Machine learning-based personalized prediction of sperm retrieval in patients with non-obstructive azoospermia prior to microdissection testicular sperm extraction: A multi-center cohort study.

Background: Non-obstructive azoospermia represents the most severe form of male infertility. The heterogeneous nature of focal spermatogenesis within the testes of non-obstructive azoospermia patients poses significant challenges for accurately predicting sperm retrieval rates.

Objectives: To develop a machine learning-based predictive model for estimating sperm retrieval rates in patients with non-obstructive azoospermia.

A Comprehensive Mass Spectrometry-Based Proteomic Dataset of Human Spermatozoa.

Male infertility is fundamentally rooted in developmental defects of germ cells and associated molecular dysregulation, yet the underlying mechanisms remain poorly understood. Data-independent acquisition (DIA) has emerged as a powerful tool in discovery proteomics, enabling the identification of disease biomarkers, therapeutic targets, and molecular pathways with high precision and reproducibility. To analyse the aberrant regulatory events in human sperm proteins associated with male reproductive disorders in a high-throughput, reproducible, and reliable manner, we employed the Orbitrap Astral mass spectrometer, which independently operates Orbitrap Full Scan and Astral MS/MS to generate high-resolution full-scan spectra and high-quality secondary maps.

Assessment of psychological resilience in adult patients with epilepsy: a cross-sectional study.

Background: Psychological resilience plays a crucial role in the quality of life and mental health of patients with epilepsy (PWE). However, there is limited research on the factors influencing psychological resilience in Chinese PWE. This study aimed to investigate the determinants of psychological resilience in PWE and explore the relationship between neurological health status and resilience.

Surface-Passivation-Enabled Electronic and Optical Property Engineering in Two-Dimensional GaSb.

Gallium antimonide (GaSb) is promising for next-generation electronics and optoelectronics due to its high carrier mobility and narrow bandgap (∼0.725 eV). However, in two-dimensional (2D) form, surface dangling bonds cause instability and Fermi-level pinning, degrading performance.

Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma.

Background: Metabolic reprogramming within the tumor microenvironment plays a pivotal role in tumor progression and therapeutic responses. Nevertheless, the relationship between aberrant glutathione (GSH) metabolism and the immune microenvironment in lung adenocarcinoma, as well as its clinical implications, remains unclear.

Methods: We leveraged genome-wide association study (GWAS) data and applied genetic causal analysis to evaluate the causal relationships among plasma 5-oxoproline levels, lung adenocarcinoma (LUAD) risk, and 731 immune phenotypes.

Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040.

Introduction: Smoking is a major environmental risk factor for nasopharyngeal carcinoma (NPC), but the global burden and epidemiological trends of NPC attributable to smoking remain unclear.

Methods: Data were obtained from the 2021 Global Burden of Disease study. A comprehensive analysis was conducted on mortality, years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life years (DALYs) attributable to NPC attributable to smoking.

Nondestructive measurement of the thickness and refractive index of polymer thin films using a single-frequency terahertz Mueller matrix ellipsometry.

Terahertz Mueller matrix ellipsometry is a nondestructive technique based on terahertz waves that can measure film thickness and optical constants with high accuracy. We propose a single-frequency terahertz Mueller matrix ellipsometry based on a dual rotating compensator configuration, which utilizes terahertz waves to achieve high-precision nondestructive measurements of the thickness and refractive index of polymer films. The system realizes the fully polarized incidence of the terahertz beam by rotating the compensator, and establishes a complete polarization measurement scheme by measuring the outgoing light intensity of the two compensators at different angles.

Alterations in Semen Quality and Immune-Related Factors in Men with Infertility who Recovered from COVID-19.

The emergence of coronavirus disease 2019 (COVID-19) has triggered research into its impact on male reproductive health. However, studies exploring the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on semen quality in infertile men remain limited. Herein, we enrolled 781 male infertile patients who recovered from COVID-19 and analyzed their semen and blood samples collected at different time points.

