The role of hope, academic thriving, and adaptive coping in fostering peace of mind among university students: a mixed-methods study.

Introduction: University students face significant academic stress, making psychological resources like hope, academic thriving, and adaptive coping essential for emotional well-being. Drawing on Snyder's Hope Theory and Schreiner's model of academic thriving, this study examines how these psychological constructs contribute to students' peace of mind.

Methods: This mixed-methods study collected quantitative data from 562 undergraduate students in mainland China using validated measures of hope, academic thriving, adaptive coping, and peace of mind.

Suppression of Spin-Orbit Torque Switching by the Magnetic Proximity Effect.

Functional magnetic multilayers are particularly interesting for enabling many emerging spintronic physics, including spin-orbit torque (SOT), magnetic proximity effect (MPE), and perpendicular magnetic anisotropy (PMA), among many others. A comprehension of these spintronic phenomena is vital for the development of advanced spintronic materials and devices. Here, we investigate the interplay between the MPE and the current-induced SOT switching in the perpendicularly magnetized Pt/[Co/Pd] multilayers (with being the number of repetitions).

Effect of Substrate Temperature on the Structural, Morphological, and Infrared Optical Properties of KBr Thin Films.

Potassium bromide (KBr) thin films were deposited by resistive thermal evaporation at substrate temperatures ranging from 50 °C to 250 °C to systematically elucidate the temperature-dependent evolution of their physical properties. Structural, morphological, and optical characteristics were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and Fourier transform infrared spectroscopy (FTIR). The results reveal a complex, non-monotonic response to temperature rather than a simple linear trend.

Organic Surface Passivation on Rh@CeO Cocatalysts for Photocatalytic Overall Water Splitting.

Decorating Rh cocatalysts with CrO overlayers can enhance the performance of photocatalytic overall water splitting (POWS). However, there is a general concern on the dissolution of CrO, calling for the development of environment-friendly metal oxides. Here, we employ phenylphosphonic acid (PPOA) as a model surface modifier to decorate the model Rh@CeO cocatalysts and demonstrate the critical role of organic surface passivation in H evolution catalysis.

Comparative transcriptome analysis of different tissues of provides new insights into the biosynthesis pathway of triterpenoid saponins.

Triterpenoid saponins are one of the main activities of roots and rhizomes of , with various pharmacological activities such as antibacterial, anticancer, and anti-inflammatory. To elucidate the biosynthesis pathway of triterpenoid saponins in , DNA nanoball sequencing technology was used to analyze the transcriptome of leaves, roots, and stems of . Out of a total of 99,404 unigenes, 78,989 unigenes were annotated by seven major databases; 49 unigenes encoded 11 key enzymes in the biosynthesis pathway of triterpenoid saponins.

A novel cataluminescence sensor for rapid detection of methanol at low working temperature based on Ni/CeO catalyst.

Cataluminescence (CTL) is an attractive chemiluminescence phenomenon that occurs at the gas-solid catalytic interface, and there is a strong anticipation for highly efficient CTL. Herein, Ni/CeO catalyst was successfully developed by using the doping method. In comparison with the CeO nanoparticles and NiO nanoparticles, Ni/CeO catalyst exhibited superior CTL performance toward methanol.

TNFAIP2 deficiency drives formation of an immunosuppressive tumor microenvironment and confers resistance to anti-PD-1 therapy in skin cutaneous melanoma.

TNFα-induced protein 2 (TNFAIP2) reportedly plays a significant role in the initiation and progression of malignancy. However, its function in skin cutaneous melanoma (SKCM) is largely unknown and urgently needs to be explored. Analysis of a publicly available database revealed that TNFAIP2 was significantly downregulated in SKCM tissues vs.

PW-BALFC, a clinical dataset for detection and instance segmentation of bronchoalveolar lavage fluid cell.

