Publications by authors named "Shaowei Han"
Pseudobulbs of Pleione bulbocodioides have been used as traditional Chinese medicine for a long time to treat cancers through decoction with water. However, as its main water-soluble ingredient, the structure of polysaccharide has not been elucidated yet. To obtain its polysaccharide with antitumor activity, a series of isolation, structural identification and antitumor evaluation experiments were performed.
View Article and Find Full Text PDFManganese inhibits HBV transcription and promotes HBsAg degradation at non-toxic levels.
Int J Biol Macromol
November 2024
Chronic hepatitis B virus (HBV) infection continues to pose a significant global health challenge. However, therapeutic measures for a cure are lacking in clinical practice. Manganese, an essential trace element, has garnered attention due to its potential to activate innate immune pathways and its significant role in antiviral and antitumor immunity.
View Article and Find Full Text PDFArticle Synopsis
- Scientists in Southern China studied three different treatments for a stomach infection called Helicobacter pylori (HP) in people who had never been treated before.
- They compared the effectiveness of two vonoprazan therapies and one bismuth therapy over 14 days.
- Both vonoprazan treatments worked almost as well as bismuth therapy, but with fewer side effects.
Development of potent pan-coronavirus fusion inhibitors with a new design strategy.
MedComm (2020)
August 2024
Development of potent and broad-spectrum drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains one of the top priorities, especially in the cases of the emergence of mutant viruses and inability of current vaccines to prevent viral transmission. In this study, we have generated a novel membrane fusion-inhibitory lipopeptide IPB29, which is currently under clinical trials; herein, we report its design strategy and preclinical data. First, we surprisingly found that IPB29 with a rigid linker between the peptide sequence and lipid molecule had greatly improved α-helical structure and antiviral activity.
View Article and Find Full Text PDFArticle Synopsis
- H. pylori infections are a significant global health issue, linked to gastric cancer and various ulcers, with a notable prevalence in China, where new treatments are necessary due to high infection rates.
- The study compares the effectiveness and safety of two new VPZ-based therapies against the traditional BI-based quadruple therapy for treating H. pylori, involving 327 participants in Shenzhen.
- Participants undergo random assignment to one of the three treatment regimens and follow-up assessments to evaluate treatment success and safety, with adjustments made if initial treatments are ineffective.
Conductive hydrogels exhibit high potential in the fields of wearable sensors, healthcare monitoring, and e-skins. However, it remains a huge challenge to integrate high elasticity, low hysteresis, and excellent stretch-ability in physical crosslinking hydrogels. This study reports the synthesis of polyacrylamide (PAM)-3-(trimethoxysilyl) propyl methacrylate-grafted super arborized silica nanoparticle (TSASN)-lithium chloride (LiCl) hydrogel sensors with high elasticity, low hysteresis, and excellent electrical conductivity.
View Article and Find Full Text PDFArticle Synopsis
- Nine new compounds called pleionosides M-U and 12 known compounds were extracted from the pseudobulbs of a certain plant.
- The structures of these compounds were determined using advanced techniques like high-resolution electrospray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR).
- Some of these new compounds demonstrated significant protective effects on liver cells against specific toxicities, improving cell viability substantially compared to the control group.
Article Synopsis
- Researchers identified 13 new phenanthrene and bibenzyl derivatives, named blestanols A-M, from the tubers of Bletilla striata, alongside 12 known compounds, using spectroscopic analysis to determine their structures.
- 15 compounds were isolated into enantiomers through chiral-phase HPLC, and their configurations were confirmed with optical rotation measurements and electronic circular dichroism (ECD) comparisons.
- Many of these compounds demonstrated potential as anti-inflammatory and anti-cancer agents, with various levels of inhibition on nitric oxide production and selective cytotoxic effects against several cancer cell lines.
Article Synopsis
- The study explores how nonmetallic inclusions in 304 stainless steel evolve during heat treatment at 1250 °C over different time intervals (0, 30, 60, and 120 minutes).
- The research finds that the density of inclusions initially increases and then decreases, while their average size follows an opposite trend.
- Furthermore, chromium oxide (CrO) content in the inclusions rises with heat treatment time, which increases their melting points but decreases their plasticity, highlighting the significance of Ostwald ripening in the process.
Article Synopsis
- About 17 compounds were isolated from a 60% ethanol extract of Clematis hexapetala roots, including three new guaianolide sesquiterpenoids and five new prenylated phenolic glycosides.
- The chemical structures of these new compounds were identified using spectroscopic data and modified Mosher's method, with insights into their potential biosynthetic pathways.
- In vitro tests revealed that compound 16 showed moderate inhibition of TNF-α secretion and significant activity against PTP1B, with inhibition ratios of 48.30-86.00%.
