Guided Bone Regeneration Membrane Materials Loaded with Chimeric Nanovesicles Promote Early Bone Defect Regeneration.

Early bone defect regeneration remains a major clinical challenge owing to a compromised osteogenic microenvironment characterized by insufficient mineralization and immature collagen deposition, which severely impede mechanical stability. Although conventional guided bone regeneration (GBR) membranes provide passive barrier functions, their lack of dynamic immune response regulation often leads to delayed ossification. To address this critical gap, a plasma-treated polycaprolactone (PT-PCL) electrospun nanofiber membrane functionalized with ultrasound sequentially extruded stromal vascular fraction chimeric vesicles (USE-SCNVs) is developed.

Development prospects of "Internet + medical and health services" in Shandong: application status and public acceptance.

Background: The integration of Internet technology into healthcare has led to the birth of the "Internet + medical and health services" model-a transformative approach to improving accessibility and efficiency in healthcare delivery.

Objective: This study aims to assess the current status, challenges, and user perceptions of the "Internet + medical and health" services platform among individuals in Shandong, China.

Methods: The cross-sectional survey was conducted between September 2023 and October 2023 on patients from public medical institutions in Shandong Province.

Reconfigurable bipolar transistors enabled by breathing-Kagome NbCl.

The breathing Kagome semiconductor NbCl offers unique electronic properties, which has emerged as a prominent area of research in condensed matter physics. However, the realization of functional devices based on breathing kagome materials remains a challenge. Here, we fabricate dual-gate NbCl field-effect transistors (FETs) using h-BN or SiO as the gate dielectric.

Syndecan-1 regulates lipid metabolism and mitigates fibrosis during the transition from acute kidney injury to chronic kidney disease.

Background: The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is characterized by persistent renal fibrosis, in which abnormal lipid metabolism plays a crucial role. Syndecan-1 (SDC-1) has been implicated in various tissue remodeling processes; however, its role in lipid metabolism and fibrosis during the progression from AKI to CKD is not well understood.

Methods: This study used a murine model of unilateral ischemia-reperfusion-induced AKI-to-CKD progression for in vivo analysis and employed transforming growth factor-beta (TGF-β)-induced fibrosis in Human Kidney-2 cells and primary mouse tubular epithelial cells for in vitro studies.

Promoting positive development among left-behind youth in rural China: A mixed-methods approach to scale development.

Integrating both the positive youth development and resilience science frameworks, this study developed and validated an instrument for assessing the individual strengths and environmental supports that promote positive development for rural, left-behind youth (LBY) in China. Following an exploratory sequential design, we first conducted 22 in-depth interviews (13 teachers and nine LBY) to inform the creation of survey items. We then conducted exploratory factor analyses on a sample of 606 LBY (48.

Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality in adults with MASLD.

Background: Inflammation plays a key role in the onset of MASLD, progression to MASH, and is associated with poor prognosis of MASLD. The aim of this study was to thoroughly investigate the association of different systemic inflammatory indicators with all-cause mortality and CVD mortality outcome in MASLD.

Methods: Data were from the NHANES cohort.

Adaptive ferroelectric memristors with high-throughput BaTiO thin films for neuromorphic computing.

Ferroelectric tunnel junctions (FTJs) and ferroelectric diodes (FDs) have been considered as promising artificial synaptic devices for constructing brain-inspired neuromorphic computing systems. However, their functionalities and applications are limited due to their strong dependence on the ferroelectric layer thickness and the thickness optimization is labour-intensive and time-consuming. Here, we demonstrate high-performance electronic synapses based on a high-throughput ferroelectric BaTiO (BTO) thin film.

OsCPK9-mediated Thr105 phosphorylation activates OsCATC to enhance drought tolerance in rice.

Introduction: Drought poses a significant environmental challenge, disrupting plant growth and reducing crop productivity. As sensors and effectors in calcium signaling, calcium-dependent protein kinases (CPKs) regulate plant development and environmental adaptation. However, the specific roles and molecular networks of many OsCPKs in rice adaptation to abiotic stress remain to be elucidated.

Unconventional Thermal Stability of Domain Framework in Ferroelectric CuInPS.

