[Retracted] Chelerythrine chloride induces apoptosis in renal cancer HEK‑293 and SW‑839 cell lines.

[This retracts the article DOI: 10.3892/ol.2016.

CCPG1 involved in corneal infection.

Aim: To investigate whether non-canonical autophagy transport receptor cell cycle progression 1 (CCPG1) is involved in the corneal antifungal immune response.

Methods: Human corneal epithelial cells (HCECs) and human myeloid leukemia mononuclear cells (THP-1) macrophages stimulated by () were used as cell models. The expression of CCPG1 mRNA was detected by qRT-PCR.

Common variants in SCN10A gene associated with Brugada syndrome.

Genome-wide association studies indicate that SCN10A plays an important role in cardiac electrophysiology. Common and rare SCN10A variants are suggested to contribute to Brugada Syndrome (BrS), an inherited channelopathy resulting from genetic-determined loss-of-function in cardiac sodium channel. This study sought to characterize the role of SCN10A common variants in BrS.

[Removal of Antibiotics and Antibiotic Resistance Genes from Urban Rivers Using Artificial Ecosystems].

Four antibiotics[azithromycin (AZM), sulfamethoxazole (SMZ), ciprofloxacin (CIP), and tetracycline (TCY)], and the antibiotic resistance genes (ARGs)[sulfonamides ( and ), tetracyclines ( and ), quinolones ( and ), macrolides (), and 16S rDNA] were selected as target compounds. Artificial ecosystems were constructed with combinations of two emergent plants and (+, algae+, algae+, and algae++) in an indoor-simulated river system. Throughout the artificial ecosystems, changes in antibiotic concentrations and other pollution indicators (i.

A novel mutation KCNQ1p.Thr312del is responsible for long QT syndrome type 1.

Patients with high-risk long QT syndrome (LQTS) mutations may experience life-threatening cardiac events. The present study sought to characterize a novel pathogenic mutation, KCNQ1p.Thr312del, in a Chinese LQT1 family.

Assessing the environmental impact of phenanthrene in different types of land use based on the binding characteristics with dissolved organic matter.

The binding characteristics of phenanthrene with dissolved organic matter (DOM) were studied by the excitation emission matrix fluorescence spectroscopy with parallel factor analysis in four types of land use which derived from forest (F), meadow (M), cropland (C), and greenhouse (G). The results showed that the humification degree and binding characteristics of phenanthrene with DOM were distinct differences in the four soils. The binding capacities of humic-like components with phenanthrene were stronger than those of protein-like components.

Crucial Role of ROCK2-Mediated Phosphorylation and Upregulation of FHOD3 in the Pathogenesis of Angiotensin II-Induced Cardiac Hypertrophy.

Cardiac hypertrophy is characterized by increased myofibrillogenesis. Angiotensin II (Ang-II) is an essential mediator of the pressure overload-induced cardiac hypertrophy in part through RhoA/ROCK (small GTPase/Rho-associated coiled-coil containing protein kinase) pathway. FHOD3 (formin homology 2 domain containing 3), a cardiac-restricted member of diaphanous-related formins, is crucial in regulating myofibrillogenesis in cardiomyocytes.

Oxidative Stress-Induced Afterdepolarizations and Protein Kinase C Signaling.

Background: Hydrogen peroxide (H₂O₂)-induced oxidative stress has been demonstrated to induce afterdepolarizations and triggered activities in isolated myocytes, but the underlying mechanisms remain not fully understood. We aimed to explore whether protein kinase C (PKC) activation plays an important role in oxidative stress-induced afterdepolarizations.

Methods: Action potentials and ion currents of isolated rabbit cardiomyocytes were recorded using the patch clamp technique.

Haplodeficiency of activin receptor-like kinase 4 alleviates myocardial infarction-induced cardiac fibrosis and preserves cardiac function.

Cardiac fibrosis (CF), a repairing process following myocardial infarction (MI), is characterized by abnormal proliferation of cardiac fibroblasts and excessive deposition of extracellular matrix (ECM) resulting in inevitable resultant heart failure. TGF-β (transforming growth factor-β)/ALK5 (Activin receptor-like kinase 5)/Smad2/3/4 pathways have been reported to be involved in the process. Recent studies have implicated both activin and its specific downstream component ALK4 in stimulating fibrosis in non-cardiac organs.

Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines.

Previous studies have demonstrated that the benzo[c]phenanthridine alkaloid chelerythrine chloride (CC) has inhibitory effects on various tumors. However, the anticancer activity of CC and its underlying mechanisms have not been elucidated in renal cancer cells. The present study examined the effects of CC on growth inhibition and apoptosis of renal cancer cells and .

Antiarrhythmic effects and potential mechanism of WenXin KeLi in cardiac Purkinje cells.

Background: Previous studies have demonstrated that WenXin KeLi (WXKL), a traditional Chinese medicine, can exert antiarrhythmic properties through complex multichannel inhibition, but its pharmacologic effect remains to be elucidated, especially in the cardiac conductive system.

Objective: To explore the antiarrhythmic property of WXKL in cardiac Purkinje cells (PCs).

Methods: PCs were isolated from rabbit hearts and action potentials (APs) and ion currents were recorded by whole-cell patch clamp technique.

Semaphorin 3a transfection into the left stellate ganglion reduces susceptibility to ventricular arrhythmias after myocardial infarction in rats.

Aims: Myocardial infarction (MI) induces neural remodelling of the left stellate ganglion (LSG), which may contribute to ischaemia-induced arrhythmias. The neural chemorepellent Semaphorin 3a (Sema3a) has been identified as a negative regulator of sympathetic innervation in the LSG and heart. We previously reported that overexpression of Sema3a in the border zone could reduce the arrhythmogenic effects of cardiac sympathetic hyperinnervation post-MI.

[Research of Yuanhu Zhitong prescription based on strategy of integrative pharmacology].

Chinese medicinal formulae (CMF) were usually used in the clinics of traditional Chinese medicines (TCM), which were critical for modernization of Chinese medicine to shed light on the interaction between CMF and biological organisms. However, correlation between system and part, macroscopic actions and microcosmic mechanism, ADME process and pharmacologic actions were usually neglected. The put-forward of integrative pharmacology provided a feasible approach to solve the problem of the fragmentation of TCM.

Synthesis of ZnGa(2)O(4) Hierarchical Nanostructure by Au Catalysts Induced Thermal Evaporation.

In this paper, ZnGa(2)O(4) hierarchical nanostructures with comb-like morphology are fabricated by a simple two-step chemical vapor deposition (CVD) method: first, the Ga(2)O(3) nanowires were synthesized and employed as templates for the growth of ZnGa(2)O(4) nanocombs; then, the as-prepared Ga(2)O(3) nanowires were reacted with ZnO vapor to form ZnGa(2)O(4) nanocombs. Before the reaction, the Au nanoparticles were deposited on the surfaces of Ga(2)O(3) nanowires and used as catalysts to control the teeth growth of ZnGa(2)O(4) nanocombs. The as-prepared ZnGa(2)O(4) nanocombs were highly crystallized with cubic spinel structure.

The solid state phase transition of gallium particles and its size dependence.

Submicrometer-sized Ga particles were dispersed in polymethylmethacrylate (PMMA) matrix by an ultrasonic vibration and sedimentation method. The solid phase transition from γ-Ga to δ-Ga and its Ga particle size dependence were studied by means of differential scanning calorimeter measurements. It was shown that a solid-solid phase transition corresponding to the [Formula: see text]-Ga one happened in Ga particles upon cooling.