Efficacy and Safety of Sarecycline in Chinese Patients with Moderate-to-Severe Acne Vulgaris: Randomized Phase 3 Clinical Trial with Open-Label Follow-Up.

Introduction: This study aimed to evaluate the efficacy and safety of sarecycline in Chinese patients with moderate-to-severe acne vulgaris (AV).

Methods: The 12-week (W) randomized, multicenter, double-blind (DB), placebo-controlled phase 3 trial was conducted from 29 October 2021 to 14 October 2022 at 34 centers in China, with a 36W open-label follow-up (OLFU) until 23 June 2023 for patients who responded to treatment during the DB period. Patients aged 9-45 years with AV were randomized (2:1) to sarecycline (approximately 1.

Multifunctional Molecular Agent for Tau-targeted Combinational Therapy of Alzheimer's Disease.

Tau aggregation inhibitors or neurotoxic-metal chelators have been extensively studied as potential treatment for Alzheimer's disease. However, it is a great challenge to improve their therapeutic effects while reducing neurotoxicity. Herein, we designed and synthesized two new compounds, (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis((3,4,5-trihydroxyphenyl)methanone) (4GA) and (4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diyl)bis((3,4,5-trihydroxyphenyl)methanone) (2GA).

The microbial metabolite isovaleric acid aggravates gelatinase-mediated periodontal tissue destruction via the NF-κB signaling pathway.

Background: Isovaleric acid, an important short-chain fatty acid, can be generated by subgingival microbial fermentation of a leucine-rich diet, such as Porphyromonas gingivalis. This study aimed to explore the impact of isovaleric acid on the destruction of periodontal tissues and to investigate the underlying mechanisms.

Methods: The level of isovaleric acid in the saliva of clinical subjects was measured via mass spectrometry.

Cardiovascular and Kidney Outcomes After Systemic Treatment for Plaque Psoriasis: A Systematic Review and Network Meta-analysis.

Introduction: Systemic immunomodulatory treatments may affect cardiovascular and renal outcomes in patients with chronic plaque psoriasis. We conducted a network meta-analysis (NMA) to compare these outcomes of systemic treatments for plaque psoriasis.

Methods: Databases were searched from inception through June 1, 2023.

Polysaccharide from Prinsepia utilis Royle maintains the skin barrier by mediating differentiation, lipid metabolism and tight junction of keratinocyte.

Prinsepia utilis Royle (PUR) exhibits moisturizing, antioxidative, and antibacterial properties, supporting skin barrier integrity. Nevertheless, the molecular mechanisms underlying these effects remain unclear. This study investigates the role of polysaccharide from PUR (PUR-P) in keratinocyte differentiation, lipid metabolism, tight junction, and skin barrier repair, focusing on PPARα involvement.

Inequality in infrastructure access and its association with health disparities.

Economic, social and environmental infrastructure forms a fundamental pillar of societal development. Ensuring equitable access to infrastructure for all residents is crucial for achieving the Sustainable Development Goals, yet knowledge gaps remain in infrastructure accessibility and inequality and their associations with human health. Here we generate gridded maps of economic, social and environmental infrastructure distribution and apply population-weighted exposure models and mixed-effects regressions to investigate differences in population access to infrastructure and their health implications across 166 countries.

Visible-Light-Driven Selective Mineralization of Organohalides on Spatially Close Au Single-Atom and Nanocluster Neighbors Over Poly(Heptazine Imides).

Organohalides are commonly found pollutants with long-term persistence in industrial wastewater and drinkable water. Although these pollutants only constitute a small portion of the total organic carbon (TOC), they contribute major toxicity, posing a threat to ecosystem, biodiversity, and public health. Selective removal of organohalides from wastewater/drinkable water is costly due to the orders of magnitude lower concentration of organohalides as compared to interferences.

Minocycline inhibits rosacea-like inflammation through the TLR4-mediated NF-κB signaling pathway in vivo and in vitro.

Background: Rosacea is a chronic inflammatory skin disease characterized by multiple intricate pathogenic factors. Previous studies have substantiated the anti-inflammatory properties of minocycline and its potential therapeutic efficacy in treating rosacea. However, further elucidation of the underlying mechanism is warranted.

