The relationship between copper metabolism and p53 activity in tumors.

Cancer is an intractable global public health problem. The p53 protein encoded by the TP53 is a tumor suppressor, but it is mutated in many tumors, which promotes the initiation and progression of tumors. The mechanisms of p53 regulates tumors are focused on regulating apoptosis, cell cycle arrest, nutrient metabolism, iron metabolism, and redox levels.

EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization.

Background: Muscle atrophy has a poor prognosis, caused by various factors. Identifying a shared treatment target could address an unmet clinical need. The exon junction complex (EJC), a protein complex assembly that binds to RNA, facilitates post-transcriptional regulation by participating in mRNA splicing, mRNA export, translation and nonsense-mediated mRNA decay.

Theory-Guide Design of Integrative Catalytic Pairs for Urea Synthesis from Nitrate and Carbon Dioxide.

Electrochemical coreduction of carbon dioxide and nitrate offers a sustainable pathway to synthesize value-added urea from greenhouse gas and nitrogen-containing waste; however, challenges remain in designing efficient catalysts. Based on the concept of "integrative catalytic pairs (ICPs)", a catalyst for urea synthesis is designed by introducing heteroatoms (B and C) into M-N-C, where a single transition metal is dispersed on N-doped carbon material. Using a two-step theoretical screening strategy, Ni-NB is identified as a promising catalyst for urea synthesis, with a low limiting potential (-0.

LIPUS promotes osteogenic differentiation of rat BMSCs and osseointegration of dental implants by regulating ITGA11 and focal adhesion pathway.

Background: Low-intensity pulsed ultrasound (LIPUS) has been used as an effective noninvasive method for treating fractures and osteoarthrosis, but the application in the field of oral implantation is in its infancy. This study aimed to clarify the effect and mechanism of LIPUS on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and implant osseointegration, and to provide an experimental basis for future clinical applications.

Methods: Dental implants were inserted into Wistar rat femurs, and LIPUS was performed for 4 weeks.

The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance.

Colorectal cancer is a major cause of mortality among the prevalent malignant tumors of the gastrointestinal tract. Although chemotherapy is a standard treatment for colorectal cancer, its efficacy is limited by chemoresistance. Recent studies have investigated targeting tumor stem cells as a potential new therapeutic approach for addressing chemoresistance in colorectal cancer.

Autophagy regulates apoptosis of colorectal cancer cells based on signaling pathways.

Colorectal cancer is a common malignant tumor of the digestive system. Its morbidity and mortality rank among the highest in the world. Cancer development is associated with aberrant signaling pathways.

Accuracy of intraoral scanning using modified scan bodies for complete arch implant-supported fixed prostheses.

Statement Of Problem: The accuracy of intraoral scanning techniques for complete arch implant-supported prostheses remains unclear.

Purpose: The purpose of this in vitro study was to evaluate the accuracy of complete arch intraoral scanning using newly modified scan bodies.

Material And Methods: A definitive cast with 6 parallel dental implants (6-246 subgroup, right first molar, right first premolar, right lateral incisor, left lateral incisor, left first premolar, and left first molar) was fabricated.

Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases.

Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function and cardiopulmonary fitness. The mechanisms of exercise-induced cardioprotective effects are still not fully understood.

Human Brain In Vitro Model for Pathogen Infection-Related Neurodegeneration Study.

Recent advancements in stem cell biology and tissue engineering have revolutionized the field of neurodegeneration research by enabling the development of sophisticated in vitro human brain models. These models, including 2D monolayer cultures, 3D organoids, organ-on-chips, and bioengineered 3D tissue models, aim to recapitulate the cellular diversity, structural organization, and functional properties of the native human brain. This review highlights how these in vitro brain models have been used to investigate the effects of various pathogens, including viruses, bacteria, fungi, and parasites infection, particularly in the human brain cand their subsequent impacts on neurodegenerative diseases.

Probing Catalytic Sites and Adsorbate Spillover on Ultrathin FeO Film on Ir(111) during CO Oxidation.

The spatially resolved identification of active sites on the heterogeneous catalyst surface is an essential step toward directly visualizing a catalytic reaction with atomic scale. To date, ferrous centers on platinum group metals have shown promising potential for low-temperature CO catalytic oxidation, but the temporal and spatial distribution of active sites during the reaction and how molecular-scale structures develop at the interface are not fully understood. Here, we studied the catalytic CO oxidation and the effect of co-adsorbed hydrogen on the FeO/Ir(111) surface.

Aging behavior of microplastics accelerated by mechanical fragmentation: alteration of intrinsic and extrinsic properties.

Microplastics (MPs) inevitably undergo multiple aging processes during their life cycle in the environment. However, the information regarding the mechanical fragmentation behavior of MPs remained unclear, including the changes in the intrinsic properties of aged MPs, the measurement of aging degree, the underlying mechanism, and the interaction with heavy metals. Here, MPs (PS, PP, PET) were aged by crushing (-CR) and ball-milling (-BM) to simulate mild and severe mechanical fragmentation, respectively.

