Integrative Transcriptomic Analysis Decodes the Interplay Between Aging, Senescence, and Cancer.

Cancer risk increases with age, and cellular senescence may be a major contributor to cellular carcinogenesis. Enormous efforts have been made to investigate the interrelation between aging and tumors, but little is known about the comparative features of normal aging, cellular senescence, and cancer at single-cell resolution. By integrating analyses of genomics, epigenomics, and bulk and single-cell transcriptomics, we revealed a directionally opposite transcriptional profile between cellular senescence and tumorigenesis at the single-cell level, which may be affected by epigenomic regulations.

Rhizophagus intraradices enhances soybean tolerance to soda saline-alkaline stress through coordinated regulation of ionic homeostasis and photosynthetic efficiency during critical growth stages.

Soil salinization and alkalization are major constraints on soybean productivity. Arbuscular mycorrhizal fungi (AMF), such as Rhizophagus intraradices (Ri), enhance crop stress tolerance, but their stage-specific regulatory mechanisms in soybeans under soda saline-alkaline stress remain unclear. Using in situ soda saline-alkaline soil in pot experiments, we evaluated Ri's effects on soybean growth, ion homeostasis, and photosynthesis across critical stages: branching (V5), pod development (R4), and full maturity (R8).

A comprehensive evaluation of de novo metastatic breast cancer trends by subtype from the Dallas Metastatic Cancer Study.

Background: The Dallas Metastatic Cancer Study is a clinical database established to examine local trends associated with the diagnosis and treatment of de novo metastatic breast cancer and identify factors for further evaluation. Clinical characteristics of patients with de novo metastatic breast cancer are often underreported in the literature.

Methods: We report data from 2010 to 2021 for patients with de novo metastatic breast cancer along with the impact of clinical variables such as age, BMI, race and ethnicity, insurance status, hypertension, diabetes, and site of metastasis with survival analysis with respect to subtype.

Clinical evaluation of 3D printed splint in the treatment of temporomandibular disorders.

Objective: To use a T-scan (Tekscan, Boston, USA) to evaluate the grinding effect of a three-dimensional (3D) printed occlusal splint and provide reference guidelines for adjusting occlusion and alleviating temporomandibular joint symptoms before orthodontic treatment.

Methods: Eighteen patients with temporomandibular disorder (TMD) were treated with 3D-printed stable occlusal plates for three months. The occlusal time (OT) of the dentition and the difference percentage of occlusal force between the left and right sides (Asymmetry index of occlusal force, AOF) were observed one week, one, two, and three months after T-scan-guided occlusal splint treatment.

The impact of a multi-micronutrient nutritional formula combined with cognitive behavioral therapy in managing symptoms of children with attention deficit hyperactivity disorder.

Background: Attention-Deficit/Hyperactivity Disorder (ADHD) characterized by symptoms of inattention, hyperactivity, and impulsivity, with substantial impacts on a child's academic performance, social interactions, and overall quality of life. This study investigates the impact of combining a multi-micronutrient nutritional formula (MNF) with cognitive behavioral therapy (CBT) in managing ADHD symptoms in children.

Methods: In a retrospective analysis of 220 children aged 6-14 years diagnosed with ADHD, patients were divided into two groups: the MNF group ( = 112) receiving only the nutritional formula, and the MNF-CBT group ( = 108) receiving both the nutritional formula and CBT.

Healthcare workers knowledge attitudes and practices regarding labor analgesia in Shaanxi Province China.

Awareness of labor analgesia among healthcare workers (HCWs) may be suboptimal. To evaluate the knowledge, attitudes, and practices of HCWs regarding labor analgesia. This cross-sectional study enrolled HCWs (obstetricians, anesthesiologists, midwives, and nurses) at hospitals in Shaanxi Province (October 2022 to December 2022).

Characterizing structure-function coupling in subjective memory complaints of preclinical Alzheimer's disease.

