Ultrathin Gallium Nitride Quantum-Disk-in-Nanowire-Enabled Reconfigurable Bioinspired Sensor for High-Accuracy Human Action Recognition.

Human action recognition (HAR) is crucial for the development of efficient computer vision, where bioinspired neuromorphic perception visual systems have emerged as a vital solution to address transmission bottlenecks across sensor-processor interfaces. However, the absence of interactions among versatile biomimicking functionalities within a single device, which was developed for specific vision tasks, restricts the computational capacity, practicality, and scalability of in-sensor vision computing. Here, we propose a bioinspired vision sensor composed of a GaN/AlN-based ultrathin quantum-disks-in-nanowires (QD-NWs) array to mimic not only Parvo cells for high-contrast vision and Magno cells for dynamic vision in the human retina but also the synergistic activity between the two cells for in-sensor vision computing.

Enhanced pollutant removal in moving bed biofilm reactor under high-salinity condition via specialized quorum sensing bacteria.

The study aims to accelerate biofilm formation and operational performance of moving bed biofilm reactor (MBBR) in a high salt environment by adding specific quorum sensing (QS) strain (Vibrio sp. LV-Q1). Results showed that the addition of QS strain significantly promoted the pollutant removal process of the bioreactor.

[Ionizing radiation-induced damage (IRD) to and repair mechanisms of the male reproductive system: Report of testicular function changes in a case of IRD].

Objective: To investigate the impact of ionizing radiation (IR) on the structure and function of the testis and provide some strategies for the prevention and treatment of IR-induced damage (IRD).

Methods: Using radiation dose simulation, semen analysis, hormone testing, electron microscopy and single-cell transcriptome sequencing, we assessed and analyzed a case of IRD. We established a mouse model of IRD to validate the results of single-cell sequencing, and investigated the specific biological mechanisms of IRD and potential strategies for its intervention.

Radical resection of a giant cell tumor of the distal ulna and reconstruction with a 3D-printed distal ulnar prosthesis: A case report.

Rationale: Giant cell tumors (GCTs) of the distal ulna are rare. Despite their benign nature, these tumors can exhibit local aggressiveness and have the potential to recur after undergoing conventional treatment involving curettage and bone grafting. For aggressive GCTs, radical resection is more suitable.

A Quasi Solid-State Hydrogel/InGaN Nanorod Heterostructure-Enabled Amphibious Sensor for Stable and Cross-Medium Optical Sensing and Monitoring.

The wearable optoelectronic systems, often employed with miniaturized and portable photosensors, can be conformably integrated with the human body to promote the advancement of health monitoring and protection. However, developing advanced photosensors with a simple structure that can be sustainable with high sensitivity in different operation conditions, e.g.

Improving diagnostic accuracy in cirrhotic patients: a comprehensive multicenter analysis of contrast-enhanced ultrasound-guided biopsy in a large cohort of 2056 patients.

Purpose: To investigate the factors influencing ultrasound-guided liver biopsy accuracy and develop a decision model for managing biopsy results.

Materials And Methods: This prospective study enrolled 2056 adult patients with focal hepatic lesions from nine Chinese hospitals. Diagnostic accuracy was calculated, and variables were analyzed using multivariate logistic regression.

Adverse effects and underlying mechanism of rare earth elements.

Background: Rare earth elements (REEs) have found broad application in a range of industries, including electronics, automotive, agriculture, and healthcare. However, their widespread utilization and release into the environment pose potential risks of human exposure. Despite extensive research on REEs toxicity, the relationship between exposure and subsequent health concerns remains ambiguous.

Highly Coupled Dynamically Modulated Electrocatalysts on Wafer-Scale InGaN/GaN Nanowires on Silicon for Successive Acidic Photoelectrochemical Water Oxidation.

