Application of a 6Sigma-Based Nursing Intervention to Improve Postoperative Recovery in Patients Undergoing Total Hip Arthroplasty: A Retrospective Study.

Aim: Total hip arthroplasty (THA) is a well-established procedure for treating various hip joint diseases. However, postoperative complications and negative outcomes can affect patient recovery and satisfaction. Conventional perioperative interventions have demonstrated limited effectiveness in addressing these challenges.

Normally Off AlGaN/GaN MIS-HEMTs with Self-Aligned p-GaN Gate and Non-Annealed Ohmic Contacts via Gate-First Fabrication.

This study introduces an enhancement-mode AlGaN/GaN metal-insulator-semiconductor high-electron-mobility transistor (MIS-HEMT) featuring a self-aligned p-GaN gate structure, fabricated using a gate-first process. The key innovation of this work lies in simplifying the fabrication process by utilizing gate metallization for both electrical contact and etching mask functions, enabling precise self-alignment. A highly selective Cl/N/O inductively coupled plasma (ICP) etching process was optimized to etch the p-GaN layer in the access regions, with a selectivity ratio of 33:1 and minimal damage to the AlGaN barrier.

Low-Pressure Chemical Vapor Deposition SiN Process Study and Its Impact on Interface Characteristics of AlGaN/GaN MISHEMTs.

This study employed low-pressure chemical vapor deposition (LPCVD) SiN as both the gate dielectric layer and surface passivation layer, systematically investigating the effects of different growth conditions on the dielectric layer quality, two-dimensional electron gas (2DEG) characteristics, interface trap density, and devices' performance, thereby optimizing the growth parameters of LPCVD SiN. The experiment investigated the effects of growth parameters such as the growth temperature, chamber pressure, and gas flow ratio on the growth rate of SiN during the process of growing SiN using the LPCVD technique. Further studies were performed to analyze the impact of SiN introduction on the 2DEG performance.

Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial.

Meplazumab, a humanized CD147 antibody, showed favorable safety and clinical benefits in phase 1 and phase 2/3 seamless clinical studies. Further evaluation of its therapeutic efficacy in patients with severe COVID-19 is needed. In this phase 3 add-on study, we randomized patients with severe COVID-19 in a 1:1 ratio to receive 0.

Application of double-row transfixion suture of the lower uterine segment in cesarean section for pernicious placenta previa complicated by placenta accreta spectrum: a comparative clinical study.

Objective: To explore the effectiveness and feasibility of double-row transfixion suture of the lower uterine segment in cesarean section (CS) in patients with pernicious placenta previa complicated by placenta accrete spectrum disorder.

Methods: This retrospective study included 91 women who received CS for pernicious placenta previa complicated by placenta accrete spectrum, which was suggested by preoperative ultrasound and MRI assessment, and confirmed by operation or postoperative pathology. Preoperative ultrasonographic scores were > 6 in all patients.

Comprehensive pan-cancer analysis of HSPG2 as a marker for prognosis.

Background: In recent years, several studies have shown that HSPG2 is associated with the prognosis of specific cancers. The aim of this study was to investigate the prognostic value of HSPG2 in pan-cancer and to analyze its possible mechanisms.

Methods: We used The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) to explore the expression of HSPG2 in 33 tumors and corresponding controls.

Study of Low-Temperature (Al)GaN on N-Polar GaN Films Grown by MOCVD on Vicinal SiC Substrates.

N-polar GaN HEMTs feature a natural back-barrier and enable the formation of low-resistance Ohmic contacts, with the potential to suppress short-channel effects and current collapse effects at sub-100 nm gate lengths, rendering them particularly promising for high-frequency communication applications. In this study, N-polar GaN films were grown on C-face SiC substrates with a 4° misorientation angle via MOCVD. By employing a two-step growth process involving LT-GaN or LT-AlGaN, the surface roughness of N-polar GaN films was reduced to varying degrees, accompanied by an improvement in crystalline quality.