Study on the mechanism of NO reduction by NH-SCR over a ZnCuFeO catalyst.

Experimental evidence shows that CuFeO exhibits excellent catalytic performance in the SCR reaction. However, there is a lack of in-depth research on its specific reaction mechanism. Our study begins by computing the adsorption model of molecules like NH and then goes on to examine the SCR reaction mechanism of NH on CuFeO before and after Zn doping.

CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.

Skeletal muscle atrophy is a common clinical feature of many acute and chronic conditions. Circular RNAs (circRNAs) are covalently closed RNA transcripts that are involved in various physiological and pathological processes, but their role in muscle atrophy remains unknown. Global circRNA expression profiling indicated that circRNAs are involved in the pathophysiological processes of muscle atrophy.

High Photocatalytic Hydrogen Production of Ag@TiO with Different Sizes by Simple Chemical Synthesis.

The photocatalytic enhancement of sliver-based metals compounded with semiconductor materials has been demonstrated. However, there are relatively few studies on the effect of particle size in the system on photocatalytic performance. In this paper, silver nanoparticles of two different sizes, 25 and 50 nm, were prepared by a wet chemical method and subsequently sintered to obtain a photocatalyst with a core-shell structure.

A completely digital workflow aided by cone beam computed tomography scanning to maintain jaw relationships for implant-supported fixed complete dentures: A clinical study.

Statement Of Problem: The conventional workflow for the fabrication of implant-supported fixed complete dentures (IFCDs) is complex and makes it impossible to maintain jaw relationships. A fully digital workflow might solve this problem.

Purpose: The purpose of this clinical study was to develop a completely digital workflow aided by a cone beam computed tomography (CBCT) scan for the fabrication of IFCDs and to evaluate the accuracy of this workflow with regard to the maintenance of jaw relationships.

Correlation study of biomechanical changes between diabetic eye disease and glaucoma using finite element model of human eye with different iris-lens channel distances.

Purpose: To find out the effect on the biomechanical response of the eye in the setting of diabetes combined with glaucoma.

Method: Five finite element models of the human eyes with various iris-lens channel (ILC) distances (2 μm-20 μm) were constructed, respectively. The human eye model used for finite element analysis contain all the ocular contents and the optic nerve head.

Biomechanical analysis of ocular diseases and its in vitro study methods.

Ocular diseases are closely related to the physiological changes in the eye sphere and its contents. Using biomechanical methods to explore the relationship between the structure and function of ocular tissue is beneficial to reveal the pathological processes. Studying the pathogenesis of various ocular diseases will be helpful for the diagnosis and treatment of ocular diseases.

Two transporters mobilize magnesium from vacuolar stores to enable plant acclimation to magnesium deficiency.

Magnesium (Mg) is an essential metal for chlorophyll biosynthesis and other metabolic processes in plant cells. Mg is largely stored in the vacuole of various cell types and remobilized to meet cytoplasmic demand. However, the transport proteins responsible for mobilizing vacuolar Mg2+ remain unknown.

Delivery of engineered extracellular vesicles with miR-29b editing system for muscle atrophy therapy.

Muscle atrophy is a frequently observed complication, characterized by the loss of muscle mass and strength, which diminishes the quality of life and survival. No effective therapy except exercise is currently available. In our previous study, repressing miR-29b has been shown to reduce muscle atrophy.

Targeting miR-30d reverses pathological cardiac hypertrophy.

Background: Pathological cardiac hypertrophy occurs in response to numerous stimuli and precedes heart failure (HF). Therapies that ameliorate pathological cardiac hypertrophy are highly needed.

Methods: The expression level of miR-30d was analyzed in hypertrophy models and serum of patients with chronic heart failure by qRT-PCR.

Accuracy of 2 direct digital scanning techniques-intraoral scanning and stereophotogrammetry-for complete arch implant-supported fixed prostheses: A prospective study.

Statement Of Problem: Conventional impression techniques for complete arch implant-supported prostheses are technique-sensitive. Stereophotogrammetry (SPG) and intraoral scanning (IOS) may offer an alternative to conventional impression making.

Purpose: The purpose of this prospective study was to compare the accuracy of IOS and SPG for complete arch implant scans and to evaluate the passive fit of frameworks fabricated with SPG.

Formation of trihalomethanes and haloacetic acids from 2,6-dichloro-1,4-benzoquinone during chlorination: Decomposition kinetics, conversion rates, and pathways.

As a typical aromatic disinfection byproduct (DBP), 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ) attracts much concern due to the potential toxicity. To further evaluate the role of 2,6-DCBQ as an intermediate DBP in water with or without chlorine, their decomposition characteristics and transformation potential to the regulated DBPs (i.e.