Molecular Engineering of Self-Folded Lithium Salts toward High-Energy and High-Power Lithium Metal Pouch Cells.

Molecular engineering of electrolytes for practical high-power and high-energy lithium metal batteries (LMBs) is a significant challenge due to the difficulty of simultaneously achieving high Li transport efficiency, minimal gas evolution, and stable cathode-electrolyte and anode-electrolyte interphases (CEI and SEI, respectively), with low charge-transfer resistance. Here, we introduce a fluorinated asymmetric lithium salt, lithium (2-(2-(2,2-difluoroethoxy)ethoxy)ethyl) ((trifluoromethyl)sulfonyl)amide (LiFOA), designed to optimize electrolyte physicochemical/electrochemical properties for stable LMB pouch cells under fast cycling conditions. LiFOA features a Li-affinitive side chain, which folds up and suppresses anion migration, resulting in a significantly heightened Li transference number ().

Identification of the IFN-γ/IL-4 ratio as a prognostic biomarker and development of an immune-related prognostic model in diffuse large B-cell lymphoma.

Background: Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous B-cell malignancy influenced by immune dysregulation, posing significant clinical challenges. Lymphocyte subsets (e.g.

Integrated temperature and humidity sensor based on the harmonic Vernier effect with a dual-MZI-in-one-fiber.

A novel, to the best of our knowledge, highly sensitive, and compact optical fiber sensor for measuring temperature and relative humidity (RH) is proposed and demonstrated. The sensor integrates two parallel Mach-Zehnder interferometers (MZIs) within a dual-side hole fiber (DSHF). One of the MZIs detects temperature with the help of polydimethylsiloxane (PDMS), and the other detects RH using polyvinyl alcohol (PVA), labeled as MZI and MZI, respectively.

Research on inner membrane complex protein 1: a novel nanovaccines against Toxoplasma gondii.

Toxoplasma gondii (T. gondii) is a globally prevalent zoonotic parasite causing severe health and economic impacts. Despite decades of research, no commercial vaccine provides comprehensive protection against both acute and chronic toxoplasmosis.

Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis.

Encapsulating peritoneal sclerosis (EPS) is a life-threatening fibrotic condition characterized by severe abdominal adhesions, chronic inflammation, and significant morbidity. The lack of effective treatments for EPS stems from a limited understanding of its underlying mechanisms. In this study, we developed a modified mouse model of PD-induced EPS and investigated the role of the STING signaling pathway in disease progression.

A Survey of Attacks on Large Vision-Language Models: Resources, Advances, and Future Trends.

With the significant development of large models in recent years, large vision-language models (LVLMs) have demonstrated remarkable capabilities across a wide range of multimodal understanding and reasoning tasks. Compared with traditional large language models (LLMs), LVLMs present great potential and challenges due to their closer proximity to the multiresource real-world applications and the complexity of multimodal processing. However, the vulnerability of LVLMs is relatively underexplored, posing potential security risks in the daily use of LVLM applications.

Enamine-Tautomerization-Driven Mannich Reaction of Alkylazaarenes with Aminals.

We have developed a readily feasible Mannich-type reaction of alkylazaarenes with aminals, demonstrating excellent functional group tolerance and scalability. Mechanistic studies reveal that the reactivity and selectivity are governed by the electronic effects in conjunction with the stability and steric hindrance of the enamine intermediates. The resulting aminomethylated products hold promising potential for applications in organic synthesis, medicinal chemistry, and ligand design.

Quasi-BIC empowered asymmetric grating for high-Q angularly tolerant THz filters with switchable transmission-reflection dualities.

THz narrowband filters are essential for various applications. Currently, they often suffer from substrate-induced parasitic losses and interference, stringent collimation requirements imposed by angle-dependent resonance excitation, and cumbersome peripheral optical components due to reflection-mode operation. To tackle these issues, geometrically protected BICs are employed in a substrate-free single-layer asymmetric dual grating structure of high-resistance silicon to achieve narrowband polarization-controlled dual transmissive/reflective THz filtering with high- factors, broad stopbands, and tolerance to incident angles, simultaneously.

The impact of intraoperative prone lumbar fluoroscopy under anesthesia on the selection of lowest instrumented vertebra and surgical outcomes in adolescent idiopathic scoliosis with lumbar structural curves.

Purpose: To explore the role of intraoperative prone lumbar fluoroscopy under anesthesia in guiding lowest instrumented vertebra (LIV) selection in adolescent idiopathic scoliosis (AIS) patients with lumbar structural curves and its subsequent impact on surgical outcomes.pap.

