DNA methylation signature of oxidative stress and its mediating role in response to metal exposure.

Metal exposure could induce oxidative stress, yet the underlying epigenetic mechanisms remain unclear. Herein, we aimed to investigate the DNA methylation signatures associated with oxidative stress biomarkers, including 8-hydroxyguanine (8-OHdG) and 8-iso-prostaglandin-F2α (8-iso-PGF2α), and evaluate their mediating role in metal-induced oxidative stress. A genome-wide DNA methylation association study was conducted in discovery panel (Shiyan, N = 155) with validation in an independent replication panel (Wuhan-Zhuhai, N = 50).

Green dual-organic salt activation synthesis of hierarchical N, S co-doping artificial humic acid-derived porous carbon toward superior cadmium capture in asymmetric capacitive deionization.

Efficient hierarchical porous carbon (HPC) and heteroatom doping electrode materials remain a formidable challenge for advanced capacitive deionization (CDI) systems for cadmium-containing wastewater purification. This study reports the successful preparation of asymmetric CDI cathodes for the electrosorption of Cd by a controlled dual-organic-salt activation strategy, and its adsorption performance and underlying mechanism were comprehensively investigated. Compared with a single KCO activation strategy, incorporating CHNOSK during activation induced a chain activation-gas etching reaction, resulting in a carbon material with high heteroatom doping, exceptional specific surface area an optimized pore distribution, and abundant edge defects.

Postpartum acute intrauterine inversion: A case report.

Rationale: Uterine inversion is a rare and dangerous obstetric emergency, often occurring in the third stage of labor and leading to severe postpartum hemorrhage. It is less common in low-risk pregnant women, yet its prompt management is crucial. This case report fills a gap in the literature by presenting a rare instance in a low-risk young female, offering clinical insights.

Additives Tailored Design for More Durable Polyethylene Oxide-Based Solid Electrolytes: A Crucial Review.

Poly (ethylene oxide) (PEO)-based solid polymer electrolytes (SPEs) are considered one of the most promising electrolytes for all-solid-state lithium metal batteries (ASSLMBs) due to their satisfactory mechanical properties, superior processability, excellent flexibility, and thermal stability. However, the low ionic conductivity at room temperature, the undesired growth of lithium dendrites and solid electrolyte interphase chemistry at the Li/PEO-based SPEs interface, as well as facile decomposition under high-voltage conditions impede their further application. Currently, most researchers devote their interest to the incorporation of various fillers or molecular modification strategies to overcome the mentioned obstacle.

Omega‑3 Modify the Adverse Effects of Long-Term Exposure to Ambient Air Pollution on the Incidence of Chronic Obstructive Pulmonary Disease: Evidence from a Nationwide Prospective Cohort Study.

We aim to assess the modification effects of omega-3 polyunsaturated fatty acid (PUFA) levels on relationships between long-term air pollutants exposure and chronic obstructive pulmonary disease (COPD) risk. A total of 82,706 nonsmokers were finally included in the UK Biobank. The concentrations of circulating omega-3 PUFA (including total omega-3 and docosahexaenoic acid [DHA]) were measured by using a targeted high-throughput nuclear magnetic resonance metabolomics platform.

Silica-induced innate immune activation drives macrophage pyroptosis and lung inflammation through glycolytic reprogramming.

Prolonged inhalation of silica causes silicosis, characterized by persistent lung inflammation and irreversible fibrosis, but the mechanism has not been fully illuminated. In the present study, silicosis cases and healthy controls were employed to access the associations between Toll-like receptor 4 (TLR4) and silicosis risk. Silicosis mouse models and macrophage models were established to investigate whether the TLR4/NF-κB pathway drives pyroptosis through glycolytic reprogramming.

The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury.

The exact molecular mechanisms of coal workers' pneumoconiosis (CWP) are still unknown. The purpose of this study is to investigate how the lung microbiota may contribute to the development of CWP. The rats were divided into five groups, including the control group, CWP group, silicosis group, CWP + antibiotic group, and CWP + MCC950 group.

Long-Term Environmental Pyrethroid Exposure, Pregnane X Receptor, and Glucose Dyshomeostasis: Unveiling Relationship and Potential Mechanism via Integrated Approaches.

Pyrethroids are extensively used in agriculture and environmental sanitation, but the associations of long-term pyrethroid exposure with glucose dyshomeostasis and the underlying mechanisms remain unclear. This repeated-measures prospective study, comprising 6160 observations (4098 participants at baseline and 2062 participants at the six-year follow-up) from the Wuhan-Zhuhai cohort, measured serum pyrethroids and glucose metabolic traits to assess the cross-sectional and longitudinal associations of pyrethroid exposure with glucose dyshomeostasis. Network toxicological analyses and gene-environment interaction analyses were integrated to identify the underlying targets and mechanisms.