BackgroundSubjective cognitive decline (SCD) is recognized as an early phase in the progression of Alzheimer's disease (AD).ObjectiveTo explore the abnormal patterns of morphological and functional connectivity coupling (MC-FC coupling) and their potential diagnostic significance in SCD.MethodsThe data of 52 individuals with SCD and 51 age-gender-education matched healthy controls (HC) who underwent resting-state functional magnetic resonance imaging and high-resolution 3D T-weighted imaging were retrieved to build the MC and FC of gray matter.

Manganese oxidation-reduction coupling denitrification performance of strain Pseudomonas sp. XFQ: Dual-function comparison and potential mechanisms.

In response to the nitrate (NO-N) and manganese (Mn) contamination in aquatic systems polluted by industrial and agricultural activities, this study isolated a strain Pseudomonas sp. XFQ that can simultaneously achieve Mn redox coupled denitrification. In the Mn(Ⅱ) oxidation-coupled denitrification system (carbon to nitrogen ratio = 2.

Machine learning-based prediction model for cognitive impairment risk in patients with chronic kidney disease.

Background: The high prevalence of cognitive impairment (CI) in Chronic kidney disease (CKD) patients impacts their quality of life and prognosis, yet risk prediction models for CI in this population remain underexplored.

Objective: This study aimed to develop a risk prediction model for CI in CKD patients using machine learning algorithms, with the objective of enhancing risk prediction accuracy and facilitating early intervention.

Methods: A total of 415 CKD patients from the 2015 China Health and Retirement Longitudinal Survey (CHARLS) dataset were included in this study.

High HPV viral load predicts worse prognosis in patients with cervical cancer treated with radiochemotherapy.

Purpose: To evaluate the prognostic value of high-risk human papillomavirus (HR-HPV) viral load in long-term survival of cervical cancer (CC) patients.

Methods: Two hundred and twenty-nine CC patients from 2009 to 2013 who underwent radiochemotherapy (RCT) or plus hyperthermia (HT) were recruited. HPV type 16, 18, 58 DNA was detected by in situ hybridization (ISH) and either HR-HPV type with the highest intensive signals was chosen as the evaluating target.

The effects and post-exercise energy metabolism characteristics of different high-intensity interval training in obese adults.

This study aimed to compare the effects of two high-intensity interval training modalities on body composition and muscular fitness in obese young adults and examined the characteristics of energy expenditure (EE) after training. Thirty-six obese young adults (eleven female, age: 22.1 ± 2.

Preparation of two kinds of immunocastration vaccines and their immune effects on male goats.

Objective: Post-pubertal male goats exhibit undesirable behaviors (fighting, mounting) and reduced growth due to high testosterone, while traditional castration causes stress. Immunocastration offers a humane alternative. This study aimed to develop effective immunocastration vaccines.

Asciminib in combination with imatinib, nilotinib, or dasatinib in patients with chronic myeloid leukemia in chronic or accelerated phase: phase 1 study final results.

Data from in vitro and animal studies suggest that asciminib, the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP), synergizes with adenosine triphosphate (ATP)-competitive tyrosine kinase inhibitors (TKIs) to prevent emergence of and overcome resistance. Combination therapy may provide new treatment options for patients with chronic myeloid leukemia (CML) with suboptimal responses to ATP-competitive TKI monotherapy. Preliminary analysis of asciminib combined with nilotinib, imatinib, or dasatinib in a phase 1 dose-escalation study suggested promising efficacy and safety for patients with CML in chronic phase or accelerated phase treated with prior ATP-competitive TKIs; herein, we present final results from the 3 combination therapy arms.

Asciminib monotherapy in patients with chronic myeloid leukemia in chronic phase without BCR::ABL1 treated with at least 2 prior TKIs: Phase 1 final results.

Asciminib is the first approved BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP). The present final analysis of the phase 1, open-label, nonrandomized trial (NCT02081378) assessed the long-term safety, tolerability, and antileukemic activity of asciminib in 115 patients with chronic myeloid leukemia in chronic phase without the BCR::ABL1 mutation who received asciminib 10-200 mg twice daily (BID) or 80-200 mg once daily (cutoff: March 14, 2023). Median exposure duration was 5.

