A rare intronic c.2654+1G>A mutation in CSF1R-microglial encephalopathy: a case report.

Objective: We report a case of CSF1R-microglial encephalopathy associated with a rare intronic c.2654 + 1G>A mutation, featuring negative diffusion-weighted imaging (DWI) findings and a cerebrospinal fluid (CSF) biomarker profile indicative of Alzheimer's disease-related changes, and we explore the associations between genetic mutations, CSF biomarker alterations, and neuroimaging manifestations.

Methods: This study documents the demographic data, detailed medical history, and clinical manifestations of a patient with CSF1R-microglial encephalopathy.

Jueling Mingmu decoction combined with ranibizumab for retinal vein occlusion induced macular edema: A randomized controlled clinical trial.

Background/aims: To investigate the efficacy of a combined treatment approach using Jueling Mingmu Decoction and ranibizumab in managing macular edema (ME) associated with retinal vein occlusion (RVO).

Methods: This prospective, randomized, controlled, outcome assessor-blinded superiority trial involved 111 patients with treatment-naïve RVO and ME, including 53 patients assigned to the ranibizumab monotherapy group and 58 to the combination therapy group. Participants were randomly assigned to receive either intravitreal injections of 0.

Synergistic Enhancement of Vaccine Efficacy Through EF-1α Antigen and Chicken XCL1 Chemokine Adjuvant Combination.

Coccidiosis is a major parasitic disease that suppresses poultry productivity and causes significant global economic losses. Currently, controlling parasites relies primarily on the use of anticoccidial drugs or live vaccines. However, these conventional control strategies face the dual constraints of escalating drug resistance and unsustainable economic expenditures.

Identification of a founder haplotype of variant in lipoprotein glomerulopathy.

Background: Lipoprotein glomerulopathy (LPG) is a rare autosomal dominant inherited kidney disease with incomplete penetrance, characterized by nephrotic-range proteinuria, hypertriglyceridemia and progressive renal dysfunction with elevated serum apoE level. More than 15 mutations have been associated with LPG, with (Arg43Cys) the leading mutation in about 200 patients. We previously observed clustering of " causing LPG" in a Han population in China.

Factors influencing Chinese young adults' intention to receive HPV vaccination: the mediating role of attitude.

Introduction: This study examines the intention of young adults to receive the Human Papillomavirus vaccination in China, with a specific focus on the mediating role of attitude within an integrated framework of the Health Belief Model and the Theory of Planned Behavior.

Methods: A convenience sampling method was utilized to collect data through an online questionnaire targeting young adults aged 18 to 26. The data were analyzed using Partial Least Squares Structural Equation modeling to explore the relationships between various factors affecting vaccination intention.

The research on cycloastragenol in the treatment of brain metastases from lung cancer: mechanistic exploration of radiotherapy sensitization and amelioration of brain injury.

Objective: This study aimed to investigate the radiosensitizing and toxicity-reducing effects of Cycloastragenol (CAG) in the radiotherapy of lung cancer brain metastases.

Methods: A brain metastasis model of lung cancer was established using stereotactic brain localization. After successful modeling, varying doses of CAG (5 mg/kg, 10 mg/kg, 20 mg/kg) were administered via intraperitoneal injection to evaluate its antitumor efficacy.

Effect of α-ketoglutarate on maternal lipid homeostasis and mitochondrial status perturbed by gestational arsenic exposure.

Arsenic is a common environmental toxicant with known hepatotoxic effects, yet its impact on maternal lipid metabolism during pregnancy remains poorly understood. In this study, we established a pregnant mouse model to investigate the effects of gestational arsenic exposure and the potential protective role of α-ketoglutarate (α-KG), a key tricarboxylic acid (TCA) cycle intermediate. In the first experiment, arsenic exposure led to significant disruptions in maternal serum and hepatic lipid profiles.

Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.

Objective: This study aimed to investigate the active ingredients and mechanisms of Fu-Fang-Qi-Di-Hua-Yu-Tang (FFQD) in alleviating atherosclerosis and insulin resistance in diabetic macrovascular disease (DMD) mice.

Methods: Chemical profiling of FFQD was performed using UPLC-Q-TOF-MS. Apoe-/- mice were injected with streptozotocin and fed a high-fat diet to establish DMD.

