Publications by authors named "Chenggong Guan"
Hereditary angioedema with normal C1 inhibitor (HAE-nC1-INH) is a rare and genetically heterogeneous disorder with an incomplete molecular understanding. This study aimed to identify novel genetic variants associated with HAE-nC1-INH, characterize their clinical manifestations, and evaluate real-world treatment responses. Whole-exome sequencing of 27 HAE patients, including eight with HAE-nC1-INH, identified four previously unreported MYOF variants and additional pathogenic variants in KNG1 and HS3ST6, expanding the genetic spectrum of the disease.
View Article and Find Full Text PDFPemphigus-associated interstitial lung disease (P-ILD) is a severe complication observed in pemphigus patients that is characterized by pulmonary interstitial inflammation and fibrosis. This study investigated the role of anti-desmoglein (Dsg) 1/3 antibodies in P-ILD pathogenesis and evaluated the therapeutic potential of molecular hydrogen (H). Using a BALB/cJGpt mouse model, we demonstrated that anti-Dsg 1 antibodies, but not anti-Dsg 3 antibodies, induced interstitial inflammation and fibrosis.
View Article and Find Full Text PDFArticle Synopsis
- Traditional Chinese herbal medicines (TCMs) are increasingly used with conventional pharmaceuticals, but concerns about cutaneous adverse drug reactions (CADRs) exist, especially in conjunction with antibiotics and NSAIDs.
- A study reviewed data from over 1.8 million patient visits from 2007 to 2022 to assess the frequency and severity of CADRs when TCMs were used alongside these medications.
- Findings indicate TCMs do not significantly increase severe CADRs when combined with antibiotics or NSAIDs, suggesting their safe use in multi-drug therapies, but ongoing monitoring and regulation are essential for drug safety.
Interstitial lung disease (ILD) has been identified as a prevalent complication and significant contributor to mortality in individuals with pemphigus. In this study, a murine model of pemphigus was developed through the subcutaneous administration of serum IgG obtained from pemphigus patients, allowing for an investigation into the association between pemphigus and ILD. Pulmonary interstitial lesions were identified in the lungs of a pemphigus mouse model through histopathology, RT-qPCR and Sircol assay analyses.
View Article and Find Full Text PDFPurpose: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy was investigated to determine whether it is superior to N-Acetylcysteine (NAC) for the treatment of patients with early-stage ILD.
Patients And Methods: A prospective, single-center, randomized, controlled clinical trial was conducted in 87 patients with early-stage ILD.