Comparison of the efficacy of 12 interventions in the treatment of diabetic foot ulcers: a network meta-analysis.

Objective: This study aimed to comprehensively compare the efficacy of 12 interventions for diabetic foot ulcer (DFU) using a network meta-analysis (NMA).

Methods: The NMA was conducted by PRISMA guidelines, and the protocol was registered in PROSPERO (CRD42023461811). PubMed, Web of Science, Cochrane Library, and Embase databases were systematically searched from inception to September 2023.

Analysis of combined shockwave therapy and aquatic exercise for chronic nonspecific low back pain.

This study evaluates the clinical efficacy of combined shockwave therapy and aquatic exercise therapy in patients with chronic nonspecific low back pain (CNLBP) and compares it with conventional treatments to provide evidence for clinical practice. A retrospective cohort study was conducted with 108 CNLBP patients who visited our hospital from April 2022 to April 2023. Patients were divided into a combined therapy group (41 cases) and a conventional therapy group (67 cases).

The comparison of clinical outcomes between volar locking plate fixation and dual-plate fixation in high-energy distal radius fractures.

Purposes: The aim of this study was to compare clinical outcomes of dual-plate fixation and volar locking plate fixation in high-energy intra-articular distal radius fractures.

Methods: In this study, 168 patients with high-energy intra-articular distal radius fractures with either volar fragments, dorsal fragments, or radial styloid fragments, who were treated with one of three kinds of fixation methods (volar locking plate fixation, volar + radial plating fixation, and dorsal + radial plating fixation) were retrospectively reviewed and divided into three groups. Functional evaluations included DASH score, Mayo wrist score, wrist joint ROM, and grip strength percentage relative to the healthy side.

Vagus nerve stimulation: innovative applications in the field of hand function rehabilitation.

Hand function disorders significantly impair patients' quality of life by limiting the ability to perform daily tasks. Vagus nerve stimulation has emerged as a promising therapeutic intervention for hand function rehabilitation. This approach operates through multiple physiological mechanisms, including anti-inflammatory effects, protection of the blood-brain barrier, enhanced angiogenesis, increased neural plasticity, optimized neurotransmitter release, and reduced cellular apoptosis.

Exploring a new direction in targeted cancer therapy through hyperbaric oxygen therapy combined with biomedical engineering techniques.

The hypoxic tumor microenvironment and dense extracellular matrix (ECM) are key factors limiting the effectiveness of cancer treatments. Hyperbaric oxygen therapy (HBOT) effectively alleviates hypoxia by increasing the oxygen partial pressure (pO) in tumor tissues, enhancing the sensitivity of chemotherapy, radiotherapy, and immunotherapy. In recent years, the rapid development of biomedical engineering technologies such as nanodrug delivery, engineered bacteria, and immunocellular therapy has provided new strategies to address issues like poor drug penetration and immunosuppressive microenvironments.

Electrochemiluminescence sensor based on upconversion nanoparticles and Zr-based porphyrinic metal-organic frameworks with recognition sites for mercaptan detection.

In light of the critical necessity for precise detection of mercaptan in gasoline, due to its potential to induce metal corrosion and catalyst poisoning, this study investigates a novel methodology that employs resonance energy transfer (RET) between upconversion nanoparticles (UCNPs) and zirconium-based porphyrinic metal-organic frameworks (MOFs) to develop a highly sensitive and selective electrochemiluminescence (ECL) sensor. The NaYF: Yb, Er@NaYF@MOFs nanocomposite has been thoroughly characterized and exhibits enhanced ECL emission. This enhancement is attributed to the efficient RET between the UV-vis absorption of the Zr-based porphyrinic MOFs and the upconversion luminescence emission of the UCNPs.

Advances in brain-computer interface controlled functional electrical stimulation for upper limb recovery after stroke.

Stroke often results in varying degrees of functional impairment, significantly affecting patients' quality of daily life. In recent years, brain-computer interface-controlled functional electrical stimulation has offered new therapeutic approaches for post-stroke rehabilitation. This paper reviews the application of BCI-FES in the recovery of upper limb function after stroke and explores its underlying mechanisms.

