Chiral Gd-DOTA-Functionalized Polymer Nanoprobe with GGT-Triggered Charge Reversal for Tumor-Specific MRI/Fluorescence Imaging.

The development of tumor-specific contrast agents with enhanced sensitivity is crucial for precise cancer diagnostics. Herein, GGTPro-A-Cy5 is presented, a γ-glutamyl transpeptidase (GGT)-responsive polymeric dual-modal probe that integrates chiral Gd-DOTA for MRI and Cy5 for fluorescence imaging (FI). This probe leverages GGT overexpression in tumors to enable charge reversal-driven accumulation, achieving selective activation in the tumor microenvironment.

Construction and validation of an anoikis-related long non-coding RNA-based prognostic model for head and neck squamous cell carcinoma.

Background: As a unique form of apoptosis, anoikis significantly influences tumor biology. Studies have revealed the diverse roles of long non-coding RNAs (lncRNAs) in cancer signaling pathways; however, the prognostic significance of anoikis-related long non-coding RNAs (ARLncs) in head and neck squamous cell carcinoma (HNSCC) remains unexplored. Therefore, this research was undertaken to establish a risk model and assess its predictive ability for prognosis and immune landscape in individuals with HNSCC.

Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging.

Manganese(II) is considered a valuable alternative to gadolinium(III) in developing contrast agents (CAs) for magnetic resonance imaging (MRI). However, due to the labile nature of common Mn(II) complexes, designing ligands that enable stable and inert complexation is essential before clinical application. Mn(1,4-Et4DO2A) bearing four ethyl groups, is found to have a log K as high as 17.

New Chiral Pyclen-Based Gadolinium(III) Complexes: Advancing Stability, Relaxivity, and Water Exchange for Improved Magnetic Resonance Imaging Probes.

The safety issues of MRI contrast agents in clinical practice have raised significant concerns, which can lead to adverse effects such as nephrogenic systemic fibrosis and metal deposition in the brain. Herein, we designed two innovative chiral pyclen-based octadentate Gd(III) complexes, and . Compared to the achiral , these chiral complexes exhibited substantial enhancements in relaxivity, by 52.

Chiral Strategy for Developing High-Performance Polymeric Gadolinium-Based MRI Contrast Agents for Vascular and Tumor Imaging.

Magnetic resonance imaging (MRI) is a critical tool in medical diagnostics, yet conventional MRI contrast agents (CAs) are often limited by their small-molecule nature, resulting in rapid clearance and low relaxivity. This study presents a chiral strategy for developing high-performance polymeric gadolinium-based CAs, PAA-EOB-GdA and PAA-EOB-GdB, tailored for enhanced vascular and tumor imaging. Notably, PAA-EOB-GdA, a chiral Gd-DOTA derivative integrated with sodium poly-(acrylic acid) (PAA), benefits from the optimized water exchange rate of chiral Gd-(III) complex and the polymer effect of PAA, exhibiting exceptionally high relaxivity ( = 37.

Preparation of controlled-release fresh-keeping cards and application in strawberry treated with simulated transport vibration.

Strawberries are highly susceptible to decay because of high moisture, microbial invasion and vibration during transportation and storage. In this study, the hydroxypropyl-β-cyclodextrin (HP-β-CD) was used to encapsulate cinnamaldehyde to form hydroxypropyl-β-cyclodextrin-cinnamaldehyde (CA@HP-β-CD). Afterwards, the CA@HP-β-CD was applied to prepare the controlled-release fresh-keeping cards using food-grade absorbent cardboard and polyvinyl alcohol water-soluble film for strawberry storage after different simulated transport vibrations.

Application of edible coatings in '' blueberry under room storage conditions and storage kinetics analysis.

Unlabelled: Blueberry is nutritious but perishable, which could be preserved using edible coatings. However, the blueberry storage kinetics at room conditions were rarely revealed. So, the '' blueberries were adopted to divided into four groups including control (CK), carboxymethylcellulose (CMC), chitosan (CS) and layer-by-layer coatings (LBL) groups, to analyze the coatings effects on the blueberry qualities and storage kinetics.

Mn(II)-MOF nanoparticles conjugated with EOB-PEG as high-performance hepatobiliary-specific MRI contrast agents.

Hepatobiliary magnetic resonance imaging (MRI) is a crucial diagnostic tool for early detection and staging of liver tumors. However, the currently available hepatobiliary-specific contrast agents (CAs), acyclic Gd chelates, suffer from limited kinetic stability and may pose serious toxicity risks to patients with specific functional impairments. In light of these concerns, Mn-based MRI CAs have gained increasing attention as potential alternatives to Gd-based agents, despite challenges in their stability and relaxivity.

