Facial Verrucous Epidermal Nevus with pruritus: Successfully treated with photodynamic therapy.

Verrucous epidermal nevus (VEN) is uncommon and is typically present at birth. The disorder is essentially cosmetic and is found more often in females which features were brown and skin-colored verrucous papules or plaques distributed linearly along Blaschko's lines. VEN on the face often adversely affect the patient's self-esteem.

Electrochemically Driven Nickel-Catalyzed Synthesis of Aryl Alkyl Ketones by the Cross-Coupling of Carboxylic Esters with Alkylpyridinium Salts.

An electrochemical Ni-catalyzed reductive cross-coupling of arylcarboxylic esters with alkylpyridinium salts has been developed. Various aryl alkyl ketones are obtained in good to excellent yields (up to 86% yield). The reaction tolerated a variety of primary alkylpyridinium salts, including substrates with protic functional groups and derivatives of bioactive molecules.

Sowing date optimization mitigates cadmium accumulation in rice-ratoon rice cropping systems.

Background: Cadmium (Cd) contamination in rice has become a global issue. However, limited information exists regarding the impact of sowing dates on Cd accumulation in ratoon rice (RR) and its associated health risks. This study involved a two-season field experiment on rice-ratoon rice, which was conducted on a mildly Cd-contaminated soil in southern China.

Electrochemical Site-Specific Dehydrogenative Hydroxyalkylation of Purine Nucleosides with Alcohols.

An electrochemical protocol for C-selective hydroxyalkylation of purine nucleosides with alcohols via direct C(sp)-C(sp) cross-coupling was established. The protocol employed -Hydroxyphthalimide (NHPI) as a hydrogen atom transfer mediator, yielding C-hydroxyalkyl purine nucleosides in moderate to excellent yields. This electrochemical method is distinguished by its mild oxidant-free conditions, good regioselectivity, readily available raw materials, and validity for the late-stage modification of bioactive molecules.

Evaluating the effects of ecological water replenishment on lake water exchange in semi-arid regions insights from an 11-year modeling study.

Under the combined impacts of climate change and human activities, lakes in arid and semi-arid regions are universally confronting critical challenges including water scarcity, surface area shrinkage, and water quality deterioration. As one of the principal measures for ecological restoration of irrigation-district lakes, ecological water replenishment projects have been widely implemented. However, given the inherent complexity of lacustrine systems, the efficacy of ecological water replenishment in enhancing water quality and hydrological exchange capacity remains scientifically contentious.

Strategic attenuation of Cd accumulation in rice through stage-specific flooding: Synergistic coordination of rhizospheric Cd bioavailability, microbial communities, and iron plaque speciation.

Continuous flooding (CF) effectively mitigates rice cadmium (Cd) contamination but raises concerns about water scarcity and greenhouse gas emissions, limiting sustainability. Therefore, there is a need for water management strategies that can reduce Cd accumulation in rice without the substantial resource demands of CF. Field trials conducted in Cd-contaminated paddy fields in southern China compared eight water management strategies, including continuous drainage (CD), stage-specific flooding, and CF, to identify alternatives for reducing rice Cd accumulation.

Multi-isotope tracer for identifying nitrate sources in shallow groundwater in a large irrigation area, China.

Nitrate pollution of groundwater associated with anthropogenic activities and social development is a global issue, especially in agricultural regions. This study investigated the source and fate of nitrate in groundwater of the Jiaokou Irrigation Area using chemical and isotopic fingerprints (isotope tracing, graphical analysis, and d-excess) in combination with end-member mixing analysis (EMMA). The hydrochemical analysis revealed that the NO concentration exceeds 20 mg/L (calculated as N) in approximately 66.

Mitochondrial dysfunction in Alzheimer's disease: a key frontier for future targeted therapies.

Alzheimer's disease (AD) is the most common neurodegenerative disorder, accounting for approximately 70% of dementia cases worldwide. Patients gradually exhibit cognitive decline, such as memory loss, aphasia, and changes in personality and behavior. Research has shown that mitochondrial dysfunction plays a critical role in the onset and progression of AD.

Progress in mitochondrial and omics studies in Alzheimer's disease research: from molecular mechanisms to therapeutic interventions.

