Deubiquitinase JOSD2 promotes acute pancreatitis by removing K63-linked poly-ubiqutin chain on PCNA in pancreatic acinar cells.

Background & Aims: Acute pancreatitis (AP) results in localized pancreatic injury or systemic inflammatory responses, contributing to high morbidity and mortality worldwide. Acinar cell death and inflammation are critical key drivers of AP progression. Some deubiquitinases (DUBs), which regulate the stability and/or activity of substrate proteins, may play a role in the development of AP.

β-elemene ameliorates metabolic dysfunction-associated steatohepatitis by targeting PPARα in experimental diet-induced models.

Background And Purpose: Metabolic dysfunction-associated steatohepatitis (MASH) is an escalating global health concern with few effective pharmacological treatment options available. β-elemene (ELE) is a natural product derived from Curcuma Rhizoma, which has anti-tumour and anti-inflammatory effects. However, its efficacy and molecular mechanism in MASH have not been elucidated.

USP13 promotes hepatic stellate cells activation and aggravates liver fibrosis through deubiquitinating SMAD3.

Background/aims: Activation of hepatic stellate cells (HSCs) is key to the development of liver fibrosis. Recent studies have highlighted the role of deubiquitinating enzymes (DUBs) in regulating protein stability and function, closely related to liver fibrosis. In this study, we screened out a key DUB, ubiquitin-specific peptidase 13 (USP13), in HSCs activation and explored its role and underlying mechanism.

Multifunctional Bacterial Cellulose Hydrogel Membranes with Antibacterial and Tissue-Regenerating Properties for Treatment of Infected Diabetic Wound.

Diabetic chronic wounds, particularly foot ulcers (DFU), are challenging due to sustained inflammation, bacterial infection, and dysregulated angiogenesis, disrupting healing. Current treatments lack effective multifunctional solutions. We developed bacterial cellulose (BC) hydrogel membranes embedding copper ion-doped, fish collagen peptide-loaded zeolite imidazole frameworks (Col-Cu@ZIFs).

Global, regional, and national burden of primary liver cancer among middle-aged and elderly populations from 2000 to 2021 with a prediction to 2050: a cross-sectional analysis from global burden of disease study 2021.

Background: Primary liver cancer (PLC) is a major cause of cancer mortality worldwide, particularly among middle-aged and elderly populations. Given increasing life expectancy, understanding PLC burden in these groups is essential.

Methods: We obtained data about incidence, deaths, and disability-adjusted-life-years (DALYs) from 2000 to 2021 for PLC aged 55 + from Global Burden of Disease (GBD) 2021.

YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.

Heart failure, marked by rising morbidity and mortality rates, poses a significant health challenge. Recent studies suggest that deubiquitinating modification of proteins in cardiomyocytes is involved in the development of heart failure. YOD1 is a deubiquitinating enzyme (DUB) implicated in various diseases, including breast cancer, hematological tumors, pancreatic cancer, and vascular endothelial diseases.

A nomogram based on peripheral blood inflammatory indices and optical coherence tomography biomarkers for early prediction of anti-VEGF response in diabetic macular edema.

Clinical Relevance: The pathogenesis of diabetic macular edema (DME) involves inflammation. Identifying relevant biomarkers can guide more effective treatment strategies.

Background: This study evaluated peripheral blood indices and optical coherence tomography (OCT) biomarkers in DME patients, constructing a nomogram to predict anti-vascular endothelial growth factor (VEGF) response based on inflammatory features.

Compound J27 alleviates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease by targeting JNK.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most characteristic form of liver diseases. As the member of MAPK family, the cJun-N-terminal-kinase (JNK) plays a crucial role in the pathogenesis of MASLD. A small molecule compound, J27, has demonstrated strong anti-inflammatory effects by inhibiting JNK phosphorylation, but its therapeutic potential in MASLD remains unclear.

Association between sarcopenia and the prevalence of gallstone in US adults: a cross-sectional analysis of NHANES.

Backgroud: Gallstones are a common disease that imposes a significant burden on public health resources. Sarcopenia is an age-related condition characterized by a decline in muscle mass, strength, and function. However, its relationship with gallstones remains unclear.

FNDC5/Irisin exacerbates APAP-induced acute liver injury through activating JNK/NF-κB and inflammatory response.

Acute liver injury (ALI) is associated with high mortality rates. Despite its severity, there are currently no effective interventions, underscoring the urgent need for research on the mechanisms driving ALI progression. Irisin, a hormone derived from its precursor FNDC5, has been shown to play a critical role in some chronic liver diseases.

The natural product-derived JM-9 alleviates high-fat diet-induced fatty liver in mice by targeting MD2.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), is gradually emerging as one of the most prevalent liver diseases worldwide. Previous research demonstrated the involvement of myeloid differentiation factor 2 (MD2), a co-receptor of TLR4, as a key mediator in MASLD pathogenesis. The current study identifies JM-9 as a novel MD2 inhibitor, and focuses on evaluating its potential therapeutic effects in mitigating MASLD progression.

OTUD1 Deficiency Alleviates LPS-Induced Acute Lung Injury in Mice by Reducing Inflammatory Response.

The ovarian tumor (OTU) family consists of deubiquitinating enzymes thought to play a crucial role in immunity. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) pose substantial clinical challenges due to severe respiratory complications and high mortality resulting from uncontrolled inflammation. Despite this, no study has explored the potential link between the OTU family and ALI/ARDS.

Depression increases the risk of gallstone: A cross-sectional study and Mendelian randomization analysis.

Background: Gallstone, a common digestive disorder, poses a significant public health burden. Concurrently, depression is acknowledged as a health risk. However, limited information exists on depression's impact on gallstone formation.

