AIE functionality ratiometric fluorescent probe based on quinoline-malononitrile for detection of ONOO and its application in bioimaging.

Peroxynitrite (ONOO), a highly reactive endogenous reactive oxygen species (ROS), plays pivotal roles in diverse physiological and pathological processes, the development of sensitive and reliable strategy for efficiently detecting ONOO is helpful to understand its biological functions in biological systems. Here, a novel AIEgen fluorescent probe QM-NP was developed by utilizing quinoline-malononitrile fluorophore as the light-emitting core and aryl borate moiety as the specific ONOO recognition group. Upon reaction with ONOO, QM-NP exhibits remarkable ratiometric fluorescence response with a distinct emission shift from red (630 nm) to green (540 nm), with higher specificity for ONOO compared to other analytes (ROS and RNS), rapid response (<10 s) and high sensitivity (LOD = 1.

Tetraaryl-functionalized hydrazine-responsive fluorescent materials with aggregation-induced emission and Photochromism for chemical sensing and time-dependent dynamic anti-counterfeiting.

Multi-stimulus-responsive materials, leveraging their dynamic tunability, demonstrate transformative potential in intelligent sensing and advanced anti-counterfeiting applications. These materials employ multimodal coordination mechanisms to perceive composite environmental stimuli simultaneously. For instance, by integrating photochromic properties with chemically responsive strategies, they enable innovative technical pathways for constructing multifunctional detection platforms and high-security anti-counterfeiting systems, thereby addressing challenges in real-time environmental monitoring and information protection.

Molecular engineering of bis(triphenylamine)-modified fluorene luminophore for immensely enriching anisotropic force-triggered high-contrast tricolor fluorescent molecular switches library.

The preparation of anisotropic mechanical force-triggered high-contrast tricolor fluorescent solid switches is both significant and extremely challenging. Herein, we report a high-efficiency molecular engineering strategy for developing mechanochromic compounds that exhibit an infrequent yet contrasting three-color fluorescence switching feature. Notably, 14 new symmetric fluorescent molecules by introducing a variety of substituents on either side of the central organic moiety involving 4,4'-((9-fluoren-9-ylidene)methylene)bis(,-diphenylaniline) are successfully obtained, and 10 new fluorogenic compounds have been discovered to exhibit seldom-observed tricolored mechanofluorochromic phenomena.

Naphthalimide-based luminogens with bright aggregative-state emission: High-contrast blue-shift mechanofluorochromism and application in ink-free secure information storage.

In recent decades, with the advancement of the field of organic luminescent materials, mechanofluorochromic materials with aggregation-induced emission (AIE) properties have become a pioneering research hotspot due to their excellent photophysical properties and wide range of applications. Herein, a series of carbazole-naphthalamide (CN-R) type derivatives containing different benzene ring substituents and their isomers were designed and synthesized. The fluorescence of the donor-acceptor type derivatives could be modulated through the introduction of diverse benzene ring substituents.

A diarylethene-based probe with HSO-activated fluorescence to photochromism: Its imaging application in living cells and zebrafish.

Sulfur dioxide (SO) and its derivatives (sulfite SO and bisulfite HSO) have important applications in industrial production and food preservation, but excessive intake can be hazardous to human health. Therefore, the development of highly sensitive and selective HSO detection methods is essential to safeguard food safety and public health. Conventional HSO probes mainly rely on colorimetric or fluorescence detection, but these methods have obvious limitations in that the fluorescence signal disappears as soon as the UV irradiation is stopped, and they cannot provide long-lasting and readable detection results.

AIE-based dual-ratiometric chemosensor for detection of sulfur dioxide derivatives and viscosity and its application in food samples and biological imaging.

Background: SO is an important gas molecular messenger that participates in many physiological activities and helps maintaining the redox homeostasis in biological system. Especially, SO can effectively regulate oxidative stress and improve mitochondrial morphology. Abnormal mitochondrial viscosity can lead to a variety of diseases.