Article Synopsis
- Two new compounds, pleionosides K and L, were discovered from the pseudobulbs of a specific orchid species, and their structures were thoroughly characterized using advanced analytical techniques.
- The study explored the possible biosynthetic pathways for these compounds and discussed their formation.
- Both pleionosides exhibited moderate protective effects on liver cells against damage from acetaminophen and showed antioxidant activity in nerve cells, improving cell survival rates in tests.
Article Synopsis
- Researchers discovered four new compounds (Bulbocodioidins E-H) from the pseudobulbs of Pleione bulbocodioides, alongside four known compounds.
- The structures of these compounds were determined using high-resolution mass spectrometry and advanced NMR techniques, while their configurations were confirmed through ECD analysis.
- Notably, compound 4a exhibited significant cytotoxic effects against various cancer cell lines, with IC values indicating effectiveness against colon, liver, and breast cancer, while compound 6 was specifically effective against breast cancer cells.
Phenanthrenequinone enantiomers with cytotoxic activities from the tubers of Pleione bulbocodioides.
Org Biomol Chem
January 2019
Article Synopsis
- Eight new phenanthrenequinones, labeled bulbocodioidins A-D, were extracted from the tubers of Pleione bulbocodioides.
- The structural details and configurations of these compounds were determined using advanced NMR analysis and ECD data.
- The cytotoxic effects of the compounds were tested on various human cancer cell lines, with compounds 1a and 4a showing significant cytotoxic activity.
Structural characterization and immunological activity of polysaccharides from the tuber of Bletilla striata.
Int J Biol Macromol
February 2019
Two water-soluble polysaccharides, BSP-1 and BSP-2, were extracted and purified from the tuber of Bletilla striata. The molecular weights of BSP-1 and BSP-2 were 83.54 kDa and 12.
View Article and Find Full Text PDFTen previously undescribed glucosyloxybenzyl succinate derivatives, pleionosides A-J, and fifteen known compounds were isolated from the pseudobulbs of Pleione bulbocodioides (Franch.) Rolfe. Their structures were elucidated by a combination of MS and NMR data, physical and chemical methods and a comparison with known compounds.
View Article and Find Full Text PDFNew dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus.
J Asian Nat Prod Res
November 2018
Article Synopsis
- Three new compounds, called cyclocariosides O, P, and Q, were discovered from the leaves of the plant Cyclocarya paliurus.
- These compounds belong to a class of chemicals known as dammarane triterpenoid saponins.
- The structures of these new saponins were determined using various spectroscopic techniques.
Article Synopsis
- The study examines the thermodynamics of the interaction between Inconel 718 alloy and specific slags (CaF-CaO-AlO-MgO-TiO) over a temperature range of 1773 to 1973 K.
- It was found that as temperature increased, aluminum content in the alloy rose while titanium content decreased, highlighting key factors that influence oxidation in the superalloy.
- A new method for analyzing the reaction kinetics was developed to avoid contamination issues from traditional sampling methods, leading to accurate determination of mass transfer coefficients and reaction rates between aluminum, titanium, and their oxides.
Article Synopsis
- Eighteen chemical compounds were extracted from the plant Bletilla striata using techniques like silica gel chromatography and RP-HPLC.
- The structures of these compounds were determined using various spectroscopic methods and their physical properties.
- Notably, compound 1 is a new discovery, while compounds 2-6, 9, and 15-18 are being reported from this genus for the first time.
[Studies on glucosyloxybenzyl 2-isobutylmalates of Pleione bulbocodioides].
Zhongguo Zhong Yao Za Zhi
March 2015
Article Synopsis
- Ten new compounds, including glucosyloxybenzyl 2-isobutylmalates and a benzyl alcohol glycoside, were extracted from the dry tuber of the orchid Pleione bulbocodioides, commonly used in traditional Chinese medicine.
- The extraction utilized various chromatography methods like ODS, macroporous adsorbent resin, Sepheadex LH-20, and preparative HPLC.
- Structures of the compounds were determined through chemical evidence and spectroscopic analysis, with seven of these compounds being isolated for the first time from this plant genus.
Article Synopsis
- Fourteen compounds were extracted from the Pleione bulbocodioides plant using various chromatographic techniques, revealing a mix of phenanthrenes, dihydrophenanthrenes, bibenzyls, a lignan, and a sterol.
- The structures of these compounds were identified through spectroscopy, leading to the discovery of new compounds including monbarbatain A and blestriarene A.
- Notably, compounds 1-3, 9, 13, and 14 were isolated from this plant genus for the first time, expanding the understanding of its chemical properties.