Dynamically monitoring pneumonia severity scores to predict the prognosis in patients with community-acquired pneumonia: an international, multicenter cohort study.

Background: Traditional pneumonia severity scores are widely used at treatment initiation to stratify disease severity and predict prognosis. Although they can be reassessed during treatment to evaluate disease progression, their predictive accuracy remains suboptimal. To address this limitation, we introduce a novel machine learning algorithm that quantifies continuous disease progression, enhancing real-time evaluation of treatment efficacy and outcome prediction in community-acquired pneumonia (CAP).

Rhizospheric Fe-S-mediated N/P cycling disparities and adaptive strategies to long-term pesticide stress among distinct constructed wetlands plant types.

The differences in rhizosphere Fe-S cycling-mediated nitrogen and phosphorus removal, as well as the corresponding adaptive strategies among different wetland plant types under long-term pesticide stress, remain largely unexplored. This study investigates the responses of constructed wetlands planted with emergent and submerged plants over 330 days, including 160 days of exposure to varying concentrations (0.5, 1.

Noncontrast CT vs CT Perfusion Imaging in Patients With Basilar Artery Occlusion: Analysis of the ATTENTION and ATTENTION IA Trials.

Background And Objectives: Acute CT perfusion (CTP) or MRI is not widely available or routinely performed across many stroke centers. We aimed to evaluate whether patients with acute basilar artery occlusion (BAO) who are selected by noncontrast CT (NCCT) for endovascular therapy (EVT) have similar outcomes compared with patients who are selected by CTP.

Methods: This was a post hoc analysis of individual patient-level data from the ATTENTION and ATTENTION IA trials.

Iron modified biochar derived from diverse feedstock: Enhancing denitrification and mechanistic insights into the detoxification and removal of Cu and Pb.

Simultaneous removal of nitrate and heavy metals (HMs) from wastewater is a critical challenge due to their distinct chemical behaviors and impacts on microbial processes. Biochar-based materials have emerged as promising multifunctional platforms for integrated pollutant remediation. This study investigates the dual functionality of iron-modified biochar (prepared from rice husk, waste shell, and crayfish shell) in enhancing denitrification by Aquabacterium sp.

Intra-Arterial Tenecteplase After Successful Reperfusion in Large Vessel Occlusion Stroke: A Randomized Clinical Trial.

Importance: The optimal dose, safety, and efficacy of intra-arterial tenecteplase after successful reperfusion by endovascular thrombectomy for large vessel occlusion (LVO) is unknown.

Objective: To evaluate the dose-dependent adverse events and signals of efficacy of intra-arterial tenecteplase in LVO after successful reperfusion with thrombectomy, defined as an Extended Treatment in Cerebral Infarction score of 2b-3.

Design, Setting, And Participants: This open-label, blinded-outcome assessment trial, incorporating a 14 + 8 dose-escalation (phase 1b, nonrandomized) and dose-expansion (phase 2a, randomized) design, was conducted in China between 2023 and 2024, with follow-up continuing through November 2024.

Manganese oxidation-reduction coupling denitrification performance of strain Pseudomonas sp. XFQ: Dual-function comparison and potential mechanisms.

In response to the nitrate (NO-N) and manganese (Mn) contamination in aquatic systems polluted by industrial and agricultural activities, this study isolated a strain Pseudomonas sp. XFQ that can simultaneously achieve Mn redox coupled denitrification. In the Mn(Ⅱ) oxidation-coupled denitrification system (carbon to nitrogen ratio = 2.

Enhanced removal of nitrate, copper, and bisphenol A from immobilized bioreactors by exogenous acyl homoserine lactones-6 (AHLs-6) and iron-cobalt modified biochar.

Currently, treating industrial wastewater with complex components and difficult-to-degrade pollutants has become a focal point for research. In this study, sodium alginate (SA), polyvinyl alcohol (PVA), and shell powder (SP) were used as a carrier backbone to embed ferric cobalt-modified biochar (FCBC), exogenous acyl homoserine lactone-6 (AHLs-6), and the salt-tolerant strain Stutzerimonas sp. ZW5, resulting in the preparation of immobilized microbial carriers.

Using sludge biochar@waste pellet ore@kelp extract to enhance Feammox and removal of heavy metals: Performance evaluation and possible metabolic mechanisms.