Prevalence of Chronic Traumatic Encephalopathy in Athletes With Repetitive Head Impacts: A Systematic Review and Meta-Analysis.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with repetitive head impacts (RHI), which is commonly observed in athletes participating in contact sports. This systematic review and meta-analysis aimed to provide a clearer elucidation of the prevalence, risk factors, and potential outcomes of CTE in athletes. Through a comprehensive search of PubMed, EMBASE, Web of Science, and Google Scholar (January 2015 to July 2024), we ultimately included eight eligible studies with a low risk of bias involving 1000 former contact sports athletes diagnosed by neuropathological methods.

Aliovalent Doping and Texture Engineering Facilitating High Thermoelectric Figure of Merit of SnSe Prepared by Low-Temperature Hydrothermal Synthesis.

The IV-VI compound SnSe is an environmentally friendly and high-performance thermoelectric material with intrinsically low lattice thermal conductivity. Recent research efforts have focused on enhancing carrier concentration and effective mass to improve power factors, thereby achieving superior thermoelectric performance as reflected in the figure of merit ZT. In context of the anisotropic crystal structure of SnSe, this study utilized a hydrothermal method to synthesize Rb-doped SnSe nanosheets.

Toxicological evaluation and metabolic profiling of earthworms (Eisenia fetida) after exposure to microplastics and acetochlor.

In recent years, microplastic (MPs) and pesticide pollution have become prominent issues in the field of soil pollution. This research endeavored to assess the impact of ultraviolet radiation (UV) on the characteristics of microplastics, as well as investigating the toxicological effect on earthworms (Eisenia fetida) when subjected to the dual stressors of microplastics and acetochlor (ACT). This research found that microplastics aged under UV were more prone to wear and tear in the environment, and produced more oxygen-containing functional groups.

Novel sodium-hydrogen exchanger 1 inhibitors with diphenyl ketone scaffold: Design, Synthesis, mechanism and evaluation in mice model of heart failure.

Sodium-hydrogen exchanger 1 (NHE1) is a potential target for drug discovery of heart failure (HF). Cardioprotection effect of empagliflozin (EMPA) was reported to be related to binding with NHE1 protein. Herein, a series of NHE1 inhibitors bearing benzhydryl and diphenyl ketone skeleton were rationally designed and efficiently synthesized.

Identification of key genes linking bisphenols exposure and breast cancer.

Breast cancer (BC) is one of the most common types of cancer and is caused by the complex interplay of genetic and environmental factors, such as an unhealthy lifestyle, family history of illness, reproductive factors, and ageing. However, increasing evidence has revealed that manufactured organic pollutants such as bisphenols are closely related to BC. Bisphenols exposure can promote the progression of BC through multiple complicated and variable molecular mechanisms.

Strategies for plant-microbe symbiosis: Mycorrhizal fungi and helper bacteria to improve cold tolerance in rice.

Cold stress is a limiting factor for rice yield. Empirical evidence has demonstrated that arbuscular mycorrhizal fungi (AMF) can bolster the cold resilience of plants. In barren environments, AMF can promote host plant growth and resistance.

Patient-Derived Organoids for Guiding Neoadjuvant Chemotherapy in Bilateral Primary Breast Cancer: A Case Report.

Neoadjuvant chemotherapy (NAC) is the standard of care for locally advanced breast cancer, but the response to chemotherapy is unpredictable due to unknown information on the tumor drug sensitivity. Patient-derived organoids (PDOs) have recently been revealed to be a promising platform for assessing drug sensitivity in many cancers. A 46-year-old woman presented to the hospital due to an accidentally discovered mass in the left breast.

Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways.

Periodontal ligament stem cells (PDLSCs) bring new hope to patients with poor periodontium recovery and impaired regeneration. However, the complex inflammatory microenvironment continually inhibits stem cell function and hinders stem cell therapy effectiveness. Melatonin is a naturally occurring neurohormone that participates in the regulation of a large spectrum of biological functions.

Distribution and accumulation dynamics of fungicide azoxystrobin in the soil-plant system.

Azoxystrobin is a widely used fungicide belonging to the strobilurin group, primarily employed to control a range of fungal diseases in crops, including pepper (Capsicum annuum L.). As a systemic pesticide, it effectively inhibits mitochondrial respiration in fungi, thereby preventing their growth and spread.