[Effects of cochlear implantation on vestibular function in patients with large vestibular aqueduct syndrome].

This study aimed to compare the effects of cochlear implantation（CI） on vestibular function in patients with large vestibular aqueduct syndrome（LVAS） and in patients with extremely severe deafness with normal inner ear structure. A total of 28 LVAS patients and 28 patients with normal inner ear structure who suffered from extremely severe deafness were selected. The parameters of caloric tests, bone conduction evoked cervical vestibular-evoked myogenic potentials（cVEMP）, bone conduction evoked ocular vestibular-evoked myogenic potentials（oVEMP） and video head impulse tests（v-HIT） were compared between the two groups before and after CI.

Phosphatase LHPP confers prostate cancer ferroptosis activation by modulating the AKT-SKP2-ACSL4 pathway.

LHPP, a novel, recognized tumor suppressor, exerts a critical influence on the regulation of tumor cell proliferation and survival by modulating various signaling pathways with its phosphatase activity. Here, we unveil a robust correlation between reduced LHPP expression and adverse prognosis in prostate cancer. We demonstrate that LHPP interacts with AKT, thereby dampening AKT phosphorylation and subsequently inhibiting ACSL4 phosphorylation at the T624 site.

Contrast-Enhanced Computed Tomography-Based Machine Learning Radiomics Predicts IDH1 Expression and Clinical Prognosis in Head and Neck Squamous Cell Carcinoma.

Rationale And Objectives: Isocitrate dehydrogenase 1 (IDH1) is a potential therapeutic target across various tumor types. Here, we aimed to devise a radiomic model capable of predicting the IDH1 expression levels in patients with head and neck squamous cell carcinoma (HNSCC) and examined its prognostic significance.

Materials And Methods: We utilized genomic data, clinicopathological features, and contrast-enhanced computed tomography (CECT) images from The Cancer Genome Atlas and the Cancer Imaging Archive for prognosis analysis and radiomic model construction.

Rational Design of Mono-Substituted Gd-DOTA as Highly Stable and Efficient MRI Contrast Agents for Hepatobiliary and Inflammation Imaging.

Hepatobiliary-specific magnetic resonance imaging contrast agents (MRI CAs) play a crucial role in the early diagnosis of hepatocellular carcinoma (HCC). However, only two acyclic CAs, Gd-BOPTA and Gd-EOB-DTPA, exhibit unfavorable kinetic inertness. Our study focused on the development of superior stable innovative macrocyclic CAs.

Enzalutamide inhibits PEX10 function and sensitizes prostate cancer cells to ROS activators.

Sharply increased reactive oxygen species (ROS) are thought to induce oxidative stress, damage cell structure and cause cell death; however, its role in prostate cancer remains unclear. Enzalutamide is a widely used anti-prostate cancer drug that antagonizes androgen binding with its receptor. Further exploration of the mechanism and potential application strategies of enzalutamide is crucial for the treatment of prostate cancer.

Targeting Non-Alcoholic Fatty Liver Disease with Hawthorn Ethanol Extract (HEE): A Comprehensive Examination of Hepatic Lipid Reduction and Gut Microbiota Modulation.

Recent studies have highlighted the lipid-lowering ability of hawthorn ethanol extract (HEE) and the role played by gut flora in the efficacy of HEE. Our study sought to explore the effects of HEE on non-alcoholic fatty liver disease (NAFLD) in normal flora and pseudo germ-free mice. The results showed that HEE effectively diminished hepatic lipid accumulation, ameliorated liver function, reduced inflammatory cytokine levels and blood lipid profiles, and regulated blood glucose levels.

Chiral Pyclen-Based Heptadentate Chelates as Highly Stable MRI Contrast Agents.

In recent years, pyclen-based complexes have attracted a great deal of interest as magnetic resonance imaging (MRI) contrast agents (CAs) and luminescent materials, as well as radiopharmaceuticals. Remarkably, gadopiclenol, a Gd(III) bishydrated complex featuring a pyclen-based heptadentate ligand, received approval as a novel contrast agent for clinical MRI application in 2022. To maximize stability and efficiency, two novel chiral pyclen-based chelators and their complexes were developed in this study.

TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression.

Background: As a novel necrosis manner, ferroptosis has been increasingly reported to play a role in tumor progression and treatment, however, the specific mechanisms underlying its development in prostate cancer remain unclear. Growing evidence showed that peroxisome plays a key role in ferroptosis. Herein, we identified a novel mechanism for the involvement of ferroptosis in prostate cancer progression, which may provide a new strategy for clinical treatment of prostate cancer.