Fast and broadband spatial-photoresistance modulation in graphene-silicon heterojunctions.

Different types of devices with modulable resistance are attractive for the significant potential applications such as sensors, information storage, computation, etc. Although extensive research has been reported on resistance effects, there is still a need for exploring new mechanisms that offer advantages of low power consumption, high sensitivity, and long-term stability. Here, we report a graphene-Si based spatial-dependence photo-rheostat (SDPR), which enables bipolar resistance modulation in the range of 5 mm with a resistance sensitivity exceeding 1,000 Ω/mm at operating wavelengths from visible to near infrared band (1,550 nm).

Different treatment modalities on the prognosis of patients with stage I-IIIa small cell lung cancer: a population based study.

Background: Several studies have shown that surgery may improve prognosis in patients with limited-stage small cell lung cancer (LS-SCLC). This study aimed to compare the effects of different treatment modalities on lung cancer specific survival (LCSS) and overall survival (OS) in LS-SCLC patients.

Methods: The Surveillance, Epidemiology and End Results (SEER) database was used to identify patients diagnosed with LS-SCLC.

Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress.

Pulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-20) is a reproductive peptide first discovered in mice with potential suppressive properties against OS and inflammatory response. Our study will explore the possible therapeutic functions of PHN-20 against PAH for future clinical application.

Exploring the link between walking and lung cancer risk: a two-stage Mendelian randomization analysis.

Background: Previous observational research showed a potential link between physical activities such as walking and the risk of lung cancer. However, Mendelian randomization (MR) studies suggested there was no association between moderate to vigorous physical activity and lung cancer risk. We speculated that specific physical activities may be associated with lung cancer risk.

Difference in mortality risk predicted by leukocyte and lymphocyte levels in COVID-19 patients infected with the Wild-type, Delta, and Omicron strains.

This study aimed to investigate the changing trends, level differences, and prognostic performance of the leukocyte and lymphocyte levels of patients infected with the Wild strains, Delta strains and Omicron strains to provide a reference for prognostic assessment. In the current study, we conducted a retrospective cross-sectional study to evaluate the changing trends, level differences, and prognostic performance of leukocyte and lymphocyte of different strains at admission and discharge may already exist in patients with coronavirus disease-2019 (COVID-19) infected with the Wild type, Delta, and Omicron strains. A retrospective cross-sectional study was conducted.

Effect of White Noise Intervention Combined with Multi-dimensional Nursing Mode on Sleep Quality and Incidence of Nosocomial Infection in Patients Undergoing Hip Replacement.

Objective: To investigate the clinical effects of white noise intervention combined with multi-dimensional nursing mode in patients receiving hip replacement (HR).

Methods: The study selected the clinical data of 161 patients who underwent HR in our hospital from February 2020 to February 2022 for retrospective analysis. According to patients' willingness, they were divided into the study group (n = 77, receiving white noise intervention combined with multi-dimensional nursing mode) and the control group (n = 84, receiving routine nursing).

Mapping progressive damage epicenters in epilepsy with generalized tonic-clonic seizures by causal structural covariance network density (CaSCNd).

Aims: Mapping progressive patterns of structural damage in epilepsies with idiopathic and secondarily generalized tonic-clonic seizures with causal structural covariance networks and multiple analysis strategies.

Methods: Patients with idiopathic generalized tonic-clonic seizures (IGTCS) (n = 114) and secondarily generalized tonic-clonic seizures (SGTCS) (n = 125) were recruited. Morphometric parameter of gray matter volume was analyzed on structural MRI.

Fibrinogen as a potential diagnostic marker for prediction and evaluation of postpartum hemorrhage: a retrospective study.

Objective: To investigate whether prenatal fibrinogen (FIB) or other related factors could be utilized to evaluate the risk of postpartum hemorrhage (PPH).