The co-occurrence of nitrogen (N) and heavy metals (HMs) in industrial wastewater has emerged as a critical environmental challenge. Feammox-mediated N removal remains constrained by limited iron (Fe(III)) bioavailability and microbial susceptibility to HMs toxicity. This study developed a multifunctional composite through strategic integration of sludge-based biochar (SBC), pellet ore (PO), and kelp extract (KE) to overcome these limitations.

Multi-response optimization and validation analysis in the detection of acetochlor and butachlor by HPLC based on D-optimal design methodology.

Acetochlor and butachlor, widely used herbicides, pose environmental and health risks through water contamination. This study developed a high-performance liquid chromatography (HPLC) method for analyzing these compounds, employing a multi-response approach and D-optimal design. The D-optimal design reduced the number of required experiments from 36 to 14.

Mechanistic insights and performance of Mn redox cycling in a dual-bacteria bioreactor for ammonium and Cr(VI) removal.

The co-contamination of hexavalent chromium (Cr(VI)) and ammonium (NH-N) in industrial wastewater has attracted considerable attention due to its serious threats to both ecological systems and public health. Manganese(IV) (Mn(IV))-driven NH-N oxidation (Mnammox) coupled with Mn(II)-mediated denitrification (MnOD), built on the Mn redox cycle, is a promising nitrogen removal process, where Mn(II) and NO-N generated during Mnammox were effectively controlled by MnOD. Herein, a bioreactor integrating Mnammox and MnOD for NH-N and Cr(VI) removal was constructed utilizing core-shell gel beads embedded with two core strains and δ-MnO.

Simultaneous removal of carbamazepine, nitrate, and copper in a biofilm reactor filled with FeMn-modified ceramsite.

Mixtures of pollutants are a significant challenge for conventional wastewater treatment processes. In the present work, the potential of a biofilm reactor to simultaneously remove nitrate (NO-N), carbamazepine (CBZ), and copper ions (Cu) was evaluated. The reactor was filled with FeMn-modified ceramsite (CS@FeMn) and inoculated with the strains of Cupriavidus sp.

Simultaneous removal of ammonia, cadmium, and oxytetracycline via a double-layer immobilized bioreactor driven by manganese redox: Optimization and potential mechanism.

The coexistence of ammonia nitrogen (NH-N), heavy metals and antibiotics in composite polluted wastewater has garnered significant attention. This study developed a novel double-layer biological carrier using sodium alginate, diatomite, polyvinyl alcohol, manganese-modified biochar, and pyrolusite, loaded with strains YZ8 and MA23 to form an efficient bioreactor (M1). Under conditions of a hydraulic retention time of 24 h, the carbon to nitrogen ratio and pH were 1.

Simultaneous removal of nitrate, carbamazepine, and copper by fulvic acid and ferric chloride composite modified ceramsite assembled fixed biofilter reactor: Performance and microbial community response.

The complex pollution and nutrient-poor characteristics of surface waters result in the limited ability of conventional reactors to remove pollutants. In this study, a novel modified ceramsite material, modified with trivalent iron (Fe(III)) and fulvic acid (FA) to form ceramsite@Fe(III)@FA (HC), was used for the first time as a biocarrier to immobilize strain Cupriavidus sp. W12, constructing a biofilter to enhance nitrate (NO-N) removal in micro-polluted water.

Intra-arterial tenecteplase after successful endovascular recanalisation in patients with acute posterior circulation arterial occlusion (ATTENTION-IA): multicentre randomised controlled trial.

Objective: To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation.

Design: Multicentre randomised controlled trial.

Setting: 31 hospitals in China, 24 January 2023 to 24 August 2023.

Understanding the clinical and molecular epidemiological characteristics of carbapenem-resistant Acinetobacter baumannii infections within intensive care units of three teaching hospitals.

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) is recognized as a common clinical conditional pathogen with bla gene-mediated multidrug-resistance that is a significant threat to public health safety. Timely and effective infection control measures are needed to prevent their spread.

Methods: We conducted a retrospective study of CRAB patients at three teaching hospitals from 2019 to 2022.

Autotrophic ammonium nitrogen removal process mediated by manganese oxides: Bioreactors performance optimization and potential mechanisms.

Manganese(IV) (Mn(IV)) reduction coupled with ammonium (NH-N) oxidation (Mnammox) has been found to play a significant role in the nitrogen (N) cycle within natural ecosystems. However, research and application of the autotrophic NH-N removal process mediated by manganese oxides (MnOx) in wastewater treatment are currently limited. This study established autotrophic NH-N removal sludge reactors mediated by various MnOx types, including δ-MnO (δ-MSR), β-MnO (β-MSR), α-MnO (α-MSR), and natural Mn ore (MOSR), investigating their NH-N removal performances and mechanisms under different initial N loading and pH conditions.