Branched-chain amino acids promote gelatinase secretion from human periodontal ligament stem cells through nuclear factor kappa-B signaling.

Objective: To explore the effects of branched-chain amino acids (BCAAs) on periodontal tissues and regulation of gelatinase secretion by human periodontal ligament stem cells (hPDLSCs).

Design: The salivary BCAA levels (leucine, isoleucine, and valine) in the clinical participants were measured using mass spectrometry. A local injection model in the periodontium of Sprague Dawley rats was established to investigate the periodontal destruction induced by BCAAs.

Circadian rhythm disruption promotes M1 macrophages polarization exacerbating the inflammatory response in rosacea.

To explore the role of macrophage polarization induced by circadian rhythm disorder (CRD) in the aggravated inflammatory response of rosacea. The rosacesis-like animal model was established by intradermal injection of Cathelicidin antimicrobial peptide LL-37 (LL37) into the back of mice. HE staining, Western blot and immunofluorescence detection were used to investigate the effect of circadian rhythm disorder on the expression of inflammatory factors and macrophage polarization in rosacea.

Asymmetric photooxidation of glycerol to hydroxypyruvic acid over Rb-Ir catalytic pairs on poly(heptazine imides).

Selective asymmetric oxidation of glycerol (GLY) to hydroxypyruvic acid (HPA) offers an attractive approach for chiral drug synthesis, but this process is highly challenging. Here we develop a photocatalytic method to achieve heterogeneous selective photooxidation of GLY to HPA over rubidium (Rb) and iridium (Ir) catalytic pairs decorated on a poly(heptazine imide) framework. The Rb sites effectively adsorb GLY molecules through the terminal -OH groups, thus inhibiting their oxidation during photoreaction, while the Ir sites enhance the oxygen reduction reaction and the in situ generated surficial oxygen-reduction radicals on Ir can protect the reactive C-centred radical intermediates produced during photooxidation.

Fibroblast growth factor 8 (FGF8) induces mitochondrial remodeling in chondrocytes via ERK/AMPK signaling pathway.

Osteoarthritis (OA) is a disease characterized by articular cartilage degeneration, and its pathogenic mechanisms are associated with mitochondrial homeostasis disorders. Fibroblast growth factor 8 (FGF8) is a multipotent protein ligand which is upregulated in OA cartilage. However, the molecular mechanisms by which FGF8 regulates mitochondria in chondrocytes are not yet fully understood.

Abrocitinib alleviates the symptoms of Netherton syndrome and is well tolerated.

Purpose: To investigate the potential genetic basis of Netherton syndrome (NS) through first- and second-generation DNA sequencing techniques. Additionally, we evaluated the therapeutic efficacy of Abrocitinib in NS patients.

Materials And Methods: We conducted whole-exome sequencing analysis on a pedigree comprising one affected individual with NS.

Mechanistic Insights into Glycerol Oxidation to High-Value Chemicals via Metal-Based Catalysts.

The oxidation of glycerol offers a valuable route for producing high-value chemicals. This review provides an in-depth analysis of the current advancements and mechanistic insights into novel metal-based catalysts for glycerol oxidation. We discuss the catalytic roles of both precious metals (e.

Evaluation of factors associated with adult skeletal fluorosis in coal-burning type of endemic fluorosis and initial screening model based on machine learning in Guizhou, Southwest China.

Skeletal fluorosis caused by coal-burning type endemic fluorosis greatly affects the health of the population in the affected areas, but large-scale diagnostic work is limited by human and material resources, making it difficult to implement comprehensively. In this study, we investigate adults in coal-burning type endemic skeletal fluorosis areas in Guizhou. The study areas are selected by a comprehensive analysis of the detection rate of dental fluorosis in children aged 8-12 years in Guizhou for the year 2023.

NLRP3-inflammasome Related Genes as Emerging Biomarkers and Therapeutic Targets in Psoriasis.

The NLRP3 inflammasome is closely associated with inflammatory diseases, including psoriasis. Objective diagnostic biomarkers and alternative therapies for psoriasis remain limited. We aimed to identify reliable biomarkers for the diagnosis of psoriasis and investigate potential therapy strategies.

Electroacupuncture regulates FTO/Nrf2/NLRP3 axis-mediated pyroptosis in cerebral ischemia-reperfusion injury.