Methods: This retrospective cohort study included 45 AIS patients with lumbar structural curves who underwent posterior spinal deformity correction surgery at the Scoliosis Center, the Third Affiliated Hospital of Sun Yat-sen University between 2020 and 2022.

Association between cardiovascular-kidney-metabolic health metrics and long-term cardiovascular risk: Findings from the Chinese Multi-provincial Cohort Study.

Background: The American Heart Association (AHA) introduced the concept of cardiovascular-kidney-metabolic (CKM) health and stage, reflecting the interaction among metabolism, chronic kidney disease (CKD), and the cardiovascular system. However, the association between CKM stage and the long-term risk of cardiovascular disease (CVD) has not been validated. This study aimed to evaluate the long-term CVD risk associated with CKM health metrics and CKM stage using data from a population-based cohort study.

Association of CVAI with BMD, FRAX scores, and osteoporosis risk in Chinese elderly patients with hypertension.

The effects of visceral fat on osteoporosis have attracted considerable attention. The Chinese visceral adiposity index (CVAI) has been demonstrated to respond more effectively than conventional measures in reflecting visceral fat characteristics in the Chinese population. This study aimed to explore the relationship between CVAI and bone mineral density (BMD), FRAX scores, and osteoporosis in Chinese elderly individuals with hypertension.

PLGA nanoparticles as an efficient carrier in GAP45: a more effective vaccine against acute toxoplasmosis than traditional ones.

Introduction: (), as a strict intracellular parasite, can infect nearly all mammals, including humans, posing significant threats to public health. Toxoplasmosis in animals also leads to substantial economic losses in animal husbandry. Currently, no effective treatments are available for toxoplasmosis, creating an urgent need for safe and efficient therapeutics.

A simple score, CKMS-BAG, to predict cardiovascular risk with cardiovascular-kidney-metabolic health metrics.

The 2023 American Heart Association (AHA) Health Presidential Advisory recommends risk assessment of cardiovascular disease (CVD) within the context of Cardiovascular-Kidney-Metabolic syndrome (CKMS). However, an intuitive and easy-to-use risk score incorporating CKM health metrics remains needed to prevent CVD in daily practice. We constructed an acronym-based clinical risk score using CKM-related predictors and externally validated its predictive performance for total CVD and its subtypes of atherosclerotic CVD and heart failure, based on two prospective community-based cohorts.

Non-linear relationship between platelet count and 30-day in-hospital mortality in ICU patients with acute myocardial infarction: a multicenter retrospective cohort study.

Acute myocardial infarction (AMI) remains a major global health challenge with high mortality rates. This study investigated the association between platelet count and 30-day in-hospital mortality in critically ill AMI patients. This multicenter retrospective cohort study analyzed 6,850 critically ill AMI patients from 208 U.

ceRNA Profiling Reveals circSAMD4A Promoted Porcine Adipocytes Differentiation via Targeting miR-127/PRKAR2B.

Pork quality is critically influenced by fat deposition patterns, with emerging evidence implicating circular RNAs (circRNAs) as key regulators of adipogenesis, though the specific circRNAs controlling lipogenesis remain incompletely characterized. To systematically elucidate the competing endogenous RNA (ceRNA) network governing porcine adipocyte differentiation, we isolated primary preadipocytes from piglets, induced differentiation, and performed comprehensive RNA sequencing that identified 504 differentially expressed (DE) circRNAs, 126 DE miRNAs, and 1615 DE mRNAs between proliferative and differentiated states, revealing an extensive transcriptomic rewiring during adipogenesis. Functional characterization demonstrated that two circRNAs, circSAMD4A and circLPAR1, significantly promoted lipid accumulation.

Protozoan-based biodiversity-safeguarding benchmark for triclosan in freshwater ecosystems.

The global usage of triclosan (TCS)-containing disinfectants posed toxicity threats to freshwater biodiversity; at the same time, the ecological risk assessments based on Species Sensitivity Distribution (SSD) models overestimated the Predicted No-Effect Concentration (PNEC) of the TCS due to neglecting toxicity data for the secondary trophic level protozoa. This study conducted acute and chronic toxicity tests to obtain the toxicity parameters of Paramecium sp. (96 h-EC=149 μg/L, 7 d-EC=41 μg/L), Colpoda sp.

Discovery of Cryptolepine and Its Derivatives as Novel Antiviral Agents.

