Endometrial microbiome during early pregnancy among women with and without chronic endometritis: a pilot study.

Introduction: Although chronic endometritis (CE) is strongly associated with infertility and adverse pregnancy outcomes, the specific microbiome of women with CE who can conceive remain unclear.

Methods: This study recruited 100 participants aged 18 to 45 years with spontaneously conceived pregnancy who opted for pregnancy termination, detected their endometrial microbiome by 16S rRNA, and made a diagnosis of CE.

Results: Among them, 19 were diagnosed with CE.

A Comparative Study of Five Large Language Models' Response for Liver Cancer Comprehensive Treatment.

Introduction: Large language models (LLMs) are increasingly used in healthcare, yet their reliability in specialized clinical fields remains uncertain. Liver cancer, as a complex and high-burden disease, poses unique challenges for AI-based tools. This study aimed to evaluate the comprehensibility and clinical applicability of five mainstream LLMs in addressing liver cancer-related clinical questions.

Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication.

Keloids are a challenging fibrotic disorder with limited treatment options. The study sought to examine the underlying mechanisms of keloid pathogenesis, emphasizing the influence of dermal adipocytes and ferroptosis resistance in driving fibrosis. Single-cell RNA sequencing (scRNA-seq) was employed for determining essential cell populations in keloid tissue.

Iron dysregulation and ferroptosis are associated with pulmonary fibrosis: Insight from idiopathic pulmonary fibrosis, systemic sclerosis, and COVID-19 patients.

Background: Pulmonary fibrosis (PF) is the leading cause of death in many lung diseases due to inflammation, tissue damage, infection, or other contributing factors. Iron metabolism and ferroptosis have been reported to participate in some PF diseases, but the universality remains elusive.

Methods: Herein, comparative studies were conducted among idiopathic pulmonary fibrosis (IPF), immune-associated systemic sclerosis (SSc), and infectious COVID-19.

Antirheumatic Medication Calendar Significantly Improves Adherence in First-Time Methotrexate Users: A Prospective, Single-Blind, Randomized Controlled Trial.

Purpose: Methotrexate is widely used to treat rheumatoid arthritis; however, the adherence rate greatly varies due to its weekly dosing schedule. Incorrect administration can lead to disease progression and toxicity. To design a graphic-based medication calendar aiming to improve adherence in first-time methotrexate users.

The stromal vascular fraction mitigates bleomycin-induced skin fibrosis in mice by modulating vascular lesions and secreting antifibrotic factors at different stages of disease.

Background: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and internal organs, leading to significant morbidity and reduced quality of life. Despite ongoing research, the underlying pathogenesis of SSc remains unclear, and treatment options are limited. Stromal vascular fraction (SVF), a naturally occurring cell population that includes mesenchymal stem cells (MSCs), has emerged as a potential therapeutic agent for various fibrotic diseases.

Beta-amyloid deposition increases in the brain with the progression of silicosis: a [F] AV45 PET study in mice.

Occupational silicosis caused by long-term inhalation of silica is a serious public-health problem in the world and is known to be a risk factor for the development of dementia. However, the progression of silicosis, including its impact on the brain and its relationship with β-Amyloid (Aβ), the early biomarker of Alzheimer's disease, remains unclear. In this study, we categorized silicosis into four stages in a mouse model and employed [F] AV45 PET imaging to quantify Aβ deposition across 19 cerebral sub-regions.

Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress.

Pemphigus-associated interstitial lung disease (P-ILD) is a severe complication observed in pemphigus patients that is characterized by pulmonary interstitial inflammation and fibrosis. This study investigated the role of anti-desmoglein (Dsg) 1/3 antibodies in P-ILD pathogenesis and evaluated the therapeutic potential of molecular hydrogen (H). Using a BALB/cJGpt mouse model, we demonstrated that anti-Dsg 1 antibodies, but not anti-Dsg 3 antibodies, induced interstitial inflammation and fibrosis.

Serum miRNA-186-3P and miRNA-382-3P constitute a novel Diagnostic miRNA signature for palindromic rheumatism.