Alzheimer's disease (Alzheimer's disease, AD) is a progressive neurological disorder characterized by memory loss and cognitive impairment. It is characterized by the formation of tau protein neurofibrillary tangles and β-amyloid plaques. Recent studies have found that mitochondria in neuronal cells of AD patients exhibit various dysfunctions, including reduced numbers, ultrastructural changes, reduced enzyme activity, and abnormal kinetics.

Quantification of the provenance contribution and sedimentary mixing effect of sediments in the Yellow River Basin, China.

Quantifying the source contributions of sediments in large fluvial systems with active wind erosion problems has crucial implications for understanding morphological evolution and ecological progression in the Earth system. Much effort have been focused on characterizing sediments of the Yellow River, but quantitation of the sediment source proportions at the basin-wide scale is lacking. To this end, the research aims to quantitatively elucidate the potential source contributions of sediments in the Yellow River based on geochemical characteristics and sediment fingerprinting technique, in order to identify sedimentary mixing effect and propose sustainable development strategies.

Efficacy and safety of intravitreal injection of conbercept for moderate to severe nonproliferative diabetic retinopathy.

Purpose: This study aimed to assess the effectiveness and safety of intravitreal injection of conbercept (IVC) in treating moderate to severe nonproliferative diabetic retinopathy (NPDR), with or without accompanying diabetic macular edema.

Methods: In this longitudinal retrospective study, 35 patients (50 eyes) with moderate to severe NPDR and Diabetic Retinopathy Severity Scale (DRSS) scores between 43 and 53 were treated at the Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, from October 2018 to January 2023. Treatment protocol included three monthly IVC injections followed by a (PRN) regimen over a two-year follow-up period.

The impact on Cd bioavailability and accumulation in rice (Oryza sativa L.) induced by dry direct-seeding cultivation method in field-scale experiments.

Dry direct-seeded rice cultivation has gained popularity and expanded its cultivated area due to reduced labor requirements and water consumption. However, the impact of this cultivation method on cadmium (Cd) bioavailability in soil and the accumulation levels in grains remains uncertain. Field experiments were conducted in acidic soils at two locations in southern China to compare rice varieties and evaluate the dry direct-seeding method alongside the wet direct-seeding and traditional transplanting methods.

The role of serum-glucocorticoid regulated kinase 1 in reproductive viability: implications from prenatal programming and senescence.

Objective: Organisms and cellular viability are of paramount importance to living creatures. Disruption of the balance between cell survival and apoptosis results in compromised viability and even carcinogenesis. One molecule involved in keeping this homeostasis is serum-glucocorticoid regulated kinase (SGK) 1.

Photodynamic therapy combined with CO laser for the treatment of seborrheic keratosis in the auricle: A case report.

Seborrheic keratosis(SK) is a very common skin tumor which is mostly frequently observed in the trunck, head, neck. SK in the auricle is rare and this condition should be excluded the possibility of malignancy by pathologic diagnosis. We report a case of 66-year-old man who presented with a brownish, papillomatous, verrucous mass in the auricle for the past seven years, which began to growing faster during the previous year.

Recombinant Human Adenovirus Type 5 (H101) Intra-Tumor Therapy in Patients with Persistent, Recurrent, or Metastatic Cervical Cancer: Genomic Profiling Relating to Clinical Efficacy.

Objective: Genomic profiles relating to H101 treatment-induced alterations are yet to be achieved. Here, we evaluated the impact of H101 via exome-sequencing approaches aiming to probe for potential biomarkers that are actionable in the treatment of persistent/recurrent/metastatic (P/R/M) cervical cancer.

Methods: Whole exome sequencing (WES) was performd on paired pre- and post-H101 samples from 17 P/R/M cervical cancer patients who received serial intra-tumor injections of H101.

Salinization of shallow groundwater in the Jiaokou Irrigation District and associated secondary environmental challenges.

Understanding groundwater salinization of irrigation areas and related secondary environmental challenges is important for ensuring sustainable development. However, the mechanism under which groundwater salinization forms under the influence of long-term anthropogenic activities remains unclear. Therefore, this study analyzed the spatiotemporal variation in groundwater salinization and the underlying mechanism, and discussed the secondary environmental challenges in an irrigation area.

Metformin regulates the LIN28B‑mediated JNK/STAT3 signaling pathway through miR‑140‑3p in subretinal fibrosis.

