were enrolled in this study. Cox proportional hazards model was used to analyze the uni- and multivariate prognosis in training cohort (n=105).

Photoredox-Catalyzed Alkene Amination: C(sp)-H/N-H Radical-Radical Cross Dehydrogenative Coupling.

Direct alkene C-H/N-H cross dehydrogenative coupling is an infrequent, highly challenging transformation. Herein, a photoredox radical-radical cross-coupling reaction between ketene dithioacetal as a persistent alkene radical cation and azole nitrogen center radical (NCR) was developed. This direct alkene amination proceeded through a synergistic photoredox and cobalt catalysis, with only H evolution.

The functional divergence of homologous GPAT9 genes contributes to the erucic acid content of Brassica napus seeds.

Background: The early allopolyploid Brassica napus was a hybrid of two Brassica species, that had undergone a whole genome duplication event followed by genome restructuring, including deletions and small scale duplications. A large number of homologous genes appeared functional divergence during species domestication. Due to the high conservation of de novo glycerolipid biosynthesis, multiple homologues of glycerol-3-phosphate acyltransferases (GPATs) have been found in B.

Comprehensive analysis of ferroptosis-related genes in immune infiltration and prognosis in multiple myeloma.

One particular type of cellular death that is known as ferroptosis is caused by the excessive lipid peroxidation. It is a regulated form of cell death that can affect the response of the tumor cells. Currently, it is not known if the presence of this condition can affect the prognosis of patients with multiple myeloma (MM).

A novel glycolysis-related gene signature for predicting the prognosis of multiple myeloma.

Metabolic reprogramming is an important hallmark of cancer. Glycolysis provides the conditions on which multiple myeloma (MM) thrives. Due to MM's great heterogeneity and incurability, risk assessment and treatment choices are still difficult.

Network Pharmacology Revealed the Mechanisms of Action of Sieb on Atopic Dermatitis.

Aim: The application of network analysis algorithms promoted the development of network pharmacology. This study aimed to combine network pharmacology and signed random walk with restart (SRWR) to reveal the mechanism by which Sieb (LES) exerts effects on atopic dermatitis (AD).

Methods: The compounds and targets of LES were retrieved from Traditional Chinese Medicine Integrated Database (TCMID) and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and important compounds and targets were identified by intersection analysis and protein-protein interaction (PPI) network.

Development and validation of a cuproptosis-associated prognostic model for diffuse large B-cell lymphoma.

Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous disease. Therefore, more reliable biomarkers are required to better predict the prognosis of DLBCL. Cuproptosis is a novel identified form of programmed cell death (PCD) that is different from oxidative stress-related cell death (e.

Study on Carbonation Resistance of Polymer-Modified Sulphoaluminate Cement-Based Materials.

The use of tricyclic copolymer latex (AMPS) can effectively improve the carbonation resistance of sulphoaluminate cement. This paper investigated polymer AMPS and polycarboxylic acid to modify sulphoaluminate cement materials by exploring the carbonation level of sulphoaluminate cement paste and mortar and the strength before and after carbonation. Then, the optimal dosage of polymer and polycarboxylic acid was obtained so that the carbonation resistance of sulphoaluminate cement reached the best state.

Binding of the transcription factor MYC2-like to the ABRE of the OsCYP2 promoter enhances salt tolerance in Oryza sativa.

Cyclophilins, a type of peptidyl-prolyl cis-trans isomerase, function as important molecular chaperones in a series of biological processes. However, the expression pattern and signal transduction pathway of cyclophilins are still unclear. Here, we showed that the promoter of OsCYP2 could function as a tissue-specific promoter by GUS staining.

A dual-site multifunctional fluorescent probe for selective detection of endogenous HO and SO derivatives based on ICT process and its bioimaging application.

In this paper, we reported a coumarin-based fluorescent probe for selective detection of HO/SO derivatives via ICT process. To the best of our knowledge, it was few reported with the same probe to enable visual detection of HO/SO derivatives in vivo and in vitro. HO and SO were selectively sensed over other analytes, and the probe displayed 20-fold and 220-fold relative fluorescence intensity respectively, as well as the good linear relationship and the excellent detection limits of 2.

Identification of GmGPATs and their effect on glycerolipid biosynthesis through seed-specific expression in soybean.

Background: Genetic improvement of soybean oil content depends on in-depth study of the glycerolipid biosynthesis pathway. The first acylation reaction catalysed by glycerol-3-phosphate acyltransferase (GPAT) is the rate-limiting step of triacylglycerol biosynthesis. However, the genes encoding GPATs in soybean remain unknown.

Enhanced production of terrein in marine-derived Aspergillus terreus by refactoring both global and pathway-specific transcription factors.

Background: Terrein, a major secondary metabolite from Aspergillus terreus, shows great potentials in biomedical and agricultural applications. However, the low fermentation yield of terrein in wild A. terreus strains limits its industrial applications.

Hyperlipemia pancreatitis onset time affects the association between elevated serum triglyceride levels and disease severity.

Background: The association of serum triglyceride (TG) levels with the severity of hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) remains controversial. This study aimed to comprehensively assess the TG levels from the initial onset and their predictive value in the disease assessment of HTG-AP.

Methods: Data collected from January 2018 to July 2021 in one institute were assessed retrospectively.

Bioinformatic analysis of key pathways and genes involved in pediatric atopic dermatitis.

The initiation of atopic dermatitis (AD) typically happens very early in life, but most of our understanding of AD is derived from studies on AD patients in adult. The aim of the present study was to identify gene signature speficic to pediatric AD comapred with adult AD. The gene expression profiles of four datasets (GSE32924, GSE36842, GSE58558, and GSE107361) were downloaded from the GEO database.