Diffuse xanthoma in early esophageal cancer: A case report.

Background: Gastrointestinal xanthomas are asymptomatic and infrequent non-neoplastic lesions that commonly occur in the stomach with -associated gastritis and rarely in the esophagus. To date, there have been no reports of esophageal xanthoma combined with esophageal cancer. Herein, we present the first case in the literature of a diffuse xanthoma complicated with early esophageal cancer.

Identification and Fine-Mapping of a Novel QTL, , That Confers Resistance to Maize Rough Dwarf Disease.

Maize rough dwarf disease (MRDD) is caused by a virus and seriously affects maize quality and yield worldwide. MRDD can be most effectively controlled with disease-resistant hybrids of corn. Here, MRDD-resistant (Qi319) and -susceptible (Ye478) parental inbred maize lines and their 314 recombinant inbred lines (RILs) that were derived from a cross between them were evaluated across three environments.

Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury.

Peripheral nerve injury triggers sequential phenotype alterations in Schwann cells, which are critical for axonal regeneration. Long noncoding RNAs (lncRNAs) are long transcripts without obvious coding potential. It has been reported that lncRNAs participate in diverse biological processes and diseases.

Recurrent KRAS, KIT and SF3B1 mutations in melanoma of the female genital tract.

Background: Malignant melanoma of the female genital tract is relatively uncommon and accounts for 3-7% of all melanoma localizations. This study aimed to identify driver genes in melanoma of the female genital tract with the purpose of enhancing understanding of disease pathogenesis and identifying potential new therapeutic targets to develop effective therapies.

Methods: KIT (CD117) and BRAF expression were detected immunohistochemically.

Effects of omalizumab in children with asthma: A protocol for systematic review and meta-analysis.

Background: It is still controversial in the current literature whether omalizumab is beneficial for children with asthma. Given that there is no high-quality meta-analysis to incorporate existing evidence, the purpose of this protocol is to design a systematic review and meta-analysis of the level I evidence to ascertain whether omalizumab is beneficial and safe for children with asthma.

Methods: The systematic literature review is structured to adhere to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.

Openness to experience and dispositional awe: The moderating role of subjective socioeconomic status and mediating role of Zhong-Yong thinking style in Chinese undergraduates.

Existing research has established that openness to experience can enhance dispositional awe. For the first time, the current study examines whether subjective socioeconomic status (SSES) moderates and a Zhong-Yong thinking style mediates this effect. A sample of 2,377 Chinese undergraduates (mean age 20.

Survival of cancer patients in Fujian, Southeast China: a population-based cancer registry study.

Survival rates are usually used to evaluate the effect of cancer treatment and prevention. No study has focused on the characteristic of population-based cancer survival in Fujian, which is regarded as one of the high-risk areas of cancer in China. This study aims to analyze the 5-year relative survival of patients in Fujian Province using population-based cancer registry data.

Fiber optic hydrogen sensor based on a Fabry-Perot interferometer with a fiber Bragg grating and a nanofilm.

Hydrogen is widely used in industrial production and clinical medicine, and as fuel. Hydrogen becomes explosive when the hydrogen-air mixture ranges from 4 to 76 vol%; thus, a rapid hydrogen concentration measurement is particularly important in practical applications. We present a novel fiber optic hydrogen sensor with fast response fabricated from a graphene-Au-Pd sandwich nanofilm and an ultrashort fiber Bragg grating.

A neuralized feature engineering method for entity relation extraction.

Making full use of semantic and structure information in a sentence is critical to support entity relation extraction. Neural networks use stacked neural layers to perform designated feature transformations and can automatically extract high-order abstract feature representations from raw inputs. However, because a sentence usually contains several pairs of named entities, the networks are weak when encoding semantic and structure information of a relation instance.

A New Strain of Virus Discovered in China Specific to the Parasitic Mite Poses a Potential Threat to Honey Bees.

The ectoparasitic mite, , feeds directly on honey bees and serves as a vector for transmitting viruses among them. The mite causes relatively little damage to its natural host, the Eastern honey bee () but it is the most devastating pest for the Western honey bee (). Using Illumina HiSeq sequencing technology, we conducted a metatranscriptome analysis of the microbial community associated with mites.

MicroRNA-27a promotes tumorigenesis in tongue squamous cell carcinoma by enhancing proliferation, migration and suppressing apoptosis.

Background: Tongue squamous cell carcinoma (TSCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer with a poor prognosis. Studies have shown that microRNAs (miRNAs) play an important role in TSCC biology. However, the expression and functions of miRNAs in TSCC remain unclear.

Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus.

Transmission routes impact pathogen virulence and genetics, therefore comprehensive knowledge of these routes and their contribution to pathogen circulation is essential for understanding host-pathogen interactions and designing control strategies. Deformed wing virus (DWV), a principal viral pathogen of honey bees associated with increased honey bee mortality and colony losses, became highly virulent with the spread of its vector, the ectoparasitic mite Varroa destructor. Reproduction of Varroa mites occurs in capped brood cells and mite-infested pupae from these cells usually have high levels of DWV.

Antiviral Activities of a Medicinal Plant Extract Against Sacbrood Virus in Honeybees.

