Sonosensitizer-doped framework theranostic nanoprobe for enhanced spatiotemporal eradication of helicobacter pylori with photoacoustic imaging guidance.

Helicobacter pylori (H. pylori) infection is the leading cause of gastric cancer. Current antibiotic-based H.

Radiomics in precision medicine for colorectal cancer: a bibliometric analysis (2013-2023).

Background: The incidence and mortality of colorectal cancer (CRC) have been rising steadily. Early diagnosis and precise treatment are essential for improving patient survival outcomes. Over the past decade, the integration of artificial intelligence (AI) and medical imaging technologies has positioned radiomics as a critical area of research in the diagnosis, treatment, and prognosis of CRC.

Mitochondrial dynamics in pulmonary disease: Implications for the potential therapeutics.

Mitochondria are dynamic organelles that continuously undergo fusion/fission to maintain normal cell physiological activities and energy metabolism. When mitochondrial dynamics is unbalanced, mitochondrial homeostasis is broken, thus damaging mitochondrial function. Accumulating evidence demonstrates that impairment in mitochondrial dynamics leads to lung tissue injury and pulmonary disease progression in a variety of disease models, including inflammatory responses, apoptosis, and barrier breakdown, and that the role of mitochondrial dynamics varies among pulmonary diseases.

Mechanism of photocatalytic CO methanation on ultrafine Rh nanoparticles.

Selective hydrogenation of CO to yield CH relies on the appropriate catalysts that can facilitate the cleavage of CO bonds and dissociative adsorption of H. Ultrafine Rh nanoparticles loaded on silica nanospheres were used as a class of photocatalysts to significantly improve the selectivity and reaction rate of producing CH from the mixture of CO and H under the illumination of a broadband visible light source. The intense light scattering resonances in the silica nanospheres generate strong electric fields near the silica surface to enhance the light absorption power in the supported ultrafine Rh nanoparticles, promoting the efficiency of hot electron generation in the Rh nanoparticles.

The role of mitochondrial dynamics in disease.

Mitochondria are multifaceted and dynamic organelles regulating various important cellular processes from signal transduction to determining cell fate. As dynamic properties of mitochondria, fusion and fission accompanied with mitophagy, undergo constant changes in number and morphology to sustain mitochondrial homeostasis in response to cell context changes. Thus, the dysregulation of mitochondrial dynamics and mitophagy is unsurprisingly related with various diseases, but the unclear underlying mechanism hinders their clinical application.

Tinopanoids K-T, clerodane diterpenoids with anti-inflammatory activity from Tinospora crispa.

A total of 17 structurally diverse clerodane diterpenoids, including ten undescribed clerodane diterpenoids (tinopanoids K-T, 1-10) and seven known compounds (11-17), were isolated from the vines and leaves of Tinospora crispa. Compound 3 has not only bear the dominant substituents of γ-hydroxy-α, β-unsaturated-γ-lactone with anti-inflammatory activity, but also a ternary epoxy structure at C-3/C-4. The planar structures and relative configurations of the clerodane diterpenoids were elucidated by spectroscopic data interpretation.

Enabling Reaction Selectivity of Platinum Catalysts by Photoinduced Electronic Effects.

Reaction selectivity is crucial to producing target molecules of importance with minimum waste. This work reports an efficient and green strategy to improve reaction selectivity in visible-light-mediated chemical transformations by employing Pt/SiO photocatalysts, which is ascribed to light-induced surface electronic modification in the small Pt nanocrystals. This strategy has been successfully applied to synthesize commercially valuable but thermodynamically unfavorable arylhydroxylamines with high selectivity via partial hydrogenation of the respective nitroarenes.

Development and evaluation of an indirect enzyme-linked immunosorbent assay based on a recombinant SifA protein to detect Salmonella infection in poultry.

Salmonella is an important zoonotic pathogen that not only endangers food safety and human health, but also causes considerable economic losses to the poultry industry. Therefore, it is essential to establish a rapid, sensitive, and specific diagnostic method for the early detection of Salmonella infection in poultry. In this study, we developed a novel enzyme-linked immunosorbent assay (ELISA) for the detection of anti-Salmonella antibodies using a recombinant SifA protein.

Synthesis and structure-activity relationships of N - (3 - (1H-imidazol-2-yl) phenyl) - 3-phenylpropionamide derivatives as a novel class of covalent inhibitors of p97/VCP ATPase.

Noncovalent inhibitors of p97 have entered clinical studies. Compared with noncovalent inhibitors, covalent inhibitors have unique advantages in maintaining inhibitory effect and improving the resistance of the target. We previously employed the activity-based protein profiling to definitely identify p97 as the protein target of FL-18 that has a unique scaffold of benpropargylamide coupled with an imidazole.

Steering Catalytic Activity and Selectivity of CO Photoreduction to Syngas with Hydroxy-Rich Cu S@R -NiCo O Double-Shelled Nanoboxes.

Simultaneous transformation of CO and H O into syngas (CO and H ) using solar power is desirable for industrial applications. Herein, an efficient photocatalyst based on double-shelled nanoboxes, with an outer shell of hydroxy-rich nickel cobaltite nanosheets and an inner shell of Cu S (Cu S@R -NiCo O ), is prepared via a multistep templating strategy. The high performance of Cu S@R -NiCo O (7.