PDE3B regulates KRT6B and increases the sensitivity of bladder cancer cells to copper ionophores.

Cuproptosis is a new Cu-dependent programmed cell death manner that has shown regulatory functions in many tumor types, however, its mechanism in bladder cancer remains unclear. Here, we reveal that Phosphodiesterase 3B (PDE3B), a cuproptosis-associated gene, could reduce the invasion and migration of bladder cancer. PDE3B is downregulated in bladder cancer tissues, which is correlated with better prognosis.

Chiral Gd-DOTA as a Versatile Platform for Hepatobiliary and Tumor Targeting MRI Contrast Agents.

The leakage of gadolinium ions (Gd) from commercial Gd-based contrast agents (GBCAs) in patients is currently the major safety concern in clinical magnetic resonance imaging (MRI) scans, and the lack of task-specific GBCAs limits its usage in the early detection of disease and imaging of specific biological regions. Herein, ultrastable GBCAs were constructed via decorating chiral Gd-DOTA with a phenylic analogue to one of the pendent arms, and the stability constant was determined as high as 27.08, accompanied by negligible decomplexation in 1 M of HCl over 2 years.

Rational Design of Gd-DOTA-Type Contrast Agents for Hepatobiliary Magnetic Resonance Imaging.

The safety risks of gadolinium (Gd)-based contrast agents (GBCAs) arise from their inevitable leakage of Gd, and the pursuit of more stable GBCAs for magnetic resonance imaging (MRI) has drawn increasing attention. Yet, Gd-EOB-DTPA and Gd-BOPTA are the only two authorized GBCAs for liver diagnosis in spite of their weak stability. In this study, one of the pendent arms of the most inert commercial Gd-DOTA was decorated with phenyl moieties, in which obvious enhancements of both kinetic and thermodynamic stability were achieved.

High Sulfur-doped hollow carbon sphere with multicavity for high-performance Potassium-ion hybrid capacitors.

S doping is an effective strategy to improve the potassium-ion storage performance of carbon-based materials. However, due to the large atomic radius of S and poor thermal stability, it is challenging to synthesize carbon materials with high sulfur content by solid-phase transformation. In this work, we designed a multi-cavity structure that can confine the molten S during heat treatment and make it fully react, then achieving high S doping (7.

SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer.

Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of tumors. Nevertheless, there have been no investigations of AOC1 and its regulatory mechanism in prostate cancer. Here, we reveal a novel action of AOC1 and a tumor suppressor mechanism in prostate cancer.

Sodium alginate-derived porous carbon: Self-template carbonization mechanism and application in capacitive energy storage.

Sodium alginate (SA) is an environment-friendly and low-cost polysaccharide carbohydrate extracted from seaweed. As a carbon precursor, sodium alginate has the advantages of clear molecular structure, small molecular weight, and easy controls of the structure and composition of the product, but there have been few studies for the mechanism for SA carbonization. In this work, the carbon skeleton cross-linking mode, heteroatom doping and defect generation mechanism in the process of SA pyrolysis are clarified.

B, N stabilization effect on multicavity carbon microspheres for boosting durable and fast potassium-ion storage.

Heteroatom-rich carbon materials deliver superior potassium storage capacity owing to the abundant active sites, but their stability and conductivity are damaged because of the numerous defects and distortion of π-conjugated system. In this work, we amended the adverse influences of heteroatoms on carbon materials through the B, N stabilization effect. Due to an amending effect of B atoms on the N-doped carbon matrix, the integrity of the carbon skeleton and stability of the system are significantly enhanced, and the undesirable defects are transformed into favorable active sites, resulting in the simultaneous improvement of K storage capacity, rate performance and cyclic stability.

GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity.

Prostate cancer is currently one of the most common fatal tumor types in men. Although multiple treatments can alleviate some cases, advanced prostate cancer, especially CRPC, still has a very poor prognosis. Therefore, early detection and diagnosis of prostate cancer have a very important role in the prognosis of patients.

Upregulated Promotes RCC Cell Migration and Invasion by Regulating the Axis in Renal Cell Carcinoma.

Background: Circular RNAs (circRNAs) are novel clusters of endogenous noncoding RNAs (ncRNAs) that are involved in the regulation of multiple biological processes in diverse types of cancers. However, the roles and precise mechanisms of circRNAs in renal cell carcinoma (RCC) occurrence and progression have not been clearly elucidated.

Methods: We identified the aberrantly expressed circRNAs in RCC by high-throughput RNA-seq assay and used qRT-PCR to test the expression level of circRNAs in RCC tissues.