Background: Palindromic rheumatism (PR) is a unique disease characterized by the intermittent inflammation of different joints that may progress to a variety of immune-related diseases. Unclear diagnostic criteria have limited the research on its pathogenesis and treatment options. Recently, microRNAs (miRNAs) have been used in the diagnosis of various diseases; however, the role of miRNAs in PR diagnosis remains unexplored.

Genetic structure and knockdown resistance (kdr) mutations in Aedes albopictus (Skuse) (Diptera: Culicidae): Implications for dengue fever transmission in southeastern China.

Dengue fever, transmitted by Aedes albopictus in China, is a major public health issue. The emergence of kdr gene mutations in Ae. albopictus has reduced the efficacy of insecticide-based control.

Krüppel homolog 1, a juvenile hormone transcription factor, regulates the reproduction and development of Aedes albopictus(Skuse) (Diptera: Culicidae).

The control of Aedes albopictus (Skuse) (Diptera: Culicidae), a vector for several important viral diseases, is crucial for mitigating mosquito-borne diseases. This study focused on the Krüppel homolog 1 (Kr-h1) gene, a transcription factor in juvenile hormone (JH) signaling, which plays a pivotal role in inhibiting metamorphosis and promoting adult reproduction. We characterized Aedes albopictus Kr-h1(AalbKr-h1), identified its eight zinc finger domains, and confirmed its orthology among insects through phylogenetic analysis.

Construction and validation of a novel liver function-tumor burden-inflammation-nutrition (LTIN) score for HCC patients underwent hepatectomy.

Objective: Liver function, tumor burden, inflammation level, and nutritional status are critical factors influencing tumor onset, progression, and metastasis. This study sought to investigate the prognostic significance and clinical relevance of biomarkers associated with these factors to develop a novel liver function-tumor burden-inflammation-nutrition (LTIN) score for patients with hepatocellular carcinoma (HCC) who received hepatectomy.

Methods: A retrospective analysis was conducted on 285 patients with HCC undergoing hepatectomy at two medical centers between July 2019 and July 2023.

Ecological response of green spaces to land use change in the Mu Us Desert-Loess Plateau transition zone, China, since the twenty-first century.

The Mu Us Desert-Loess Plateau transition zone in China, a fragile ecosystem prone to desertification, has undergone substantial ecological restoration since the early twenty-first century. This study utilized land use/cover data from 2000 to 2023 to assess the ecological response of green spaces to these efforts. A comprehensive set of ecological indices-including the green ecosystem index (GEI), equivalent ecological quality (EEQ) index, and green ecological contribution (GEC) rate-was used to quantify changes in green space extent and ecosystem quality.

Increased melanin induces aberrant keratinocyte - melanocyte - basal - fibroblast cell communication and fibrogenesis by inducing iron overload and ferroptosis resistance in keloids.

Background: Keloid is a typical skin fibrotic disease with unclear mechanisms and limited therapeutic options. Fibroblast-induced fibrogenesis is a crucial cause of KD. However, the types of cells involved in fibroblast fibrogenesis in KD and the specific mechanisms are unclear.

Toll Like Receptors Promote High Glucose-Induced Vascular Endothelial Cell Dysfunction by Regulating Neutrophil Extracellular Traps Formation.

Diabetic retinopathy (DR) is a major cause of blindness globally. Neutrophils and neutrophil extracellular traps (NETs) are believed to play a role in the development of DR. However, the specific contribution of NETs to hyperglycemia-induced vascular endothelial cell dysfunction remains unclear.

CO dynamics and sequestration potential in high-nutrient, low-chlorophyll bays: A case study of Yueqing Bay.

Bays, as transitional zones in the land-sea continuum, exhibit fluctuating sea-air CO fluxes influenced by climate change and human activities. The role of eutrophic bays as CO sinks is debated, highlighting the need to understand CO dynamics and controlling factors. This research employs the subtropical semi-enclosed Yueqing Bay as a case to investigate the dynamics of pCO and sea-air CO flux, as well as the carbon sink potential in high-nutrient, low-chlorophyll (HNLC) bays through high-resolution underway surveys.

The Role of AaPGRP-LB in the Immune Response of Against Bacteria Infection.