Photoelectrochemical water splitting is considered one of the most promising paths for sustainable hydrogen production. However, the sluggish kinetics of the water oxidation reaction and poor stability of the photoanode significantly limit the overall performance of the photoelectrochemical device, particularly under acidic conditions, which poses great challenges for practical applications. Herein, the coupling of unique CoRuO nanoclusters with dynamic electronic modulation effects to wafer-scale InGaN nanowires is proposed, demonstrating superior photoelectrochemical activity and stability for acidic water oxidation.

Comparative study of low-power versus high-power holmium laser enucleation of the prostate for large volume benign prostatic hyperplasia.

Benign prostatic hyperplasia (BPH) is a prevalent condition among the elderly male population, characterised by prostate enlargement and bothersome urinary symptoms. Holmium Laser Enucleation of the Prostate (HoLEP) is a minimally invasive surgical option that is preferred for larger prostates due to its precision and minimal complications. Although high-power HoLEP is an efficacious procedure, recent studies indicate that low-power settings may offer comparable benefits with diminished postoperative discomfort.

Technological innovation of HoLEP: a multicenter, randomized, controlled study for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia.

Purpose: The purpose of this study was to investigate the efficacy of Transurethral Holmium Laser of the Prostate (HoLEP) with Double-n Technology in the treatment of benign prostatic hyperplasia (BPH), with a focus on preserving sexual function postoperatively.

Methods: Conducted as a multicenter, prospective, single-blind randomized controlled trial, this study enrolled sexually active male patients with BPH. Participants were randomized into three groups: standard HoLEP (Group A), single-n technology (Group B), and innovative double-n technology (Group C), which emphasizes the preservation of the urethral mucosa and nearby structures.

Comparative analysis of low-power versus high-power holmium laser enucleation of the prostate for symptomatic small-volume benign prostatic hyperplasia: a prospective randomized controlled trial.

Objective: To compare the safety and efficacy of low-power (LP) and high-power (HP) holmium laser enucleation of the prostate (HoLEP) in patients with symptomatic small-volume benign prostatic hyperplasia (BPH).

Methods: In this prospective, multicenter, single-blind, randomized controlled trial, men with symptomatic BPH (prostate volume <40 mL, peak urinary flow rate [Qmax] <10 mL/s, International Prostate Symptom Score [IPSS] ≥18) underwent either LP (24 W) or HP HoLEP (80 W). The primary outcome was IPSS at 6 months postoperatively.

Metagenomics combined with untargeted metabolomics to study the mechanism of miRNA-150-5p on SiO -induced acute lung injury.

Acute lung injury is a significant global health issue, and its treatment is becoming a hot topic of the researchers. To investigate the feasibility of miRNA-150-5p tail vein injection in the treatment of SiO-induced acute lung injury through the regulation of gut microbiota and serum metabolites based on multiomics technology. Twenty-four mice were randomly divided into the control, SiO and miRNA-150-5p intervention groups.

Network-level crash risk analysis using large-scale geometry features.

Road traffic crashes are common occurrences that create substantial losses and hazards to society. A complex interaction of components, including drivers, vehicles, roads, and the environment, can impact the causes of these crashes. Due to its complexity, crash identification, and prediction research over large-scale areas faces several obstacles, including high costs and challenging data collecting.

Reply to "Matters arising: cost-effectiveness of first-line immunotherapy combinations with or without chemotherapy for advanced non-small cell lung cancer: a modelling approach".

In this article, we read with great attention the correspondence by Bullement et al., regarding our published study on cost-effectiveness of first-line immunotherapy combinations with or without chemotherapy for advanced non-small cell lung cancer. We referred to a few the most important comments from Bullement et al.

Mitotic catastrophe heterogeneity: implications for prognosis and immunotherapy in hepatocellular carcinoma.

Background And Aims: The mitotic catastrophe (MC) pathway plays an important role in hepatocellular carcinoma (HCC) progression and tumor microenvironment (TME) regulation. However, the mechanisms linking MC heterogeneity to immune evasion and treatment response remain unclear.

Methods: Based on 94 previously published highly correlated genes for MC, HCC patients' data from the Cancer Genome Atlas (TCGA) and changes in immune signatures and prognostic stratification were studied.