Transcriptome and metabolome analysis revealed that phenylpropanoid and flavonoid biosynthesis respond to drought in tiger nut.

Tiger nuts (Cyperus esculentus) have emerged as a novel oil crop, being utilized as raw materials for obtaining industrial ink. Drought is a serious stress that significantly affects the entire plant and reduces its yield. The seedling stage is crucial as it determines the future growth and yield.

Correlation between chronic kidney disease and all-cause mortality in diabetic foot ulcers: evidence from the 1999-2004 national health and nutrition examination survey (NHANES).

Background: The poor prognosis of diabetic foot ulcers (DFUs) often leads to amputation and high mortality rates, becoming a heavy economic burden on the healthcare system. Several clinical studies have been conducted to investigate the risk factors for DFU mortality and to provide clinical guidance for better prevention and control of DFU mortality.

Methods: We used R to organize the mortality data of patients with DFU, collected from the NHANES database during the 1994-2004 period, along with three kidney function indicators including Albumin-to-Creatinine Ratio (ACR), estimated Glomerular Filtration Rate (eGFR) and cystatin C, used to assess chronic kidney disease (CKD).

Boron Ligands Boosting the Electrochemiluminescence Performance of Europium Metal-Organic Frameworks by Facilitating the Electronic Bridging.

For optimal energy transfer in self-luminous lanthanide metal-organic frameworks (Ln-MOFs), the energy of the lowest triplet excited state must align with ideal energy levels. Failure to meet this condition can lead to reverse energy transfer, reducing luminous efficiency. In this study, we developed a mixed-ligand MOF, Eu-TCPP-BOP, which exists as an ECL self-enhancing luminophore.

A new distal radius fracture classification depending on the specific fragments through machine learning clustering method.

Purposes: The objective of this study was to investigate intra-articular distal radius fractures, aiming to provide a comprehensive analysis of fracture patterns and discuss the corresponding treatment strategies for each pattern.

Methods: 294 cases of intra-articular distal radius fractures lines were collected and clustered thorough K-means and hierarchical clustering algorithm. The demographic data of patients and the clinical treatment outcomes were recorded.

Comparison of Inferior Extensor Retinacular Reinforcement Versus Nonreinforcement in Arthroscopic Isolated Anterior Talofibular Ligament Repair for Chronic Lateral Ankle Instability: A Systematic Review and Meta-analysis.

Background: Approximately 20% of acute ankle sprains progress to chronic lateral ankle instability (CLAI), requiring surgical intervention. When only the anterior talofibular ligament (ATFL) is ruptured, it is controversial whether to perform arthroscopic inferior extensor retinacular (IER) reinforcement.

Purpose: To assess the postoperative outcomes of IER reinforcement versus nonreinforcement in arthroscopic treatment of CLAI with ATFL-only injury.

Functional Near-Infrared Spectroscopy in neurodegenerative disease: a review.

In recent years, with the aggravation of aging, the incidence of neurodegenerative diseases is increasing year by year, and the prognosis of patients is poor. Functional Near-Infrared Spectroscopy (fNIRS) is a new and non-invasive neuroimaging technology, which has been gradually deepened in the application research of neurodegenerative diseases by virtue of its unique neurooxygen signal brain functional imaging characteristics in monitoring the disease condition, making treatment plans and evaluating the treatment effect. In this paper, the mechanism of action and technical characteristics of fNIRS are briefly introduced, and the application research of fNIRS in different neurodegenerative diseases is summarized in order to provide new ideas for future related research and clinical application.

Insight into the charge transfer behavior of an electrochemiluminescence sensor based on porphyrin-coumarin derivatives with a donor-acceptor configuration.

The excellent photophysical and electrochemical properties of porphyrins have inspired widespread interest in the realm of electrochemiluminescence (ECL). The aggregation-caused deficiency of ECL emission in aqueous solution, however, still severely impedes further applications. Herein, a molecule with a donor-acceptor (D-A) configuration, ATPP-Cou, consisting of monoaminoporphyrin as an electron donor and coumarin as an electron acceptor, was designed as an ECL luminophore to address the susceptibility of the porphyrin to aggregation-caused quenching (ACQ) in aqueous solution.

Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures.

Purpose: Gustilo IIIB/C injuries are common for tibia diaphysis fractures with high rates of nonunion, osteomyelitis, and amputation. However, the managements on tibial Gustilo IIIB/C injuries are still controversial and individual. The aim of this study is to introduce the tibial periosteum flap combined with autologous bone grafting to treat Gustilo-IIIB/IIIC injuries.

Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19.

We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1.

Research progress in the mechanism of acupuncture regulating microglia in the treatment of Alzheimer's disease.

Alzheimer's disease (AD) is the most common neurodegenerative disease in the central nervous system, characterized by memory and cognitive dysfunction. Acupuncture is an effective means to alleviate the symptoms of AD. Recent studies have shown that microglia play an important role in the occurrence and development of AD.

Comparison between anterior-to-posterior screw fixation versus posterolateral approach plate fixation for posterior malleous fracture: A systematic review and meta-analysis.

Purpose: There are two main surgical fixation methods for the posterior malleolar fractures (PMFs), the anterior-to-posterior (AP) screws or via the posterolateral (PL) approach utilizing a buttress plate. This review aims to compare the clinical outcome between the AP screw fixation and the PL plate fixation for treating PMFs.

Methods: We searched all relevant publications about PMFs treated with AP screws or PL plates through electronic databases including the PubMed, the Cochrane Library, the Embase, the Wiley online library and the Web of Science.

The learning curve for minimally invasive Achilles repair using the "lumbar puncture needle and oval forceps" technique.

Introduction: An acute Achilles tendon rupture represents a common tendon injury, and its operative methods have been developed over the years. This study aimed to quantify the learning curve for the minimally invasive acute Achilles tendon rupture repair.

Methods: From May 2020 to June 2022, sixty-seven patient cases who received minimally invasive tendon repair were reviewed.

Supramolecular deep eutectic solvent: a powerful tool for pre-concentration of trace metals in edible oil.

The utilization of supramolecular deep eutectic solvent eddy-assisted liquid-liquid microextraction utilizing 2-hydroxypropyl β-cyclodextrin (SUPRADES) has been identified as a successful method for pre-enriching Cu, Zn, and Mn in vegetable oil samples. Determination of each element was conducted by inductively coupled plasma optical emission spectrometry (ICP-OES) after digestion of metal-enriched phases. Various parameters were examined, including the composition of SUPRADES species [2HP-β-CD: DL-lactic acid], a cyclodextrin mass ratio of 20 wt%, a water bath temperature of 75 °C, an extractor volume of 800 μL, a dispersant volume of 50 μL, and an eddy current time of 5 min.

Integrated genetic analysis of diabetic complications: Bioinformatics insights into foot ulcers, neuropathy and peripheral artery disease.

Diabetic foot ulcers (DFU), diabetic peripheral neuropathy (DPN) and peripheral arterial disease (PAD) are common complications of diabetes mellitus, while diabetic peripheral neuropathy and peripheral arterial disease contribute to the pathogenesis of diabetic foot ulcers, and the pathogenic mechanisms between these three diseases still need further investigation. The keywords 'diabetic foot ulcer', 'diabetic peripheral neuropathy' and 'atherosclerosis' were used to search for related gene sets in the GEO database. Differentially expressed genes (DEGs) were screened and analysed for GO, KEGG and enrichR functional enrichment.

Three-Dimensional Heat Map: The OTA/AO Type 43C Pilon Fracture Lines Distribution.

Background: This study aimed to create three-dimensional heat map and study the characteristic of fracture lines and represented fragments of OTA/AO type 43C pilon fractures.

Methods: CT scan was performed in105 fractures diagnosed with OTA/AO type 43C pilon fractures between January 2017 and December 2022. Three-dimensional pilon fracture maps were created and converted into fracture heat maps.