A Multi-Algorithm Machine Learning Model for Predicting the Risk of Preterm Birth in Patients with Early-Onset Preeclampsia.

Purpose: To analyze the risk factors for preterm birth in patients with early-onset preeclampsia (EOPE) based on multi-algorithm machine learning and to construct a predictive model to explore the predictive value of the model.

Methods: A retrospective analysis was conducted on 442 EOPE patients from a single tertiary center, divided into preterm birth (<37 weeks, n=358) and term-born (≥37 weeks, n=84) groups. Univariate analysis, random forest importance assessment, lasso regression combined with multivariate regression analysis were used for feature evaluation.

The Biased Reaction and Higher Cortical Coherence Under Smoking Cue in Young Smokers.

Introduction: Nicotine addiction is a widespread problem globally, causing millions of deaths and illnesses every year. People who start smoking at a young age are more likely to become addicted to nicotine. The cue-induced craving paradigm is used to study the nervous system related to nicotine dependence.

Organ-system-based subclassification of preeclampsia using machine learning predicts pregnancy outcomes.

Background: Preeclampsia (PE) is a complex disorder with significant variability in organ involvement. It remains unclear whether machine learning can identify organ-system-based subclasses of PE. This study aimed to identify novel subclasses of PE using organ-system biomarkers to improve pregnancy outcome prediction.

Advanced analysis of depression tendency in China: an investigation of environmental and social factors based on geographical and temporal weighted regression.

The spatiotemporal distribution of depressive tendencies across China from 2011 to 2022 was investigated using the Baidu Depression Search Index (BDSI). We examined key influencing natural factors, such as water pollution, air pollution, and deforestation, along with economic indicators, such as gross domestic product per capita, disposable income per capita, and health professionals per 10,000 population. Geographical and Temporal Weighted Regression (GTWR) was applied to capture the spatiotemporal heterogeneity of the BDSI determinants.

Prognostic value of heart rate deceleration capacity for functional outcomes in acute ischemic stroke: a prospective study.

Purpose: Acute ischemic stroke (AIS) is a leading cause of disability and mortality, with poor functional outcomes often linked to autonomic dysfunction. Deceleration capacity (DC), a marker of vagal activity, has been shown to predict cardiovascular outcomes, but its prognostic value in AIS remains underexplored. This study investigates the role of DC in predicting stroke recovery at 2 weeks and 3 months post-stroke.

L-Shaped Association of 24-Hour Urine Output with 3-Month and 1-Year All-Cause Mortality in Patients with Acute Pulmonary Embolism: A Retrospective Cohort Study.

Aim: To explore the prognostic value of the first 24-h urine output (UO) after admission in patients with acute pulmonary embolism (APE) in the intensive-care unit (ICU) for short- and long-term all-cause mortality risk.

Methods: This retrospective cohort study used the MIMIC-IV database. Patients with APE were divided into 4 teams (T1-T4) by their first 24-h UO after admission: T1 (UO ≤ 400 ml), T2 (400＜UO ≤ 800 ml ), T3 (800＜UO ≤ 2500 ml), and T4 (UO＞2500 ml).

Hydrophobic carbon/bamboo-like carbon nanotube supported Fe/Co nanocomposites with antibacterial activity for wound healing.

The development of novel nanozymes with excellent enzyme simulation ability provides a new perspective for antibacterial and wound healing. However, the enzyme activity of traditional simplex nanozyme is not sufficient, meanwhile the nanozymic catalytic therapy alone cannot fulfill the purpose of effective antibacterial and wound healing. Hence, we develop novel multifunctional nanocomposites composed of FeCo alloys integrate with carbon spheres and carbon nanotubes (FeCo-C/CNT NCs) with hydrophobic property, enhanced oxidase-like (OXD-like) activity and photothermal property.

Control of Conformational Transitions by the Conserved GXP Motif in the Fifth Transmembrane Domain of Neurotransmitter Sodium Symporters.

