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Purpose: To grade nuclear cataracts using the Lens Opacity Classification System III (LOCS III) and the correlation with maximum nuclear density on Scheimpflug imaging and phacoemulsification parameters.
Setting: Tertiary care center.
Design: Longitudinal interventional study.
Methods: The nuclear density of significant age-related cataracts was evaluated by comparing slitlamp images with standard photographic charts of the LOCS III system. Maximum nuclear density was calculated using a Scheimpflug imaging system (Pentacam). All patients had phacoemulsification and posterior chamber intraocular lens implantation. Intraoperatively, parameters (eg, phaco time, power consumed, balanced salt solution used) were noted and compared with different grades of cataract and maximum nuclear densities.
Results: One hundred patients with visually significant age-related cataract were evaluated. There was a positive linear correlation between the LOCS III grading and Scheimpflug maximum nuclear density (P<.001). The LOCS III grading and Scheimpflug maximum nuclear density had a linear correlation with preoperative corrected distance visual acuity (r = 0.588 and r = 0.525, respectively), cumulative dissipated energy (CDE) (r = 0.607 and r = 0.847, respectively), total ultrasound (US) time (r = 0.627 and r = 0.802, respectively), and fluid used (r = 0.623 and r = 0.678, respectively).
Conclusion: Both systems had a linear correlation with total US power, CDE, and fluid used; however, the Scheimpflug imaging system had a stronger correlation with these phacoemulsification parameters.
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http://dx.doi.org/10.1016/j.jcrs.2013.05.052 | DOI Listing |
Adv Mater
September 2025
Department of Engineering, School of Computing and Engineering, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK.
A new family of nanostructured ternary intermetallic compounds - named the ZIP phases - is introduced in this work. The ZIP phases exhibit dualistic atomic ordering, i.e.
View Article and Find Full Text PDFFront Pharmacol
August 2025
General Surgery Department Three, Gansu Province Central Hospital, Lanzhou, China.
Fast and early detection of low-dose chemical toxicity is a critical unmet need in toxicology and human health, as conventional 2D culture models often fail to capture subtle cellular responses induced by sub-toxic exposures. Here, we present a bioengineered three-dimensional (3D) electrospun nanofibrous scaffold composed of polycaprolactone that enhances chromatin accessibility and primes fibroblasts for improved sensitivity to low-dose chemical stimuli in a short period. The scaffold mimics the extracellular matrix, providing topographical cues that reduce cytoskeletal tension and promote nuclear deformation, thereby increasing chromatin openness.
View Article and Find Full Text PDFNewton
September 2025
Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA.
In confluent cell monolayers, patterns of cell forces and motion are systematically altered near topological defects in cell shape. In turn, defects have been proposed to alter cell density, extrusion, and invasion, but it remains unclear how the defects form and how they affect cell forces and motion. Here, we studied +1/2 defects, and, in contrast to prior studies, we observed the concurrent occurrence of both tail-to-head and head-to-tail defect motion in the same cell monolayer.
View Article and Find Full Text PDFMed Phys
September 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
Background: Dual-energy computed tomography (DECT) enhances material differentiation by leveraging energy-dependent attenuation properties particularly for carbon ion therapy. Accurate estimation of tissue elemental composition via DECT can improve quantification of physical and biological doses.
Objective: This study proposed a novel machine-learning-based DECT (ML-DECT) method to predict the physical density and mass ratios of H, C, N, O, P, and Ca.
Adv Mater
September 2025
Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, 999077, P. R. China.
Alkaline zinc-iron flow batteries (AZIFBs) are one of the promising aqueous redox chemistries for large-scale energy storage due to their intrinsic safety and low cost. However, the energy efficiency (EE) and power density of batteries with low-cost polybenzimidazole (PBI) membranes are still limited due to the relatively poor ionic conductivity of PBI in an alkaline medium. Here, this study proposes a novel chemical approach for regulating the chemical environment of the PBI membrane.
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