Methods: A retrospective study was conducted in a database from January 2015 to December 2019. A total of 128 patients were enrolled and evaluated with FIB, in which 55 patients were assigned to low FIB and 73 in normal FIB.

Effects of Lianhuaqingwen Capsules in adults with mild-to-moderate coronavirus disease 2019: an international, multicenter, double-blind, randomized controlled trial.

Background: In a randomized trial, Lianhuaqingwen (LHQW) capsule was effective for accelerating symptom recovery among patients with coronavirus disease 2019 (COVID-19). However, the lack of blinding and limited sample sizes decreased the level of clinical evidence.

Objectives: To evaluate the efficacy and safety of LHQW capsule in adults with mild-to-moderate COVID-19.

Clinical Value of Platelets and Coagulation Parameters in Predicting the Severity of Delta Variant SARS-CoV-2.

Introduction: The present study aimed to analyze the clinical features and laboratory markers of patients with Delta variant SARS-CoV-2 and explore the role of platelet in predicting the severity of Delta.

Methods: This retrospective, observational study was conducted on 863 patients laboratory-confirmed Delta variant SARS-CoV-2. These cases were sub-classified based on disease severity into mild (n = 304), moderate (n = 537), and severe (n = 22).

Deletion of BACH1 alleviates ferroptosis and protects against LPS-triggered acute lung injury by activating Nrf2/HO-1 signaling pathway.

Multiple lines of evidences have unraveled the emerging role of ferroptosis in the pathophysiological process of acute lung injury (ALI). In this study, we aimed to decipher the role of BACH1 in the onset and progression of ALI with a focus on ferroptosis and elucidated potential molecular mechanism. We observed that BACH1 expression was drastically elevated in BEAS-2B cells upon exposure to LPS.

Computational study of metformin hydrochloride nucleation in hydroxylic solvents: Experimental kinetics and DFT simulation.

Metformin hydrochloride (MET-HCl) was applied as a model compound to investigate the nucleation behavior in four hydroxylic solvents based on the experimental and simulated methods. Over 320 induction time experiments were measured in four solvents, and the induction time increased in the order: water < methanol < ethanol < n-propanol. The metastable zone widths were determined with different cooling rates and saturation temperatures.

Photodynamic therapy for primary tracheobronchial malignancy in Northwestern China.

Background: Photodynamic therapy (PDT) has been routinely performed to treat tracheobronchial malignancy. However, the experience in tracheobronchial adenoid cystic carcinoma (ACC) and peripheral lung cancer is still insufficient. This study aimed to share the experience of PDT for patients with primary tracheobronchial malignancy, especially the adenoid cystic carcinoma and peripheral lung cancer, and evaluated the efficacy and safety of PDT in Northwestern Chinese patients.

Lymphocyte blood levels that remain low can predict the death of patients with COVID-19.

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been rapidly spreading on a global scale and poses a great threat to human health. However, efficient indicators for disease severity have not been fully investigated. Here, we aim to investigate whether dynamic changes of lymphocyte counts can predict the deterioration of patients with COVID-19.

TPD7 inhibits the non-small cell lung cancer HCC827 cell growth by regulating EGFR signalling pathway.

Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer cases, and is characterized by more insensitivity to chemotherapy and poor prognosis. Epidermal growth factor receptor (EGFR) has been confirmed as a tumorigenic driving factor of NSCLC. Taspine has been proved effective in the inhibition of malignant tumours.

High expression of PSMC2 promotes gallbladder cancer through regulation of GNG4 and predicts poor prognosis.

Gallbladder cancer (GBC) is a common malignant tumor of the biliary tract, which accounts for 80-95% of biliary tumors worldwide, and is the leading cause of biliary malignant tumor-related death. This study identified PSMC2 as a potential regulator in the development of GBC. We showed that PSMC2 expression in GBC tissues is significantly higher than that in normal tissues, while high PSMC2 expression was correlated with more advanced tumor grade and poorer prognosis.