Bronchoalveolar lavage fluid (BALF) cytology provides an important basis for the diagnosis and treatment of lung diseases. Current cytological analysis of BALF relies on manual microscopic examination, which is time-consuming, laborious, and experience-dependent. Automated identification of BALF cytology helps increase the accuracy and speed of screening qualified samples and subsequent cytomorphology analysis.

Hydrogel-assisted chemiluminescence and electrochemiluminescence systems for bioanalytical applications.

Hydrogels, a class of polymer materials with a three-dimensional network, are widely used in biosensors due to their remarkable biocompatibility, abundant availability, and good solubility. In recent years, hydrogels have attracted considerable attention as promising candidates for the construction of chemiluminescence (CL) biosensors and electrochemiluminescence (ECL) biosensors, particularly for biological detection. This paper presents the advances in hydrogel-based CL and ECL sensors for bioanalytical applications.

The endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis.

Liver sinusoidal endothelial cells (LSECs) are essential for maintaining liver function by actively sensing nutrients and producing angiocrine factors. LSECs also regulate systemic iron metabolism by secreting bone morphogenetic proteins (BMPs), key modulators of systemic iron homeostasis. However, the mechanism by which LSECs sense iron to regulate iron metabolism remains unclear.

Preoperative Assessment of Lymph Node Metastasis in Rectal Cancer Using Deep Learning: Investigating the Utility of Various MRI Sequences.

Purpose: This study aimed to develop a deep learning (DL) model based on three-dimensional multi-parametric magnetic resonance imaging (mpMRI) for preoperative assessment of lymph node metastasis (LNM) in rectal cancer (RC) and to investigate the contribution of different MRI sequences.

Patients And Methods: A total of 613 eligible patients with RC from four medical centres who underwent preoperative mpMRI were retrospectively enrolled and randomly assigned to training (n = 372), validation (n = 106), internal test (n = 88) and external test (n = 47) cohorts. A multi-parametric multi-scale EfficientNet (MMENet) was designed to effectively extract LNM-related features from mpMR for preoperative LNM assessment.

NUTF2 Promotes Proliferation of Oral Squamous Cell Carcinoma Through PI3K/AKT Signaling Pathway.

Background: Oral squamous cell carcinoma (OSCC) is associated with a poor prognosis. Nuclear transport factor 2 (NUTF2) participates in nucleoprotein transport. However, the mechanism of NUTF2 in OSCC remains unclear.

Low-Refractive-Index SiO Nanocolumnar Thin Films Fabricated by Oblique Angle Deposition.

The refractive index is one of the most important optical parameters of optical thin films. Optical films with a low refractive index can effectively reduce the residual reflection on the film surface, which is one of the most important parameters pursued by scholars. In this research, SiO thin films with a low refractive index and nanocolumnar structures were prepared by oblique angle deposition (OAD).

Isodon rubescens research literature based on Web of Science database for visual analysis: A review.

Isodon rubescens has been used as an herbal medicine in China for a long time. The significant value of development and utilization is affirmative. Bibliometrics is used as an approach to sort out, analyze, and visualize relevant literature in a particular field.

Malignant gastric glomus tumor with heterochronous liver metastases: a case report and review of the literature.

Background: Glomus tumors are mesenchymal tumors originating from the neuromuscular arterial canal or vascular lumen. While most gastric glomus tumors are benign and solitary, rare cases can be malignant and have a poor prognosis. Definitive treatment options remain limited for multifocal metastases, often necessitating salvage therapy.

Antenna effect-modulated luminescent lanthanide complexes for biological sensing.

With the discovery and further exploitation of the antenna effect, the optical properties of luminescent lanthanide complexes (LLCs) have been greatly improved. Antenna effect-modulated LLCs exhibit long luminescence lifetimes, large Stokes shifts, narrow emission spectra, pure chromaticity, and high photostability. Meanwhile, LLCs have garnered considerable attention in recent years and are widely used as biosensors in the fields of food safety, environmental monitoring, clinical diagnosis, and drug analysis.

Hydrogen sulfide preserves the function of senescent endothelium through SIRT2 mediated inflammatory inhibition.