Superior AlGaN/GaN-Based Phototransistors and Arrays with Reconfigurable Triple-Mode Functionalities Enabled by Voltage-Programmed Two-Dimensional Electron Gas for High-Quality Imaging.

High-quality imaging units are indispensable in modern optoelectronic systems for accurate recognition and processing of optical information. To fulfill massive and complex imaging tasks in the digital age, devices with remarkable photoresponsive characteristics and versatile reconfigurable functions on a single-device platform are in demand but remain challenging to fabricate. Herein, an AlGaN/GaN-based double-heterostructure is reported, incorporated with a unique compositionally graded AlGaN structure to generate a channel of polarization-induced two-dimensional electron gas (2DEGs).

Exploring driving anger-caused impairment of takeover performance among professional taxi drivers during partially automated driving.

Partially automated systems are expected to reduce road crashes related to human error, even amongst professional drivers. Consequently, the applications of these systems into the taxi industry would potentially improve transportation safety. However, taxi drivers are prone to experiencing driving anger, which may subsequently affect their takeover performance.

Time-dependent efficacy analysis of first-line immunotherapies for advanced non-small cell lung cancer.

Background: Many randomized controlled trials (RCTs) and network meta-analyses have demonstrated that the progression-free survival (PFS) and overall survival (OS) of advanced non-small cell lung cancer (NSCLC) patients can be improved through combination immunotherapy or monotherapies. However, time-dependent analysis of the treatment effect is currently lacking. Thus, we aimed to evaluate the efficacy of first-line immunotherapy, and establish a hazard ratio function to reflect the time-varying progression or mortality risk of patients with NSCLC.

Biological Functions and Potential Therapeutic Significance of O-GlcNAcylation in Hepatic Cellular Stress and Liver Diseases.

O-linked-β-D-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation), which is dynamically regulated by -GlcNAc transferase (OGT) and -GlcNAcase (OGA), is a post-translational modification involved in multiple cellular processes. O-GlcNAcylation of proteins can regulate their biological functions via crosstalk with other post-translational modifications, such as phosphorylation, ubiquitination, acetylation, and methylation. Liver diseases are a major cause of death worldwide; yet, key pathological features of the disease, such as inflammation, fibrosis, steatosis, and tumorigenesis, are not fully understood.

Bidirectional two-sample mendelian randomization analysis identifies causal associations of MRI-based cortical thickness and surface area relation to NAFLD.

Background: Non-alcoholic fatty liver disease (NAFLD) patients have exhibited extra-hepatic neurological changes, but the causes and mechanisms remain unclear. This study investigates the causal effect of NAFLD on cortical structure through bidirectional two-sample Mendelian randomization analysis.

Methods: Genetic data from 778,614 European individuals across four NAFLD studies were used to determine genetically predicted NAFLD.

Facilitating nitrification and biofilm formation of Vibrio sp. by N-acyl-homoserine lactones in high salinity environment.

The N-acyl-homoserine lactones (AHLs)-mediated quorum-sensing (QS) system played a crucial role in regulating biological nitrogen removal and biofilm formation. However, the regulatory role of AHLs on nitrogen removal bacteria in high salinity environment has remained unclear. This study evaluated the roles and release patterns of AHLs in Vibrio sp.

The Clinical and Cellular Impact of RBMS2 on the Progression and Prognosis of Kidney Renal Clear Cell Carcinoma.

This research delves into the implications of the RNA binding motif, single stranded interacting protein 2 (RBMS2)-a gene associated with tumor-suppressing functions-in the context of kidney renal clear cell carcinoma (ccRCC). Through meticulous exploration of online databases, we have identified a negative association between RBMS2 expression and adverse clinico-pathological features, such as advanced TNM stage. Furthermore, our findings indicate that RBMS2 acts as a prognostic predictor for clinical outcomes in ccRCC, evidenced by both univariate and multivariate analyses.