Programmable Nanostructure Assembly of a Paclitaxel Derivative Enables Tunable Anticancer Therapy via Hydrogen Bond Engineering.

Precise control of the morphology of self-assembling drugs is critical for optimizing their pharmacokinetics and therapeutic efficacy. However, adapting a single drug for diverse therapeutic applications by tailoring its structure remains a central challenge. Here, we report a hydrogen-bond-guided strategy to program the morphology of a paclitaxel derivative, PTP, by introducing a phosphate group to promote supramolecular organization.

A cross-linguistic depression detection method based on speech data.

Background: Depression is a common and disabling psychological disorder that affects patients and their social circles. With advances in artificial intelligence, researchers have focused on automated depression detection using speech data. However, most current AI methods rely on monolingual data, limiting their cross-linguistic generalization.

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma.

Previous studies have identified that lens epithelium-derived growth factor (LEDGF) interacts with SETD2-dependent histone H3 trimethylated at lysine 36 (H3K36me3) to mediate transcriptional elongation. However, the original LEDGF recognition H3K36me3 epigenetic regulatory axis no longer exists in SETD2 mutant clear cell renal cell carcinoma (ccRCC) patients, and a new transcription system needs to be discovered. In this study, the authors demonstrated the novel interaction between LEDGF and H3R17me2a.

Meta-Analysis and Clinical Guidance of Oxygenated Hypothermic Machine Perfusion for Kidney Transplantation.

Background: It remains unclear whether oxygenated hypothermic machine perfusion (HMPO) during kidney preservation is beneficial for prognosis.

Methods: A comprehensive search of databases and clinical trial registries was conducted to identify eligible studies on HMPO application during kidney transplantation. A multisubgroup analysis was further conducted to explore the heterogeneity among studies.

Assessing seasonal and weather effects on depression and physical activity using mobile health data.

Seasonal and weather changes can significantly impact depression severity, yet findings remain inconsistent across populations. This study explored depression variations across the seasons and the interplays between weather changes, physical activity, and depression severity among 428 participants in a real-world longitudinal mobile health study. Clustering analysis identified four participant subgroups with distinct patterns of depression severity variations in 1 year.

Large-scale digital phenotyping: Identifying depression and anxiety indicators in a general UK population with over 10,000 participants.

Background: Digital phenotyping offers a novel and cost-efficient approach for managing depression and anxiety. Previous studies, often limited to small-to-medium or specific populations, may lack generalizability.

Methods: We conducted a cross-sectional analysis of data from 10,129 participants recruited from a UK-based general population between June 2020 and August 2022.

The P2X7-Mediated Mitochondrial ROS as an Emerging Core Target of Tuftsin Nanoparticles in Severe Acute Pancreatitis Therapy via Regulating Mitophagy.

20% acute pancreatitis (AP) develops into severe AP (SAP), a global health crisis, with an increased mortality rate to 30%-50%. Mitochondrial damage and immune disorders are direct factors, which exacerbate the occurrence and progression of AP. So far, mitochondrial and immunity injury in SAP remains largely elusive, with no established treatment options available.

HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation.

Background: Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular diseases, and multiple types of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately characterized.

CaCO-encircled hollow CuS nanovehicles to suppress cervical cancer through enhanced calcium overload-triggered mitochondria damage.

Cervical cancer stands is a formidable malignancy that poses a significant threat to women's health. Calcium overload, a minimally invasive tumor treatment, aims to accumulate an excessive concentration of Ca within mitochondria, triggering apoptosis. Copper sulfide (CuS) represents a photothermal mediator for tumor hyperthermia.

Increased magnesium intake does not mitigate MAFLD risk associated with magnesium deficiency.

Serum magnesium cannot accurately assess magnesium deficiency. The association between magnesium deficiency and metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear. Selecting 3,377 participants in the United States, we assessed the degree of magnesium deficiency in the population using magnesium depletion score (MDS).

Machine Learning-Guided Discovery of Copper(I)-Iodide Cluster Scintillators for Efficient X-ray Luminescence Imaging.

Developing efficient scintillators with environmentally friendly compositions, adaptable band gaps, and robust chemical stability is crucial for modern X-ray radiography. While copper(I)-iodide cluster crystals show promise, the vast design space of inorganic cores and organic ligands poses challenges for conventional approaches. In this study, we present machine learning-guided discovery of copper(I)-iodide cluster scintillators for efficient X-ray luminescence imaging.

Digital Phenotyping of Mental and Physical Conditions: Remote Monitoring of Patients Through RADAR-Base Platform.

