Organ-Preserving Complete Response to Sequential Induction Chemoimmunotherapy and Concurrent Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Floor of the Mouth: A Case Report.

A 52-year-old male with T4aN0M0 floor of the mouth squamous cell carcinoma who refused surgery received sequential organ-preserving therapy: induction chemoimmunotherapy (3 cycles of tislelizumab 200 mg d1, docetaxel 75 mg/m d1, cisplatin 75 mg/m d1-3) followed by concurrent chemoradiotherapy (cisplatin 100 mg/m q21d + radiotherapy 69.96 Gy/33f). Complete clinical response was achieved.

Influence of Free Space on Lithium Growth Behavior at Open Surfaces and Internal Cracks of Sulfide-Based Solid Electrolyte.

Lithium dendrite penetration through solid electrolyte has been the major obstacle for practical sulfide-based all-solid-state lithium metal batteries (ASSLMBs). Herein, a series of tailored model solid cells are designed to investigate the intrinsic lithium growth behavior at open surfaces and internal cracks of sulfide solid electrolyte. It is shown that when plating lithium on the open surface of electrolyte (free space), the lithium exhibits an intrinsic columnar growth behavior perpendicular to the electrolyte surface, preferentially along the (110) crystal axis.

Structural Reversibility of Nanoscaled Sn Anodes.

Alloying-type anode materials provide high capacity for lithium-ion batteries; however, they suffer pulverization problems resulting from the volume change during cycling. Realizing the cycling reversibility of these anodes is therefore critical for sustaining their electrochemical performance. Here, we investigate the structural reversibility of Sn NPs during cycling at atomic-level resolution utilizing high-resolution TEM.

Unconsciousness as the main nonfocal symptom of anterior circulation transient ischemic attack: A case report.

Rationale: Unconsciousness is a nonfocal symptom of transient ischemic attack (TIA) that is frequently observed in patients with vertebrobasilar artery stenosis or occlusion. Conversely, loss of consciousness due to anterior circulation involvement (e.g.

One-dimensional semimetal contacts to two-dimensional semiconductors.

Two-dimensional (2D) semiconductors are promising in channel length scaling of field-effect transistors (FETs) due to their excellent gate electrostatics. However, scaling of their contact length still remains a significant challenge because of the sharply raised contact resistance and the deteriorated metal conductivity at nanoscale. Here, we construct a 1D semimetal-2D semiconductor contact by employing single-walled carbon nanotube electrodes, which can push the contact length into the sub-2 nm region.

Treatment of diabetic foot during the COVID-19 pandemic: A systematic review.

Background: In the context of the novel coronavirus disease 2019 (COVID-19) pandemic, people have had to stay at home more and make fewer trips to the hospital. Furthermore, hospitals give priority to the treatment of COVID-19 patients. These factors are not conducive to the treatment of diabetic foot, and even increase the risk of amputation.

Stable Solid Electrolyte Interphase In Situ Formed on Magnesium-Metal Anode by using a Perfluorinated Alkoxide-Based All-Magnesium Salt Electrolyte.

Passivation of the Mg anode surface in conventional electrolytes constitutes a critical issue for practical Mg batteries. In this work, a perfluorinated tert-butoxide magnesium salt, Mg(pftb) , is codissolved with MgCl in tetrahydrofuran (THF) to form an all-magnesium salt electrolyte. Raman spectroscopy and density function theory calculation confirm that [Mg Cl ·6THF] [Mg(pftb) ] is the main electrochemically active species of the electrolyte.

Recent advances in research on anodes for safe and efficient lithium-metal batteries.

The revival of lithium metal anodes (LMAs) makes it a potent influence on the battery research community in the recent years after the popularity of Li-ion batteries with graphite anodes. The main reason is due to the over ten-fold increase in the capacity of LMAs when compared with that obtained when using graphite, as well as the low redox potential of Li/Li. However, the full potential of LMAs is heavily inhibited by several factors, such as dendrite growth, pulverization, side reactions, and volume changes.

Male axillary accessory breast cancer: A case report.

Rationale: Accessory breast cancer is extremely rare among all cancerous diseases, especially in male patients. There were only few male axillary accessory breast cancer cases that have been reported in scientific literatures so far. Hereby, we would like to discuss a case of male axillary accessory breast cancer found in our hospital.

Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation.

With the increase of population aging and the proportion of overweight and obese, a growing number of people are suffering from diabetes. Insulin (INS) as the most widely used hypoglycemic agent was always chosen as the most effective treatment method of diabetes. In this study, fumaryl diketopiperazine (FDKP) was used as a carrier for the pulmonary delivery of insulin.

Targeting STAT3 restores BRAF inhibitor sensitivity through miR-759-3p in human cutaneous melanoma cells.

Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic benefits, but the common emergence of drug resistance remains a challenge. To define molecular mechanisms of vemurafenib resistance, we generated A375-R, WM35-R cell lines resistant to vemurafenib and found that the p-STAT3 was upregulated in these cells and . In particular, activation of the STAT3 pathway was associated with vemurafenib resistance.

Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss.

Despite long-term efforts to elucidate the mechanisms responsible for age-related hearing loss (AHL), there is currently no available treatment strategy able to provide a cure. Apoptotic cell death, including that of hair cells and spiral ganglion neurons (SGNs) in the cochlea has been proposed to be the classic theory behind the development of AHL. As calcium signaling plays key roles in signal transduction in apoptosis, in this study, we selected ethosuximide, which is able to block T-type calcium (Ca2+ion) channels, suppressing Ca2+.

Expression of calcitonin gene-related peptide, adenosine A2a receptor and adenosine A1 receptor in experiment rat migraine models.

A migraine is a disabling neurovascular disorder characterized by a unilateral throbbing headache that lasts from 4 to 72 h. The headache is often accompanied by nausea, vomiting, phonophobia and photophobia, and may be worsened by physical exercise. The trigeminovascular system (TVS) is speculated to have an important role in migraines, although the pathophysiology of this disorder remains to be elucidated.

Nerve growth factor for Bell's palsy: A meta-analysis.

A meta-analysis was performed to evaluate the efficacy and safety of nerve growth factor (NGF) in the treatment of Bell's palsy. PubMed, the Cochrane Central Register of Controlled Trials, Embase and a number of Chinese databases, including the China National Knowledge Infrastructure, China Biology Medicine disc, VIP Database for Chinese Technical Periodicals and Wan Fang Data, were used to collect randomised controlled trials (RCTs) of NGF for Bell's palsy. The span of the search covered data from the date of database establishment until December 2013.