Micropulse transscleral cyclophotocoagulation in the treatment of autosomal recessive bestrophinopathy combined with angle closure glaucoma: a case report.

Background: Autosomal recessive bestrophinopathy (ARB) comprises remarkable retinal dystrophy characterized by yellowish subretinal lesions scattered in the posterior pole and is always accompanied with refractory angle-closure glaucoma (ACG). The treatment of ACG patients with ARB is a major challenge for all ophthalmologists.

Case Presentation: A 12-year-old female child was diagnosed with ARB and ACG and presented with discrete, round, yellow-white deposits of variable sizes scattered in the retina, retinoschisis in the macular, shallow anterior chamber depth and angle closure with uncontrolled intraocular pressure (IOP).

Comparative Study of Catalytic Oxidation of Toluene over Porous Metal Oxide Catalysts Derived from (Mn, Ce, Co)-MOFs.

This study presents a systematic investigation into the catalytic oxidation of toluene using metal-organic framework (MOF)-derived porous metal oxide catalysts obtained through controlled pyrolysis. The MOF-derived catalysts (MnO-BTC, CeO-BTC, CoO-BTC) demonstrated remarkable improvements in catalytic activity and stability compared to their commercial counterparts (MnO-c, CeO-c, CoO-c), achieving 90% toluene conversion () at significantly lower temperatures of 240 °C, 241 °C, and 237 °C, respectively. Besides, a comprehensive suite of characterization techniques was employed to elucidate the structure-activity relationships.

Diatomic Zn-Functionalized Carbon Sphere for Microplastics Remediation in Natural Seawater at Environmentally Relevant Concentration.

Microplastics remediation in natural seawater is challenging due to their low environmental concentrations and chemical inertia under environmental conditions. Here, a novel approach is presented for the in situ capture and degradation of polyester microplastics using zinc-functionalized carbon material, for the first time at environmentally relevant concentrations in natural seawater. The capture of microplastics is driven by their multilevel non-covalent interactions with the high-surface-area carbon, while the degradation is realized by the nucleophile bridged to the dinuclear zinc sites.

Mining UDP-Glucosyltransferases to Develop High-Efficiency Production Strategies for Emodin Glucosides.

Emodin-6--β-d-glucoside (E6G) and Emodin-8--β-d-glucoside (E8G) are promising plant-derived bioactive compounds with significant pharmaceutical potential. However, their large-scale production is hindered by low natural abundance and complex extraction processes. In this study, the biosynthesis of emodin glucosides in filamentous fungi was comprehensively investigated using synthetic biology approaches.

Characterizing structure-function coupling in subjective memory complaints of preclinical Alzheimer's disease.

BackgroundSubjective cognitive decline (SCD) is recognized as an early phase in the progression of Alzheimer's disease (AD).ObjectiveTo explore the abnormal patterns of morphological and functional connectivity coupling (MC-FC coupling) and their potential diagnostic significance in SCD.MethodsThe data of 52 individuals with SCD and 51 age-gender-education matched healthy controls (HC) who underwent resting-state functional magnetic resonance imaging and high-resolution 3D T-weighted imaging were retrieved to build the MC and FC of gray matter.

Serum insulin-like growth factor binding protein 2 is associated with hepatic steatosis in adults with metabolic dysfunction-associated steatotic liver disease.

Objective: To evaluate the association between serum insulin-like growth factor binding protein 2 (IGFBP2) and the degree of hepatic steatosis in patients with MASLD.

Methods: A total of 347 patients with metabolic dysfunction-associated steatotic liver disease (MASLD) were enrolled, adhering to the inclusion criteria. The controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were measured by FibroScan, while serum IGFBP2 levels were quantified by ELISA.

Self-Evolving Discovery of Carrier Biomaterials with Ultra-Low Nonspecific Protein Adsorption for Single Cell Analysis.

Carrier biomaterials used in single-cell analysis face a bottleneck in protein detection sensitivity, primarily attributed to elevated false positives caused by nonspecific protein adsorption. Toward carrier biomaterials with ultra-low nonspecific protein adsorption, a self-evolving discovery is developed to address the challenge of high-dimensional parameter spaces. Automation across nine self-developed or modified workstations is integrated to achieve a "can-do" capability, and develop a synergy-enhanced Bayesian optimization algorithm as the artificial intelligence brain to enable a "can-think" capability for small-data problems inherent to time-consuming biological experiments, thereby establishing a self-evolving discovery for carrier biomaterials.

Management of trigeminal neuralgia in a rat model using intranasal administration of Bulleyaconitine A.

Introduction: Trigeminal neuralgia (TN), characterized by severe facial pain triggered by mild stimuli, is challenging to treat effectively and non-invasively. Traditional treatments, including microvascular decompression and medications like carbamazepine, have limitations. This study investigates the potential of Bulleyaconitine A (BAA), an alkaloid that selectively inhibits specific sodium channels, for managing TN in a rat model via intranasal administration.

Integrated breath volatolomics and metabolomics analyses reveals novel biomarker panels for the diagnosis of chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease (COPD) represents a major public health challenge, underscoring the need for reliable diagnostic biomarkers. Breath analysis has emerged as a rapid, convenient, and non-invasive diagnostic approach for various diseases. This study aimed to identify potential breath biomarkers associated with COPD using mass spectrometry and bioinformatic analysis.