Background: The use of digital biomarkers through remote patient monitoring offers valuable and timely insights into a patient's condition, including aspects such as disease progression and treatment response. This serves as a complementary resource to traditional health care settings leveraging mobile technology to improve scale and lower latency, cost, and burden.

Objective: Smartphones with embedded and connected sensors have immense potential for improving health care through various apps and mobile health (mHealth) platforms.

Conduction and validation of a novel mitotic spindle assembly related signature in hepatocellular carcinoma: prognostic prediction, tumor immune microenvironment and drug susceptibility.

We have developed a risk-scoring model using gene expression levels related to mitotic spindle assembly (MSA) to predict the prognosis of liver cancer. Initially, we identified 470 genes related to MSA from public databases. Subsequently, through analysis of sequencing data from liver cancer patient samples in online databases, we identified 7 genes suitable for constructing the risk-scoring model.

Longitudinal Assessment of Seasonal Impacts and Depression Associations on Circadian Rhythm Using Multimodal Wearable Sensing: Retrospective Analysis.

Background: Previous mobile health (mHealth) studies have revealed significant links between depression and circadian rhythm features measured via wearables. However, the comprehensive impact of seasonal variations was not fully considered in these studies, potentially biasing interpretations in real-world settings.

Objective: This study aims to explore the associations between depression severity and wearable-measured circadian rhythms while accounting for seasonal impacts.

IGFBP7 promotes endothelial cell repair in the recovery phase of acute lung injury.

IGFBP7 has been found to play an important role in inflammatory diseases, such as acute lung injury (ALI). However, the role of IGFBP7 in different stages of inflammation remains unclear. Transcriptome sequencing was used to identify the regulatory genes of IGFBP7, and endothelial IGFBP7 expression was knocked down using Aplnr-Dre mice to evaluate the endothelial proliferation capacity.

Chemical Reaction of FA Cations Enables Efficient and Stable Perovskite Solar Cells.

Organometal halide perovskite solar cells (PSCs) have received great attention owing to a rapid increase in power conversion efficiency (PCE) over the last decade. However, the deficit of long-term stability is a major obstacle to the implementation of PSCs in commercialization. The defects in perovskite films are considered as one of the primary causes.

The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis.

Kaempferol (KA), an natural antioxidant of traditional Chinese medicine (TCM), is extensively used as the primary treatment for inflammatory digestive diseases with impaired redox homeostasis. Severe acute pancreatitis (SAP) was exacerbated by mitochondrial dysfunction and abundant ROS, which highlights the role of antioxidants in targeting mitochondrial function. However, low bioavailability and high dosage of KA leading to unavoidable side effects limits clinical transformation.

BioisoIdentifier: an online free tool to investigate local structural replacements from PDB.

Within the realm of contemporary medicinal chemistry, bioisosteres are empirically used to enhance potency and selectivity, improve adsorption, distribution, metabolism, excretion and toxicity profiles of drug candidates. It is believed that bioisosteric know-how may help bypass granted patents or generate novel intellectual property for commercialization. Beside the synthetic expertise, the drug discovery process also depends on efficient in silico tools.

Nanosized Prussian blue and its analogs for bioimaging and cancer theranostics.

Prussian blue (PB) nanoparticles (NPs) and Prussian blue analogs (PBAs) can form metal-organic frameworks through the programmable coordination of ferrous ions with cyanide. PB and PBAs represent a burgeoning class of hybrid functional nano-systems with a wide-ranging application spectrum encompassing biomedicine, cancer diagnosis, and therapy. A comprehensive overview of recent advancements is crucial for gaining insights for future research.

Mesoporous Silica Nanoparticles for the Uptake of Toxic Antimony from Aqueous Matrices.

Contamination of water sources by toxic antimony Sb(III) ions poses a threat to clean water supplies. In this regard, we have prepared a mesoporous silica nanoparticle (MSN)-derived adsorbent by reverse microemulsion polymerization, using cetyltrimethylammonium chloride (CTAC) and triethanolamine (TEA) as co-templates. The physical and chemical properties were characterized using advanced tools.

Identified Isosteric Replacements of Ligands' Glycosyl Domain by Data Mining.

Biologically equivalent replacements of key moieties in molecules rationalize scaffold hopping, patent busting, or R-group enumeration. Yet, this information may depend upon the expert-defined space, and might be subjective and biased toward the chemistries they get used to. Most importantly, these practices are often informatively incomplete since they are often compromised by a try-and-error cycle, and although they depict what kind of substructures are suitable for the replacement occurrence, they fail to explain the driving forces to support such interchanges.