Background: Sacbrood is an infectious disease of the honey bee caused by Scbrood virus (SBV) which belongs to the family Iflaviridae and is especially lethal for Asian honeybee Apis cerana. Chinese Sacbrood virus (CSBV) is a geographic strain of SBV. Currently, there is a lack of an effective antiviral agent for controlling CSBV infection in honey bees.

Spectral control of terahertz radiation from inhomogeneous plasma filaments by tailoring two-color laser beams.

Terahertz (THz) radiation from an inhomogeneous plasma filament generated by focusing two-color femtosecond laser pulses into argon gas filled in a chamber is investigated experimentally by tailoring the Gaussian pump laser beams with an iris, where broadband THz emission over 10 THz is produced. It is found that the collected far-field THz radiation includes not only coherent but also partial-coherent components of the THz waves, which are emitted from the different parts of the inhomogeneous plasma filament with different plasma densities, contributing correspondingly to the different frequencies of the THz spectrum. Our results suggest that the THz spectrum can be manipulated by controlling the plasma density distribution of the filaments.

Precisely Engineering Architectures of Co/C Sub-Microreactors for Selective Syngas Conversion.

Fischer-Tropsch synthesis (FTS) is an effective route to produce olefins, gasoline, diesel, and oxygenates from syngas (CO + H ). However, it still remains a challenge for regulating the product distribution of FTS. Here, a series of Co/C sub-microreactors with precise designed nanoarchitectures are synthesized for selective syngas conversion.

The possible role of visceral fat in early pregnancy as a predictor of gestational diabetes mellitus by regulating adipose-derived exosomes miRNA-148 family: protocol for a nested case-control study in a cohort study.

Background: Gestational diabetes mellitus (GDM) has become alarming public health concern. It is associated with adverse pregnancy outcomes and increased risk of postpartum type 2 diabetes. Pre-pregnant body mass index (BMI), waist circumference and other anthropometric parameters have been proposed to predict GDM.

Molecular and clinical characteristics of congenital hypothyroidism in a large cohort study based on comprehensive thyroid transcription factor mutation screening in Henan.

Background: Congenital hypothyroidism (CH), the most common neonatal endocrine disorder worldwide, can be caused by variants in thyroid transcription factor (TTF) genes including NKX2-1, FOXE1, PAX8, NKX2-5 and HHEX. This study aims to perform targeted next-generation sequencing (NGS) panel for comprehensive mutation screening on these genes in a cohort of 606 CH patients with various types from Henan Province, China, to investigate the mutation rate of TTF genes, and to analyze the clinical, biochemical and molecular characteristics of our CH cohort.

Methods: High-throughput sequencing combined with statistical calculation were applied for mutation screening and analyses of the clinical data.

Development of a chitosan-modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice.

Background: Escherichia coli K1 (E. coli K1) caused neonatal meningitis remains a problem, which rises the urgent need for an effective vaccine. Previously, we rationally designed and produced the recombinant protein OmpAVac (Vo), which elicited protective immunity against E.

Seasonal variation of viral infections between the eastern honey bee (Apis cerana) and the western honey bee (Apis mellifera).

It is a widespread practice in China to keep colonies of both the western honey bee, Apis mellifera, and the eastern honey bee, Apis cerana, in close proximity. However, this practice increases opportunities for spillover of parasites and pathogens between the two host bee species, impacting spatial and temporal patterns in the occurrence and prevalence of the viruses that adversely affect bee health. We conducted a 1-year large-scale survey to assess the current status of viral infection in both A.

Clinicopathological characterization of follicular helper T-cell-derived peripheral T-cell lymphoma involving Waldeyer's ring.

Follicular helper T-cell-derived peripheral T-cell lymphoma (TFH-derived PTCL) initially present in the Waldeyer's ring is a rare condition with a challenging diagnosis. This study aimed to evaluate the clinicopathological characteristics and diagnosis of Waldeyer's ring TFH-derived PTCL and raise awareness of this type of lymphoma. A series of 13 cases of Waldeyer's ring TFH-derived PTCL were retrospectively analyzed.

Ionic liquid functionalized carbon nanotubes as metal-free catalyst for efficient electrocatalytic hydrogen evolution reaction.

The development of cost-effective and high-performance catalysts for the production of hydrogen via electrocatalytic water splitting is crucial for meeting the increasing energy demand and expanding the hydrogen economy. In this study, a series of metal-free carbon nanotube (CNT) catalysts were designed and in situ functionalized by imidazolium ionic liquids (ILs) for enhanced electrocatalytic hydrogen evolution reaction (HER). The theoretical calculations and experimental results reveal that the functionalization of CNTs with imidazolium ILs facilitated the electron transfer process and exhibited superior hydrogen adsorption, thereby enhancing the performance of the HER.

miR-142-5p promotes cervical cancer progression by targeting LMX1A through Wnt/β-catenin pathway.

Background: Previous work has shown that miR-142-5p in cervical cancer tissues increased significantly compared with adjacent normal tissues. However, the function and the mechanism of miR-142-5p in cervical cancer have not been reported.

Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to determine the gene expression levels.

Molecular profiling of Chinese systemic anaplastic large cell lymphoma patients: novel evidence of genetic heterogeneity.

Background: Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin lymphoma. A comprehensive understanding of the genetic and clinical heterogeneity of ALCL may help to improve the clinical management of patients with ALCL. However, due to the rarity of the disease, the genetic heterogeneity of ALCL has not been well elucidated.