Based on the widespread utilization of aliphatic amines in pesticide research and development, a series of cryptolepine derivatives containing aliphatic amine moieties were designed and synthesized, and their antiviral activities were evaluated for the first time. The bioassay results indicated that most of these derivatives exhibited activity against the tobacco mosaic virus. Derivative demonstrated inactivation, curative, and protection activities of 57.

Profiles of echocardiographic features associated with blood pressure in patients with hypertension.

The multidimensional echocardiographic features associated with BP level are unclear. This study aimed to identify the multidimensional echocardiographic features associated with BP. In total, 2 092 adult participants (aged ≥18 years) with hypertension who underwent echocardiography in Beijing between July 2017 and January 2020 as part of the Multi-provincial Cohort for Hypertension study were enrolled.

METTL14-Mediated MA Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex.

Tumor cells reprogram their energy metabolism patterns to meet the needs of rapid growth and metastasis. The underlying mechanisms of long noncoding RNAs (lncRNAs) in glucose metabolism remodeling in breast cancer (BC) are still not well understood. Herein, the expression of a tumorigenic lncRNA, LINC01094 are demonstrated that, is significantly increased in BC tissues and is associated with poorer patient survival.

Plasma Aldosterone Elevation in Hypertensive Patients and Association with Urinary Stone Formation: A Large-Scale Population Study from Northwest China.

Background: Previous studies have suggested a potential association between plasma aldosterone concentration (PAC) and calcium regulation. However, it remains unclear whether elevated PAC levels increase the risk of urinary stones. Therefore, this study aimed to investigate the relationship between PAC levels and urinary stones, including their subtypes, in patients with hypertension.

Preparation, optimizations, and applications of (carboxymethyl cellulose)-chitosan polyelectrolyte composite films in food packaging: a review.

The development of new, environmentally friendly, and efficient food packaging materials has always been a research hotspot in food science. Carboxymethyl cellulose (CMC) and chitosan (CS) are two renewable, biodegradable, environmental-friendly, and bio-based materials, which are widely found in nature and have great environmental and economic values. However, the presence of carboxyl and hydroxyl groups in the structure of CMC makes it highly sensitive to water, and CS can only be dissolved in acidic systems and has insufficient rheological properties, which limits the application of these two materials in the field of food packaging.

A hybrid algorithm-based ECG risk prediction model for cardiovascular disease.

Aims: Little is known about the role of electrocardiography (ECG) in the community population independent of physical and laboratory examinations. Thus, this study developed and validated several ECG-based models for cardiovascular disease (CVD) risk assessment, with or without simple questionnaire-based variables.

Methods And Results: Using a derivation cohort of 3734 Chinese participants aged ≥40 years, we developed the ECG-based models to predict the risk of developing CVD (comprising fatal and non-fatal coronary heart disease, unstable angina, stroke, and heart failure).

Gamba: Marry Gaussian Splatting With Mamba for Single-View 3D Reconstruction.

We tackle the challenge of efficiently reconstructing a 3D asset from a single image at millisecond speed. In this work, we introduce Gamba, an end-to-end 3D reconstruction model from a single-view image, emphasizing two main insights: (1) Efficient Backbone Design: introducing a Mamba-based GambaFormer network to model 3D Gaussian Splatting (3DGS) reconstruction as sequential prediction with linear scalability of token length, thereby accommodating a substantial number of Gaussians; (2) Robust Gaussian Constraints: deriving radial mask constraints from multi-view masks to eliminate the need for warmup supervision of 3D point clouds in training. We trained Gamba on Objaverse and assessed it against existing optimization-based and feed-forward 3D reconstruction approaches on the GSO Dataset, among which Gamba is the only end-to-end trained single-view reconstruction model with 3DGS.

Iron rust for efficient photocatalytic hydrogen evolution.

Iron (Fe) corrosion typically results in significant damage to Fe-based devices and structures. However, the corrosion products can be repurposed as active materials in electrocatalytic and photocatalytic reactions. In this study, we have strategically induced oxygen corrosion in Fe foams to synthesize cost-effective Fe rust cocatalysts (Orthorhombic FeOOH) for enhancing the photocatalytic hydrogen evolution reaction (HER), exemplifying the concept of "turning waste into treasure".

Odour-Specific Identification Impairment Is Associated With Cognitive Dysfunction in Older Adults: A Contemporary Community-Based Study.

Background: To delay or prevent the development of MCI, identifying a potential target is essential. Olfactory dysfunction has been linked to MCI. However, it remains unclear to what extent odour-specific identification impairment affects domain-specific cognition.