Comparative Toxicity and P450-Mediated Detoxification of Flonicamid in and .

The tarnished plant bug, (TPB), (Palisot de Beauvois), and the western tarnished plant bug (WTPB), , Knight, are major agricultural pests that cause significant damage to a wide range of crops in the southeastern and southwestern United States. Flonicamid (commercial name: Carbine 50WG) is generally effective against various sap-feeding pests, including both and . This study evaluated the toxicity of flonicamid on third-instar nymphs and adults of both species under laboratory conditions.

Injectable composite microspheres/hydrogel membranes for Achilles tendon regeneration.

Tendon injury is a common condition with potential for disability. Severe injuries such as tendon rupture often require surgical suturing to restore their structure and function. The healing process of tendons is a critical factor affecting clinical outcomes; however, their poor blood supply and low cellular density limit self-regeneration capabilities.

Quantum Disorder Induced by Nuclear Tunneling in Lattice.

Lattice degrees of freedom (d.o.f.

Proteomics-based prognostic signature in colon adenocarcinoma patients with familial adenomatous polyposis.

Background: Familial adenomatous polyposis (FAP) is regarded as a precancerous stage of colon adenocarcinoma (COAD). COAD concurrent with FAP is quite rare in colorectal cancer screening. In order to create a new COAD prognostic prediction model and to shed light on the landscape of the tumor immune microenvironment in COAD, we examined differentially expressed genes (DEGs) between COAD and FAP in this study.

Investigation of an algae-derived polymer as a pollinator-friendly pesticide adjuvant.

Chemical applications in croplands can be a major source of pesticide exposure to pollinators, including off-target drift. Adjuvants are added to pesticides to improve spray characteristics. The major goal of this study was to identify the possibility of using sodium alginate (SA) as a drift-reducing pesticide adjuvant that is less/nontoxic to honeybees than polyacrylamide (PAM) an industry standard.

Multi-omic analysis identifies cholesterol metabolism related protein ARV1 as a novel biomarker for Colon adenocarcinoma patients with adenomatous polyposis.

Objectives: Familial adenomatous polyposis (FAP) is typically characterized by numerous adenomatous polyps that will inevitably progress to adenocarcinomas. To enhance the clinical management of colon adenocarcinoma (COAD), a deeper understanding of the molecular mechanisms driving malignant transformation in pre-cancerous adenomatous polyposis, as well as the identification of predictive biomarkers, is essential.

Methods: In the present study, clinical samples were collected from rare patients with COAD and FAP, and metabolomic and proteomic analyses were performed to elucidate the mechanisms of canceration in FAP patients.

Risk Assessment of Effects of Essential Oils on Honey Bees ( L.).

The toxicity of synthetic pesticides to non-target organisms has prompted a shift towards more environmentally friendly agricultural pest control methods, including the use of essential oils as possible biopesticides. Before these natural chemicals can be widely adopted for protecting food supplies and human health, it is crucial to evaluate their impacts on pollinators, such as honey bees. In this study, we examined the effects of one commercially available essential oil mixture (EcoTec+) and four essential oil components (β-bisabolene, cinnamaldehyde, 1,8-cineole, and eugenol) on honey bee workers using feeding or spray treatment.

Honey bee immune response to trace concentrations of clothianidin goes beyond the macronutrients found in artificial diets.

Honey bees (Apis mellifera) often encounter a variety of stressors in their environment, including poor nutrition and pesticides. These stressors interact and can be exacerbated in large-scale agroecosystems. We investigated how diets varying in macronutrient ratios can affect nurse bee susceptibility to pesticide stressors.

Environmental concentrations of TCEP and TDCIPP induce dysbiosis of gut microbiotal and metabolism in the honeybee (Apis mellifera L.).

Organophosphorus flame retardants (OPFRs) have emerged as significant global pollutants, yet their harmful effects on pollinating insects remain largely unexplored. This study explored the toxicological effects of tri(2-chloroethyl) phosphate (TCEP) and tri(1,3-dichloro-2-propyl) phosphate (TDCIPP) on the gut microbiota and metabolic pathways of honeybees (Apis mellifera L.).

Compassionate Use of Omadacycline in a Down Syndrome Pre-Schooler With Critically Ill Atypical Pneumonia Caused by Macrolide-Resistant Mycoplasma Pneumoniae.