Electroacupuncture (EA) demonstrates neuroprotective in cerebral ischemia-reperfusion (I/R) injury. N6-methyladenosine (m6A) is found to contribute to the pathogenesis of neurological conditions recently. The objective of this study is to investigate the effects of EA on m6A and related mechanism in cerebral I/R injury.

Assessment of adverse events of the novel antiepileptic drug lamotrigine: a real-world pharmacovigilance study based on FAERS.

Background: Lamotrigine (LTG), a medication frequently prescribed for epilepsy. Despite its widespread use, there remains a lack of clarity regarding the drug's safety profile when used over extended periods in large patient populations. This study evaluated the safety profile of LTG using the FDA Adverse Event Reporting System (FAERS), aiming to enhance clinical decision-making.

Elevated Type 2 Inflammatory Factors, Th2/Th1 Balanced Status, and Exosomes as a Marker of Severity in Chronic Actinic Dermatitis.

Chronic actinic dermatitis (CAD) is a skin inflammation triggered by light exposure, occurring at the exposed site and potentially causing widespread inflammation throughout the body. While we hypothesize that severe CAD could progress to atopic dermatitis, the exact inflammatory mechanisms and pathogenesis remain unclear. We aimed to investigate the relationships between CAD severity and clinical and immunological parameters.

Modulation of Single-Iron-Atom Coordination Environment Toward Three-Electron Oxygen Reduction for Photocatalytic CH Conversion to CHOH.

By modifying the coordination environment of single-Fe-atom active site, effective regulation of the photocatalytic oxygen reduction pathway can be achieved to attain high activity for photocatalytic oxidation of CH to CHOH in an aqueous solution. A comprehensive investigation is conducted to study the impact of different coordination numbers of single Fe atoms on photocatalytic CH oxidation reaction over carbon nitride. Among which, Fe/CN with a Fe-N3 coordination exhibit an exceptional photocatalytic performance in CH oxidation, reaching a remarkable methanol yield of 928.

Significance of HLA-B*15 in three pemphigus patients with rituximab-triggered severe cutaneous drug reactions.

Introduction: Rituximab, a CD20 inhibitor, has swiftly become the primary treatment for pemphigus patients.

Aim: We present 3 cases of pemphigus patients who had undergone rituximab treatment.

Material And Methods: After the second intravenous administration of rituximab, the primary rash developed into severe cutaneous drug reactions.

Effects of HIV exposure on anemia and vitamin D nutritional status in children aged 6-24 months: a hospital-based cross-sectional study.

There is little research on anemia and vitamin D deficiency in HIV-exposed uninfected (HEU) children. This study was aimed to describe and compare the prevalence of anemia and vitamin D inadequacy in HEU children and HIV-unexposed uninfected (HUU) children, and to examine the associations of HIV exposure with anemia and vitamin D inadequacy. This was a hospital-based descriptive cross-sectional study nested within the Prevention of Mother-to-Child Transmission (PMTCT) of HIV program in Hunan Province during July and September 2022.

Effectiveness and safety of full-thickness versus circular muscle myotomy in peroral endoscopic myotomy: a retrospective single-center analysis of 152 patients.

Background: Achalasia is a primary esophageal motility disorder, which shows impaired relaxation of the lower esophageal sphincter (LES) and the absence of peristalsis, leading to dysphagia, weight loss, and chest pain. In recent years, peroral endoscopic myotomy (POEM) has become a popular method for treating achalasia. However, the effectiveness and safety of full-thickness myotomy (FTM) versus circular muscle myotomy (CMM) in POEM require further investigation.

Highly electroactive thiazolium [5,4-d]thiazol-2,5-dicarboxylic acid-silver electrochemiluminescent metal-organic frameworks: synthesis, properties and application in glutathione detection.

Thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid (HThz), a thiazolothiazole (TTz) derivative with carboxylic acid groups, was synthesized as a ligand for the creation of five MOFs, each associated with distinct metal ions including Ag, Mn, Co, Zn, and Cu. The cathodic electrochemiluminescence (ECL) of HThz and the resulting MOFs was investigated. HThz was found to generate ECL signals, but this process was heavily reliant on potassium persulfate (KSO) as a co-reactant.