Integrative network pharmacology and multi-omics reveal anisodamine hydrobromide's multi-target mechanisms in sepsis.

Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integrated network pharmacology, machine learning, immunological profiling, molecular simulations, and single-cell transcriptomics to elucidate Ani HBr's multi-target actions.

Association between statins use and mortality in critically ill patients with sepsis included myocardial injury: a retrospective cohort study.

Background: The treatment of patients with sepsis included myocardial injury (SIMI) remains a subject of debate. Given the pharmacological effects of statins in both sepsis and cardiovascular disease, this study aimed to investigate the association between statins use and the prognosis of SIMI.

Methods: Patients with SIMI were primarily identified from the MIMIC-IV database.

Machine learning models for predicting in-hospital mortality from acute pancreatitis in intensive care unit.

Background: Acute pancreatitis (AP) represents a critical medical condition where timely and precise prediction of in-hospital mortality is crucial for guiding optimal clinical management. This study focuses on the development of advanced machine learning (ML) models to accurately predict in-hospital mortality among AP patients admitted to intensive care unit (ICU).

Method: Our study utilized data from three distinct sources: the Medical Information Mart for Intensive Care III (MIMIC-III), MIMIC-IV databases, and Beijing Chaoyang Hospital.

Prevalence of sarcopenia and its association with frailty and malnutrition among older patients with sepsis-a cross-sectional study in the emergency department.

Background: Studies on the prevalence of sarcopenia and its relationship with other geriatric syndromes among older patients with sepsis in the emergency department (ED) are scarce. This study aimed to investigate the prevalence of sarcopenia among older patients with sepsis and explore its association with specific geriatric symptoms: frailty and malnutrition.

Methods: This cross-sectional study was carried out in China from January to November 2022.

Machine Learning-Based Mortality Risk Prediction Model in Patients with Sepsis.

Objective: The aim of our study was to establish and validate a machine learning-based predictive model for mortality risk in elderly patients with sepsis. By integrating traditional biomarkers, novel biomarkers, clinical data, and established scoring systems, the model seeks to enhance predictive accuracy and thereby improve clinical outcomes in high-risk patient population.

Methods: Conducted at Beijing Chao-Yang Hospital from August 2021 to August 2023, our study included 180 emergency department patients meeting Sepsis 3.

Predictive Value of Serum β2-Microglobulin for 28-Day Mortality in Sepsis Patients in the Emergency Department.

Background: Sepsis is an infection-induced systemic inflammatory response syndrome with high morbidity and mortality. β2-microglobulin (β2-MG), a low-molecular-weight protein involved in immune processes, shows potential for predicting the prognosis of various diseases. However, its role in sepsis prognosis remains unclear, necessitating further exploration.

Neutralization of IL-33 ameliorates septic myocardial injury through anti-inflammatory, anti-oxidative, and anti-apoptotic by regulating the NF-κB/STAT3/SOCS3 signaling pathway.

Septic myocardial injury, a severe sepsis complication linked to high morbidity and mortality, remains a major global clinical challenge. Interleukin-33 (IL-33), a damage-associated pro-inflammatory factor, has been implicated in regulating immune responses and inflammation, but its specific role in septic myocardial injury has not been fully elucidated. This study examined IL-33's role in septic myocardial injury using Gene Expression Omnibus (GEO) database datasets, alongside in vitro and in vivo experiments.

Clinical significance and immune infiltration analyses of the coagulation factor V gene in brain lower grade glioma.

Background: Coagulation factor V (FV) is an essential cofactor in the coagulation cascade. However, the precise function of FV in lower grade glioma (LGG) is little known.

Methods: We first performed a pan-cancer investigation of FV expression and prognosis using TCGA and GTEx databases.

A survey of emergency medicine physicians' knowledge, attitude, and practice towards esophagogastric variceal bleeding.