The initial phase of an insect's innate immune response to foreign pathogens is triggered by the identification of exogenous invaders, a mechanism facilitated by pattern recognition receptors. Among these receptors, peptidoglycan recognition proteins (PGRPs), abundant in insects, are essential components of the innate immune system. The roles of PGRPs have been extensively elucidated in ; however, the mechanism underlying the immune response of to pathogens is unclear.

Efficacy and safety of postoperative adjuvant HAIC with FOLFOX combining PD-1 inhibitors in HCC patients with microvascular invasion: a propensity score matching analysis.

Purpose: To evaluate the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy (PA-HAIC) plus programmed death-1 (PD-1) inhibitors versus PA-HAIC alone for hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI).

Methods: This retrospective study included HCC patients with MVI who were treated with either PA-HAIC or PA-HAIC plus PD-1 inhibitors between February 2021 and February 2024. The differences in baseline characteristics, disease-free survival (DFS), and overall survival (OS) were compared between the two groups before and after propensity score-matching (PSM).

Electrostatic Co-Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy.

Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging-guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high-contrast photoacoustic imaging and efficient therapeutic capabilities. In this work, a supramolecular strategy is employed to construct a molecular pair phototheranostic agent via the direct self-assembly of two cyanines, C5TNa (anionic) and Cy-Et (cationic).

Advancements in Hyperspectral Imaging for Assessing Nutritional Parameters in Muscle Food: Current Research and Future Trends.

Assessing the nutritional value of muscle food (MF) necessitates comprehensive component analysis. Traditional chemical analytical methods are often time-intensive, destructive, and environmentally detrimental, requiring specialized laboratory expertise. Hyperspectral imaging (HSI) emerges as an innovative technique that effectively integrates spectral and spatial information to enable rapid, nondestructive, and multidimensional predictions of nutritional parameters in MF.

Integrating transfer learning and spectroscopy for enhanced pork spoilage assessment using correlation analysis.

Accurate Total Viable Count (TVC) detection is vital for food quality monitoring. In this study, we investigated the feasibility of using visible near-infrared (VNIR) spectroscopy (400-1000 nm) combined with transfer learning (TL) to track the chemical spoilage of pork. The base models developed using the full band for pork TVC, total volatile basic nitrogen, pH, and color showed predictability; the correlation coefficient of prediction set (R) for all models ranged from 0.

miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades.

Introduction: Fibroblast abnormalities are crucial causes of skin fibrosis, including systemic sclerosis (SSc) and keloids. However, their mechanisms, including underlying microRNA regulatory mechanisms, remain elusive.

Objectives: This study aimed to evaluate the roles, mechanisms, and therapeutic potential of miR-3606-3p in regulating multiple fibroblast abnormalities.

The gut microbial metabolite indole-3-aldehyde alleviates impaired intestinal development by promoting intestinal stem cell expansion in weaned piglets.

Background: Weaning stress-induced diarrhea is widely recognized as being associated with gut microbiota dysbiosis. However, it has been challenging to clarify which specific intestinal microbiota and their metabolites play a crucial role in the antidiarrhea process of weaned piglets.

Results: In this study, we first observed that piglets with diarrhea exhibited a lower average daily gain and higher diarrhea score, and elevated levels of lipopolysaccharide (LPS) and D-lactate (D-LA) compared to healthy piglets.

Altered Functional Connectivity of Unimodal Sensory and Multisensory Integration Networks Is Related to Symptom Severity in Autism Spectrum Disorder.

Background: Atypical sensory processing is a prevalent feature of autism spectrum disorder (ASD) and constitutes a core diagnostic criterion in DSM-5. However, the neurocognitive underpinnings of atypical unimodal and multimodal sensory processing and their relationships with autism symptoms remain unclear.

Methods: In this study, we examined intrinsic functional connectivity (FC) patterns among 5 unimodal sensory and multisensory integration (MSI) networks in ASD using a large multisite dataset (N = 646) and investigated the relationships between altered FC, atypical sensory processing, social communicative deficits, and overall autism symptoms using correlation and mediation analyses.