Lactococcus formosensis and its metabolite 4-acetamidobutanoic acid induced caspase-11 dependent myenteric neuronal pyroptosis in intractable functional constipation.

Intractable functional constipation (IFC), a severe form of chronic constipation characterized by slow transit and resistance to conventional treatments, posed a significant clinical challenge. Here, we identified Lactococcus formosensis (Lf), a Gram-positive bacterium prevalent in IFC patients, as a novel contributor to intestinal motility impairment. Clinically, IFC patients exhibited increased colonic mucosal colonization of Lf and significant myenteric neuronal loss and pyroptosis, particularly in excitatory choline acetyltransferase (ChAT) neurons, but not inhibitory neuronal nitric oxide synthase (nNOS) neurons.

Dry Film Photoresist Enabled Sustainable Large-Area Manufacturing for Flexible Electronics.

Flexible electronics have attracted significant attention for their wide-range applications in flexible displays, human-machine interfaces, epidermal sensor systems, and biomedical engineering. Transfer printing serves as an effective approach to enable the manufacture of flexible electronics with high resolution, multiscale, and mass production features, which requires a lithographic process and the transfer of the devices from rigid substrates onto flexible substrates. However, typical wet transfer printing faces a series of challenges such as time consumption, instability of devices, and chemical solvent wastes, which cause harmful effects on the environment and health.

Insulin resistance as a mediator of the association between obesity, high-intensity binge drinking, and liver enzyme abnormalities in young and middle-aged adults: a cross-sectional study.

Background: Binge drinking (BD) and obesity are well-established risk factors for liver enzyme abnormalities, but how varying intensities of BD interact with obesity to affect liver function remains unclear. This study aims to examine whether insulin resistance (IR) mediates the associations between different levels of BD, obesity, their interaction, and liver enzyme abnormalities.

Methods: This cross-sectional study included 137,878 young and middle-aged adults who underwent physical examinations in southern China between August 2017 and March 2024.

Metagenomic analysis of algal-bacteria symbiosis system (ABSS) under aniline stress: Synergistic optimization of aniline degradation and nitrogen metabolism.

As an energy-efficient and environmentally friendly algae-bacteria symbiotic system (ABSS), the underlying mechanisms governing its response to aniline remained inadequately explored. To address this, our research conducted a metagenomics-bathe superior performance of an ABSS (R2) over conventional activated sludge (R1) for aniline wastewater treatment. Specifically, R2 exhibited more stable aniline and COD removal capabilities compared to R1, with a 20 % significant increase in total nitrogen removal efficiency.

A Skin-Like Transparent, Low-Hysteresis, and Highly Conductive Ionogel for Human Motion Monitoring and Deep-Learning Assisted Human-Machine Interface.

Human skin functions not only as a barrier but also as a sensitive interface responding to environmental stimuli. Skin-attachable conductive materials are gaining increasingly attention in the field of on-skin electronics for applications in health monitoring and human-machine interfaces (HMIs). However, achieving both low modulus and low hysteresis in skin-attachable conductive materials remains challenging.

Genetically supported causality between gut microbiota, prefrontal cortex and depression: insights from multiple Mendelian randomization, multi-omics analysis, and network pharmacology.

Background: Gut microbiota (GM) alterations have been implicated in depression, potentially mediated via changes in the prefrontal cortex (PFC). However, the causal relationship and underlying biological mechanisms remain unclear.

Methods: Summary statistics from genome-wide association studies (GWAS) of 473 GM (n = 5959), depression (43,280 cases, 329,192 controls), and 3935 brain imaging-derived phenotypes (IDPs) (n = 33,224) were utilized.

Sustainable Lithography Paradigm Enabled by Mechanically Peelable Resists.

Lithography is critical in micro- and nanofabrication processes, enabling the development of integrated circuits, semiconductor devices, and various advanced electronic and photonic systems. However, there are challenges related to sustainability, efficiency, and yield, as well as compatibility with transient electronics. This work introduces a sustainable lithography paradigm employing mechanically peelable resists compatible with existing cleanroom processes.