The neurotransmitter sodium symporters (NSSs) play critical roles in the neurotransmission of monoamine and amino acid neurotransmitters and are the molecular targets of therapeutic agents in the treatment of several psychiatric disorders. Despite significant progress in characterizing structures and transport mechanisms, the management of conformational transitions by structural elements coupled with ion and substrate binding remains to be fully understood. In the present study, we biochemically identified a conserved GXP motif in the fifth transmembrane domain (TM5) of the serotonin transporter (SERT) that plays a vital role in its transport function by facilitating conformational transitions.

Lactate dehydrogenase to albumin ratio and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study.

Background: Chronic obstructive pulmonary disease (COPD) is a global public health challenge and a major cause of death. The lactate dehydrogenase to albumin ratio (LAR) is a simple and practical indicator of disease prognosis, but its prognostic value in acute exacerbation of COPD (AECOPD) remains unclear. Therefore, we aimed to explore the prognostic value of LAR for the short-term all-cause mortality risk in patients with AECOPD.

Integrated metabolomics and transcriptomics reveal differences in terpenoids and the molecular basis among the roots of three Bupleurum species.

Background: Radix Bupleuri is a popular traditional Chinese medicinal plant. Its root contains saikosaponin and volatile oil compounds with antipyretic, anti-inflammatory, and hepatoprotective pharmacological effects. However, there are differences in the content and type of main chemical components in the roots of three Bupleurum species: Bupleurum chinense DC.

USF2 EXACERBATES SEPSIS-INDUCED ACUTE KIDNEY INJURY AND FERROPTOSIS THROUGH LPCAT3-MEDIATED NRF2/HO-1/GPX4 PATHWAY.

Background: Sepsis-acute kidney injury (AKI) is a common complication in critically ill patients with a very high mortality rate. Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is crucial in lipid metabolism; however, its role in the pathogenesis of sepsis-AKI remains unclear. Methods: Human renal tubular epithelial (HK2) cells stimulated with lipopolysaccharide (LPS) were used to establish sepsis-AKI cell models.

Spatiotemporal composition and diversity of endophyte communities in on Hainan Island.

Introduction: produces a red resin known as Dragon's blood, which is used worldwide in traditional medicine and as a dye. The role of endophytes in the resin-formation process remains underexplored. Understanding the endophyte communities and their functional roles in resin production could enable the development of efficient induction techniques for resin production.

Adaptive Changes and Genetic Mechanisms in Organisms Under Controlled Conditions: A Review.

Adaptive changes encompass physiological, morphological, or behavioral modifications occurring in organisms in response to specific environmental conditions. These modifications may become established within a population through natural selection. While adaptive changes can influence individuals or populations over short timeframes, evolution involves the inheritance and accumulation of these changes over extended periods under environmental pressures through natural selection.

Impact of sediment microbial fuel cells on the distribution of different forms of phosphorus in lake sediment and water.

The continuous release of phosphorus from sediments by geochemical processes can cause endogenous eutrophication. This study examined the effect of carbon felt-sediment microbial fuel cells (CF-SMFCs) on the release of deposited phosphorus into the overlying water. In the CF-MFC system, the voltage ranged from 27 to 584 mV and the anode electrode potential increased from -130 mV to 202 mV.

Multifunctional Lanthanide Metal-Organic Frameworks Act as Fluorescent Probes for the Detection of CrO, Fe, and TNP, White Light-Emitting Diodes, and Luminescence Thermometers.

Two basically isostructural lanthanide-based metal-organic frameworks (Ln-MOFs), {[Eu(dptz)(HO)]Cl·3HO} (, JLNU = Jilin Normal University) and {[Tb(dptz)(NO)(HO)]·7HO} (), have been successfully synthesized by employing 3-(3,5-dicarboxylphenyl)-5-(pyrid-2-yl)-1-1,2,4-triazole (Hdptz) as a flexible carboxylic acid ligand through solvothermal reactions. Single-crystal structural studies on Ln-MOFs manifested that the compounds have a two-dimensional (2D) layered structure. Furthermore, fluorescence sensing experiments indicated that and had significant fluorescence quenching effects on CrO, Fe, and TNP.

Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension.