Using ventilation hood during cooking reduced household air pollution exposure and brought cardiometabolic and pulmonary health benefits: A community-based, cluster-randomized controlled intervention study.

Trial evidence is lacking from real-world community setting regarding whether use of ventilation hood during cooking could reduce household air pollution exposure and bring health benefits. We conducted a cluster-randomized controlled intervention study of using ventilation hood during cooking at five economically underdeveloped villages in southwest China over an 8-month period, where wood remained the dominant cooking fuel. We assessed changes in personal 24-h PM exposure and indicators of cardiometabolic and pulmonary health pre- to post-intervention among 115 intervention and 60 control participants.

Revealing the mechanisms of warfarin-induced vascular calcification through metabolomics and network toxicology.

Warfarin is widely used in clinical anticoagulation therapy, but the exact mechanism by which it induces vascular calcification (VC) remains unclear. This study aimed to explore the mechanisms of warfarin-induced VC using metabolomics and network toxicology approaches. Initially, normal rats were orally administered warfarin for 2 weeks, and VC was then assessed by serum biochemistry and histopathology.

[The impact of oral occlusal exercises on occlusal performance of oral cancer patients following segmental mandibulectomy without simultaneous reconstruction].

Purpose: To investigate the effects of oral occlusion exercises on occlusal performance of oral cancer patients who underwent segmental mandibular resection without simultaneous reconstruction.

Methods: From October 2022 to May 2023, a total of 63 oral cancer patients who underwent segmental mandibular resection without reconstruction at the Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were selected. They were randomly divided into control group (30 patients) and experimental group (33 patients).

The impacts of long-term carbon disulfide exposure on glucose homeostasis and type 2 diabetes: a multifaceted gene-environment-lifestyle interaction study of Chinese adults.

Introduction: The long-term impacts of exposure to carbon disulfide (CS), a highly concerning air toxicant listed by the Clean Air Act, and its interactions with genetic susceptibility and lifestyle on glucose homeostasis and type 2 diabetes (T2D) in the general population remain unclear and require urgent clarification.

Objectives: To investigate the interactions of CS exposure, genetic susceptibility, and lifestyle on glucose homeostasis and T2D.

Methods: In this prospective study, urinary CS metabolite (2-Thiothiazolidine-4-carboxylic acid, TTCA) and fasting plasma glucose (FPG) and insulin (FPI) for 5294 observations from 2523 participants were repeatedly measured to examine the cross-sectional and longitudinal associations of CS exposure with glucose homeostasis and T2D by performing generalized linear mixed models or COX models.

Sulfur-Rich Hole-Transporting Materials for Inverted Perovskite Solar Cells.

We introduce an electron-rich hole-transporting material (HTM), , based on a sulfur-rich terthiophene core. This HTM features two triphenylamine donor groups at the 4,4″ positions and four additional triphenylamine groups at the 5,5″ positions connected by vinylene linkages. Its good hole-transporting properties, reduced series resistance, and effective defect passivation contribute to the improved performance.

Volatile organic compounds exposure, biological ageing, and increased sarcopenia risk: Association, interaction, and mechanistic exploration.

Evidence on the impacts of volatile organic compounds (VOCs), a class of ubiquitous environmental toxics, on sarcopenia, a major age-related global health issue, remains scarce. Data from 3007 adults in the National Health and Nutrition Examination Survey (2011-2018) were analyzed to assess the individual and mixture effects of 16 VOCs metabolites (VOCMs) on sarcopenia using multivariate logistic regression, weighted quantile sum (WQS), and Bayesian kernel machine regression (BKMR) models. Network pharmacology was employed to explore potential underlying mechanisms.

Association of the Appendicular Skeletal Muscle Mass-to-Visceral Fat Area Ratio with Cause-Specific Mortality in Diabetes.

The relationship between muscle mass and visceral fat with mortality risk in diabetes has been extensively studied. This study investigates the association between the appendicular skeletal muscle mass-to-visceral fat area ratio (SVR) and cardiovascular and cancer-related mortality in diabetic patients in the United States. A nationwide cohort study was conducted using NHANES data (2011-2018), including 1439 diabetic patients with dual-energy X-ray absorptiometry (DXA) measurements.

Identification of synthetic lethality-associated subtypes and construction of risk model to predict breast cancer prognosis and immune characteristics.

