Electrostatic Co-Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy.

Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging-guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high-contrast photoacoustic imaging and efficient therapeutic capabilities. In this work, a supramolecular strategy is employed to construct a molecular pair phototheranostic agent via the direct self-assembly of two cyanines, C5TNa (anionic) and Cy-Et (cationic).

Cyclometalated Iridium(III) Schiff Base Complexes for Chemiluminogenic Bioprobes.

Chemiluminogenic bioimaging has emerged as a promising paradigm due to its independence from light excitation, thereby circumventing challenges related to light penetration depth and background autofluorescence. However, the availability of effective chemiluminophores remains limited, which substantially impedes their bio-applications. Herein, we discovered for the first time that cyclometalated iridium(III) Schiff base complexes can unexpectedly generate chemiluminescence.

Theranostic Fluorescent Probes.

The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal control, in the context of drug delivery makes theranostic fluorescent probes an attractive and intensely investigated research topic. This interest is reflected in the steep rise in publications on the topic that have appeared over the past decade. Theranostic fluorescent probes, in their various incarnations, generally comprise a fluorophore linked to a masked drug, in which the drug is released as the result of certain stimuli, with both intrinsic and extrinsic stimuli being reported.

Exosomes Secreted by Hypoxia-Pre-conditioned Adipose-Derived Mesenchymal Stem Cells Reduce Neuronal Apoptosis in Rats with Spinal Cord Injury.

Neuronal death is the main cause of nerve function impairment after spinal cord injury (SCI). Exosome-based therapy has become a novel strategy for tissue injury repair. We designed a method to treat SCI using exosomes secreted by adipose tissue-derived stromal cells (ADSCs) under hypoxic conditions.

Tuning the organelle specificity and cytotoxicity of iridium(III) photosensitisers for enhanced phototheranostic applications.

Luminescent cyclometallated iridium(III) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient theranostic agents that displayed tuneable organelle-targeting properties, minimal dark cytotoxicity and substantial photocytotoxicity even under hypoxic conditions.

Luminescent Neutral Cyclometalated Iridium(III) Complexes Featuring a Cubic Polyhedral Oligomeric Silsesquioxane for Lipid Droplet Imaging and Photocytotoxic Applications.

New neutral iridium(III) complexes featuring a cubic polyhedral oligomeric silsesquioxane (POSS) unit, [Ir(NC)(L1-POSS)] [HNC = 2-phenylpyridine (Hppy; ), 2-phenylbenzothioazole (Hbt; ), and 2-(1-naphthyl)benzothiazole (Hbsn; ); L1-POSS = ()-4-[(2-hydroxybenzylidene)amino]benzyl 3-heptakis(isobutyl)POSS-propyl carbamate], were designed and synthesized. Their POSS-free counterparts, [Ir(NC)(L1)] [L1 = ()--(4-hydroxymethylphenyl)-1-(2-hydroxyphenyl)methanimine; HNC = Hppy (), Hbt (), and Hbsn ()], and the poly(ethylene glycol) (PEG) derivatives [Ir(NC)(L1-PEG)] [L1-PEG = ()-4-[(2-hydroxybenzylidene)amino]benzyl 3-[2-[ω-methoxypoly(1-oxapropyl)]ethyl]carbamate; HNC = Hppy (), Hbt (), and Hbsn ()] were also prepared. The photophysical, photochemical, and biological properties of the POSS complexes were compared with those of their POSS-free and PEG-modified counterparts.

Tenosynovial giant cell tumor involving the cervical spine: A case report.

Background: Tenosynovial giant cell tumors (TGCTs) are a frequent benign proliferative disease originating from the synovial membrane. However, TGCTs rarely occur in the spine. The purpose of this paper is to report a case of TGCT occurring in the cervical spine.

The complete chloroplast genome of (Oleaceae, Oleoideae).

is one of the commonly used ecological restoration tree species in rocky desertification areas. It has high medicinal and timber value. And has high marketization prospects.

PTEN-silencing combined with ChABC-overexpression in adipose-derived stem cells promotes functional recovery of spinal cord injury in rats.

The efficiency of cell therapy after spinal cord injury (SCI) depend on the survival of transplanted cells. However, sterile microenvironment and glial scar hyperplasia extremely reduce their numbers. Our previous study found overexpression of ChABC gene is positively correlated to migration ability.

Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane (POSS) Core and Iridium(III) Polypyridine Arms: Synthesis, Aggregation Induced Emission, Cellular Uptake, and Bioimaging Studies.

A new class of luminescent molecular hybrids in which eight cyclometalated iridium(III) polypyridine complexes are grafted onto a polyhedral oligomeric silsesquioxane (POSS) unit [POSS-{Ir(N^C) (py-im)} ](PF ) [py-im=pyridine imine; HN^C=N-phenylpyrazole (Hppz) (1 a), 2-phenylpyridine (Hppy) (2 a), 2-phenylquinoline (Hpq) (3 a)] were synthesized and characterized. On photoexcitation, the complexes showed intense and long-lived orange-red to red emission in fluid solutions at room temperature and in low-temperature glasses. The photophysical properties including aggregation-induced emission and biological properties of these complexes were studied and compared with those of their POSS-free counterparts [Ir(N^C) (py-im)](PF ) [HN^C=Hppz (1 b), Hppy (2 b), Hpq (3 b)].

Selective colorimetric and fluorescent quenching determination of uranyl ion via its complexation with curcumin.

Under pH4.0 HAc-NaAc buffer medium, curcumin alone possesses extraordinary weak fluorescence emission. Nevertheless, the introduction of Triton X-100 micelles can largely enhance the fluorescence intensity of curcumin.