Age-related nomogram revealed optimal therapeutic option for older patients with primary liver cancer: less is more.

Background: Age bias in therapeutic decisions for older patients with cancer exists. There is a clear need to individualize such decisions.

Methods: Based on the Surveillance, Epidemiology and End Results (SEER) database, 5081 primary liver cancer (PLC) patients between 2010 and 2014 were identified and divided into <64, 64-74 and >74 years group.

Shorter telomere length increases the risk of lymphocyte immunodeficiency: A Mendelian randomization study.

Background: For a long time, the prevailing viewpoint suggests that shorter telomere contribute to chromosomal instability, which is a shared characteristic of both aging and cancer. The newest research presented that T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to some cancers. However, the relationship between genetically determined telomere length (TL) and immune cells remains unclear.

Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a.

Heart failure (HF) is one of the major causes of death among diabetic patients. Although studies have shown that curcumin analog C66 can remarkably relieve diabetes-associated cardiovascular and kidney complications, the role of SJ-12, SJ-12, a novel curcumin analog, in diabetic cardiomyopathy and its molecular targets are unknown. 7-week-old male C57BL/6 mice were intraperitoneally injected with single streptozotocin (STZ) (160 mg/kg) to develop diabetic cardiomyopathy (DCM).

Potential role of SNP rs2071475 in rheumatoid arthritis and inflammatory bowel disease in the East Asian population: a Mendelian randomization study.

Background: Previous observational studies have identified an association between rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). However, the causal relationship between RA and IBD in the East Asian population remains uncertain.

Methods: The two-sample Mendelian randomization (MR) analysis was conducted to elucidate the potential causal relationship between RA and IBD.

Determination of intermolecular and intramolecular isotopic compositions of low-abundance gaseous hydrocarbons using an online hydrocarbon gas concentration method.

The stable isotopic composition of natural gas can be used to identify its origin and source. However, low concentrations of gaseous hydrocarbons in high-mature natural and shale gases hinder accurate determination of their compound- and position-specific isotopic compositions. In this study, an online C hydrocarbon gas concentration system combined with gas chromatography-isotope ratio mass spectrometry (GC-IRMS) or gas chromatography-pyrolysis-gas chromatography-isotope ratio mass spectrometry (GC-Py-GC-IRMS) was developed to determine compound- and position-specific isotopic compositions of low-abundance gaseous hydrocarbons.

Circ_0000284 upregulates RHPN2 to facilitate pancreatic cancer proliferation, metastasis, and angiogenesis through sponging miR-1179.

Background: Circular RNA (circRNA) has been confirmed to be a key regulator for pancreatic cancer (PC) progression, but the role of circ_0000284 in PC development remains unclear.

Methods: Quantitative real-time PCR was used to measure the expression of circ_0000284, microRNA (miR)-1179, and rhophilin 2 (RHPN2). PC cell proliferation, metastasis, angiogenesis, and apoptosis were assessed by EdU assay, transwell assay, tube formation assay, and flow cytometry.

Using Nanoindentation to Characterize the Mechanical and Creep Properties of Shale: Load and Loading Strain Rate Effects.

The mechanical and creep properties of shale strongly influence artificial hydraulic fracturing, wellbore stability, and the evaluation of reservoir performance in shale gas exploration. This study characterized these mechanical and creep properties at the microscale through nanoindentation tests and evaluated their dependence on the indentation test parameters, specifically, the indentation load and the loading strain rate. The mechanical parameters (the Young's modulus and hardness) of shale were strongly influenced by the magnitude of an indentation load (2-400 mN).

Nonflammable, robust and flexible electrolytes enabled by phosphate coupled polymer-polymer for Li-metal batteries.

Liquid organic electrolytes commonly employed in commercial Li-ion batteries suffer from safety issues such as flammability and explosions. Replacing liquid electrolytes with nonflammable electrolytes has become increasingly attractive in the development of safe, high-energy Li-metal batteries (LMBs). In this work, nonflammable, robust, and flexible composite polymer-polymer electrolytes (PPEs) were successfully fabricated by flame-retardant solution casting with polyimide (PI) and polyvinylidene fluoride (PVDF).

Determination of carbon isotopic composition of crocetane in sediments by heart-cutting two-dimensional gas chromatography-isotope ratio mass spectrometry.

Compound-specific isotope analysis of crocetane in sediments can be used to determine its origin. However, the co-elution of crocetane with phytane and complex substrates hinders the accurate determination of its isotopic composition. A heart-cutting two-dimensional gas chromatography-isotope ratio mass spectrometry (2D-GC-IRMS) method was developed to determine δC values of crocetane.

Preparation and Antimicrobial Activity of Antibacterial Silver-Loaded Polyphosphazene Microspheres.

Poly(cyclotriphosphazene-co-4,4'-diaminodiphenyl ether) (PPO) microspheres were prepared via a precipitation polymerization method, using hexachlorocyclotriphosphazene (HCCP) and 4,4'-diaminodiphenyl ether (ODA) as monomers. Silver-loaded PPO (PPOA) microspheres were generated by the in situ loading of silver nanoparticles onto the surface by Ag reduction. Our results showed that PPOA microspheres were successfully prepared with a relatively uniform distribution of silver nanoparticles on microsphere surfaces.

Pore Size Distribution and Fractal Characteristics of the Nanopore Structure in Organic-Rich Shales Using the Neimark-Kiselev Fractal Approach.

Shale gas has been playing an increasingly important role in meeting global energy demands. The heterogeneity of the pore structure in organic-rich shales greatly affects the adsorption, desorption, diffusion and flow of gas. The pore size distribution (PSD) is a key parameter of the heterogeneity of the shale pore structure.