Research Progress on Histone Lactylation Modification in Ischemic Stroke: Mechanisms and Therapeutic Potential.

Ischemic stroke (IS) is a leading cause of death and disability worldwide, with a complex pathogenesis involving neuroinflammation, oxidative stress, and disruption of the blood-brain barrier. Recent research has brought histone lactylation into focus as a novel epigenetic modification that plays a crucial role in IS. Under cerebral ischemia and hypoxia, lactate levels rise, providing an alternative energy source to support ischemic brain regions.

Occurrence and microbial remediation of polycyclic aromatic hydrocarbons and heavy metals pollution in soils.

The presence of soils contaminated with polycyclic aromatic hydrocarbons and heavy metals presents a widespread environmental challenge in industrial areas. Unlike single-pollutant systems, co-pollution by polycyclic aromatic hydrocarbons and heavy metals exhibits synergistic toxicity that weakens traditional remediation technologies. This review systematically examines microbial remediation strategies for such co-polluted soils, focusing on three levels of intervention: functional microorganisms, compost-based enhancement, and engineered microbial solutions.

Correction: The cGAS-STING pathway in atherosclerosis.

[This corrects the article DOI: 10.3389/fcvm.2025.

Genome-wide identification, molecular docking and expression analysis of enzymes involved in the primary and secondary metabolic branching points of the selenium metabolic pathway in Cardamine hupingshanensis.

Background: Cardamine hupingshanensis is a plant known for its unique selenium tolerance, making it a key model for selenium metabolism research. Adenosine phosphosulfate kinase (APK) and adenosine phosphosulfate reductase (APR) are widely distributed in plants and play a crucial role in selenium metabolism. While genome-wide analyses of the APK and APR families have been conducted across various plant species, a systematic identification and analysis of these gene families in Cardamine hupingshanensis is still lacking.

Regulation of Surface Terminal Hydroxyl Coverage of FeOCl Catalyst via Crystal Facet Protection for Enhanced HO Activation.

The unique Fe coordination environment in the FeOCl catalyst confers superior reducible electronic properties, rendering them attractive Fenton-like active sites. DFT calculations reveal that the U-shaped coordinated Fe sites formed with 50% terminal hydroxyl coverage exhibit the best HO activation performance, which allows the adsorbed HO to form a ·OH directly with much lower activation energy. Herein, a crystal facet protection strategy induced by rapid high-temperature annealing is developed to synthesize FeOCl with high exposure of Fe atoms while regulating the surface hydroxyl coverage.

Association Between Obstructive Sleep Apnea and Regional Fat: A Cross-Sectional Analysis of National Health and Nutrition Examination Survey 2015-2018.

The relationship between regional fat and obstructive sleep apnea (OSA) remains poorly understood. This study seeks to explore the link between regional fat and OSA, utilizing data from the National Health and Nutrition Examination Survey (NHANES). This cross-sectional analysis used NHANES 2015-2018 data.

The cGAS-STING pathway in atherosclerosis.

Atherosclerosis (AS), a chronic inflammatory disease, remains a leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of the cGAS-STING pathway-a key innate immune signaling cascade-in driving AS progression. This pathway is activated by cytoplasmic DNA from damaged cells, thereby triggering inflammation and accelerating plaque formation.

Heat-Induced Preparation of Myofibrillar Protein Gels Reinforced Through Ferulic Acid, α-Cyclodextrin and Fe(III).

Phenolic acids have a positive effect on the processing quality of myofibrillar protein (MP) gels. However, in this study, the addition of ferulic acid (FA) did not have a positive effect on MP gels. To address this issue, we performed the addition and observed the effects on the structure of MP gels by both surface coating and internal cross-linking: addition of FA alone, addition of α-cyclodextrin (CD) to encapsulate FA (MP-FA/CD), and addition of Fe(III) to form a metal-phenolic network structure (Fe @MP-FA) and a metal-cyclodextrin-phenolic acid structure (Fe@MP-FA /CD).

The In Situ Assembly of an Equipotential Cathode for Nitrite Enrichment Enabling Electrochemical Nitrate Reduction to N.

Electrocatalytically reducing NO to N is of great significance for environmental remediation and global nitrogen cycling. However, it is currently hindered by low N selectivity since adsorbate N-intermediates are hard to migrate and couple each other during the N-N coupling step. Herein, an in situ assembly strategy was taken to attach Pd@CuO nanoparticles with CuO nanowire arrays to form an equipotential cathode CuO-Pd@CuO, which optimized N selectivity to 91%, much higher than that of directly loaded Pd-Cu cathode (55%).

SETBP1-R54P mutation promotes malignant transformation of cadmium-induced 16HBE cells by down-regulating circ_0007095 expression.

Some cancers are strongly associated with exposure to environmental carcinogens, and genetic and epigenetic alterations are crucial in carcinogenesis. However, the interaction between genetic mutations and epigenetic regulation in cancer development has not been sufficiently examined. Here, we investigated the roles of gene mutations and altered circRNA expression in the malignant transformation of human bronchial epithelial cells after continuous exposure to CdCl2 (10 µM).

Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis.

Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse model. Systemic administration of the selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain in mice of both sexes.