Salinity stress and recovery of the algal-bacterial granular sludge (ABGS) system under the influence of different N-acyl-homoserine lactones (AHLs).

The algal-bacterial granular sludge (ABGS) system was established to explore the effect of 1% salinity condition, determine the recovery process following salinity disturbance, and probe the impacts of two N-acyl-homoserine lactones (AHLs) on the system. Exposure to 1% salinity led to the reduction of filaments and an increase in TB-EPS contents within the ABGS system. The phosphorus removal performance of the ABGS system severely decreased at 1% salinity and did not restore fully during the subsequent recovery stage, demonstrating that salinity stress induced long-term inhibition.

Simultaneous removal of ammonia, copper ions and sulfamethoxazole from aquaculture wastewater with low carbon to nitrogen ratio enhanced by manganese redox driven by a two-stage synergistic bioreactor: Optimization and potential mechanism.

The problem of low carbon-nitrogen ratio (C/N) in wastewater is a major challenge for biological treatment, especially the complex pollution of ammonia nitrogen (NH-N), sulfamethoxazole (SMX), and copper ions (Cu(II)). Herein, a strain of Pseudoxanthomonas sp. MA23 with manganese (Mn) reduction-coupled ammonia oxidation properties was isolated.

Nano-FeO/FeCO modified red soil-based biofilter for simultaneous removal of nitrate, phosphate and heavy metals: Optimization, microbial community and possible mechanism.

The pollution of nitrogen, phosphorus and heavy metals in surface water is becoming more and more serious, affecting the safety of water quality. In this study, three biofilters were constructed using iron-modified red soil-based filler carriers (RSC, nano-FeO@RSC, and FeCO@RSC) combined with strain Zoogloea sp. ZP7 to simultaneously remove nitrate (NO-N), phosphate (PO-P), copper (Cu), and zinc (Zn).

Dual application of lotus stem in fabricating a bioreactor for the remediation of nitrate, plumbum, and carbamazepine in industrial wastewater.

Addressing the treatment of complex industrial wastewater continues to be a substantial challenge within the realm of water treatment. A biofilm reactor was engineered, integrating lotus stem biochar, lotus stem biological filler, and the ZW5 strain for enhanced wastewater treatment. The removal efficiencies of nitrate (NO-N), calcium (Ca), chemical oxygen demand (COD), phosphorus (PO-P), plumbum (Pb), and carbamazepine (CBZ) were 98.

Bioremediation of oligotrophic waters by iron-humus-containing bio-immobilized materials: Performance and possible mechanisms.

The combined pollution and oligotrophic characteristics of surface water led to poor self-purification capacity of water bodies. In this study, humic acid (HA) and fulvic acid (FA) were used to promote the denitrification process of strain Zoogloea sp. ZP7.

Simultaneous removal of nitrate, copper, carbamazepine, and calcium from micropolluted water by fulvic acid through promotion of denitrification and microbial-induced calcium precipitation: Performance and mechanism.

In this paper, a study of the denitrification strain Cupriavidus sp. W12 was conducted to remove copper (Cu), carbamazepine (CBZ), and calcium (Ca) by microbial-induced calcium precipitation (MICP) after adding fulvic acid (FA). After the addition of 20 mg/L FA, the removal efficiencies of nitrate (NO-N), Cu, CBZ, and Ca reached 100.

Fe/Fe cycling drove novel ammonia oxidation and simultaneously removed lead, cadmium, and copper.

The discharge of several pollutants, such as ammonia (NH-N), nitrate (NO-N), and heavy metals, from aquaculture wastewater into the aquatic environment can cause severe pollution issues. In this work, microbial techniques were employed to enable concurrent elimination of NH-N and NO-N by Fe/Fe cycling. The greatest NH-N and NO-N removal efficiencies of 96.

Reduction of prolonged excitatory neuron swelling after spinal cord injury improves locomotor recovery in mice.

Spinal cord injury (SCI) results in acute damage and triggers secondary injury responses with sustained neuronal loss and dysfunction. However, the underlying mechanisms for these delayed neuronal pathologies are not entirely understood. SCI results in the swelling of spinal neurons, but the contribution of cell swelling to neuronal loss and functional deficits after SCI has not been systematically characterized.