Combined treatment with mesenchymal stem cells and ROCK inhibitor Y-27632 ameliorates PM-induced lung injury.

Particulate matter 2.5 μm (PM) can directly enter the human respiratory tract and cause damage to lungs. Mesenchymal stem cells (MSCs) transplantation has emerged as a promising therapeutic strategy for ameliorating lung injury.

Proteomics identify pathogenesis and novel biomarkers for monitoring and early prognostication of brain injury after cardiac arrest: a randomized animal study.

Aim: Post-cardiac arrest brain injury (PCABI) is the leading cause of death and disability after resuscitation. This study aimed to investigate the pathogenesis and novel biomarkers for monitoring the progression and early prognostication of PCABI.

Methods: Mouse model of PCABI was induced by hyperkalemia-induced asystole and successful resuscitation.

Clinical characteristics and impact of comorbidities on the prognosis of senile epilepsy in Southwest China: a retrospective cohort study.

Background: Senile epilepsy and its comorbidities pose a tremendous burden on patients and the society. This study was aimed to investigate the clinical characteristics and comorbidities of senile epilepsy, as well as the impact of comorbidities on the prognosis of senile epilepsy.

Methods: Information of patients with senile epilepsy was retrospectively collected from three tertiary hospitals in Southwest China between December 2014 and December 2022.

A survey of ictal physical examination during VEEG monitoring in a tertiary epilepsy center.

Background: Ictal examination based on video-based electroencephalography (EEG) is crucial for locating and lateralizing seizures. In this study, we aimed to evaluate the quality of ictal examination in the Comprehensive Epilepsy Center of West China Hospital, Sichuan University, in order to provide information for quality improvement in daily clinical practice.

Methods: Video recordings of 100 patients with epilepsy were retrospectively reviewed.

Comparative Virulence of Entomopathogenic Nematodes to the Small Hive Beetle ( Murray, Coleoptera: Nitidulidae).

The small hive beetle (SHB), Murray (Coleoptera: Nitidulidae), has become a ubiquitous, invasive, and highly destructive pest of western honeybee ( Linnaeus) hives worldwide. Beekeepers often attempt to control this beetle chemically. Still, ineffective registered control options and rampant off-label chemical use in the beekeeping industry have driven research toward alternative pest management strategies.

[Spatial Correlation Network Effect and Influencing Factors of Green and Low-carbon Development in Logistics Industry].

As the logistics infrastructure network constantly improves and the demand for low-carbon transition continues to increase, the green, low-carbon development of the logistics industry has displayed distinctive features of spatial association. Therefore evaluating the effects and causes of spatial association comprehensively and objectively to promote the low-carbon transition of the logistics industry and coordinated development between regions, is important. Based on the global EBM model of undesirable output, this study measured the green, low-carbon development level of inter-provincial logistics in China and revealed the spatial association features of low-carbon development in the logistics industry, as well as the formation mechanism.

Puerarin Reversing Autophagy-Lysosomal Dysfunction via Acid Sphingomyelinase Inhibition in Cardiomyocytes.

Heart failure (HF) is a major cardiovascular disorder characterised by high prevalence and mortality rate. Recent studies have emphasised the role of autophagy in development and progression of HF. Dysfunctions in lysosomes and autophagic processes are closely associated with the aetiology of HF.

Sodium butyrate attenuates microglia-mediated neuroinflammation by modulating the TLR4/MyD88/NF-κB pathway and microbiome-gut-brain axis in cardiac arrest mice.

Cardiac arrest (CA) is one of the most common illnesses worldwide. Post-CA brain injury (PCABI) is a major cause of death and poor recovery in CA patients and the current CA treatments are not very effective. The microbiome-gut-brain axis has been found to significantly affect brain ischemia injury.

In Silico-Guided Discovery of Polysaccharide Derivatives as Adjuvants in Nanoparticle Vaccines for Cancer Immunotherapy.

Cancer vaccines utilizing nanoparticle (NP) structures that integrate antigens and adjuvants to enhance delivery and stimulate immune responses are emerging as a promising avenue in cancer immunotherapy. However, the development of cancer vaccines has been significantly hindered by the low immunogenicity of tumor antigens. To address this challenge, substantial efforts have been made in developing innovative adjuvants to elicit effective immune responses.

Study on the use of intravascular ultrasound-guided coronary intravascular lithotripsy compared with rotational atherectomy: a single-center, retrospective study.

Objective: This study aimed to compare the efficacy and safety of intravascular ultrasound (IVUS)-guided coronary intravascular lithotripsy and rotational atherectomy in treating severe coronary artery calcification.

Methods: A retrospective analysis of 60 patients who underwent percutaneous coronary intervention at the General Hospital of Ningxia Medical University from October 2022 to August 2023 was conducted. The patients were divided into two groups: 30 received IVUS-guided coronary intravascular lithotripsy and 30 underwent IVUS-guided rotational atherectomy.

The dynamic of physicochemical properties, volatile compounds and microbial community during the fermentation of Chinese rice wine with diverse cereals.

This study investigates the impact of liquid state fermentation on the key flavor compounds and microbial community structure in Chinese rice wine brewed from five different raw materials: buckwheat, sorghum, japonica rice, glutinous rice, and black rice. Using HS-SPME-GC-MS and HPLC, the volatile compounds were analyzed across various grain liquefaction methods, detecting 82 volatiles, including esters, alcohols, aldehydes, and acids. The concentration of flavor compounds such as esters, amino acids, phenolic acids, and organic acids varied significantly depending on the raw material used.