Harnessing diurnal dynamics: Understanding the influence of light-dark cycle on algal-bacterial symbiotic system under aniline stress.

To assess the inherent effects of light-dark cycle on the aniline degradation and nitrogen removal in algal-bacterial symbiotic system, three groups with different photoperiods (0L:12D;6L:6D;12L:0D) were set up. The results revealed that the aniline degradation rate of the three systems all surpassed 99 %, the total nitrogen removal rate of Z2-6L:6D was approximately 36 % higher than Z1-0L:12D eventually, the Z1-0L:12D was restrained by NH-N assimilation and nitrification while anoxic denitrification in Z3-12L:0D. The disappearance of microalgae biomass was accompanied by the sharp decreased of polysaccharide in Z1 and longer illumination suppressed the secretion of extracellular polymeric substances, the Z3 yielded slightly superior biomass production despite the double illumination compared with Z2.

Research on intensive nitrogen removal of municipal sewage by mainstream anaerobic ammonia oxidation process.

The anaerobic ammonia oxidation (anammox) process is a pivotal nitrogen removal technique, playing a significant role in the field of wastewater treatment. The paper commences by delineating the merits of the anammox process in comparison to conventional nitrification-denitrification techniques. Subsequently, it delves into the characteristics of different sludge morphologies process of the behavior of anammox bacteria and their reactions to environmental factors.

Phase-Change Stamp with Highly Switchable Adhesion and Stiffness for Damage-Free Multiscale Transfer Printing.

Transfer printing is a technology widely used in the production of flexible electronics and vertically stacked devices, which involves the transfer of predefined electronic components from a rigid donor substrate to a receiver substrate with a stamp, potentially avoiding the limitations associated with lithographic processes. However, the stamps typically used in transfer printing have several limitations related to unwanted organic solvents, substantial loading, film damage, and inadequate adhesion switching ratios. This study introduces a thermally responsive phase-change stamp for efficient and damage-free transfer printing inspired by the adhesion properties observed during water freezing and ice melting.

Follicular fluid-derived exosomal HMOX1 promotes granulosa cell ferroptosis involved in follicular atresia in geese (Anser cygnoides).

The proliferation and death of granulosa cells (GCs) in poultry play a decisive role in follicular fate and egg production. The follicular fluid (FF) contains a variety of nutrients and genetic substances to ensure the communication between follicular cells. Exosomes, as a new intercellular communication, could carry and transport the proteins, RNA, and lipids to react on GCs, which had been found in FF of various domestic animals.

Temporin-GHaR Peptide Alleviates LPS-Induced Cognitive Impairment and Microglial Activation by Modulating Endoplasmic Reticulum Stress.

Neuroinflammation is considered an important factor that leads to cognitive impairment. Microglia play a crucial role in neuroinflammation, which leads to cognitive impairment. This study aimed at determining whether temporin-GHaR peptide (GHaR) could improve cognitive function and at uncovering the underlying mechanisms.

Protein-enriched and anti-inflammatory dietary patterns, healthy lifestyle index and depressive symptoms: A cross-sectional study of 287,945 adults in China.

Objectives: Depressive symptoms have a considerable negative impact on mental health. This study aimed to understand the relationship between the protein-enriched and anti-inflammatory dietary index scores, modified healthy lifestyle index scores (Modified HLIS), and depressive symptoms.

Methods: This study used convenience sampling to conduct a single-center cross-sectional survey.

Bidirectional associations between dietary diversity and depressive symptoms in Chinese adult women: A retrospective cohort study.

Objective: This study aimed to examine the bidirectional associations between dietary diversity and clinical depressive symptoms in adult women, and influencing factors of clinical depressive symptoms.

Methods: This longitudinal study included a total of 22,385 participants, each of whom underwent at least two data collections. We used convenience sampling to recruit women from a health management center of a general hospital in southern China from April 2015 to December 2021.