Achieving stable and persistent polarization characteristics in ferroelectric (FE) materials is crucial for fabricating high-density, low-power multifunctional memories. In this study, we conducted a comprehensive investigation of the 2D FE material CuInPS (CIPS), employing piezoelectric force microscopy (PFM), scanning transmission electron microscopy (STEM), and Raman spectroscopy. By comparing CIPS with and without the nonferroelectric (NFE) phase, we observed unexpected stability of the domain framework at high temperatures.

Effective simultaneous removal of 17β-estradiol and tetracycline by a novel Alkalibacterium strain: characteristics, mechanisms, and application in livestock wastewater treatment.

The environmental risk posed by 17β-estradiol (E2) and tetracycline (TC) contamination within livestock wastewater has been widely concerned. Especially, the co-occurrence of these pollutants poses a tremendous challenge to their efficient bioremediation, highlighting the need for strains capable of simultaneous E2 and TC removal. In this study, a novel strain of Alkalibacterium sp.

An injector testbed based on a direct current gun and an interchangeable very high frequency gun for superconducting continuous-wave free-electron lasers.

The continuous-wave free-electron laser (CW-FEL), based on superconducting radiofrequency (SRF) technology with an electron bunch repetition rate of up to MHz levels, is one of the most advanced light sources, providing exceptionally high average and peak-brightness FEL pulses. Among the new CW-FEL facilities worldwide, the recently proposed Dalian Advanced Light Source (DALS) occupies a unique position as an extreme ultraviolet (EUV) facility primarily designed for chemical physics research. Since the beam emittance requirement for DALS is not as stringent as that for X-ray CW-FEL facilities, a direct current (DC) gun is considered as the primary electron source, with a very high frequency (VHF) gun also planned.

Evaluation of free-breathing, non-ECG-triggered magnetic resonance T1 mapping derived from multitasking imaging at 3.0 T in patients with ischaemic and non-ischaemic cardiomyopathy.

Objective: To evaluate the image quality of the free-breathing, non-ECG-multitasking T1 mapping and to compare T1 values, lesion area, and ROC curve with those derived from the traditional MOLLI sequence in ischaemic and non-ischaemic cardiomyopathy.

Methods: In vitro, T1 values from CMR multitasking and MOLLI images were compared in 4 phantoms. In vivo studies included 108 patients (38 ischaemic cardiomyopathy, 70 non-ischaemic cardiomyopathy) and 31 healthy volunteers.

A Review of Research on the Utilization of Ligularia Plants Based on their Functional Compositions.

The genus Ligularia belongs to the family Asteraceae, with approximately 150 species worldwide. It is primarily distributed from Europe and the Himalayas to Japan, and it is rich in resources, with many species possessing medicinal value. According to the research reports on the functional compositions, the research progress and resource utilization of this genus were summarized from 2016 to the present.

Isolation and Characterization of Aerobic and Facultative Anaerobic 17β-Estradiol Degrading Bacteria in Paddy Soils and Their Potential Mechanisms.

17β-estradiol (E2) contamination resulting from the widespread use of animal manure poses a new threat to the agricultural environment. Since anaerobic environments have been reported to significantly extend the persistence of E2, estrogen pollution of anaerobic farmland soils (e.g.

Magnesium Lithospermate B Protects Against Ischemic AKI-to-CKD progression via regulating the KLF5/CDK1/Cyclin B1 pathway.

Background: Ischemia-reperfusion injury (IRI) is the primary cause of acute kidney injury (AKI), which can result in chronic kidney disease (CKD) with renal fibrosis. Magnesium lithospermate B (Mlb), a bioactive compound produced from Salvia miltiorrhiza Bunge, exerts nephroprotective effects against AKI. However, the significance of Mlb in the evolution of IRI-induced AKI in patients with CKD remains unclear.

STING-activable immunomodulatory bio-glue for multiple postsurgical management.