Background: Esophageal-gastric variceal bleeding (EVB) is one of the leading causes of mortality in patients with cirrhotic portal hypertension. Rapid, accurate, and effective emergency care is crucial for successful patient outcomes.

Aims: This study aims to evaluate the knowledge, attitudes, and practices of Chinese emergency physicians regarding EVB, with the goal of improving the diagnosis and treatment of gastrointestinal bleeding in emergency settings.

Correction: Zhang et al. Deficiency of S100A9 Alleviates Sepsis-Induced Acute Liver Injury through Regulating AKT-AMPK-Dependent Mitochondrial Energy Metabolism. . 2023, , 2112.

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The independent predictive value of admission serum ferritin concentration for prognosis in elderly patients with community-acquired pneumonia in the emergency department.

Background: Community-acquired pneumonia (CAP) poses a significant health threat to the elderly population, leading to high morbidity and mortality rates. Serum ferritin, a critical indicator of iron metabolism, plays a pivotal role in inflammation and immune regulation. Nevertheless, its specific prognostic relevance in elderly patients with CAP remains unclear.

Heart failure subphenotypes based on mean arterial pressure trajectory identify patients at increased risk of acute kidney injury.

Background: Acute kidney injury (AKI) is a common complication in heart failure (HF) patients. Patients with heart failure who experience renal injury tend to have a poor prognosis. The objective of this study is to examine the correlation between the occurrence of AKI in heart failure patients and different mean arterial pressure (MAP) trajectories, with the goal of improving early identification and intervention for AKI.

Predictive value of IL-8 for mortality risk in elderly sepsis patients of emergency department.

Background: Sepsis significantly impacts morbidity and mortality, particularly among older adults. Despite extensive research, early recognition and prognosis prediction of sepsis remain challenging. IL-8, a chemokine produced by inflammatory cells like monocytes and endothelial cells, has shown potential in predicting mortality in sepsis patients, though its role in elderly sepsis remains unexplored.

Anthropometrics and cancer prognosis: a multicenter cohort study.

Background: Anthropometric indicators have been shown to be associated with the prognosis of patients with cancer. However, any single anthropometric index has limitation in predicting the prognosis.

Objectives: This study aimed to observe the predictive role of 7 anthropometric indicators based on body size on the prognosis of patients with cancer.

Diagnostic and prognostic significance of apelin-13, APJ for sepsis in the emergency department: A prospective study.

Objectives: This study aimed to assess the diagnostic, risk stratification, and prognostic capabilities of apelin-13 and APJ in comparison to procalcitonin (PCT) for septic patients presenting to the emergency department (ED).

Methods: Two hundred and thirty-eight patients meeting the Third International Consensus Definition (Sepsis-3) criteria were enrolled from Beijing Chaoyang Hospital's ED, along with a control group of forty healthy individuals. Patients were categorized into two groups based on disease severity: those with sepsis or septic shock.

ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway.

Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a neuroprotective factor due to its anti-inflammatory and antioxidant properties. However, the role of ACE2 on myeloid cells in regulating SAE and the underlying mechanism warrants further exploration.

The Role of AGGF1 in the Classification and Evaluating Prognosis of Adult Septic Patients: An Observational Study.

Purpose: Angiogenic factor with G patch and FHA domains 1 (AGGF1) is a crucial angiogenic factor that is involved in a variety of diseases and in the regulation of inflammatory responses. However, its role in sepsis is poorly understood. We have investigated the role of AGGF1 in the classification and prognostic evaluation of adult septic patients in a clinical context.

Persistent high sepsis-induced coagulopathy and sequential organ failure assessment scores can predict the 28-day mortality of patients with sepsis: A prospective study.

Background: The performance of the sepsis-induced coagulopathy (SIC) and sequential organ failure assessment (SOFA) scores in predicting the prognoses of patients with sepsis has been validated. This study aimed to investigate the time course of SIC and SOFA scores and their association with outcomes in patients with sepsis.

Methods: This prospective study enrolled 209 patients with sepsis admitted to the emergency department.