Molecular mechanism of Tralopyril-induced enteritis in Pacific oyster (Crassostrea gigas) through multi-pathway modulation: Network toxicology and experimental validation.

Tralopyril (TP), a representative bromopyrrolonitrile, functions as a broad-spectrum insecticide, raising growing concerns about its potential impact on aquatic organisms and human intestinal health. However, the key targets and toxicity mechanisms underlying TP-induced enteritis remain unclear. In this study, we utilized network toxicology combined with molecular docking to comprehensively explore the potential molecular mechanisms underlying TP-induced enteritis.

Network-based investigation of norfloxacin-induced nasal immune-related inflammatory responses in carp (Cyprinus carpio) and its cross-species implications for olfactory immune disturbance.

Norfloxacin (NOR), a widely used fluoroquinolone antibiotic, has raised environmental concerns due to its persistent presence in aquatic ecosystems. This study integrates a common carp (Cyprinus carpio) model, network toxicology, and molecular docking to investigate the potential mechanisms of NOR-induced nasal inflammation. Common carp were exposed to environmentally relevant NOR concentrations, and histopathological, biochemical, and molecular analyses were conducted.

Molecular mechanisms underlying multi-generational skeletal abnormalities in marine medaka induced by the quinolone antibiotic norfloxacin (NOR).

Norfloxacin (NOR), a quinolone antibiotic, has caused substantial environmental pollution and exhibits toxicity to the reproductive, immune, and endocrine systems of organisms. Proper skeletal function is crucial for overall health. This study demonstrates the toxic effects of NOR on the skeletal maturation of multiple generations of marine medaka (Oryzias melastigma) and explores the underlying mechanisms.

Toxic effects of emerging pollutants on mucosal organs of teleost fish: A review focusing on mucosal microbiota, physical barrier and immune barrier.

The urgency of emerging pollutants driven by human activities presents an increasing threat to the health of fish. The mucosal system, serving as a primary barrier against environmental pollutants, has emerged as a central focus in toxicological research. Alterations in the mucosal microbiota can impact health at both local and systemic levels.

Characteristics of microbial carbon pump in the sediment of kelp aquaculture zone and its contribution to recalcitrant dissolved organic carbon turnover: insights into metabolic patterns and ecological functions.

The study delves into the microbial carbon pump (MCP) within the sediments of kelp aquaculture zones, focusing on its influence on the turnover of recalcitrant dissolved organic carbon (RDOC). Following kelp harvest, significant alterations in the microbial community structure were noted, with a decrease in complexity and heterogeneity within co-occurrence networks potentially impacting RDOC production efficiency. Metabolic models constructed identified four key microbial lineages crucial for RDOC turnover, with their abundance observed to decrease post-harvest.

Bioremediation potential of sulfadiazine-degrading bacteria: Impacts on ryegrass growth and soil functionality.

The extensive use of antibiotics, particularly sulfadiazine (SDZ), has led to significant environmental contamination and the proliferation of antibiotic resistance genes (ARGs). This study investigates the bioremediation potential of two SDZ-degrading bacterial strains, Acinetobacter sp. M9 and Enterobacter sp.

Sex-specific effects of triphenyltin on gut microbiota and intergenerational effects in marine medaka (Oryzias melastigma).

In this study, a mixed model was applied to the marine medaka to investigate the intergenerational effects of parental exposure to Triphenyltin (TPT) and the subsequent perturbations in parental gut microbiota on the gut microbiota of offspring. In addition, "microgenderome" has been focused on elucidating the different responses of males and females to environmental stress. The results indicated that TPT exhibited androgenic effects and long-term toxicological consequences, influencing the internal steroid hormone levels of the offspring and leading to their abnormal growth and development.

Multigenerational effects of combined exposure of triphenyltin and micro/nanoplastics on marine medaka (Oryzias melastigma): From molecular levels to behavioral response.

In natural environments, micro/nanoplastics (MNP) inevitably coexist with various pollutants, making it essential to examine their combined toxicity and intergenerational effects on marine organisms. This study investigated the combined toxicity and intergenerational effects of exposure to triphenyltin (T), microplastics (M), nanoplastics (N), a combination of microplastics and triphenyltin (MT), and a combination of nanoplastics and triphenyltin (NT) on marine medaka. The results showed that all treatments had adverse and intergenerational effects on marine medaka.

Ecological influences of sulfadiazine on rhizosphere soil microbial communities in ryegrass (Lolium perenne L.)-soil potting systems: Perspectives on diversity, co-occurrence networks, and assembly processes.

Microorganisms in the soil are crucial constituents of land ecosystems, significantly influencing their structure and functionality. However, the accumulation of antibiotics in agricultural practices may negatively affect these microbial communities. The objective of this study was to explore the ecological effects of the sulfonamide drug sulfadiazine (SDZ) on the rhizosphere soil microbial communities of ryegrass (Lolium perenne L.

Seasonal variations of microbial communities and viral diversity in fishery-enhanced marine ranching sediments: insights into metabolic potentials and ecological interactions.

Background: The ecosystems of marine ranching have enhanced marine biodiversity and ecological balance and have promoted the natural recovery and enhancement of fishery resources. The microbial communities of these ecosystems, including bacteria, fungi, protists, and viruses, are the drivers of biogeochemical cycles. Although seasonal changes in microbial communities are critical for ecosystem functioning, the current understanding of microbial-driven metabolic properties and their viral communities in marine sediments remains limited.