Metabolite and mineral contents in root, seed, testa, stem and leaf of L.

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Caloric requirement targets for nutritional support in adult autoimmune encephalitis: a retrospective cohort study.

Background: Autoimmune encephalitis (AE) is a severe neurological disease often accompanied by consciousness disturbances, severe swallowing difficulties, and gastrointestinal dysfunction, increasing the risk of malnutrition. However, the optimal caloric intake target during the acute phase of AE remains unclear.

Objective: This study aims to evaluate the impact of caloric intake on short-term clinical outcomes in AE patients, specifically focusing on the improvement in Clinical Assessment Scale for Autoimmune Encephalitis (CASE) scores, to provide recommendations for nutritional support during the acute phase.

Experiences of caregivers of patients with traumatic brain injury during hospitalization in western China: A qualitative study.

Family members frequently provide both physical and emotional support to patients. Previous studies have focused primarily on the experiences of patients with traumatic brain injury (TBI) and their caregivers during home care and the transition from hospital care to the community, with less emphasis on their experiences during acute hospital care immediately after TBI. This study aimed to explore the experiences of caregivers of patients with TBI during acute hospitalizations.

The effect of prone-position ventilatory strategy among neurology patients with SARS-CoV-2: A cross-sectional survey.

Awake-prone position combined with noninvasive ventilation or high-flow nasal cannula ventilation has been shown to be safe in the treatment of patients with moderate to severe ARDS and COVID-19, and may avoid intubation and reduce patient mortality. We conducted a cross-sectional study in a hospital to observe the effect of prone position on neurological patients with SARS-CoV-2. A total of 52 neurological patients with SARS-CoV-2 participated in the survey.

Chitosan/rutin multifunctional hydrogel with tunable adhesion, anti-inflammatory and antibacterial properties for skin wound healing.

Effective wound care remains a significant challenge due to the need for infection prevention, inflammation reduction, and minimal tissue damage during dressing changes. To tackle these issues, we have developed a multifunctional hydrogel (CHI/CPBA/RU), composed of chitosan (CHI) modified with 4-carboxyphenylboronic acid (CPBA) and the natural flavonoid, rutin (RU). This design endows the hydrogel with body temperature-responsive adhesion and low temperature-triggered detachment, thus enabling painless removal during dressing changes.

Extracerebral multiple organ dysfunction and interactions with brain injury after cardiac arrest.

Cardiac arrest and successful resuscitation cause whole-body ischemia and reperfusion, leading to brain injury and extracerebral multiple organ dysfunction. Brain injury is the leading cause of death and long-term disability in resuscitated survivors, and was conceptualized and treated as an isolated injury, which has neglected the brain-visceral organ crosstalk. Extracerebral organ dysfunction is common and is significantly associated with mortality and poor neurological prognosis after resuscitation.

Identification, expression, and characterization of a marine-derived chitinase Ce0303 from Chitiniphilus eburneus YS-30 with exo- and endo-hydrolytic properties.

N-acetyl-oligosaccharides exhibit antioxidant and antibacterial activities. However, the low catalytic efficiency of chitinase on crystalline chitin hinders the eco-friendly production of N-acetyl-oligosaccharides. A marine-derived chitinase-producing strain Chitiniphilus eburneus YS-30 was screened in this study.

Susceptibility of Yellow Squash and Zucchini Cultivars to the Sweetpotato Whitefly, Gennadius (MEAM1), in the Southeastern United States.

The sweetpotato whitefly, (Gennadius) Middle East-Asia Minor 1 (MEAM1), causes significant losses to vegetable crops directly by sap-feeding, inducing plant physiological disorders, and elevating the build-up of sooty mold, and indirectly by transmitting plant viruses. In this study, we evaluated the susceptibility of 20 yellow squash and zucchini () cultivars to MEAM1, across three growing seasons in the southeastern United States. Weekly sampling of the numbers of MEAM1 adults, nymphs, and eggs were conducted from the fourth week after seed sowing and across 6 weeks during the summer and fall of 2021 and five weeks during the fall of 2022.

Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study.

Context: Yi-Shen-Hua-Shi (YSHS) is a traditional Chinese medicine that treats chronic kidney disease (CKD). However, its efficacy in reducing proteinuria and underlying mechanisms is unknown.

Objective: This single-center randomized controlled trial explored whether YSHS could improve proteinuria and modulate the gut microbiota.

Successful true cavity pathfinding with balloon assisted CTO with bifurcation lesions: Two case reports.

Background: Coronary artery disease is a prevalent global cardiovascular ailment, with percutaneous coronary intervention (PCI) standing out as a crucial method for relieving symptoms and enhancing the quality of life in patients with coronary heart disease. However, the presence of concurrent chronic total occlusion (CTO) and bifurcation lesions within coronary arteries elevates the complexity and treatment risks, especially when the entry point of the CTO is ambiguous.

Objective: This study aims to present an innovative approach for treating CTO complicated with bifurcation lesions, focusing on true cavity pathfinding assisted by a balloon.

Disposal of drilling waste in salt mines in China.

A lot of drilling wastes are produced during oil/gas exploration and exploitation in China. Many countries have built and successfully run projects to dispose of wastes in salt mines, which fully demonstrates the feasibility and superiority of this technology. The application prospects of using salt mines to dispose of drilling wastes is comprehensively evaluated from many aspects.