Effect of the cervical and thoracic "Daoyin" training on posture and pulmonary function in patients with upper crossed syndrome: a randomized controlled trial.

Objectives: With the growing ubiquity of electronic devices, the incidence of upper crossed syndrome (UCS) is increasing every year and tends to affect younger populations. The study was designed to assess the effect of cervical and thoracic "Daoyin" training on pain, posture, pulmonary function, cervical range of motion, and emotional state in college students with UCS.

Design: We conducted a parallel-group randomized control study.

Gold nanomaterials capped with bovine serum albumin for cell and extracellular vesicle imaging.

Bovine serum albumin-capped gold nanoclusters (AuNC@BSA) are ionic, ultra-small, and eco-friendly nanomaterials that exhibit red fluorescence emission. Upon modification, these nanomaterials can serve as imaging probes with multimodal functionality. Owing to their nanoscale properties, AuNC@BSA-based nanomaterials can be readily endocytosed by cells for imaging.

Trimethylamine-N-oxide accelerates osteoporosis by PERK activation of ATF5 unfolding.

Imbalances in gut microbiota and their metabolites have been implicated in osteoporotic disorders. Trimethylamine-n-oxide (TMAO), a metabolite of L-carnitine produced by gut microorganisms and flavin-containing monooxygenase-3, is known to accelerate tissue metabolism and remodeling; however, its role in bone loss remained unexplored. This study investigates the relationship between gut microbiota dysbiosis, TMAO production, and osteoporosis development.

Screening Environmentally Benign Ionic Liquids for CO Absorption Using Representation Uncertainty-Based Machine Learning.

Screening ionic liquids (ILs) with low viscosity, low toxicity, and high CO absorption using machine learning (ML) models is crucial for mitigating global warming. However, when candidate ILs fall into the extrapolation zone of ML models, predictions may become unreliable, leading to poor decision-making. In this study, we introduce a "representation uncertainty" (RU) approach to quantify prediction uncertainty by employing four IL representations: molecular fingerprint, molecular descriptor, molecular image, and molecular graph.

Impact of Postoperative Chemotherapy on Survival in Patients with Primary Central Nervous System Lymphoma: A Study Based on the SEER Database.

We aimed to investigate the impact of postoperative chemotherapy (POCT) on survival in patients with primary central nervous system lymphoma (PCNSL) using data from the Surveillance, Epidemiology, and End Results (SEER) database. This study included 786 PCNSL patients, of which 605 received chemotherapy after surgery, and 181 did not. Data from the SEER registry database (2007-2020) were used to analyze PCNSL.

Interaction mechanism of AlO abrasive in tantalum chemical mechanical polishing.

AlO abrasive is expected to enhance chemical mechanical polishing (CMP) efficiency compared to the SiO abrasive. However, AlO powder has dispersion issues and the material removal mechanism by AlO remains unclear. This study investigated the role of AlO abrasive in the tantalum CMP.

Construction of a quality of life scale for older individuals with neuro-co-cardiological diseases.

Purpose: This study aimed to develop a Quality of Life (QOL) assessment scale for older patients with Neuro-co-Cardiological Diseases (NCCD) and to evaluate the reliability and validity of the scale.

Method: The study participants were derived from the Elderly Individuals with NCCD Registered Cohort Study (EINCCDRCS), a multicenter registry of patients with NCCD. The preliminary testing of the questionnaire was conducted among 10 older individuals aged 65 years and older who had NCCD and were recruited from the registry.

Berberine Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaque through NRF2/SLC7A11/GPX4 Pathway.

Objective: To investigate potential mechanisms of anti-atherosclerosis by berberine (BBR) using ApoE mice.

Methods: Eight 8-week-old C57BL/6J mice were used as a blank control group (normal), and 56 8-week-old AopE mice were fed a high-fat diet for 12 weeks, according to a completely random method, and were divided into the model group, BBR low-dose group (50 mg/kg, BBRL), BBR medium-dose group (100 mg/kg, BBRM), BBR high-dose group (150 mg/kg, BBRH), BBR+nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor group (100 mg/kg BBR+30 mg/kg ML385, BBRM+ML385), NRF2 inhibitor group (30 mg/kg, ML385), and positive control group (2.5 mg/kg, atorvastatin), 8 in each group.

Iodinated gadolinium-gold nanomaterial as a multimodal contrast agent for cartilage tissue imaging.

Cartilage damage, a common cause of osteoarthritis, requires medical imaging for accurate diagnosis of pathological changes. However, current instruments can acquire limited imaging information due to sensitivity and resolution issues. Therefore, multimodal imaging is considered an alternative strategy to provide valuable images and analyzes from different perspectives.

Use of Drug Sensitisers to Improve Therapeutic Index in Cancer.

The clinical management of malignant tumours is challenging, often leading to severe adverse effects and death. Drug resistance (DR) antagonises the effectiveness of treatments, and increasing drug dosage can worsen the therapeutic index (TI). Current efforts to overcome DR predominantly involve the use of drug combinations, including applying multiple anti-cancerous drugs, employing drug sensitisers, which are chemical agents that enhance pharmacokinetics (PK), including the targeting of cellular pathways and regulating pertinent membrane transporters.