Ocean acidification alters shellfish-algae nutritional value and delivery.

The ecological effects of climate change and ocean acidification (OA) have been extensively studied. Various microalgae are ecologically important in the overall pelagic food web as key contributors to oceanic primary productivity. Additionally, no organism exists in isolation in a complex environment, and shifts in food quality may lead to indirect OA effects on consumers.

Micro(nano)plastics in marine medaka: Entry pathways and cardiotoxicity with triphenyltin.

The simultaneous presence of micro(nano)plastics (MNPs) and pollutants represents a prevalent environmental challenge that necessitates understanding their combined impact on toxicity. This study examined the distribution of 5 μm (PS-MP5) and 50 nm (PS-NP50) polystyrene plastic particles during the early developmental stages of marine medaka (Oryzias melastigma) and assessed their combined toxicity with triphenyltin (TPT). Results showed that 2 mg/L PS-MP5 and PS-NP50 could adhere to the embryo surface.

Deciphering characterization of seasonal variations in microbial communities of marine ranching: Diversity, co-occurrence network patterns, and assembly processes.

Offshore coastal marine ranching ecosystems are one of the most productive ecosystems. The results showed that the composition and structure of the microbial communities varied considerably with the season. Co-occurrence network analysis demonstrated that the microbial network was more complex in summer and positively correlated links (cooperative or symbiotic) were dominated in autumn and winter.

Biodegradation of sulfadiazine by ryegrass (Lolium perenne L.) in a soil system: Analysis of detoxification mechanisms, transcriptome, and bacterial communities.

The indiscriminate use of sulfadiazine has caused severe harm to the environment, and biodegradation is a viable method for the removal of sulfadiazine. However, there are few studies that consider sulfadiazine biodegradation mechanisms. To comprehensively investigate the process of sulfadiazine biodegradation by plants in a soil system, a potted system that included ryegrass and soil was constructed in this study.

Metagenomics analysis reveals the effects of norfloxacin on the gut microbiota of juvenile common carp (Cyprinus carpio).

Norfloxacin (NOR) is an early third-generation quinolone antibiotic that has been widely used in animal husbandry and aquaculture because of its bactericidal properties. As an emerging contaminant, NOR may have toxic effects on fish. This study assessed the chronic toxicity (6 weeks) of 0 (control group), 100 ng/L (environmental concentration), and 1 mg/L NOR to the gut microbiota of juvenile common carp (Cyprinus carpio) based on metagenomic sequencing.

The Optimum Lipid Level for the Juvenile Redclaw Crayfish : Practical Diets with Soybean Oil as the Lipid Source.

As a new species in aquaculture, the lipid nutrition requirement for the juvenile redclaw crayfish on a dietary basis on a practical formula needs to be evaluated accurately. In this study, the optimum dietary lipid level was explained by analyzing the growth performance, antioxidant state, lipid metabolism, and gut microbiota of after an eight-week cultivation trial. Six diets with different soybean oil levels (named L0, L2, L4, L6, L8, and L10) were fed to (11.

Shellfish-algal systems as important components of fisheries carbon sinks: Their contribution and response to climate change.

In the context of global climate change, ocean acidification and warming are becoming increasingly serious. Adding carbon sinks in the ocean is an important part of efforts to mitigate climate change. Many researchers have proposed the concept of a fisheries carbon sink.

Physiological and molecular responses in the silver carp (Hypophthalmichthys molitrix) larvae after acute mercury exposure.

The current study was performed to examine the acute toxicity of mercuric chloride (HgCl) on the silver carp (Hypophthalmichthys molitrix) larvae. Probit analysis was used to determine the median lethal concentration (LC). The LC values of Hg for the fish larvae at 24, 48, 72, and 96 h were 267.

Physiological responses in Nile tilapia (Oreochromis niloticus) induced by combined stress of environmental salinity and triphenyltin.

Triphenyltin (TPT) has attracted considerable attention owing to its vitality, bioaccumulation, and lurking damage. TPT widely exists in complex salinity areas such as estuaries and coastal regions. However, there are few studies on the toxicological behavior of TPT under different salinity.

Exploring the interactions between the gut microbiome and the shifting surrounding aquatic environment in fisheries and aquaculture: A review.

The rise of "new" sequencing technologies and the development of sophisticated bioinformatics tools have dramatically increased the study of the aquaculture microbiome. Microbial communities exist in complex and dynamic communities that play a vital role in the stability of healthy ecosystems. The gut microbiome contributes to multiple aspects of the host's physiological health status, ranging from nutritional regulation to immune modulation.

Exposure to enrofloxacin and depuration: Endocrine disrupting effect in juvenile grass carp (Ctenopharyngodon idella).

This study aimed to determine the effects of Enrofloxacin (ENR) exposure and depuration on the disruption of thyroid function and growth of juvenile grass carp (Ctenopharyngodon idella) as well as to assess the risk of ENR exposure to human health. Juvenile grass carp were treated with ENR solutions at different concentration gradients for 21 days and then depurated for 14 days. The results indicated ENR accumulation in the juvenile grass carp muscles, which persisted after depuration.