Natural Flavonoids from Licorice as Potent Inhibitors of β-Glucuronidase Elucidated Through Computational Studies.

Gut bacterial β-glucuronidase is an important molecular target in several therapeutic applications. β-glucuronidase inhibitors can effectively alleviate gastrointestinal toxicity caused by certain drugs. Licorice, a traditional Chinese medicine, harmonizes various herbs and mitigates the toxicity of hundreds of herbs.

Aptamer-Induced Spatially Confined Electron Donors Enable BiS/ZnInS Heterostructures for Attomolar Photoelectrochemical Detection of Antibiotic Resistance Genes.

Despite the fact that the exploration of novel materials with excellent photoelectrochemical (PEC) performance is the sought-after objective for its detection of low abundance targets, the introduction of electron donors in a rational and efficient manner to further boost the PEC signals is still desirable. In this work, highly efficient PEC materials BiS/ZnInS (BZ) heterojunctions were synthesized, and a strategy of aptamer-induced spatially confined electron donors (ASED) was, for the first time, proposed for highly enhanced and stable photocurrent generation. With dopamine (DA) or ascorbic acid (AA) as the electron donor model, ∼ 22-fold PEC signal enhancement could be obtained in the system using the ASED strategy.

Global impacts of land use on terrestrial carbon emissions since 1850.

Since the Industrial Revolution, significant changes in global land-use patterns have occurred, which have disrupted terrestrial carbon emissions. However, the disturbance processes, change trends, and distribution patterns are not clear. Therefore, the changes in terrestrial carbon emissions (E) caused by land-use change (LUC) since 1850 were analyzed in this study.

Related factors and safety of reaching the therapeutic target of warfarin after heart valve surgery in hospitalized patients: A retrospective cohort study.

Warfarin is a commonly employed anticoagulant drug aimed at rapidly reaching the optimal international normalized ratio (INR), potentially reducing the hospitalization time in clinical settings. However, limited research has been conducted on the influencing factors and the safety implications of promptly reaching the target INR range in patients with valvular heart disease who have undergone valve replacement or repair. The present study aimed to assess the factors related to the safety considerations of rapidly reaching the target INR range in patients treated with warfarin.

Huanglian-Jiedu decoction promotes adipose thermogenesis in obese mice by suppressing the expression of HDAC3.

Ethnopharmacological Relevance: Huanglian Jiedu Decoction (HLJDD) is an ancient formula of traditional Chinese medicine that is commonly utilized in a range of disorders, and it has been shown to have pharmacological effects on glucose and lipid metabolism. However, the specific mechanism of HLJDD for the treatment of obesity and related metabolic disorders remains to be further investigated.

Aim Of The Study: It has been thought that encouraging adipose thermogenesis to raise the body's energy expenditure is a useful tactic for improving metabolic abnormalities and losing weight.

Cell cycle-regulated transcription factor AP2XII-9 is a key activator for asexual division and apicoplast inheritance in tachyzoite.

Unlabelled: is an intracellular parasitic protozoan that poses a significant risk to the fetus carried by a pregnant woman or to immunocompromised individuals. tachyzoites duplicate rapidly in host cells during acute infection through endodyogeny. This highly regulated division process is accompanied by complex gene regulation networks.

VEGF-B is involved in diabetic peripheral neuropathy in patients with type 2 diabetes.

This study aims to explore the potential role of vascular endothelial growth factor-B (VEGF-B) in the pathogenesis of diabetic peripheral neuropathy (DPN). The expression of VEGFRs were reanalysed by using gene arrays of peripheral nerve samples from mouse models of DPN retrieved from the GEO database. 213 T2D patients as well as 31 healthy individuals were recruited.

Unexpected response of terrestrial carbon sink to rural depopulation in China.

China is experiencing large-scale rural-urban migration and rapid urbanization, which have had significant impact on terrestrial carbon sink. However, the impact of rural-urban migration and its accompanying urban expansion on the carbon sink is unclear. Based on multisource remote sensing product data for 2000-2020, the soil microbial respiration equation, relative contribution rate, and threshold analysis, we explored the impact of rural depopulation on the carbon sink and its threshold.

Forskolin is an effective therapeutic small molecule for the treatment of hypertrophic cardiomyopathy through ADCY6/cAMP/PKA pathway.

Hypertrophic cardiomyopathy (HCM) arises from a pathogenic variant in the gene responsible for encoding the myocardium-associated protein. Forskolin (FSK), a labdane diterpene isolated from Sphingomonas capillaris, exhibits diverse pharmacological effects, including bronchospasm relief, intraocular pressure reduction, and glaucoma treatment. However, whether FSK could regulate HCM and its associated mechanism remains unclear.

AP2XII-1 and AP2XI-2 Suppress Schizogony Gene Expression in .

is an intracellular parasite that is important in medicine and veterinary science and undergoes distinct developmental transitions in its intermediate and definitive hosts. The switch between stages of is meticulously regulated by a variety of factors. Previous studies have explored the role of the microrchidia (MORC) protein complex as a transcriptional suppressor of sexual commitment.

Experimental and computational study on anti-gastric cancer activity and mechanism of evodiamine derivatives.

Human topoisomerase 1 (TOP1) is an important target of various anticancer compounds. The design and discovery of inhibitors targeting TOP1 are of great significance for the development of anticancer drugs. Evodiamine and thieno [2,3-d] pyridine hybrids show potential antitumor activity.