Subretinal fibrosis (SF) is an important cause of submacular neovascularization that leads to permanent vision loss, but has no effective clinical treatment. The present study examined the influence of metformin on SF, and investigated whether the mechanism involves the microRNA (miR)-140-3p/LIN28B/JNK/STAT3-mediated regulation of oxidative stress, angiogenesis and fibrosis-associated indicators. A mouse model of laser-induced SF was established.

Genome-Wide Identification, Expression and Evolution Analysis of m6A Writers, Readers and Erasers in .

N6-methyladenosine modifications (m6A) is one of the most abundant and prevalent post-transcriptional RNA modifications in plants, playing the crucial role in plant growth and development and stress adaptation. However, the m6A regulatory machinery in , the D genome progenitor of common wheat, is not well understood at present. Here, we systematically identified the m6A-related genes in with a genome-wide search approach.

Natural-human driving factors of groundwater salinization in a long-term irrigation area.

Salinization of groundwater is a major challenge for groundwater management in long-term irrigation areas, decoupling its complex influencing factors can provide insights for the sustainable development of irrigation areas. In this study, the natural-human driving factors of groundwater salinization in the Yinchuan Plain, a typical irrigated area, were identified using isotope analysis, information entropy, and self-organizing map. Results show that groundwater in the study area is seriously salinized with obvious spatial heterogeneity.

The impacts of minimally invasive surgery on intermediate- or high-risk cervical cancer patients received adjuvant radiotherapy.

Background: Adjuvant chemoradiotherapy (CRT) has been shown to reduce the risk of recurrence for patients with risk factors after radical hysterectomy (RH). Early initiated CRT could result in superior oncological outcomes. Here, we aimed to compare the survival outcome of intermediate- or high-risk cervical cancer (CC) patients who, received adjuvant CRT between minimally invasive surgery (MIS) and open surgery.

Insights into an NEk2 inhibitory profile of nitidine chloride by molecular docking and biological evaluation.

Deregulation of NEK2(NIMA-related serine/threonine 2) confers chemotherapeutic resistance to apoptosis and is closely correlated with poor prognosis in hepatocellular carcinoma (HCC). Here, we find that nanoparticles are prepared through hemisynthesis from natural nitidine chloride (NC) with enhanced antitumor activity. Nitidine chloride nanoparticle (TPGS-FA/NC) treatment show good therapy effect in Li-7 hepatocellular carcinoma cells.

A novel nitidine chloride nanoparticle overcomes the stemness of CD133EPCAM Huh7 hepatocellular carcinoma cells for liver cancer therapy.

Background: Stemness of CD133EPCAM hepatocellular carcinoma cells ensures cancer resistance to apoptosis,which is a challenge to current liver cancer treatments. In this study, we evaluated the tumorcidal activity of a novel nanoparticle of nitidine chloride (TPGS-FA/NC, TPGS-FA: folic acid modified D-α-tocopheryl polyethylene glycol 1000 succinate, NC: nitidine chloride), against human hepatocellular carcinoma (HCC) cell line Huh7 growth in vitro and in vivo.

Methods: Huh7 cells were treated with TPGS-FA/NC.

Efficacy and Safety of Recombinant Human Adenovirus Type 5 (H101) in Persistent, Recurrent, or Metastatic Gynecologic Malignancies: A Retrospective Study.

Background: To assess the efficacy and safety of recombinant human adenovirus type 5 (H101) in patients with persistent, recurrent, or metastatic gynecologic malignancies.

Methods: The study retrospectively enrolled patients with persistent/recurrent/metastatic gynecologic malignancies who received H101-containing treatment at The First Affiliated Hospital of Xi'an Jiaotong University from September 1, 2019 to September 30, 2021. H101 was injected intratumorally into target lesions and dosage was calculated based on tumor diameter once a day for five consecutive days.

Characterization of soil salinization and its driving factors in a typical irrigation area of Northwest China.

Salinization of irrigation areas is a global environmental challenge. The uncertainty in the distribution of salinization is increased by the complexity of the natural environment. This study adopted Yinchuan Plain as a typical irrigation area to study the relationship between soil salinity and the environment from the perspective of macro-environmental elements and micro-ion composition.