Serum insulin-like growth factor binding protein 2 is associated with hepatic steatosis in adults with metabolic dysfunction-associated steatotic liver disease.

Objective: To evaluate the association between serum insulin-like growth factor binding protein 2 (IGFBP2) and the degree of hepatic steatosis in patients with MASLD.

Methods: A total of 347 patients with metabolic dysfunction-associated steatotic liver disease (MASLD) were enrolled, adhering to the inclusion criteria. The controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were measured by FibroScan, while serum IGFBP2 levels were quantified by ELISA.

Epigenetically-Upregulated CD98 Shed Light on the Precancerous Diagnosis and Prognosis Prediction of Esophageal Cancer.

Esophageal squamous cell carcinoma (ESCC) has a significantly low survival rate, primarily due to the lack of diagnostic markers for early diagnosis and effective therapies. Recently, CD98 has been proposed as a specific marker of mature esophageal basal cells, which may be associated with esophageal carcinogenesis. Therefore, we aimed to investigate the clinical significance and biological function of CD98 in ESCC progression, as well as the value of CD98 as a potential new marker for the early diagnosis of ESCC.

Multiple intraneural glomus tumors in scapularis region: A rare case report and review.

Rationale: Glomus tumors (GTs) are painful and typically benign neoplasms found in the subungual region of the fingertips. However, the occurrence of multiple GT within nerve fascicles in the scapular region is rare.

Patient Concerns: A 41-year-old male presented with a 5-year history of progressive tenderness in the scapular region, accompanied by elevated local skin temperature.

Optimization of supercritical carbon dioxide extraction process for total flavonoids in Suaeda salsa by orthogonal experiment.

To determine the optimal method for extracting flavonoids from Suaeda salsa, this study investigated the impact of various factors, including extraction time, temperature, pressure, and ethanol concentration, on the yield of total flavonoids obtained through the utilization of supercritical carbon dioxide (SFE-CO) as the extraction medium. The study employed both single-factor experiments and orthogonal experiments to accomplish this objective. The single-factor experiment adopted the control variable method, with fixed parameters for each factor: Temperature of 40, pressure of 30 MPa, time of 1.

Clinicopathologic and molecular mutational analysis of inflammatory fibroid polyps.

Objective: To study the clinicopathologic features, molecular mutations, as well as the potential cellular origin of the inflammatory fibroid polyps (IFPs).

Methods: We retrospectively analyzed 97 IFPs from 91 patients at Nanjing Drum Tower Hospital between 2005 and 2018. The clinical and pathological features were compared between gastric IFPs and non-gastric IFPs.

HGCMLDA: predicting lncRNA-disease associations using hypergraph contrastive learning and multi-scale attentional feature fusion.

Research has consistently indicated that long non-coding RNAs (lncRNAs) significantly influence the development of numerous diseases. Predicting lncRNA-disease associations (LDAs) will contribute to the prevention and treatment of diseases. However, most existing computational models suffer from several challenges: (i) difficulty in capturing complex higher-order relationships among nodes; (ii) limited number of known associations and neglect of consistency of representations across views; (iii) inadequate fusion of multi-view data.

Surface wettability engineering of MoS quantum dot-decorated NiCoO nanospheres for enhanced oxygen evolution reaction.

Modulating MoS quantum dots enhances the hydrophilicity of NiCoO, accelerates bubble detachment, promotes mass transfer, and consequently enhances catalytic activity. The optimized catalyst achieves a low overpotential of 272 mV at 10 mA cm and a Tafel slope of 76.3 mV dec in 1.

Genome-wide association study reveals as a novel susceptibility gene associated with primary spontaneous pneumothorax in the Chinese Han population.

Background: Primary spontaneous pneumothorax is a rare disease commonly found in young adults with unknown etiology. We aimed to investigate the susceptibility genes and the downstream signaling involved in the development of primary spontaneous pneumothorax.

Methods: We conducted the first large-scale genome-wide association study (GWAS) composed of 2223 patients and 3838 controls.

Prenatal arsenic exposure disrupts placental angiogenesis by altering Pdgfb promoter epigenetic modification.

Abnormal placentation causes adverse pregnancy and birth outcomes. This study aimed to explore the influence of prenatal arsenic (As) exposure on placental angiogenesis and its mechanism. Dams were orally administered with NaAsO throughout pregnancy.

