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Article Abstract
The 2023 American Heart Association (AHA) Health Presidential Advisory recommends risk assessment of cardiovascular disease (CVD) within the context of Cardiovascular-Kidney-Metabolic syndrome (CKMS). However, an intuitive and easy-to-use risk score incorporating CKM health metrics remains needed to prevent CVD in daily practice. We constructed an acronym-based clinical risk score using CKM-related predictors and externally validated its predictive performance for total CVD and its subtypes of atherosclerotic CVD and heart failure, based on two prospective community-based cohorts. We found the Cholesterol, Kidney function, Male [Doubled], Smoker [Doubled]-Blood pressure, Age, and fast blood Glucose (CKMS-BAG) score exhibited good-to-excellent and robust performance regarding discrimination and risk stratification for total CVD and its subtypes in internal and external validation. Using clinical routine data, the CKMS-BAG score accurately discriminates participants at cardiovascular low, intermediate, and high risk. Thus, it might help improve CVD prevention and management in clinical practice without any paper or electronic tools.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209976 | PMC |
| http://dx.doi.org/10.1016/j.isci.2025.112780 | DOI Listing |
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