Nonlinear correction of terahertz FMCW based on time-domain phase compensation.

Terahertz frequency-modulated continuous-wave (THz FMCW) technology has become a widely used nondestructive testing tool due to its imaging and detection advantages. Nonlinearity is one of the most common problems with FMCW technology. This is due to the inability to maintain strict linearity during the high-frequency sweep process, resulting in multiple frequencies in the calculated intermediate frequency (IF) signal.

SLC35A2-mediated bisected GlcNAc-modified extracellular vesicles enhance immune regulation in breast cancer lung metastasis.

This study investigates the role of SLC35A2-mediated bisected GlcNAc-modified small extracellular vesicles (sEVs) in breast cancer (BC) lung metastasis. By modulating B3GALT1 expression, these sEVs regulate the pre-metastatic immune microenvironment, enhancing CD8+ T cell infiltration and reducing immune evasion. The use of β-peptide-loaded sEVs further amplifies anti-metastatic effects, as demonstrated in vivo mouse models and molecular analyses.

The prognosis prediction value of CD69+ CD8+ tissue-resident memory T cell as a novel indicator of pathologic complete response heterogeneity following different neoadjuvant therapy regimen in esophageal squamous cell carcinoma.

Background: Improving pathological complete response (pCR) rate is currently the main goal of neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma (LA-ESCC). However, improved pCR rates do not consistently translate into better prognosis, likely due to regimen-specific pCR heterogeneity. We investigated this heterogeneity and potential biomarkers between two common neoadjuvant regimens.

Postoperative Adjuvant Therapy Benefits Non-pCR Patients Rather Than pCR Patients for Locally Advanced ESCC: A Multicenter Real-World Study.

Background: There is no unified standard in adjuvant therapy (AT) for patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant therapy and surgery. We evaluated the significance of AT for these patients and explored its influencing factors.

Methods: ESCC patients who underwent neoadjuvant therapy and surgery from 2019 to 2022 at three centers were divided into AT (n = 227) and non-AT groups (n = 435).

The Role of Lymphocyte Recovery Index in Prognosis Prediction for Locally Advanced Cervical Cancer With Radiation-Induced Lymphopenia.

Background: In patients with locally advanced cervical cancer (LACC) undergoing concurrent chemoradiotherapy (CCRT), the high incidence of radiation-induced lymphopenia significantly affects prognosis. There are significant variations in lymphocyte count (ALC) recovery patterns among patients, and their impact on prognosis remains unclear. This study aims to quantify the lymphocyte recovery patterns by the lymphocyte recovery index (LRI) and evaluate its prognostic value.

The Combined Prognostic Value of F-FDG PET/CT Metabolic Parameters of Immune Organs and Hematological Immune-Related Markers in Patients With Locally Advanced Cervical Cancer.

Background: This study aimed to explore the prognostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) metabolic parameters of immune organs and hematological immune-related markers for patients with locally advanced cervical cancer (LACC) undergoing concurrent chemoradiotherapy (CCRT), and to establish prognostic nomograms based on these potential biomarkers.

Methods: A total of 180 patients with LACC undergoing CCRT were retrospectively reviewed and randomly divided into training and validation groups at a 7:3 ratio. Cox regression analysis was performed to identify independent prognostic factors for progression-free survival (PFS) and overall survival (OS) from hematological immune-related markers and F-FDG PET/CT metabolic parameters of the primary tumor, spleen, and bone marrow (BM).

Efficacy and safety of aumolertinib in EGFR-mutated non-small cell lung cancer with leptomeningeal metastasis: a single‑center retrospective study.

Purpose: To evaluate the efficacy and safety of aumolertinib in treating non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) and epidermal growth factor receptor (EGFR) mutations.

Methods: We conducted a retrospective analysis of clinical data from 79 patients with EGFR-mutated advanced NSCLC treated with aumolertinib after being diagnosed with LM at Shandong Cancer Hospital and Institute between April 2020 and July 2023. We evaluated overall survival (OS), progression-free survival (PFS), LM-PFS, and safety.

