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Lattice degrees of freedom (d.o.f.) may induce quantum disorder (QD) when nuclear tunneling outvies long-range order, but conventional phonon theory is incapable of describing such QD phases. Here we develop a method based on path-integral molecular dynamics to solve this problem. Its accuracy is verified in a double-well chain model and it is applied to a real material from first principles. A quantum order-disorder-order phase transition sequence is demonstrated when varying the strength of quantum fluctuations using the lattice constants as the tuning factor. Combining the excitation spectra and Rényi entanglement entropy, we pinpoint the QD region. This picture may be general in lattice systems having soft phonon modes, not limited to quantum paraelectricity, in which novel entangled lattice motion and its coupling with other d.o.f. can be expected.
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http://dx.doi.org/10.1103/9gkl-w2lm | DOI Listing |
Redox Biol
September 2025
Multi-Omics Platform, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Human Biology Microbiome Quantum Research Center, Keio University School of Medicine, Tokyo, Japan. Electronic address:
Ferroptosis, an iron-dependent cell death mechanism characterized by excessive lipid peroxidation, has been implicated in numerous human diseases and organ pathologies. However, current detection methods necessitate invasive tissue sampling to assess lipid peroxidation, making noninvasive detection of ferroptosis in human subjects extremely challenging. In this study, we employed oxidative volatolomics to comprehensively characterize the volatile oxidized lipids (VOLs) produced during ferroptosis.
View Article and Find Full Text PDFDiscov Nano
September 2025
Department of Rehabilitation Medicine, Rehabilitation Medical Center, Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Immunoelectron Microscopy (IEM) is a technique that combines specific immunolabeling with high-resolution electron microscopic imaging to achieve precise spatial localization of biomolecules at the subcellular scale (< 10 nm) by using high-electron-density markers such as colloidal gold and quantum dots. As a core tool for analyzing the distribution of proteins, organelle interactions, and localization of disease pathology markers, it has irreplaceable value, especially in synapse research, pathogen-host interaction mechanism, and tumor microenvironment analysis. According to the differences in labeling sequence and sample processing, the IEM technology system can be divided into two categories: the first is pre-embedding labeling, which optimizes the labeling efficiency through the pre-exposure of antigenic epitopes and is especially suitable for the detection of low-abundance and sensitive antigens; the second is post-embedding labeling, which relies on the low-temperature resin embedding (e.
View Article and Find Full Text PDFChemistry
September 2025
International School for Optoelectronic Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by β-amyloid (Aβ) deposition, imposing significant social and economic burdens globally. Despite extensive efforts have been devoted to developing fluorescent probes for Aβ imaging, further improving the luminescent efficiency of prevailing probes still remains a significant challenge. Herein, we investigated the inner mechanism of constructing high-efficient Aβ probes via a structural cyclization strategy.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
School of Applied Sciences and Technology, Gujarat Technological University, Gujarat, India. Electronic address:
This chapter examines advancements and future trajectories in wearable biosensing technologies, a multidisciplinary field encompassing healthcare, materials science, and information technology. Wearable biosensors are revolutionizing real-time physiological and biochemical monitoring with applications in personalized health monitoring, disease diagnosis, fitness, and therapeutic interventions. In addition to Internet of Things (IoT) and wireless connectivity technologies such as Bluetooth Low Energy (BLE) and 5G, which facilitate transparent remote monitoring and data exchange, other notable innovations such as machine learning and artificial intelligence enhance real-time processing of data, predictive analytics, and personalized healthcare solutions.
View Article and Find Full Text PDFAlzheimers Dement (N Y)
September 2025
Brain Watch Coalition Rockville Maryland USA.
Introduction: This study investigated evidence for or against a difference in treatment effect between women and men for lecanemab and donanemab.
Methods: Data were derived from supplementary analyses of the regulatory studies CLARITY-AD (lecanemab) and TRAILBLAZER-ALZ2 (donanemab). Bayes factor functions were used to analyze treatment effects on Clinical Dementia Rating Sum of Boxes (CDR-SB) scores.