Endothelial aging is an independent risk factor of cardiovascular diseases, and this study aims to explore the mechanism of endothelial aging. We first applied two animal aging models and two cellular aging models to observe the characteristics of senescent endothelium at the morphological, functional, and molecular levels. It was confirmed that the aging of endothelial cells was accompanied by activation of Nod like receptor protein 3 (NLRP3) inflammasome pathway, reduced levels of hydrogen sulfide (HS) and sirtuin2 (SIRT2) activity.

Cardiac Slc25a49-Mediated Energy Reprogramming Governs Doxorubicin-Induced Cardiomyopathy through the G6P-AP-1-Sln Axis.

Doxorubicin (Dox), a potent antitumor drug, is linked to cardiac toxicity. Few mechanism-based therapies against cardiotoxicity are available. Dysfunction in mitochondrial energy metabolism contributes to Dox-induced cardiomyopathy.

Efficient Separation-Free and Wash-Free Immunoassay for Sensitive Detection of Biomarkers Based on the Distance-Driven Chemiluminescent Technique.

The wash-free method represents a promising strategy for enhancing the detection efficiency of automated chemiluminescent (CL) immunoassay analyzers. Herein, a novel separation-free and wash-free immunoassay was developed for the first time based on the distance-driven CL technique. In the CL immunoassay, the well-designed Au-Co metal nanoclusters (NCs) exhibited excellent peroxidase-like activity and good stability, allowing for efficient catalysis of luminol or its analogue (ABEI)-HO system even at low concentrations.

Trimethylamine N-oxide induces cardiac diastolic dysfunction by down-regulating Piezo1 in mice with heart failure with preserved ejection fraction.

Aims: The present study aimed to investigate the direct link between trimethylamine N-oxide (TMAO) and diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF).

Materials And Methods: Diastolic dysfunction is the main manifestation of HFpEF, so the "two-hit" mouse HFpEF model are used. After treated with high-fat diet (HFD) and N-nitro-l-arginine methyl ester (L-NAME) for 8 weeks, the cardiac function, myocardial fibrosis, oxidative stress levels, and molecular alterations were assessed.

The efficacy and underlying mechanisms of berberine in the treatment of recurrent Clostridioides difficile infection.

Recurrent Clostridioides difficile infection (rCDI) is a global health threat that has received considerable attention. Berberine (BBR), a natural pentacyclic isoquinoline alkaloid, has been used as a cost-effective treatment for intestinal infections in Asia for many years. However, the effect of BBR on rCDI is not clear.

TNFAIP2 promotes NF-κB signaling mediate lymph node metastasis of oral squamous cell carcinoma by protecting IKKβ from ubiquitin proteasome degradation.

Background: Tumor dissemination is a life-threatening event which confers to most cancer-related deaths with limited effective therapeutic option. TNFα-induced protein 2 (TNFAIP2) reveals pro-metastasis potential in several cancers. However, its definite role and underlying mechanism in oral squamous cell carcinoma (OSCC) is largely unknown.

Aorticorenal ganglion ablation for blood pressure lowering in canine models.

Studies have shown that renal denervation (RDN) can lower blood pressure (BP) in patients with refractory hypertension, but issues such as renal sympathetic nerve reinnervation and suboptimal BP reduction remain unresolved. In this study, we identified the aorticorenal ganglion (ARG) in canines by observing ambulatory BP responses following electrical stimulation of the ARG. We injected cholera toxin subunit B combined with Alexa Fluor™ 555, a nerve tracer, into the identified ARG and confirmed its innervation of the renal artery and kidney by observing fluorescence in adjacent tissues.

Hydrogen sulfide attenuates sepsis-induced cardiac dysfunction in infant rats by inhibiting the expression of cold-inducible RNA-binding protein.

Sepsis-induced cardiac dysfunction is one of the most common complications of sepsis. It is also a major cause of death in pediatric intensive care units. The underlying mechanism of sepsis-induced cardiac dysfunction remains elusive.