Spatial distribution data of cultural sites from the Paleolithic to Bronze Age in Xinjiang, China.

The published map recording cultural sites in Xinjiang shows that there is a lack of data collection on the distribution of sites in the area, and no relevant data sets have been released. Existing written materials indicate that there are more cultural sites in this area. For this reason, we have collected and sorted out information.

Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3)-ones from -nitrobenzamide and alcohols.

Palladium-catalyzed 2-substituted quinazolin-4(3)-one formation from readily available -nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3)-ones were obtained in good to high yields. The cascade reaction including alcohol oxidation, nitro reduction, condensation, and dehydrogenation occurs without any added reducing or oxidizing agent.

The study of early human settlement preference and settlement prediction in Xinjiang, China.

When studying the human settlement process, it is of great significance to understand the prehistoric environment, economy and society by exploring the human-land relationship and the evolution of civilization reflected by the settlement environment. This paper explores the natural and social environmental preferences of early human settlements in Xinjiang, China, from the Palaeolithic to the Bronze Age (45 ka BP-2250 a BP). Through the characteristics of settlement preferences, the distribution of settlements is accurately predicted, and the relationship between settlement preferences and the evolution of the environment and civilization is verified and discussed.

Yeast-induced formation of graphene hydrogels anode for efficient xylose-fueled microbial fuel cells.

Microbial fuel cells (MFCs) are of great interest due to their capability to directly convert organic compounds to electric energy. In particular, MFCs technology showed great potential to directly harness the energy from xylose in the form of bioelectricity and biohydrogen simultaneously. Herein, we report a yeast strain of Cystobasidium slooffiae JSUX1 enabled the reduction and assembly of graphene oxide (GO) nanosheets into three-dimensional reduced GO (3D rGO) hydrogels on the surface of carbon felt (CF) anode.

Design, synthesis, and structure-activity relationship of PD-1/PD-L1 inhibitors with a benzo[d]isoxazole scaffold.

Blocking the programmed cell death protein 1 (PD-1) and programmed death-ligand (PD-L1) interaction has emerged as one of the most promising treatments for cancer immunotherapy. A novel series of compounds bearing a benzo[d]isoxazole scaffold was developed as PD-1/PD-L1 inhibitors, among them, compound P20 exhibited the most potent inhibitory activity, with an IC value of 26.8 nM.

Design, synthesis, and biological evaluation of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction.

Blockade of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signalling pathway is a promising tumour immunotherapeutic approach, and small molecule drugs have more advantages than monoclonal antibody macromolecules in clinical applications. Therefore, a series of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as PD-1/PD-L1 interaction novel small-molecule inhibitors were designed employing a ring fusion strategy. The inhibitory activity of compounds was evaluated by the HTRF assay, among which D38 was identified as the most potent PD-1/PD-L1 interaction inhibitor with an IC value of 9.

Design, synthesis, and structure-activity relationship of programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing a benzo[d]isothiazole scaffold.

Blockade of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway is an attractive strategy for immunotherapy. A novel series of compounds bearing a benzo[d]isothiazole scaffold were developed, among which CH20 exhibited promising activity, with an IC value of 8.5 nM.

Highly Dispersed RuOOH Nanoparticles on Silica Spheres: An Efficient Photothermal Catalyst for Selective Aerobic Oxidation of Benzyl Alcohol.

Photothermal catalysis represents a promising strategy to utilize the renewable energy source (e.g., solar energy) to drive chemical reactions more efficiently.

Reduction of carbon dioxide on photoexcited nanoparticles of VIII group metals.

The photocatalytic reduction of carbon dioxide on nanoparticles of group VIII transition metals represents an emerging research area in recent years because of their promise in transforming carbon dioxide, a greenhouse gas, into value-added chemicals and fuels with the energy input of light. This mini review summarizes the fundamentals of the reduction of carbon dioxide and addresses how the photoexcitation of the metal nanoparticles can influence the reactions. The important roles of non-thermal hot electrons and photothermal effect in the photocatalytic reduction of carbon dioxide are highlighted, and the recent research reported in the literature are overviewed.

Mesoporous SiO Nanoparticles: A Unique Platform Enabling Sensitive Detection of Rare Earth Ions with Smartphone Camera.

Fast and sensitive detection of dilute rare earth species still represents a challenge for an on-site survey of new resources and evaluation of the economic value. In this work, a robust and low-cost protocol has been developed to analyze the concentration of rare earth ions using a smartphone camera. The success of this protocol relies on mesoporous silica nanoparticles (MSNs) with large-area negatively charged surfaces, on which the rare earth cations (e.

Geometric Symmetry of Dielectric Antenna Influencing Light Absorption in Quantum-Sized Metal Nanocrystals: A Comparative Study.

Silica nanoparticles, optically transparent in the visible spectral region, represent a class of dielectric antenna to tune the propagation and local field distribution of the visible light through surface scattering while the energy loss is minimized. The light scattering on the surface of silica nanoparticles include resonant scattering and random scattering that strongly depend on their geometry: spherical silica nanoparticles with the highest geometrical symmetry favors the light scattering resonances on the nanoparticle surfaces to promote resonant scattering while non-spherical silica nanoparticles mainly support random scattering. Both resonant scattering and random scattering of light on the silica nanoparticles are capable of enhancing the light absorption in quantum-sized metal nanocrystals attached to the surfaces of the silica nanoparticles.