Background: Pulmonary arterial hypertension (PAH) is a severe and progressive cardiovascular disease. While potential links between clonal hematopoiesis (CH) and cardiovascular diseases have been identified, the causal relationship between CH and PAH remains unclear. This study aims to investigate the causal effect of CH on the risk of PAH using a two-sample Mendelian randomization (MR) approach.

Electromechanics of the Molecule-Electrode Interface and Interface-Mediated Effects in Single-Molecule Junctions.

The molecule-electrode interface can regulate both the efficiency and pathways of electron transport through single-molecule junctions (SMJs). The electromechanics of the interface has proven crucial in exposing the underlying mechanisms of electron transmission through SMJs, providing a theoretical base and practical guidance for designing and constructing functional molecular devices. Here we encompass several currently developed methodologies for investigating the electromechanics of molecule-electrode interface and provide an account of their application in elucidating the effects of the molecule-electrode interface on electron transport properties of SMJs.

Nonconventional Full-Color Luminescent Polyurethanes: Luminescence Mechanism at the Molecular Orbital Level.

The study of structure-activity relationships is a top priority in the development of nontraditional luminescent materials. In this work, nonconjugated polyurethanes (PUs) with full-color emission (red, green, and blue) are easily obtained by control of the diol monomer structure and the polymerization conditions. Selected diol monomers introduced single, double, or triple bond repeating units into the main chain of the PUs, in order to understand how unsaturated bonds and H-bonds affect their luminescence from a molecular orbital viewpoint.

Integrated Carbon Nanotube and Ketoenamine-Linked Covalent Organic Framework with Positive Charge Structure as High-Performance Capacitive Materials.

A series of composite materials, ETB@CNT (ETB@CNT10, ETB@CNT20, ETB@CNT30, ETB@CNT40, ETB@CNT50) with different carbon nanotubes (CNTs) contents are successfully prepared by using one-pot method. Compared with the pure ET-B-COF, which is a ketoenamine-linked covalent organic framework (COF) with a positive charge structure, CNTs can effectively improve the electrochemical performance of ET-B-COF, and the specific capacitance increased with the increase of the mass of carbon nanotubes added during the preparation process. Among them, ETB@CNT40 exhibits the best electrochemical performance (37.

Varied CO photoreduction activities of UiO-66-NH MOFs with different aggregation morphologies.

Several kinds of UiO-66-NH with different aggregation morphologies were prepared to verify that the morphology of the photocatalyst could influence charge transfer. That showing poor aggregation exhibits superior CO photoreduction performance, attributed to the small particle size related to the poor aggregation and to the resulting high efficiency of separation of photogenerated electrons and holes.

Marital status as an independent prognostic factor for survival in women with vaginal cancer: evidence from the SEER database analysis.

This study aimed to evaluate the influence of marital status on the survival outcomes of women diagnosed with vaginal cancer, considering the potential role of sociodemographic factors in patient prognosis. Utilizing data from the Surveillance, Epidemiology, and End Results database, the study included 6046 women with primary vaginal cancer diagnosed between 2000 and 2020. The propensity score matching (PSM) method was employed to balance comparison groups and account for confounding factors.

Dietary inflammatory index as a predictor of prediabetes in women with previous gestational diabetes mellitus.

Introduction: Gestational diabetes mellitus (GDM) is associated with an increased risk of developing type 2 diabetes mellitus (T2DM). The inflammatory potential of diet is crucial in GDM development. This study compares dietary inflammatory indices (DII) in females with and without a history of GDM and constructs a predictive model for prediabetes risk.

Rate Optimization of Intelligent Reflecting Surface-Assisted Coal Mine Wireless Communication Systems.

This paper proposes a three-step joint rate optimization method for intelligent reflecting surface (IRS)-assisted coal mine wireless communication systems. Different from terrestrial IRS-assisted communication scenarios, in coal mines, IRSs can be installed flexibly on the tops of rectangular tunnels to address the issues of signals being blocked and interfered with by mining equipment. Therefore, it is necessary to optimize the IRS deployment position, the transmit power and IRS phase shifts to achieve the maximum effective achievable rate at user stations equipped with the proposed system.