Background: Rapid and accurate identification of causative organisms and prompt initiation of pathogen-targeted antibiotics are crucial for managing atypical pneumonia. The widespread application of targeted next-generation sequencing (t-NGS) in clinical practice demonstrates significant targeted advantages in rapid and accurate aetiological identification and antimicrobial resistance genes detection, particularly for difficult-to-culture, rare, or unexpected pathogens. An alarming surge of acquired macrolide resistance (MR) in (MP) presents a substantial challenge for the clinical selection of pathogen-targeted antibiotics worldwide, especially for fluoroquinolone-restricted pediatric patients with limited options available.

Near-complete genome sequence of a type-A deformed wing virus discovered from in Mississippi, USA.

Deformed wing virus (DWV) can cause a major disease in honeybees worldwide and has been detected in many other arthropods (S. J. Martin and L.

Strengthening H gas-liquid mass transfer using superaerophobic cathodes for enhanced methane production from CO in H-mediated microbial electrosynthesis system.

H-mediated microbial electrosynthesis (MES) could run under a high current density, but the low solubility of H limited its performance. Reducing the H bubble size facilitates H gas-liquid mass transfer and it has been reported to be realized on superaerophobic electrodes. Therefore, we adopted a CoP nanowire-modified nickel foam (CoP-NiF) as the superaerophobic cathode in a H-mediated MES reactor to enhance the methane production from CO.

Clinical Impact of High-dose Esomeprazole-amoxicillin Dual Therapy as Rescue Treatment for Helicobacter pylori Infection : A Prospective, Multicenter, Randomized Trial.

Objective: This study aimed to compare the effectiveness and safety of high-dose dual therapy (HDDT) using esomeprazole and amoxicillin to furazolidone-based quadruple therapy (FBQT) in treating nonresponsive patients with Helicobacter pylori ( H. pylori ) infection.

Materials And Methods: A total of 209 patients with H.

Effectiveness and residual activity of four common insecticides used in the Mississippi Delta to control tarnished plant bugs in cotton.

The tarnished plant bug, (TPB) Lygus lineolaris Palisot de Beauvois (Hemiptera: Miridae) is a key pest of cotton in the midsouth region and some areas of the eastern United States. Its control methods have been solely based on chemical insecticides which has contributed to insecticidal resistance and shortened residual periods for control of this insect pest. This study was conducted over a two-year period and examined the efficacy and residual effect of four commercial insecticides including lambda-cyhalothrin (pyrethroid), acephate (organophosphate), imidacloprid (neonicotinoid), and sulfoxaflor (sulfoxamine).

Robust Gaussian Process Regression Method for Efficient Tunneling Pathway Optimization: Application to Surface Processes.

Simulation of surface processes is a key part of computational chemistry that offers atomic-scale insights into mechanisms of heterogeneous catalysis, diffusion dynamics, and quantum tunneling phenomena. The most common theoretical approaches involve optimization of reaction pathways, including semiclassical tunneling pathways (called instantons). The computational effort can be demanding, especially for instanton optimizations with an ab initio electronic structure.

Insecticide Susceptibilities and Enzyme Activities of Four Stink Bug Populations in Mississippi, USA.

In Mississippi, the Pentatomidae complex infesting soybean is primarily composed of , , , and . This study employed spray bioassays to evaluate the susceptibilities of these stink bugs to seven commonly used formulated insecticides: oxamyl, acephate, bifenthrin, λ-cyhalothrin, imidacloprid, thiamethoxam, and sulfoxaflor. Stinks bugs were collected from soybeans in Leland, MS, USA during 2022 and 2023, as well as from wild host plants in Clarksdale, MS.

Microarray and Functional Pathway Analyses Revealed Significantly Elevated Gene Expressions Associated with Metabolic Resistance to Oxamyl (Vydate) in .

The tarnished plant bug (TPB, ) remains a major pest for a variety of crops. Frequent sprays on row crops, especially cotton, prompted resistance development in field populations. To maintain chemical control as an effective tool against the pest, knowledge of global gene regulations is desirable for better understanding and managing the resistance.

Predictive and Prognostic Potentials of Lymphocyte-C-Reactive Protein Ratio Upon Hospitalization in Adult Patients with Acute Pancreatitis.

