Antigenic and structural insights into a Henipavirus attachment glycoprotein.

The novel henipavirus, Langya henipavirus (LayV), was identified in China in 2022. The invasion of host cells by the henipavirus is facilitated through the interaction between viral attachment (G) and fusion (F) glycoproteins with receptors on the cell surface. The G proteins of LayV and Mojiang virus (MojV) exhibit high amino acid homology (86%), while they are located in a unique evolutionary clade within the Henipavirus genus.

Single amino acid substitution in Hendra virus attachment glycoprotein induces cross-neutralizing antibodies against Nipah virus.

Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses within the Paramyxoviridae family, causing severe respiratory and neurological diseases in humans and animals with fatality rates up to 75%, and no licensed human vaccines or therapeutics. In this study, we identified a unique vulnerable epitope on the NiV attachment glycoprotein (G) recognized by the potent neutralizing antibody 14F8, which targets a receptor-binding site and neutralizes NiV effectively. Using the 2.

Immunogenicity of differentially glycosylated Marburg virus glycoproteins expressed in mammalian and insect cells.

Marburg virus (MARV) infection can cause severe disease, and there is no available vaccine or therapeutic method. Research into potential vaccine design is focused on the glycoprotein (GP), which mediates the adherence and invasion process of the virus. However, it is unclear whether the degree of GP glycosylation is associated with vaccine efficacy.

MBD2 deficiency attenuates CCl-induced hepatic fibrosis by inhibiting M2 macrophage polarization.

Purpose: Methyl-CpG-binding domain protein 2 (MBD2) serves as a pivotal reader of DNA methylation and has been linked to fibrosis in the kidney and lung. However, its role and the underlying mechanisms in liver fibrosis remain unclear.

Materials And Methods: Hepatic fibrosis (HF) was induced in C57BL/6 mice using carbon tetrachloride (CCl).

A systematic review on the impact of social support on college students' wellbeing and mental health.

In recent years, growing attention has been directed toward undergraduate students' mental health and overall well-being. The transition to university life, coupled with academic and social demands, has been shown to strain students' psychological functioning considerably. Social support is often cited as a protective factor that can help mitigate these pressures; however, in-depth investigations focusing specifically on this relationship within the college student demographic remain relatively limited.

Ozone rectal insufflation inhibits the development of atherosclerosis in ApoE-/-mice, which is mediated by the regulation of gut microbiota and metabolites.

Introduction: Atherosclerotic cardiovascular disease is the world's leading cause of death. Researches have proven that ozone therapy can effectively inhibit the development of atherosclerosis; however, the underlying mechanisms remain unclear. This study aims to explore how ozone rectal insufflation (O3-RI) prevents atherosclerosis.

Inhibits Ferroptosis and Mitophagy to Alleviate Heart Failure by Activating .

Background: Heart failure (HF) continues to represent a significant global public health concern. Transient receptor potential cation channel subfamily V member 1 () is a calcium-permeable channel that has been linked to cardiac disease and function. However, its significance in HF and underlying processes is unknown.

A validated predictive model for mid- and long-term mortality risk assessment after elective endovascular repair in abdominal aortic aneurysm patients.

Background: Risk scoring systems for open surgical repair of abdominal aortic aneurysm (AAA) may overestimate mortality after endovascular aneurysm repair (EVAR). A model for mid-term and long-term mortality after EVAR is still lacking.

Material And Method: MEDLINE, Embase and WOS were searched from January 1, 2000 to December 31, 2022.

AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway.

Obesity poses serious health risks and is trending younger, developing effective strategies to prevent obesity is crucial. Calcium intake is a potential strategy to reduce weight/fat, as it generally enhances the body's energy metabolism. However, calcium's effects on appetite and its specific mechanisms remain unclear.

The gut-brain axis mechanism of normal appetite induced by kynurenic acid.

Feeding is essential for both host-organism survival and gut-microbiota maintenance. Our research focuses on how kynurenic acid (KYNA), a gut-microbiota metabolite, regulates appetite during fasting. We find that fasting significantly raises KYNA levels in the intestine, which increases short-term food intake by inhibiting vagal afferent nerve in the nodose ganglion (NG) and activating AgRP neurons in arcuate nucleus (ARC).

Mediating effect of AI attitudes and AI literacy on the relationship between career self-efficacy and job-seeking anxiety.

As artificial intelligence (AI) technology quickly grows, college students have new worries and fears. Using Marx's theory of labour alienation, this study explores the complex relationship between college students' job-seeking anxiety (JSA) and career self-efficacy (CSE) in the context of the AI era. A structural equation modeling (SEM) study of data from 455 Chinese students indicates that CSE adversely affects JSA.

Research on the traceability and treatment of nitrate pollution in groundwater: a comprehensive review.

The preservation of groundwater quality is essential for maintaining the integrity of the water ecological cycle. The preservation of groundwater quality is crucial for sustaining the integrity of the water ecological cycle. Nitrate (NO) has emerged as a pervasive contaminant in groundwater, attracting significant research attention due to its extensive distribution and the potential environmental consequences it poses.

Longitudinal Trajectories of Psychological Resilience and Cognitive Impairment Among Older Adults: Evidence From a National Cohort Study.