Assessment of stigma among patients living with Parkinson's disease: an exploratory study.

Objective: This cross-sectional study aims to assess the levels of stigma among patients with Parkinson's disease (PD) and identify the demographic and clinical factors influencing both internal and external stigma.

Materials And Methods: A total of 200 patients diagnosed with PD were recruited from Beijing Tiantan Hospital between June 2023 and June 2024 using convenience sampling. Data were collected through face-to-face interviews, including demographic information, disease severity assessed via the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), and stigma levels measured using the 24-item Stigma Scale for Chronic Illness (SSCI).

The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson's disease.

Sleep difficulties affect up to 98% of Parkinson's disease (PD) patients and are often not well treated. How globus pallidus internus (GPi)-DBS could help is less understood. We retrospectively analyzed sleep outcomes in 32 PD patients after GPi-DBS with a two-year follow-up.

Exploring Unlabeled Data in Multiple Aspects for Semi-Supervised MRI Segmentation.

MRI segmentation offers crucial insights for automatic analysis. Although deep learning-based segmentation methods have attained cutting-edge performance, their efficacy heavily relies on vast sets of meticulously annotated data. In this study, we propose a novel semi-supervised MRI segmentation model that is able to explore unlabeled data in multiple aspects based on various semi-supervised learning technologies.

Isopsoralen Improves Glucocorticoid-induced Osteoporosis by Regulating Purine Metabolism and Promoting cGMP/PKG Pathway-mediated Osteoblast Differentiation.

Background: The effects of Isopsoralen (ISO) in promoting osteoblast differentiation and inhibiting osteoclast formation are well-established, but the mechanism underlying ISO's improvement of Glucocorticoid- Induced Osteoporosis (GIOP) by regulating metabolism remains unclear.

Methods: This study aims to elucidate the mechanism of ISO treatment for GIOP through non-targeted metabolomics based on ISO's efficacy in GIOP. Initially, we established a GIOP female mouse model and assessed ISO's therapeutic effects using micro-CT detection, biomechanical testing, serum calcium (Ca), and phosphorus (P) level detection, along with histological analyses using hematoxylin and eosin (HE), Masson, and tartrate-resistant acidic phosphatase (TRAP) staining.

Nondestructive measurement of terahertz optical thin films by machine learning based on physical consistency.

Optical scattering measurement is one of the most commonly used methods for non-contact online measurement of film properties in industrial film manufacturing. Terahertz photons have low energy and are non-ionizing when measuring objects, so combining these two methods can enable online nondestructive testing of thin films. In the visible light band, some materials are transparent, and their thickness and material properties cannot be measured.

The role of spleen radiomics model for predicting prognosis in esophageal squamous cell carcinoma patients receiving definitive radiotherapy.

Background: The spleen plays an important role in systemic antitumor immune response, but whether spleen imaging features have predictive effect for prognosis and immune status was unknown. The aim of this study was to investigate computed tomography (CT)-based spleen radiomics to predict the prognosis of patients with esophageal squamous cell carcinoma (ESCC) underwent definitive radiotherapy (dRT) and to try to find its association with systemic immunity.

Methods: This retrospective study included 201 ESCC patients who received dRT.

Sperm retrieval outcomes of contralateral testis in men with nonobstructive azoospermia and unsuccessful unilateral microdissection testicular sperm extraction.

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Predicting the progression-free survival of gastrointestinal stromal tumors after imatinib therapy through multi-sequence magnetic resonance imaging.

Purpose: Identify radiomics features associated with progression-free survival (PFS) and develop a predictive model for accurate PFS prediction in liver metastatic gastrointestinal stromal tumor patients (GIST).

Methods: This multi-center retrospective study involved a comprehensive review of clinical and imaging data pertaining to 211 patients with gastrointestinal stromal tumors (GIST) from Center A and B. A total of 147 patients with hepatic metastatic GIST were included, with 102 cases as the training set and 45 cases as the external validation set.