Purpose: In this study, our objective was to investigate the potential utility of lymphocyte-C-reactive protein ratio (LCR) as a predictor of disease progression and a screening tool for intensive care unit (ICU) admission in adult patients with acute pancreatitis (AP).

Methods: We included a total of 217 adult patients with AP who were admitted to the First Affiliated Hospital of Harbin Medical University between July 2019 and June 2022. These patients were categorized into three groups: mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP), based on the presence and duration of organ dysfunction.

Crystal-Structure Matches in Solid-Solid Phase Transitions.

The exploration of solid-solid phase transition suffers from the uncertainty of how atoms in two crystal structures match. We devised a theoretical framework to describe and classify crystal-structure matches (CSM). Such description fully exploits the translational and rotational symmetries and is independent of the choice of supercells.

Compassionate use of contezolid in a toddler with severe community-acquired pneumonia induced by staphylococcus aureus: a case report and follow-up.

Background: Initial choices of antimicrobial therapy for most cases of community-acquired pneumonia (CAP) in children under 5 years of age are typically based on local epidemiology, risk factors assessment, and subsequent clinical parameters and positive cultures, which can lead to the underdiagnosis and underestimation of lung infections caused by uncommon pathogens. Contezolid, an orally administered oxazolidinone antibiotic, gained approval from the National Medical Products Administration (NMPA) of China in June 2021 for managing complicated skin and soft tissue infections (cSSTI) caused by staphylococcus aureus (SA), streptococcus pyogenes, or streptococcus agalactis. Owing to its enhanced safety profile and ongoing clinical progress, the scope of contezolid's clinical application continues to expand, benefiting a growing number of patients with Gram-positive bacterial infections.

Co-exposure ochratoxin A and triadimefon influenced the hepatic glucolipid metabolism and intestinal micro-environment in mice.

Ochratoxin A (OTA) is a mycotoxin, and triadimefon (TDF) is a triazole fungicide. These compounds are prevalent in the environment, and their residues have been detected in crops. However, the precise health risks associated with mycotoxins and fungicides are not fully elucidated.

Accurate calculation of tunneling splittings in water clusters using path-integral based methods.

Tunneling splittings observed in molecular rovibrational spectra are significant evidence for tunneling motion of hydrogen nuclei in water clusters. Accurate calculations of the splitting sizes from first principles require a combination of high-quality inter-atomic interactions and rigorous methods to treat the nuclei with quantum mechanics. Many theoretical efforts have been made in recent decades.

The mechanisms of metabolic resistance to pyrethroids and neonicotinoids fade away without selection pressure in the tarnished plant bug Lygus lineolaris.

Background: Heavy selection pressure prompted the development of resistance in a serious cotton pest tarnished plant bug (TPB), Lygus Lineolaris in the mid-southern United States. Conversely, a laboratory resistant TPB strain lost its resistance to five pyrethroids and two neonicotinoids after 36 generations without exposure to any insecticide. It is worthwhile to examine why the resistance diminished in this population and determine whether the resistance fade away has practical value for insecticide resistance management in TPB populations.

Detect Cytochrome C Oxidase- and Glutathione-S-Transferase-Mediated Detoxification in a Permethrin-Resistant Population of .

Frequent sprays on cotton prompted resistance development in the tarnished plant bug (TPB). Knowledge of global gene regulation is highly desirable to better understand resistance mechanisms and develop molecular tools for monitoring and managing resistance. Novel microarray expressions of 6688 genes showed 3080 significantly up- or down-regulated genes in permethrin-treated TPBs.

Semiclassical Vibrational Spectroscopy of Real Molecular Systems by Means of Cross-Correlation Filter Diagonalization.

We applied the harmonic inversion technique to extract vibrational eigenvalues from the semiclassical initial value representation (SC-IVR) propagator of molecular systems described by explicit potential surfaces. The cross-correlation filter-diagonalization (CCFD) method is used for the inversion problem instead of the Fourier transformation, which allows much shorter propagation time and is thus capable of avoiding numerical divergence issues while getting rid of approximations like the separable one to the pre-exponential factor. We also used the "Divide-and-Conquer" technique to control the total dimensions under consideration, which helps to further enhance the numerical behavior of SC-IVR calculations and the stability of harmonic inversion methods.