Objectives: The relationship between resilience trajectories and cognitive health is not well understood. This study aimed to identify clusters of psychological resilience trajectories in a national sample of older adults and to examine the association with cognitive impairment over time.

Methods: This study used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2008 to 2018, and 2,788 respondents were included in this prospective analysis.

Structure-guided design of a prefusion GPC trimer induces neutralizing responses against LASV.

Lassa virus (LASV) belongs to the Arenaviridae family and causes severe hemorrhagic fever in humans. Although many vaccine candidates for Lassa fever exist, no vaccines have been approved for clinical use currently. The precursor glycoprotein complex (GPC), which is expressed as a trimer on the viral surface, is the main target for vaccine development.

Epitope-focused vaccine immunogens design using tailored horseshoe-shaped scaffold.

The continuous emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants highlights the need to update coronavirus 2019 disease (COVID-19) vaccine components. Epitope-based vaccine designs targeting conserved and immunorecessive regions of SARS-CoV-2 are critically needed. Here, we report an engineered epitope-focused immunogen design based on a novel horseshoe-shaped natural protein scaffold, named ribonuclease inhibitor 1 (RNH1), that can multiply display of conserved neutralizing epitopes from SARS-CoV-2 S2 stem helix.

The role of B cells in the pathogenesis of type 1 diabetes.

Type 1 diabetes (T1D) is a metabolic disorder caused by a complete lack of insulin, primarily manifested by hyperglycemia. The mechanisms underlying the onset of T1D are complex, involving genetics, environment, and various unknown factors, leading to the infiltration of various immune components into the islets. Besides T cells, B cells are now considered important contributors to the pathogenesis of T1D, according to recent studies.

Evaluation of the impact of continuous nursing and cluster nursing on carpal tunnel syndrome release surgery.

Background: This study aimed to estimate the influence of continuous and cluster nursing on carpal tunnel syndrome (CTS) release surgery.

Methods: Ninety-six patients with CTS were treated in our hospital from November 2019 to December 2021. These patients were randomly divided into two groups of 48 patients.

Early Diagnosis of Bloodstream Infections Using Serum Metabolomic Analysis.

Background: Bloodstream infections (BSIs) pose a great challenge to treating patients, especially those with underlying diseases, such as immunodeficiency diseases. Early diagnosis helps to direct precise empirical antibiotic administration and proper clinical management. This study carried out a serum metabolomic analysis using blood specimens sampled from patients with a suspected infection whose routine culture results were later demonstrated to be positive.

High-rate nitrogen and phosphorus removal in a sulfur and pyrrhotite modified foam concrete constructed wetland.

In order to develop constructed wetland (CW) with high-rate N and P removal, sulfur and pyrrhotite modified foam concrete (SPFC) was prepared and used as a substrate to construct CW (SPFC-CW). At hydraulic retention time 6 h, SPFC-CW achieved effluent total nitrogen (TN) 9.96 mg/L and PO-P 0.

Foam FeSO modified limestone sulfur concrete for non-stink and high-rate nitrogen and phosphorus removal from wastewater.

Aiming at disadvantages of conventional sulfur-limestone autotrophic denitrification system, such as producing stink (HS) and low-rate nitrogen and phosphorus removal from wastewater with low C/N, foam FeSO modified limestone sulfur concrete (FFLSC) was prepared. Experimental parameters of FFLSC biofilter, such as hydraulic retention time (HRT), influent NO-N, additional alkalinity and COD addition, were tested. For wastewater without COD, FFLSC biofilter could simultaneously remove TON (NO-N+NO-N) from 22.

Investigating the causal relationship between immune factors and ankylosing spondylitis: insights from a Mendelian Randomization study.

Background: Despite previous studies indicating a close relationship between immune system and ankylosing spondylitis (AS), the causal relationship between them remains unclear.

Methods: Genome-wide association data were utilized to explore the causal link between 731 immune cells and AS using a bidirectional two-sample MR approach. The data included immune cell data from Orrù et al.

Gut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora.

In this editorial, we comment on Liu s article published in the recent issue of the . Biochemically and pathologically, Liu proved that the urate-lowering activity of leech total protein (LTP) was mainly attributed to the rectification of gut microbiota. Specifically, we noticed the change in and after LTP administration.

The relationship between dietary vitamin B1 intake and severe abdominal aortic calcification among the general population in the United States.

Background: Vitamin B1 deficiency is closely associated with vascular system damage, but the relationship between dietary vitamin B1 intake and abdominal aortic calcification (AAC) remains unclear and warrants further investigation.

Methods: 2,640 participants from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were included in the study. Severe AAC was defined as Kauppila score >5.

Peripheral molecular and brain structural profile implicated stress activation and hyperoxidation in methamphetamine use disorder.

Aim: Methamphetamine use disorders (MUDs) cause widespread disruptions in metabolomic and immunologic processes, highlighting the need for new therapeutic approaches. The purpose of this study was to find molecular and neuroimaging biomarkers for methamphetamine addiction.

Methods: In this study, we recruited 231 patients with MUD at varying stages of withdrawal and 40 healthy controls to quantify the blood levels of 52 molecules using enzyme-linked immunosorbent assay.