A novel AIEgen fluorescent probe based on quinoline-malononitrile for monitoring and imaging ClO and viscosity in biosystem.

Hypochlorite (ClO) and viscosity play a pivotal role in biological immune defense systems, it has been demonstrated that alterations in ClO may link to the modifications in intracellular viscosity. Consequently, it is crucial to develop a tool that can accurately assess these changes of ClO and viscosity concurrently. In this work, a dual-responsive fluorescent probe QM-WV based on the ICT effect for simultaneous detection of ClO and viscosity was constructed.

Photo-responsive color/fluorescence efficient dual-switching properties of diarylethene modified Eu-doped ZnO@Silane quantum dots.

Photo-responsive switches are very promising materials due to their potential applications in many fields. However, photo-controlled color/fluorescence dual-switching with higher modulation efficiency has rarely been reported. Herein, two new optical responsive switches were constructed by Eu-doped ZnO@Silane quantum dots (Eu:ZnO@Silane QDs) and two diarylethenes.

AIE luminogens based on 9, 10-dithienylanthracene with a D-A-D structure: Design, synthesis and application in cell imaging.

Three novel D-A-D-structured emitters derived from 9, 10-dithienylanthracene derivatives (DTAs) were synthesized and characterized. These DTAs consist of substituted 9-phenyl-9H-carbazole (BPCB-DTA), triphenylamine (BTPA-DTA) and N, N-dimethylaniline (BDMA-DTA) as donor units, with the phenylacetonitrile group serving as the acceptor. The impact of steric hindrance and electronic effect of the substituents on the optical properties has been thoroughly discussed.

Rational Construction of a Pyrimido[2,1-b] Benzothiazole-Based Photoswitchable Smart AIE Material: A Theoretical Insight into Fluorescence Switching Mechanism of the Chimeric Dyad.

Currently, AIEgen-photochromics conjugates and intrinsic photochromic AIEgens are the two major molecular design strategies for photoresponsive AIE materials. However, these two strategies still have their own limitations. In our previous research, we discovered pyrimido[2,1-b][1,3]benzothiazole (PBT) as a novel core structure of AIEgens.

A turn-on mitochondria-targeted iridium (Ⅲ) Complex-Based probe for glutathione detection and photodynamic therapy of cancer cells.

As one of the most abundant biothiols in cells, glutathione (GSH) usually exists in a dynamic equilibrium of oxidized glutathione (GSSG) and reduces glutathione redox, and plays an essential reducing substance to maintain the REDOX balance of the microenvironment. So, the development of a reliable GSH sensor will be important for living cells and organisms. We fabricated a mitochondria targeted "turn-on" fluorescent sensor based on Ir (III) complex and successfully detected endogenous and exogenous GSH in living cells and zebrafish.

Phytic Acid Functionalized Hierarchical Porous Metal-Organic Framework Microspheres for Efficient Extraction of Uranium from Seawater.

Uranium is a critical resource in the development of nuclear energy, and its extraction from natural seawater has been identified as a potential solution to address uranium resource shortages. In this study, hierarchical meso-/micro- porous metal-organic framework functionalized with phytic acid (PA) microspheres (denoted H-UiO-66-PA) are rationally synthesized for efficient uranium extraction. This unique design allowed for a large adsorption capacity and fast adsorption kinetics, making it a promising material for uranium extraction.

A europium (III) functionalized hydrogen-bonded organic framework for sensitively ratiometric fluorescent sensing of tetracycline.

As a kind of antibiotic, tetracycline (TC) might remain in animal blood and milk products during use, which poses a risk to humans after consumption. Therefore, a ratiometric fluorescence probe was proposed for the detection of TC, which was based on an Eu functionalized hydrogen-bonded organic framework (HOF). Since there are a large number of N and O atoms in the skeleton of HOF, more Eu could be loaded onto HOF by forming coordinate bonds, while preserving the fluorescence of luminol monomer in HOF.

