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Background: The outbreak of the highly infectious coronavirus disease 2019 (COVID-19) renders a huge physical and psychological risk to the public, especially to the medics. Additionally, self-leadership has proven to improve self-efficacy and mediate tension, such as nervousness and depression. Therefore, a cross-sectional survey was conducted to explore the association of self-leadership with acute stress responses (ASRs) and acute stress disorders (ASDs) in medics during the COVID-19 epidemic.
Methods: Self-reported online questionnaires were administered, and 627 participants were finally included. The data were analyzed using the univariate analysis and the logistical regression model to identify whether self-leadership and sociodemographic and epidemic characteristics were associated with mental health, including ASRs and ASDs.
Results: Initially, 790 medics responded. Of these, 627 remained after excluding for invalid questionnaires and those with a substantial amount of missing data. Therefore, the participation validity rate was 79.37%. Frontline medical staff (β = 0.338; < 0.001), possibility of infection among people around the medic being mild (β = 0.141; < 0.001), subjective estimation of epidemic duration being 3-6 months (β = 0.074; < 0.05), self-sets (β = -0.022; < 0.001), self-punishment (β = 0.229; < 0.001), belief hypothesis and evaluation (β = -0.147; < 0.05), and successful foresight (β = 0.105; < 0.05) were statistically significant with ASRs. Marital status [adjusted odds ratio (AOR) =1.813; 95% CI (1.141, 2.881); = 0.012], being a frontline worker [AOR = 25.760; 95% CI (14.220, 46.667); < 0.001], visiting Hubei in the previous 14 days [AOR = 3.656; 95% CI (1.500, 8.911); = 0.004], self-punishment [AOR = 1.352; 95% CI (1.180, 1.548); < 0.001], and self-dialogue [AOR = 1.256; 95% CI (11.063, 1.483); = 0.007] were the risk factors for ASD. Conversely, having frontline medical staff in one's family [AOR = 0.523; 95% CI (0.297, 0.923); = 0.025], self-sets [AOR = 0.814; 95% CI (0.715, 0.826); = 0.002], and belief hypothesis and evaluation [AOR = 0.796; 95% CI (0.672, 0.943); = 0.038] were the protective factors.
Conclusion: The special working environment of the COVID-19 epidemic resulted in ASR and ASD. Notably, findings revealed a positive association between ASR symptoms and frontline medical staff, the subjective estimation of epidemic duration, self-punishment, and successful foresight. Nevertheless, marital status, having visited Hubei in the previous 14 days, and self-dialogue were the risk factors accounting for ASD symptoms. Surprisingly, having frontline medical staff in one's family, self-sets, and belief hypothesis and evaluation had potential benefits for ASD symptoms.
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http://dx.doi.org/10.3389/fpsyt.2022.836950 | DOI Listing |
Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine that acts as a central regulator of inflammation and immune responses across diverse organ systems. Functioning upstream in immune activation cascades, MIF influences macrophage polarization, T and B cell differentiation, and cytokine expression through CD74, CXCR2/4/7, and downstream signaling via NF-κB, ERK1/2, and PI3K/AKT pathways. This review provides a comprehensive analysis of MIF's mechanistic functions under both physiological and pathological conditions, highlighting its dual role as a protective mediator during acute stress and as a pro-inflammatory amplifier in chronic disease.
View Article and Find Full Text PDFAust N Z J Psychiatry
September 2025
Department of Psychological Medicine, Sydney Children's Hospitals Network, Sydney, NSW, Australia.
Objective: Art therapy offers a predominantly non-verbal form of creative self-expression for people experiencing mental health issues. This systematic review aims to investigate the effectiveness and acceptability of art therapy for children and adolescents experiencing acute or severe mental health conditions.
Methods: Following PRISMA guidelines, five electronic databases were searched (Embase, MEDLINE, Web of Science Core Collection, PsychINFO, CINAHL) using the search terms ('art therap*' OR 'art psychotherap*') AND ('child*' OR 'adolescen*' OR 'youth' OR 'young' OR 'teen*').
Nan Fang Yi Ke Da Xue Xue Bao
August 2025
Key Laboratory of Occupational Environment and Health, Guangzhou Twelfth People's Hospital, Guangzhou 510620, China.
Objectives: To investigate the role of ferroptosis in diquat-induced acute kidney injury (AKI) and its molecular mechanisms.
Methods: Transgenic zebrafish models with Tg (Eco.Tshb:EGFP) labeling of the renal tubules and Tg (lyz:dsRed2) labeling of the neutrophils were both divided into control group, gentamicin (positive control) group, diquat poisoning group, ferroptosis inhibitor group.
Pestic Biochem Physiol
November 2025
Marine College, Shandong University, Weihai, Shandong 264209, China. Electronic address:
Tralopyril (TP), a representative bromopyrrolonitrile, functions as a broad-spectrum insecticide, raising growing concerns about its potential impact on aquatic organisms and human intestinal health. However, the key targets and toxicity mechanisms underlying TP-induced enteritis remain unclear. In this study, we utilized network toxicology combined with molecular docking to comprehensively explore the potential molecular mechanisms underlying TP-induced enteritis.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Yantai Academy of Agricultural Sciences, Yantai 265500, China. Electronic address:
The diamide insecticide cyantraniliprole (CYA) and the triazole fungicide difenoconazole (DIF) are frequently co-detected in bee-related matrices. However, the interactive effects of these compounds on honey bee (Apis mellifera L.) physiology remain insufficiently elucidated.
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