Synthetic lethality has emerged as a pivotal concept in cancer therapy, offering novel and promising strategies for treatment. In this study, we identified molecular subtypes associated with synthetic lethality in breast cancer and developed a prognostic signature based on synthetic lethality-related genes. Using the TCGA cohort, we screened differentially expressed synthetic lethal genes (DESLGs) and stratified patients into two distinct molecular subtypes based on their expression patterns.

Arsenic exposure, genetic susceptibility, lifestyle, and glucose-insulin homeostasis impairment: Revealing the association and interaction in a repeated-measures prospective study.

Arsenic exposure, genetic factors, and lifestyle are individually associated with glucose-insulin homeostasis, yet no study focuses on their interactions. We aimed to investigate the combined effects and interactions of urinary total arsenic (UTAs), genetic susceptibility, and lifestyle on glucose-insulin homeostasis. We included 6136 and 5408 observations from the Wuhan-Zhuhai cohort for cross-sectional and longitudinal analyses, respectively.

Key challenges and coping strategies for the detection of bacteria at ultralow concentrations.

Bacterial contamination is often characterized by high infectivity, even at very low doses. Developing rapid, cheap, and simple methods to detect bacteria at ultralow-concentrations is essential for improving public health. Most of the published reviews are about particular detection principles, such as optical and electrochemical biosensors.

The relationship of fish oil supplements and plasma fatty acids with lung function decline.

Purpose: Fish oil supplements and plasma fatty acid levels were reported to be associated with lung function. We aimed to investigate the association of fish oil supplements and plasma fatty acids with lung function.

Methods: We included 248,133 participants with complete data on relative index of plasma fatty acids from the UK Biobank.

Low-dose cyclophosphamide combined with chinese herbal medicine Shuli Fenxiao formula for the treatment of intermediate-to-high risk primary membranous nephropathy.

Background: At present, the side effects of hormonal and immunosuppressant therapy for intermediate-to-high risk primary membranous nephropathy (PMN) are relatively large, and the remission rate is limited, so more safe and effective regimens are needed.

Methods: This study is a clinical prospective case series study. 31 patients were finally included.

Terthiophene-Based Dopant-Free Hole-Transporting Materials for Inverted Perovskite Solar Cells.

The interfaces of perovskite solar cells are essential for high power conversion efficiency and long-term stability. This study showcases two innovative materials, WZ40 and WZ102, triarylamine end-capped functionalized terthiophene derivatives. These materials serve as hole-transporting materials (HTMs), enabling the production of efficient mixed-halide inverted perovskite solar cells.

National Monitoring and Analysis of Internal Exposure of Nuclear Medicine Workers in I Treatment - China, 2021-2023.

What Is Already Known On This Topic?: Healthcare workers in I treatment facilities face potential occupational internal exposure through inhalation of volatile radioiodine, in addition to external exposure.

What Is Added By This Report?: This study presents the first comprehensive national monitoring data on internal exposure among Chinese nuclear medicine (NM) workers. Approximately one-fifth of personnel working at radioiodine treatment sites showed detectable levels of I in their thyroid tissue.

Relationship between serum uric acid and ventricular diastolic dysfunction in type 2 diabetes mellitus patients.

Objective: To investigate the correlation of serum uric acid (SUA) levels with ventricular diastolic dysfunction (DD) in the diabetic population.

Methods: Clinical data from 702 patients with type 2 diabetes mellitus (T2DM), including 394 males and 308 females, were retrospectively analyzed in this study. The data included demographic characteristics, biochemical test results, and echocardiography findings.

SVM-LncRNAPro: An SVM-Based Method for Predicting Long Noncoding RNA Promoters.

Long non-coding RNAs (lncRNAs) are closely associated with the regulation of gene expression, whose promoters play a crucial role in comprehensively understanding lncRNA regulatory mechanisms, functions and their roles in diseases. Due to limitations of the current techniques, accurately identifying lncRNA promoters remains a challenge. To address this challenge, we propose a support vector machine (SVM)-based method for predicting lncRNA promoters, called SVM-LncRNAPro.

The potential role of miR-450a-1-3p in chromium-associated heart rate variability reduction.

Chromium (Cr) exposure has been reported to be associated with heart rate variability (HRV) decline, whereas the underlying mechanism remains unknown. In present study, a cross-sectional study was conducted in Chinese urban adults to explore the potential role of microRNAs (miRNAs) in the relationship between urinary chromium and HRV decline. In the discovery stage, 20 Cr-related miRNAs were screened out by high-throughput sequencing.