In addition to the robust adhesive properties, there is a pressing demand for ideal adhesives in tumor surgery that possess anti-tumor therapeutic effects. In this study, we introduce BSA-MnO-GP@Ca-Y (BMGY) bio-glue by integrating bovine serum albumin (BSA)-MnO, genipin (GP), and Ca-Y zeolite. Ca-Y zeolite exhibits the thrombin activity for hemostasis, while the cross-linking of BSA, GP, and skin tissue induces wound adherence upon laser irradiation for normalized skin structure within nine days.

Insight into the effect of lactic acid fermentation on soy protein immunoreactivity: emphasizing the difference in epitope destruction of varied fermentation terminal pH levels during gastrointestinal digestion.

This study delves into the immunoreactivity of lactic acid bacterium (LAB)-fermented soy protein isolates (FSPIs), with various structural features, during gastrointestinal digestion and absorption. Additionally, the structural breakdown and epitope degradation of major allergens were investigated for their gastrointestinal behavior. Allergenicity and IgE-binding capacity assays revealed that at the initial and middle stages of digestion, FSPI-5.

Modulation of soymilk immunoglobulin E-binding through germination: Emphasis on the specific degradation of major allergens and their epitopes.

This study explores the influence of seed germination on the immunoreactivity of soymilk produced from three soybean cultivars. The degradation patterns of allergens and their epitopes were investigated. Antigenicity and IgE-binding capacity assays indicated that soymilk derived from the NN cultivar on the third day of germination (NN-SSM-3) demonstrated the greatest reduction in immunoreactivity (9.

Superior Strain-Adapted Sacrificial Layer for the Synthesis of Freestanding Perovskite Oxide Films.

Freestanding perovskite oxide films possess extra features of structural tunability and stacking ability when exfoliated from rigid substrates, providing potential applications in silicon-based semiconductors and flexible electronics. Well epitaxial growth on sacrificial layers is crucial to preserve fascinating physical properties in freestanding oxide membranes. However, the weak strain adaptability of sacrificial layers limits their coherent epitaxial growth on different substrates.

A systematic review and meta-analysis of the comparison of laparoscopic radiofrequency ablation to percutaneous radiofrequency ablation for hepatocellular carcinoma.

Background: The comparative evaluation of laparoscopic and percutaneous techniques for liver radiofrequency ablation remains unexplored. This study aims to determine the most effective ablation technique and patient selection for hepatocellular carcinoma (HCC) by analyzing the efficacy and safety of laparoscopic radiofrequency ablation (LRFA) versus percutaneous radiofrequency ablation (PRFA).

Methods: Two investigators (Y-QW and PZ) independently performed a literature search in the Cochrane Library, PubMed, Web of Science and Embase databases.

Expert consensus on clinical genome sequencing interpretation and reporting.

Genome sequencing (GS) refers to a technology that comprehensively and systematically detects the DNA sequences of an individual's nuclear and mitochondrial genomes. It aims to identify genetic variants and investigate their roles in human health and disease progression. As an emerging diagnostic tool, GS offers significant support for clinical diagnosis due to its high throughput, accuracy, and comprehensiveness.

Proton-controlled Dzyaloshinskii-Moriya interaction and topological Hall effect in hydrogenated strontium ruthenate.

The Topological Hall effect (THE) is a fascinating physical phenomenon related to topological spin textures, serving as a powerful electrical probe for detecting and understanding these unconventional magnetic orders and skyrmions. Recently, the THE has been observed in strontium ruthenate (SrRuO, SRO) thin films and its heterostructures, which originates from the disruption of interfacial inversion symmetry and Dzyaloshinskii-Moriya interaction (DMI). Here, we demonstrate a practically pure proton doping effect for controlling the DMI and THE in the SRO epitaxial films using the Pt electrode-assisted hydrogenation method.

Titanium-Catalyzed Reaction of Silacyclobutanes with Alkenes: Mimicking the Reactivity and Reversing the Selectivity Towards Late Transition Metals.

Transition metal-catalyzed ring opening and expansion reactions of silacyclobutanes (SCBs) constitute an atom- and step-economical strategy to construct value-added silicon-containing chemicals. Despite extensive studies, the reaction of SCBs with simple alkenes has only one precedent. Moreover, most reported reactions of SCBs use late transition metals (Pd, Ni, Rh) as catalysts.