The application of high-intensity interval training in college physical education and the improvement of students' physical and mental quality.

Purpose: With the increase of employment pressure in modern society and the influence of the long-term static learning mode, the obesity problem of college students is becoming more and more serious, which has become an important factor affecting their physical and mental health. The traditional methods of losing weight, such as dieting, are not effective and have health risks. High-intensity interval training (HIIT), as a new form of exercise, for patients, can significantly boost the basal metabolic rate, thereby aiding in fat burning and facilitating weight management.

Lightweight and Mechanically Robust Ambient-Electrospun Nanofibrous Sponges Combined with Solar-Driven Active Heating and Low-Temperature Superinsulation.

Traditional fibrous warmth retention materials suffer from limited performance improvement due to their micrometer-scale diameter and fail to meet the requirements of lightweight yet high-efficiency cold protection in extreme environments. Herein, we present a novel, facile, and ecofriendly strategy to fabricate a lightweight, mechanically robust nanofibrous sponge with integrated solar-driven active heating and low-temperature superinsulation. The high-porosity structure is achieved through urea-induced phase separation during ambient electrospinning, which overcomes the energy-intensive and unsafe high-humidity processing challenges.

Discovery and comprehensive analysis of a congenital chimerism via paternity testing using short tandem repeat genotyping.

In medical forensics, the detection of more than two alleles at a single locus is generally interpreted as a mixed sample or contamination. However, this can also indicate chimerism, in which an individual contains two or more distinct cell lines with different genomes. Multiple alleles at a single locus can be identified using short tandem repeat (STR) genotyping.

Identification of HIBCH and MGME1 as Mitochondrial Dynamics-Related Biomarkers in Alzheimer's Disease Via Integrated Bioinformatics Analysis.

Mitochondrial dynamics (MD) play a crucial role in the genesis of Alzheimer's disease (AD); however, the molecular mechanisms underlying MD dysregulation in AD remain unclear. This study aimed to identify critical molecules of MD that contribute to AD progression using GEO data and bioinformatics approaches. The GSE63061 dataset comparing AD patients with healthy controls was analysed, WGCNA was employed to identify co-expression modules and differentially expressed genes (DEGs) and LASSO model was developed and verified using the DEGs to screen for potential biomarkers.

G0S2 Promotes PD-L1 Expression in Monocytes and Influences the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a prevalent and highly lethal form of liver cancer, with limited effective treatment options, particularly in the advanced stages. Immunotherapy using PD-1 inhibitors has emerged as a promising treatment modality, yet a substantial proportion of patients exhibit resistance or fail to respond to such therapies. This study aimed to elucidate the role of G0/G1 Switch 2 (G0S2) in regulating PD-L1 expression in monocytes within the HCC tumor microenvironment and to investigate its impact on the efficacy of PD-1 inhibitors.

Toxicity of microplastics and nanoplastics to benthic Sargassum horneri: The role of nitrogen availability in modulating stress responses.

Over the past few decades, the accumulation of micro- and nanoplastics (MNPs) have identified as enduring contaminants, posing significant risks to aquatic organisms. However, the interplay of MNPs and environmental stressors (e.g.

Comparing scleral wound suturing and non-suturing in 23-gauge vitrectomy combined with cataract phacoemulsification for the management of proliferative diabetic retinopathy.

Purpose: To compare the outcomes of scleral wound suturing and non-suturing in 23-gauge vitrectomy combined with cataract phacoemulsification on eyes with severe proliferative diabetic retinopathy.

Methods: This retrospective cohort study enrolled patients with proliferative diabetic retinopathy who underwent a 23-step vitrectomy combined with cataract phacoemulsification. Scleral wounds were either sutured or left unsutured in sutured group and unsutured group, respectively.

Integrating polarization diversity into 3 × 3 coupler passive demodulation for interferometric fiber-optic sensors.

In this paper, polarization diversity is integrated into a 3 × 3 coupler-based passive demodulation system for the first time to mitigate polarization-induced fading (PIF) in interferometric fiber-optic sensors (IFOSs). This study investigates the impact of single-mode fiber at the receiving end of a polarization diversity receiver (PDR) on signal demodulation. This impact causes variations in the fixed phase difference introduced by the 3 × 3 coupler in passive systems, leading to demodulation failure.