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Article Abstract
Hypochlorite (ClO) and viscosity play a pivotal role in biological immune defense systems, it has been demonstrated that alterations in ClO may link to the modifications in intracellular viscosity. Consequently, it is crucial to develop a tool that can accurately assess these changes of ClO and viscosity concurrently. In this work, a dual-responsive fluorescent probe QM-WV based on the ICT effect for simultaneous detection of ClO and viscosity was constructed. QM-WV exhibited a signally turn-on fluorescence signal at 552 nm for ClO with favorable selectivity. Meanwhile, QM-WV displayed an exceptional 'off-on' fluorescence response at 650 nm to viscosity changes in glycerol-ethanol system. More importantly, QM-WV is capable of visually detecting ClO by using smartphone as a portable signal processing device. Based on its low cytotoxicity and stability under physiological conditions, QM-WV further enabled the detection and imaging of ClO and viscosity in HeLa cells and zebrafish.
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| http://dx.doi.org/10.1016/j.saa.2025.126176 | DOI Listing |
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