Influence of metabolic syndrome and lifestyle factors on thyroid nodules in Chinese adult men: a cross-sectional study.

Introduction: Given the high prevalence of thyroid nodules and the potential for malignancy, it is imperative to understand the various factors that contribute to their development. This study aimed to explore the relationship between metabolic syndrome, lifestyle, and thyroid nodules in adult men in southern China.

Methods: This study enrolled a total of 183,990 subjects at a medical examination center in a general hospital in southern China between January 1, 2015, and December 31, 2020.

Construction and Validation of a Reliable Disulfidptosis-Related LncRNAs Signature of the Subtype, Prognostic, and Immune Landscape in Colon Cancer.

Disulfidptosis, a novel form of regulated cell death (RCD) associated with metabolism, represents a promising intervention target in cancer therapy. While abnormal lncRNA expression is associated with colon cancer development, the prognostic potential and biological characteristics of disulfidptosis-related lncRNAs (DRLs) remain unclear. Consequently, the research aimed to discover a novel indication of DRLs with significant prognostic implications, and to investigate their possible molecular role in the advancement of colon cancer.

Assessment on compatibility and safety of labels for pharmaceutical packaging.

Although the secondary packing materials do not directly contact the finished drug products, compound migration may still happen between them. To ensure drug quality and safety, extractables and leachables of the packing materials should be analyzed. In this study, 2,6-di-tert-butyl-4-methylphenol (BHT) was first found in the labels for pharmaceutical packaging.

Dry-Transferable Photoresist Enabled Reliable Conformal Patterning for Ultrathin Flexible Electronics.

Photolithographic techniques, which are widely used in the silicon-based semiconductor industry, enable the manufacture of high-yield and high-resolution features at the micrometer and nanometer scales. However, conventional photolithographic processes cannot accommodate the micro/nanofabrication of flexible and stretchable electronics. In this study, a microfabrication approach that uses a synthesized, environmentally friendly, and dry-transferable photoresist to enable the reliable conformal manufacturing of thin-film electronics is reported, which is also compatible with the existing cleanroom processes.

The moderating role of physical activity on the relationship between work intensity and depressive symptoms among the employees.

Our aim was to examine the associations between work intensity and depressive symptoms among the working population, as well as to identify the impact of physical activity (PA) on these relationships. Spearman correlation analysis was conducted to analyze the correlations among work intensity, PA, and depressive symptoms. Working hours and working days were positively correlated with depressive symptoms ( = 0.

The effects of modified problem-solving therapy on depression, coping, and self-efficacy in elderly nursing home residents.

Background: With the increasing trend of aging, the mental health problems of the elderly require urgent attention. Depression is a common psychological problem of the elderly, which affects their quality of life and physical health. Problem-solving therapy can effectively improve depression in the elderly, but there are few studies on problem-solving therapy for depression in the elderly in China.

Additional health education and nutrition management cause more weight loss than concurrent training in overweight young females.

Objective: This study aimed to compare the effect of concurrent training and the addition of health education and nutrition management on body composition and health-related outcomes.

Methods: Twenty-four healthy overweight females (20.42 ± 1.

Dietary diversity, physical activity and depressive symptoms among middle-aged women: A cross-sectional study of 48,637 women in China.

Objective: Depression is the leading cause of mental health-related disease burden. This study aimed to investigate the relationship among dietary diversity, physical activity and depressive symptoms in middle-aged women.

Method: Based on the WHO guidelines on physical activity, subjects who meet moderate-intensity aerobic physical exercise of 150-300 min per week were qualified or otherwise unqualified.

The prevalence of thyroid nodules and its factors among Chinese adult women: A cross-sectional study.

Objective: To determine the prevalence of thyroid nodules in Chinese adult women. To analyze the relationships between lifestyle, metabolic syndrome and thyroid nodules.

Methods: We conducted a retrospective cross-sectional study in the tertiary hospital from 2017 to 2019.