Rh(III)-catalyzed [4 + 1] annulation of 1-arylindazolones with alkynyl cyclobutanols: access to indazolo[1,2-]indazolones.

A convenient and efficient synthesis of structurally diverse indazolo[1,2-]indazolones a Rh(III)-catalyzed [4 + 1] annulation of 1-arylindazolones with alkynyl cyclobutanols has been achieved by combining C-H and C-C bond cleavage. This cascade reaction features readily available starting materials, good functional group tolerance, broad substrate scope, and excellent atom-economy.

Tetraphenylethene-based mononuclear aggregation-induced emission (AIE)-active mechanofluorochromism gold(I) complexes with different auxiliary ligands.

In this study, a series of tetraphenylethene-containing gold(I) complexes with different auxiliary ligands have been synthesized. These complexes were characterized using a variety of techniques including nuclear magnetic resonance spectroscopy, mass spectrometry, and single crystal X-ray diffraction. Their aggregation-induced emission (AIE) behaviors were investigated through ultraviolet/visible and photoluminescence spectrum analyses, and dynamic light scattering measurements.

Rapidly responsive and highly selective NIR fluorescent probe for detecting hydrogen sulfide in food samples and living cells.

Hydrogen sulfide (HS) is a pungent gas that is one of the key mediators of signal transduction in biological systems, and its presence is related to the freshness of some protein foods. Using phenothiazine derivatives as fluorophores and 2, 4-dinitrobenzene sulfonate (DNBS) fragments as reaction groups, a near-infrared (NIR) probe WX-HS for HS identification was designed. With the addition of HS, WX-HS appeared a strong fluorescence signal at 660 nm with short reaction time (90 s) and high sensitivity, and fluorescence state change from non-fluorescent to orange-red.

A mitochondrial targeted dual ratiometric near-infrared fluorescent probe based on ICT effect for the detection of SO derivative and its bioimaging.

SO derivatives play an important role in many metabolic processes, excessive ingestion of them can lead to serious complications of various diseases. In this work, a novel dual ratiometric NIR fluorescent probe XT-CHO based on ICT effect was synthesized for detecting SO derivative. In the design of the probe, the α, β-unsaturated bond formed between benzopyran and coumarin was used as the reaction site for SO, meanwhile, the extended π-conjugate system promoted maximum emission wavelength of the probe up to 708 nm.

Construction of hierarchical porous and polydopamine/salicylaldoxime functionalized zeolitic imidazolate framework-8 controlled etching for uranium adsorption.

Efficient uranium extraction from seawater is critical for the development of the nuclear industry. Herein, a polydopamine/salicylaldoxime decorated hierarchical zeolitic imidazolate framework-8 (H-PDA/SA-ZIF-8) is constructed by using a controlled etching process. Benefiting from the combination of PDA/SA and the zeolitic imidazolate framework-8 (ZIF-8), as well as a controlled etching process, the H-PDA/SA-ZIF-8 possesses multiaffinity sites, excellent specific surface area (1234.

Near-infrared fluorescent probe for detection of hydrogen sulfide in water samples and food spoilage.

Hydrogen sulfide (HS) is a common toxic gas that threatens the quality and safety of environmental water and food. Herein, a new near-infrared fluorescent probe DTCM was synthesized and characterized by single crystal X-ray diffraction for sensing HS. It exhibited a remarkable "turn-on" near-infrared (NIR) emission response at 665 nm with a remarkably massive Stokes shift of 175 nm, super-rapid detection ability (within 30 s), excellent photostability, high selectivity and sensitivity (limit of detection, LOD = 58 nM).

Mechanistic insights into diversified photoluminescence behaviours of BF complexes of -benzoyl 2-aminobenzothiazoles.

Many BF complexes of heteroaromatics are well known for their dual-state emission (DSE) properties. However, AIE and ACQ effects have also been observed in certain cases. To date, no rational explanations have been proposed for these uncommon photoluminescence (PL) behaviours.